• Proceedings of the PSK Conference
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• 2002.10a
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• pp.367.2-367.2
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• 2002

Cnidium Rhizome is a frequently prescribed herbal medicine in Korea, Japan as well as China, which has been successfully used in these countries for the treatment of diseases related to. gynecology, blood circulations and dental troublers in the name of 천궁. And it is circulated as the same chinese character, which is 천궁, although original plants are different as Cnidium officinale in pharmacopoeia of Korea or Japan and Ligusticum chuanxiong Hort. In that of China. (omitted)

• Proceedings of the PSK Conference
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• 2002.10a
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• pp.418.2-418.2
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• 2002

With the Sunshine policy. exchange of goods and cultures inter Koreas is broaden and expectancy of reunification is getting higher. Especially. medical supplies and medicines is one of the biggest parts in the exchanges. So. need for preparing new medical administration system for reunification is needed. We are going to compare inter Koreas drug administration system in medical services. (omitted)

• Proceedings of the PSK Conference
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• 2003.04a
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• pp.283.1-283.1
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• 2003

This study was designed to develop and validate an isocratic reversed phase high performance liquid chromatographic(HPLC) method for the quantitation of sobrerol in drug preparations, and obtain the data pool that can be used in the revision of pharmacopoeia. The separation of sobrerol and the other compounds (S-carboxymethylcysteine, acetaminophen, methyl paraben, propyl paraben, and sobrerol degradants) was achieved in a C18 column with an acetonitrile-methanol-water(24.5:10.5:65.0) mobile phase. (omitted)

• The Journal of Korean Medicine
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• v.36 no.4
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• pp.56-68
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• 2015

Objectives: This study investigated quality among three herb medicine extract granules(DSGOST) which were made from different companies to check quality control of herb medicine extract granules. Methods: we selected three DSGOST extract granules which were made from different companies. And we experimented extract granules by method from K.P(Korean Pharmacopoeia), K.H.P(Korean Herbal Pharmacopoeia) of KFDA. Results: In qualitative analysis of DSGOST, we indentified Akebiae Caulis (木通), Asari Herba Cum Radix (細辛), Evodiae Fructus (吳茱萸) in three different DSGOST extract granules. In quantitative analysis of DSGOST, Medication A,B,C contained similar content of Paeoniflorin & Glycyrrhizic acid. However Medication B contains especially lowest value of Cinnamic acid & total Decursin. Conclusions: Herb medicine extract granules have different contents of ingredients although those were made by same prescription. And these differences may influence medicinal effect to patients. So we need to make system of quality control with various research of quantitative & qualitative analysis about herb medicine extract granules.

• Korean Journal of Plant Resources
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• v.30 no.1
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• pp.58-77
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• 2017

This study was carried out to investigate the vascular plants of Mt. Nochu (1,322m) from April, 2014 to October, 2015. The vascular plants were summarized as 515 taxa, including 89 families, 304 genera, 448 species, 4 subspecies, 57 varieties and 6 forms. Among the investigated 515 taxa, 11 Korean endemic plants and 14 rare and endangered plants were included. The floristic regional indicator plants found in this area were 11 taxa of grade IV, 30 taxa of grade III. Naturalized plants consisted of 24 taxa that made up 4.6% of the total vascular plants in this area. Medicinal plants of the Korean Pharmacopoeia and Korean Herbal Pharmacopoeia distributed in this area consisted of 67 taxa.

• YAKHAK HOEJI
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• v.57 no.4
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• pp.258-264
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• 2013

Herbal medicine has been traditionally used in Asian countries for a long time. Many pharmacological effects are identified in the herbs and these herbs are believed to be safe for human. However, the safety or adverse effect of some traditional herbal medicines has not been established. We have chosen Cyperi rhizoma based on the Korea Herbal Pharmacopoeia and which have been widely used for an anti-inflammatory effect in Korea. The object of the study was to evaluate safety of Cyperi rhizoma in rats. The aqueous extract of Cyperi rhizoma was prepared according to the standard hot water extraction method of the Korea Pharmacopoeia. In the sub-chronic study, the aqueous extract of Cyperi rhizoma was orally administered once daily as 0, 125, 250, 500, 1000 and 2000 mg/kg/day to male and female F344 rats for 13 weeks. There were no treatment related abnormalities in mortality, clinical signs, food consumption, ophthalmologic examination, hematology, serum chemistry, urinalysis, gross observation, organ weight and histopathologic examination. In conclusion, The NOAEL (No Observed Adverse Effect Level) for Cyperi rhizoma aqueous extract was determined as more than 2000 mg/kg/day in the present experimental condition.

• Korean Journal of Plant Resources
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• v.28 no.2
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• pp.178-192
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• 2015

This study was carried out to investigate the vascular plants of Neunggyeong-bong, Gangwond-do, South Korea. The vascular plants that were collected 7 times from 2008 and 2013 consisted a total of 440 taxa; 75 families, 261 genera, 383 species, 4 subspecies, 48 varieties and 5 forms. Among them, 15 taxa of Korean endemic plants and 11 taxa of rare and endangered plants were included. The floristic regional indicator plants found in this area were 11 taxa of grade IV, 22 taxa of grade III. Naturalized plants consisted of 29 taxa that made up 6.6% of the total vascular plants in this area. Medicinal plants of the Korean Pharmacopoeia and Korean Herbal Pharmacopoeia distributed in this area consisted of 60 taxa.

• Journal of Ginseng Culture
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• v.6
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• pp.80-104
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• 2024

Ginseng, a representative medicinal plant of South Korea, is also highly valued in North Korea. However, due to limited access to information about North Korea, the actual cultivation, research and development trends, and related industry status of ginseng in North Korea are not well known. In this study, we aimed to understand the current status and research trends of the ginseng industry in North Korea based on limited available literature. In the North Korean pharmacopoeia, ginseng is referred to as "Koryo ginseng" and is defined as the roots of 6-year-old ginseng cultivated in the Kaesong region. The pharmacopoeia includes 22 types of ginseng preparations. In addition, 10 ginseng preparations are included in North Korea's Essential Drug List, and various health supplements, cosmetics, and toothpastes containing ginseng have been developed, distributed, and sold. Since 2014, the ginseng industry and research in North Korea have become more active overall. During this period, the ginseng cultivation area in Kaesong has been significantly expanded, and the facilities have been renovated. The Kaesong Koryo Ginseng Processing Plant has been equipped with sterilized, modernized facilities since 2016 and has been in operation. Since 2017, there has been a growing interest in quality control research, leading to the introduction of quality management regulations and certification systems in 2019. In the 1990s, there was significant research on ginseng product development, and since the 2000s, studies on the pharmacological effects and clinical research of ginseng have been reported. Additionally, research on ginseng cultivation and ginseng processing industries to increase yield has been emphasized. Ginseng, as a representative medicinal crop of Korea, holds great importance for both South and North Korea. Given its significance and the potential for synergy through mutual cooperation, ginseng serves as an ideal subject for inter-Korean exchange and collaboration.

• Bulletin of the Korean Chemical Society
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• v.29 no.6
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• pp.1185-1189
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• 2008

Two HPLC methods such as cefadroxil and cefalexin methods were compared in their performance for the quantitative analysis of the content and purity of $\beta$ -lactamic antibiotic, cefradine, for six bulk drug samples. Between the two methods, the cefadroxil method prescribed by the European Pharmacopoeia (EP) for the determination of impurities in cefradoxil was superior to the cefalexin method prescribed by the EP and by the United States Pharmacopeia (USP) for the determination of cefalexin impurity in cefradine in terms of the greater stability of the chromatogram baselines and the higher precision, i.e., the lower % relative standard deviation (RSD). Based on the comparison of the two HPLC methods, the cefadroxil method was recommended to replace the TLC method, which has been prescribed by the EP as the official method for determination of extraneous impurities in cefradine.

• KSBB Journal
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• v.29 no.5
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• pp.361-371
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• 2014

Mycoplasma is well recognized as one of the most prevalent and serious microbial contaminants of biologic manufacturing processes. Conventional methods for mycoplasma testing, direct culture method and indirect indicator cell culture method, are lengthy, costly and less sensitive to noncultivable species. In this report, we describe a new TaqMan probe-based real-time PCR method for rapid and quantitative detection of mycoplasma contamination during manufacture of biologics. Universal mycoplasma primers were used for mycoplasma PCR and mycoplasma DNA was quantified by use of a specific TaqMan probe. Specificity, sensitivity, and robustness of the real-time PCR method was validated according to the European Pharmacopoeia. The validation results met required criteria to justify its use as a replacement for the culture method. The established real-time PCR assay was successfully applied to the detection of mycoplasma from human keratinocyte and mesenchymal stem cell as well as Vero cell lines artificially infected with mycoplasma. The overall results indicated that this rapid, specific, sensitive, and robust assay can be reliably used for quantitative detection of mycoplasma contamination during manufacture of biologics.