• Journal of Korean Society of Industrial and Systems Engineering
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• v.33 no.1
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• pp.1-9
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• 2010

Quality design methodologies have received constituent attention from a number of researchers and practitioners for more than twenty years. Specially, the quality design for drug products must be carefully considered because of the hazards involved in the pharmaceutical industry. Conventional pharmaceutical formulation design problems with mixture experiments have been typically studied under the assumption of an unconstrained experimental region with a single quality characteristic. However, real-world pharmaceutical industrial situations have many physical limitations. We are often faced with multiple quality characteristics with constrained experimental regions. ln order to address these issues, the main objective of this paper is to propose a robust desirability function (RDF) model using a desirability function (DF) and mean square error (MSE) to simultaneously consider a number of multiple quality characteristics. This paper then present L-pseudocomponents and U-pseudocomponents to handle physical constraints. Finally, a numerical example shows that the proposed RDF can efficiently be applied to a pharmaceutical process design.

• Journal of Korea Society of Industrial Information Systems
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• v.29 no.2
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• pp.133-151
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• 2024

The purpose of this study is to analyze the core values of Donghwa Pharmaceutical, which has been in the pharmaceutical industry in South Korea for 126 years, and examine the core competencies that have consistently enabled it to maintain a competitive advantage. When applying the VRIO Framework, various general pharmaceuticals, including Donghwa Pharmaceutical's 'Hwalmyeongsoo,' which has maintained the top position in the liquid digestive medicine market for 126 years, are identified as powerful resources (Value) that generate 'sustained competitive advantage.' The principles of ethical management based on the Donghwa spirit, the long-standing principles of trust and belief, and the entrepreneurial spirit possess rarity. Having won four Guinness World Records and holding numerous new drug patents, Donghwa Pharmaceutical has consistently secured the top position in the digestive medicine category of the Korean Industrial Brand Power for 19 consecutive years. The company has been designated as a 'Golden Brand,' and its products have high levels of awareness, making them highly difficult to imitate. Lastly, the organization is structured to efficiently utilize resources such as a transparent hierarchical system, fair personnel management, diverse training programs, and high employee welfare and salaries. This study systematically analyzes the core values of Donghwa Pharmaceutical from a managerial perspective and proposes directions for the company to evolve into a long-lasting enterprise. The research outcomes will provide valuable insights for formulating long-term management strategies.

• Health Policy and Management
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• v.21 no.1
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• pp.132-157
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• 2011

The purpose of this article is to examine the cause of policy non-compliance in the case of pharmaceutical rebates from the perspective of rational choice institutionalism. In Korea, there have been rebates practices between pharmaceutical companies and hospitals since the introduction of the Actual Remuneration System for insured medicine in 1999. The government has chosen the policy means of punishment to eliminate pharmaceutical rebates but the illegal practices are still widespread. Institution in rational choice institutionalism usually reflects the incentives and preferences of actors, and the Actual Remuneration System has resulted in a the lack of procedures to ensure savings on drug expenditures. Pharmaceutical rebates are the product of the institutions which reflect their incentives: the Actual Remuneration System, the current pricing policy for generic drugs, the drug distribution system, and so on. In the end, the problem of the rebates is the consequence of policy non-compliance as actors' rational choice because their incentives lead to opportunistic behaviors. We should therefore understand the incentive structure of policy stakeholders, which is derived from the view of new institutionalism; also, the newly designed Korean drug pricing policy reform must be compatible with the incentive structure.

• Natural Product Sciences
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• v.26 no.3
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• pp.236-243
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• 2020

Salvia plebeia R. Br. is a plant which has been used as an edible crop and traditional medicine in Asian countries. In this study, HPLC-PDA analysis and countercurrent chromatography (CCC) coupled with reversed-phase (RP) HPLC method were applied to isolate ten isolates from 3.3 g of n-butanol soluble extract from hot-water extract of S. plebeia. The use of CCC enabled us to efficiently fractionate the starting material with less sample loss and facilitate the isolation of compounds from S. plebeia extract using RP-HPLC. The isolates were determined to be caffeic acid (1), 6-hydroxyluteolin 7-O-β-D-glucoside (2), eudebeiolide B (3), (R)-rosmarinic acid (4), homoplantaginin (5), eudebeiolide D (6), plebeiolide C (7), salpleflavone (8), eupafolin (9) and hispidulin (10) based on the spectroscopic evidence.

• Journal of Distribution Science
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• v.18 no.8
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• pp.55-64
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• 2020

Purpose: This paper addresses issues that concern business-to-business marketing, namely informational justice in the supply chain or organizations. As previously reported by other studies, there is information asymmetry in organizations. The present study explores and addresses this in the medical industry, aiming to investigate how informational justice relates to information quality or logistics performance in the medical industry. This study also suggests a method for development of informational justice in medicine-related fields. Design, methodology, approach: The hypothesis and model were developed through a review of the literature. To this end, we surveyed 293 valid survey samples collected from occupational pharmacists and used structural equation modelling for analysis. Findings: The results of the empirical analysis of the hypotheses showed that symmetric sharing of information between pharmacists and employees of pharmaceutical companies has a positive effect on the perceived quality. Moreover, the results showed that quality information has a positive impact on logistics performance, whereas informational justice does not. Conclusions, implications: If information and explanations are exchanged fairly, information and logistics performance-as well as operational expenses-will be enhanced. Furthermore, our study has immense implications outside of academic applications since it suggests practical solutions to government and medical industry employees.

• The Journal of Asian Finance, Economics and Business
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• v.7 no.2
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• pp.119-129
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• 2020

The main purpose of this study is to examine the impact of intellectual capital disclosure (ICD) on firm performance in the pharmaceutical and chemical industry of Bangladesh. In this study, 21 listed pharmaceutical and chemical companies have been selected as sample for 2016 and 2017. This study used the intellectual capital disclosure index developed by Rahman, Sobhan, and Islam. Return on assets and return on equity have been used as the proxy variable of firm performance. In this study, content analysis is performed to assess the level of disclosure regarding intellectual capital and pooled cross-sectional analysis is used to assess the relationship between ICD and firm performance. The study has found a positive and significant relationship between ICD and firm performance. Besides, an in-depth analysis of this study shows that all the components of ICD namely internal capital disclosure, external capital disclosure, and human capital disclosure are also positively and significantly associated with firm performance. The study suggests the development of an intellectual capital disclosure framework by the regulatory authority for mandatory compliance. This will improve the quality and quantity of ICD in the annual reports. Besides, firms should more emphasize on ICD which will help to improve their performance.

• The Journal of Economics, Marketing and Management
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• v.11 no.1
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• pp.31-44
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• 2023

Purpose: This study aims to figure out the characteristics of corporate life cycle and resource input in terms of the sustainability diagnosis of pharmaceutical companies in Korea. Research design, data, and methodology: Using the Gompertz model under the assumption that companies have finite resources, this study tries quantitative interpretation of life cycle and resource input pattern for longevity companies with 25 years of experience among 158 pharmaceutical companies listed on Korean stock market based on maturity of revenue. Results: The study found revenue maturity through Gompertz model was statistically correlated with enterprise value. According to the life cycle analysis, more than 95% of 59 pharmaceutical companies were in the growth and maturity phase and have an average life cycle of 88 years and an average remaining life of 52 years. Regarding maturity profile of resource input, maturity of employees was generally high more than 60% and this meant there was jobless growth in Korean pharmaceutical industry. Conclusion: This study demonstrated there is a high statistical correlation between the maturity of a company's resource input and its revenue and enterprise value. It is believed that these results could be utilized as a basis for high fidelity function that predict revenue and enterprise value based on resource input information.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.15 no.5
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• pp.1630-1648
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• 2021

Owing to the unprecedented COVID-19 pandemic, the pharmaceutical industry has attracted considerable attention, spurred by the widespread expectation of vaccine development. In this study, we collect relevant topics from news articles related to COVID-19 and explore their links with two South Korean pharmaceutical indices, the Drug and Medicine index of the Korea Composite Stock Price Index (KOSPI) and the Korean Securities Dealers Automated Quotations (KOSDAQ) Pharmaceutical index. We use generalized Dirichlet-multinomial regression (g-DMR) to reveal the dynamic topic distributions over metadata of index values. The results of our analysis, obtained using g-DMR, reveal that a greater focus on specific news topics has a significant relationship with fluctuations in the indices. We also provide practical and theoretical implications based on this analysis.

• Journal of Life Science
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• v.20 no.12
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• pp.1807-1811
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• 2010

In order to evaluate estrogenic compounds in brown algae, an in vitro test system for the verification of estrogenic activity was applied. Fractions from ethanol extracts of each brown alga were prepared by a systematic fractionation procedure with solvents such as $H_2O$, hexane, butanol and methanol. Aqueous fractions of brown algae showed the highest estrogenic activities. Estrogenic activities of $500\;{\mu}g/ml$ aqueous fractions of Undaria pinnatifida and Laminaria japonica showed almost the same strength as that of $10^{-7}\;M$ standard solution ($17{\beta}$-estradiol). Furthermore, estrogenic activities of $500\;{\mu}g/ml$ aqueous fractions of Ecklonia stolonifera and Porphyra suborbiculate represented higher activities than that of $10^{-8}\;M$ $17{\beta}$-estradiol. These observations suggest that aqueous fractions of all these brown algae are expected to possess estrogenic compounds and could be developed as estrogenic agents for postmenopausal disorder.

• The Journal of the Korea Contents Association
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• v.21 no.11
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• pp.361-374
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• 2021

The purpose of this study is to analyze the efficiency and productivity of technological innovation activities of companies certified as innovative pharmaceutical companies by the government to diagnose their competitiveness and derive measures to strengthen them. This study collected pharmaceutical input (R&D expenditures and number of employees) and output (sale, operating profit and patent) data between 2017 and 2019 for 38 innovative pharmaceutical companies. This study analyzed them using the data envelopment analysis (DEA) method, Tobit model and the Malmquist Productivity Index (MPI). First, the DEA result of the innovative pharmaceutical companies show that between the value of the CCR model of the scale efficiency and the value of the BCC model to diagnose the internal operation efficiency is differences. Second, efficiency does not differ between corporate characteristics. Third, Tobit model shows that number of patents held have positive effects on efficiency. Forth, overall MPI is 0.89. This can be interpreted as the rate of TECI decreased 3%p and TCI has increased 4%p. The results of this study can be used as decision-making data for response strategies to improve efficiency by identifying the cause of inefficiency and presenting target values.