• Aerospace Engineering and Technology
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• v.1 no.2
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• pp.132-140
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• 2002

By utilizing OSMI (Ocean Scanning Multi-spectral Imager) onboard KOMPSAT-1, the moon can be imaged. Because the moon has no atmosphere and reflects sun lights at a constant rate, it can be the radiance source for calibration of OSMI. But there are a lot of risks which made KOMPSAT-1 enter into safe-hold mode. So planning the imaging of the moon with OSMI should be determined seriously with consideration to information on KOMPSAT-1 operation, the moon, the sun, etc. But it takes a long time for determining the imaging time of the moon using MCE(Mission Control Element) simulator and there are operational problems to be solved. In this paper, fast simulator for determining imaging time for the moon with OSMI has been developed. The proper timeline for imaging the moon and the position of the moon image in OSMI image coordinates and the phase of the moon are determined. STK was used for acquiring information on KOMPSAT-1, the moon, the sun and the characteristitcs of OSMI are considered. As a result, we can determine imaging time of the moon with OSMI much faster and efficiently.

• Archives of Pharmacal Research
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• v.29 no.6
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• pp.514-519
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• 2006

A simple HPLC method using UV detection was developed and validated for the determination of levodropropizine (LDP) In dog plasma. The sample was prepared for injection using a liquid-liquid extraction method with 1-phenypiperazine as the internal standard. The mobile phase was methanol - diethylamine solution (0.05 M) (20:80, v/v, pH adjusted to 3.0 with $H_3PO_4$) with a detection wavelength of 240 nm. The limit of quantitation (LOQ) of LDP in a biological matrix was determined to be 25.25 ng/mL. The calibration curve was linear across the concentration range of 25.25 to 2020 ng/mL. The intra-day and inter-day precision values (CV%) were within 7% and accuracy (R.E. %) was within 6% of the nominal values for medium (252.5 ng/mL) and high (2020 ng/mL) LDP concentrations. For the LDP concentration at the LOQ, the intra-day and inter-day precision and accuracy were within 20% and 10%, respectively. The average absolute recovery for LDP was 70.28%. This method was successfully used to analyze plasma samples in a steady-state bioavailability study of a newly developed sustained-release LDP tablets (SR) using immediate-release tablets (IR) as the reference. The relative bioavailability of the SR was determined to be $106.3\;{\pm}\;12.8%$ (n=6). The $C_{max}$ of the SR was significantly lower (p<0.05), and the $t_{max}$ was significantly longer than that of the IR (p<0.05). The results of ANOVA and two one-sided tests indicated that the SR exhibited acceptable sustained release properties and was bioequivalent to the IR.

• Archives of Pharmacal Research
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• v.19 no.6
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• pp.529-534
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• 1996

A high-performance liquid chromatographic (HPLC) assay has been developed for the determination of ketorolac in human serum using a new extraction method with a good recovery. Human serum samples (1.0 ml) spiked with known concentrations of ketorolac tromethamine and 10${\mu}g$ of ketoprofen as the internal standard (IS) were acidified with 200${\mu}l$ of 1 N HCl and extracted with 7 ml of n-hexane-ether (7:3 v/v). Extracts were centrifuged and organic layer was back-extracted with 400${\mu}l$ of 0.1% tromethamine solution. Twenty .mu.l of centrifuged aqueous layer was injected onto a reversed-phase octyl column and eluted with a mixture of acetonitrile, water, methanol, and triethylamine [35:55:10:0.1 (v/v), pH 3.0] at a flow rate of 1.0 ml/min. Ultraviolet detection of ketorolac and IS was carried out at 300 nm. The calibration curve obtained using peak area ratios showed a good linearity (in concentration range 10-150 ng/ml $r^2$=O.9944; in range 50-2000 ng/ml, r$^{2}$=0.9998). The mean intra-day accuracy and precision for this HPLC method were found to be 3.6 and 3.7%, respectively. The mean inter-day accuracy and precision were found to be 4.0 and 3.7%, respectively, in the concentration range 50-2000 ng/ml. The recovery of ketorolac from serum was 92.0 $({\pm}5.7)$ % at the concentration of 100 ng/ml. This method proved to be readily applicable to the assay of ketorolac in human serum.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• v.2
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• pp.83-88
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• 2006

Many applications in the area of location-based services and personal navigation require nowadays the location determination of a user not only in outdoor environment but also indoor. To locate a person or object in a building, systems that use either infrared, ultrasonic or radio signals, and visible light for optical tracking have been developed. The use of WiFi for location determination has the advantage that no transmitters or receivers have to be installed in the building like in the case of infrared and ultrasonic based location systems. WiFi positioning technology adopts IEEE802.11x standard, by observing the radio signals from access points installed inside a building. These access points can be found nowadays in our daily environment, e.g. in many office buildings, public spaces and in urban areas. The principle of operation of location determination using WiFi signals is based on the measurement of the signal strengths to the surrounding available access points at a mobile terminal (e.g. PDA, notebook PC). An estimate of the location of the terminal is then obtained on the basis of these measurements and a signal propagation model inside the building. The signal propagation model can be obtained using simulations or with prior calibration measurements at known locations in an offline phase. The most common location determination approach is based on signal propagation patterns, namely WiFi fingerprinting. In this paper the underlying technology is briefly reviewed followed by an investigation of two WiFi positioning systems. Testing of the system is performed in two localization test beds, one at the Vienna University of Technology and the second at the Hong Kong Polytechnic University. First test showed that the trajectory of a moving user could be obtained with a standard deviation of about ${\pm}$ 3 m.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2010.05a
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• pp.512-515
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• 2010

SIGINT(SIGnal INTelligence) includes several parameters intercepted by measurement and analysis of the RF(Radio frequency) signal from free space. One of the important parameters is frequency information. Expecially, in order to perform instantaneous frequency measurement of Radar and Missile seeker's RF signals, we use dedicated RF modules as a DFD(Digital Frequency Discriminator) to provide frequency information by measurement of the relative phase difference between signals via intended RF delay lines. It must measure and provide realtime based frequency information on short pulsed RF signal up to 100 nSec or less. This document proposes Ultra wideband DFD consisted of a RF input section of Wideband 4 channel RF delay line and correlator, a digital processing section to measure and provide frequency information from I/Q signal, and a frequency calibration section. Also, it will show design suitability based on test results measured under test condition of very short input pulse signals.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.18 no.10
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• pp.2417-2426
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• 2014

Remote gaze tracking system calculates the gaze from captured images that reflect infra-red LEDs in cornea. Glint is the point that reflect infra-red LEDs to cornea. Recently, remote gaze tracking system uses a number of IR-LEDs to make the system less prone to head movement and eliminate calibration procedure. However, in some cases, some of glints are unable to spot. In this case, it is impossible to calculate gaze. This study examines patterns of glints that are difficult to detect in remote gaze tracking system. Afterward, we propose an algorithm to reconstruct positions of missing glints that are difficult to detect using other detected glints. Based on this algorithm, we increased the number of valid image frames in gaze tracking experiments, and reduce errors of gaze tracking results by correcting glint's distortion in the reconstruction phase.

• Korean Journal of Pharmacognosy
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• v.46 no.2
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• pp.160-166
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• 2015

Yijung-tang (YJT) is a traditional herbal formula comprising 4 medicinal herbs. In the present study, we performed the simultaneous analysis for three compounds of YJT and examined anti-allergic effects in vitro. The column for separation of three compounds was used Gemini C18 column and maintained at 40$^{\circ}C$. The mobile phase for gradient elution consisted of two solvent systems. To evaluate Th2 chemokines, YJT was treated into tumor necrosis factor (TNF)-${\alpha}$ and interferon (IFN)-${\gamma}$-stimulated HaCaT cells, and performed ELISA for thymus and activation regulated chemokine (TARC) and regulated on activation, normal T-cell expressed and secreted (RANTES). To measure Th2 cytokines, YJT was added into primary mouse splenocytes, and performed ELISA for interleukin (IL)-4, 5, 13. Calibration curves were acquired with r² >0.9999. The contents of liquiritin, glycyrrhizin, and 6-gingerol in YJT were 4.50 mg/g, 11.10 mg/g, and 1.33 mg/g, respectively. YJT inhibited production of TARC and RANTES in TNF-${\alpha}$ and IFN-${\gamma}$-treated HaCaT cells. YJT also reduced production of IL-4, 5, and 13 in primary mouse splenocytes. In conclusion, our data will be a valuable information to improve quality control and anti-allergic effects of YJT.

• Natural Product Sciences
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• v.16 no.2
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• pp.116-122
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• 2010

A high-performance liquid chromatography (HPLC) with diode array detector (DAD) and electrospray ionization mass spectrometry (ESI-MS) was established for the simultaneous determination of five representative metabolites of the iridoid and phenolic classes from Rehmannia glutinosa. The optimal chromatographic conditions were obtained on an ODS column (5 mm, $4.6{\times}250\;mm$) with the column temperature at $25^{\circ}C$. The mobile phase was composed of water and acetonitrile using a gradient elution with the flow rate 0.3 mL/min. Detection wavelength was set at 205 nm. All calibration curves showed good linear regression ($r^2$ > 0.997) within test ranges. Limits of detection (LOD) and quantitation (LOQ) values were lower than 0.123 and $0.373\;{\mu}g/mL$, respectively. The developed method provided satisfactory precision and accuracy with overall intra-day and inter-day variations of 0.09 - 0.76% and 0.16 - 1.41%, respectively, and the overall recoveries of 99.03 - 102.67% for all of the compounds analyzed. In addition, effectiveness of diverse extraction methods was compared to each other for the development of standard analytic method. The verified method was successfully applied to the quantitative determination of five representative metabolites in twenty-one commercial Rehmannia glutinosa samples from different markets in Korea and China. The analytical results showed that the contents of the five analytes vary significantly with sources.

• YAKHAK HOEJI
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• v.48 no.3
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• pp.207-212
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• 2004

An analytic method was developed for the quantitation of $\Delta$$^{9}-$ tetrahydrocannabinol (THC) and 11-nor-9-carboxy THC (THC-COOH) in human hair. After hair samples were pulverized using Freezer Mill, deuterated internal standards were added and digested in 1 N NaOH at $100^{\circ}C$ water bath for 30 min. Digest solutions were extracted by 5 ml hexane：ethyl acetate (90：10) after acidification with acetic acid. The organic phase was evaporated under N 2 and derivatized by BSTFA (with 1% TMCS) at $85^{\circ}C$ for 45 min. The derivatized solution was separated on HP-5MS column ($30m{\times}0.25mm{\times}0.25mm$) and detected using EI-GC-MS with selective ion monitoring mode. The assay of calibration was ranged from 5 to 100 ng/50 mg hair ($r^2$＞0.99) for THC and THC-COOH. Within and between-run precision were calculated at 6, 30, 60 ng/50 mg hair with coefficients of variation less than 11%. Within and between run accuracies at the same concentrations were$\pm$14% and $\pm$30% of target for both analytes, respectively. Absolute and relative recovery at 10 and 100 ng were 60∼91％. The method was used to detect and quantify THC and THC-COOH in cannabis abuser's hairs (N = 16) and SRM (N=5, THC 1 ng/mg, NIST). We detected THC and THC-COOH in only one hair sample. In SRM, % accuracy was 93% (range 86∼103%) and precision (% CV) was 8.14. We began to set up a quantitative analysis of THC and THC-COOH using EI-GC-MS. Continuously, we need to modify and develop this method in order to apply for identification in cannanbis users' hair.

• Journal of the Mineralogical Society of Korea
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• v.31 no.4
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• pp.277-285
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• 2018

Azurite ($Cu_3(CO_3)_2(OH)_2$) was compressed up to 21.52 GPa for its behaviors at ambient temperature. High pressure experiment was performed using the symmetrical diamond anvil cell employed in the angle dispersive X-ray diffraction method. Pressure was determined by ruby fluorescence calibration method. No phase transitions were observed within the present pressure limit and bulk modulus was determined to be 54.4 GPa when ${K_0}^{\prime}$ is fixed to be 4. Applying the normalized pressure-strain analysis, reliability of the azurite compression pattern was checked.