• FOCUS: LIFE SCIENCE
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• no.1
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• pp.6.1-6.9
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• 2024

The document is a white paper on Hydrophilic Interaction Liquid Chromatography (HILIC) analysis method development. HILIC is a type of chromatography that uses an organic/aqueous mobile phase and a polar stationary phase. In HILIC, water is a strong solvent, and unlike in Reversed Phase Liquid Chromatography (RPLC), increasing the proportion of water in the mobile phase reduces the retention time of the analyte. The paper discusses when to consider HILIC analysis methods, the advantages of HILIC, and the challenges often encountered due to the lack of understanding of HILIC mechanisms compared to RPLC. It also provides a systematic flowchart for intelligent solutions for HILIC analysis method development, which includes a three-step approach for chromatography analysis method development. The first step involves gathering as much information as possible about the analyte (e.g., pKa, log P, log D). The second step involves analyzing the sample under different pH conditions using three HILIC columns in either isocratic or gradient mode to identify the suitable column/pH combination for the analyte. The third step involves optimizing the separation by investigating other parameters such as temperature and ionic strength, and assessing the robustness of the method. The paper emphasizes that the selection of the appropriate stationary/mobile phase combination, based on the differences between the HILIC stationary phases and the mobile phase pH, can provide high selectivity in the analysis. This step-by-step approach can help users develop an efficient analysis method.

• Investigative Magnetic Resonance Imaging
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• v.22 no.1
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• pp.37-49
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• 2018

Purpose: The effect of global inhomogeneity on quantitative susceptibility mapping (QSM) was investigated. A technique referred to as Simultaneous Unwrapping Phase with Error Recovery from inhomogeneity (SUPER) is suggested as a preprocessing to QSM to remove global field inhomogeneity-induced phase by polynomial fitting. Materials and Methods: The effect of global inhomogeneity on QSM was investigated by numerical simulations. Three types of global inhomogeneity were added to the tissue susceptibility phase, and the root mean square error (RMSE) in the susceptibility map was evaluated. In-vivo QSM imaging with volunteers was carried out for 3.0T and 7.0T MRI systems to demonstrate the efficacy of the proposed method. Results: The SUPER technique removed harmonic and non-harmonic global phases. Previously only the harmonic phase was removed by the background phase removal method. The global phase contained a non-harmonic phase due to various experimental and physiological causes, which degraded a susceptibility map. The RMSE in the susceptibility map increased under the influence of global inhomogeneity; while the error was consistent, irrespective of the global inhomogeneity, if the inhomogeneity was corrected by the SUPER technique. In-vivo QSM imaging with volunteers at 3.0T and 7.0T MRI systems showed better definition in small vascular structures and reduced fluctuation and non-uniformity in the frontal lobes, where field inhomogeneity was more severe. Conclusion: Correcting global inhomogeneity using the SUPER technique is an effective way to obtain an accurate susceptibility map on QSM method. Since the susceptibility variations are small quantities in the brain tissue, correction of the inhomogeneity is an essential element for obtaining an accurate QSM.

• 한국전산유체공학회:학술대회논문집
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• 2007.10a
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• pp.249-257
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• 2007

A high resolution numerical method aimed at solving gas-liquid two-phase flow is proposed and applied to gas-liquid two-phase shock tube problem. The present method employs a finite-difference 4th-order Runge-Kutta method and Roe's flux difference splitting approximation with the MUSCL TVD scheme. By applying the homogeneous equilibrium cavitation model, the present density-based numerical method permits simple treatment of the whole gas-liquid two-phase flow field, including wave propagation and large density changes. The speed of sound for gas-liquid two-phase media is derived on the basis of thermodynamic relations and compared with that by eigenvalues. By this method, a Riemann problem for Euler equations of one dimensional shock tube was computed. Numerical results such as detailed observations of shock and expansion wave propagations through the gas-liquid two-phase media and some data related to computational efficiency are made. Comparisons of predicted results and exact solutions are provided and discussed.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.32 no.6
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• pp.429-445
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• 2008

Two-phase compressible flow fields of air-water are investigated numerically in the fixed Eulerian grid framework. The phase interface is captured via volume fractions of each phase. A way to model two phase compressible flows as a single phase one is found based on an equivalent equation of states of Tait's type for a multiphase cell. The equivalent single phase field is discretized using the Roe‘s approximate Riemann solver. Two approaches are tried to suppress the pressure oscillation phenomena at the phase interface, a passive advection of volume fraction and a direct pressure relaxation with the compressible form of volume fraction equation. The direct pressure equalizing method suppresses pressure oscillation successfully and generates sharp discontinuities, transmitting and reflecting acoustic waves naturally at the phase interface. In discretizing the compressible form of volume fraction equation, phase interfaces are geometrically reconstructed to minimize the numerical diffusion of volume fraction and relevant variables. The motion of a projectile in a water-filled tube which is fired by the release of highly pressurized air is simulated presuming the flow field as a two dimensional one, and several design factors affecting the projectile movement are investigated.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.21 no.1
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• pp.125-130
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• 2007

Single-phase is used widely power of field of appliance because can use commercialized power directly without power transform. Specially, because condenser nu-drive style single-phase induction motor efficiency is excellent, and most suitable in embodiment as economical. It is established true that method by crossing self-discipline and method by revolving magnetic field are interpretation of net single-phase induction motor, but method to calculate electric motor inside proper move in existent theory or method is some complex. That arbor in the law of circuit constant that combine equivalent circuit law with numerical analysis law according to development of the latest computer or microprocessor is suggested and does the calculation processing fast and correct. In this paper, measurement wishes to present method that calculate after calculate digital measurement that measures correctly and measures impossible the first and the second leakage reactance and no-load test locked-rotor test, DC test and resistance measurement of stator winding in circuit parameter calculation program that is had for MatLab program individually in single-phase power.

• Nuclear Engineering and Technology
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• v.53 no.4
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• pp.1304-1310
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• 2021

Two-phase flow, especially gas-liquid two-phase flow, has a wide application in industrial field. The diagnosis of two-phase flow parameters, which directly determine the flow and heat transfer characteristics, plays an important role in providing the design reference and ensuring the security of online operation of two-phase flow system. Computer tomography (CT) is a good way to diagnose such parameters with imaging method. This paper has proposed a novel image reconstruction method for thermal neutron CT of two-phase flow with improved simulated annealing (ISA) algorithm, which makes full use of the prior information of two-phase flow and the advantage of stochastic searching algorithm. The reconstruction results demonstrate that its reconstruction accuracy is much higher than that of the reconstruction algorithm based on weighted total difference minimization with soft-threshold filtering (WTDM-STF). The proposed method can also be applied to other types of two-phase flow CT modalities (such as X(𝛄)-ray, capacitance, resistance and ultrasound).

• Proceedings of the KIEE Conference
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• 2008.04c
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• pp.16-18
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• 2008

Several methods are proposed in the literature for losses segregation of single phase induction motor. Generally we could divide two methods for experimental determination of losses segregation for single phase induction motor. The one is relatively complicated method based on Parameter estimation of single phase induction motor. The other is simple method based on IEEE Standard 114. Segregation of losses in single phase induction motor is more complicated than that in three phase induction motor, because of the backward magnetic field component in the motor and multiplicity of different single phase type. In this paper, therefore, we studied losses segregation of capacitor-run single phase induction motor.

• Proceedings of the KIEE Conference
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• 2003.10b
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• pp.125-127
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• 2003

The single phase switched reluctance motor(SRM) is more simpler and robust in the structure than poly phase SRM. It has the merits that it reduces the switching elements and the energy density per volume is very high. Recently, it has been researched and developed in various types and starting method due to the technique of power electronics and the computer added design. The single phase SRM is tried to apply to many industrial appliance field to substitutethe the induction motor by the single phase SRM. On the previous studies, we decided the design parameters of the single phase SRM for the blower driver to adapt the design method of the conventional machine and the poly phase SRM. In this studies, it is proposed the conditions to decide the optimal pole arcs because the stator and rotor pole arcs is very important in the characteristics of the single phase SRM. For this reason, it is analysed the characteristics of current on/off angle vs. pole arc, pole arcs vs. average torque.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.58 no.4
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• pp.795-800
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• 2009

Surface plasmon resonance (SPR) has been widely used for biological and chemical sensing applications. The present study investigates numerically the optical characteristics for the single Au film and bimetallic Ag/Au film SPR configurations by using the multiple beam interference matrix (MBIM) method. We use the prism coupling method, especially Kretschmann configuration for excitation of surface plasmon wave (SPW). The estimated results of reflectance, phase shift and magnetic field intensity enhancement factor are provided for finding out the optimum configuration with high sensitivity for SPR measurement. As a result, the optimum thicknesses are found to be 52 nm for a single Au film and 5 nm to 36 nm for bimetallic Ag-Au film. From the comparison of full width half maximum (FWHM) values for reflectance, phase shift, and enhancement of magnetic field intensity, it is concluded that the highest sensitivity can be obtained when using the phase shift for SPR sensor.

• The Transactions of the Korean Institute of Power Electronics
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• v.23 no.4
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• pp.290-293
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• 2018

This paper proposes a new magnetic resonant wireless power transfer system. Two transmitters are arranged to secure a range wider than the existing one-to-one resonance, thereby enhancing the practicality of the system. Two identical transmission units are arranged to strengthen the magnetic field and to subsequently increase the magnitude and distance of the power transmitted to the reception unit. A constant power can be maintained in a wide range through the phase control of different output powers according to the positions of the transmitting and receiving coils. A constant power can also be obtained by transmitting to the receiver. The experiment results show that the proposed method outperforms the conventional method.