• 산업경영시스템학회지
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• 제33권1호
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• pp.1-9
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• 2010

Quality design methodologies have received constituent attention from a number of researchers and practitioners for more than twenty years. Specially, the quality design for drug products must be carefully considered because of the hazards involved in the pharmaceutical industry. Conventional pharmaceutical formulation design problems with mixture experiments have been typically studied under the assumption of an unconstrained experimental region with a single quality characteristic. However, real-world pharmaceutical industrial situations have many physical limitations. We are often faced with multiple quality characteristics with constrained experimental regions. ln order to address these issues, the main objective of this paper is to propose a robust desirability function (RDF) model using a desirability function (DF) and mean square error (MSE) to simultaneously consider a number of multiple quality characteristics. This paper then present L-pseudocomponents and U-pseudocomponents to handle physical constraints. Finally, a numerical example shows that the proposed RDF can efficiently be applied to a pharmaceutical process design.

• 한국산업정보학회논문지
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• 제29권2호
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• pp.133-151
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• 2024

본 연구는 126년간 제약업을 이어온 동화약품의 핵심가치를 분석하고 꾸준히 경쟁우위를 가질 수 있었던 핵심역량을 살펴보는 것을 목적으로 한다. VRIO Framework을 적용했을 때 126년간 액상형 소화제 시장에서 1위를 지키고 있는 동화약품의 '활명수'를 비롯한 다양한 일반의약품은 '지속적 경쟁우위'를 발생시키는 강력한 자원(Value)이다. 동화정신을 바탕으로 지켜온 원칙경영과 오랜 시간 굳건히 지켜온 믿음, 신뢰 그리고 기업가 정신은 희소성(Rarity)을 가진다. 기네스북 4관왕을 비롯한 다수의 신약 특허를 보유하고 있으며, '한국산업 브랜드파워' 소화제 부문 19년 연속 1위를 차지하며 '골든 브랜드'에 선정되었을 뿐 아니라 다수의 제품이 소비자에게 인지도가 매우 높은 점 등은 모방불가능성(Imitability)이 높다고 할 수 있다. 마지막으로 명확한 직급체계, 공정한 인사고가, 다양한 교육훈련, 높은 수준의 직원복지와 연봉 등 자원을 효율적으로 활용할 수 있도록 조직(Organization)되어 있다. 본 연구는 동화약품의 경영적 측면에서 핵심가치를 체계적으로 분석하였으며 더불어 장수기업으로 나아가기 위한 방향을 제시하였다. 이러한 연구결과는 장기적인 경영전략 수립 시 유용한 시사점을 제공할 것으로 기대한다.

• 보건행정학회지
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• 제21권1호
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• pp.132-157
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• 2011

The purpose of this article is to examine the cause of policy non-compliance in the case of pharmaceutical rebates from the perspective of rational choice institutionalism. In Korea, there have been rebates practices between pharmaceutical companies and hospitals since the introduction of the Actual Remuneration System for insured medicine in 1999. The government has chosen the policy means of punishment to eliminate pharmaceutical rebates but the illegal practices are still widespread. Institution in rational choice institutionalism usually reflects the incentives and preferences of actors, and the Actual Remuneration System has resulted in a the lack of procedures to ensure savings on drug expenditures. Pharmaceutical rebates are the product of the institutions which reflect their incentives: the Actual Remuneration System, the current pricing policy for generic drugs, the drug distribution system, and so on. In the end, the problem of the rebates is the consequence of policy non-compliance as actors' rational choice because their incentives lead to opportunistic behaviors. We should therefore understand the incentive structure of policy stakeholders, which is derived from the view of new institutionalism; also, the newly designed Korean drug pricing policy reform must be compatible with the incentive structure.

• Natural Product Sciences
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• 제26권3호
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• pp.236-243
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• 2020

Salvia plebeia R. Br. is a plant which has been used as an edible crop and traditional medicine in Asian countries. In this study, HPLC-PDA analysis and countercurrent chromatography (CCC) coupled with reversed-phase (RP) HPLC method were applied to isolate ten isolates from 3.3 g of n-butanol soluble extract from hot-water extract of S. plebeia. The use of CCC enabled us to efficiently fractionate the starting material with less sample loss and facilitate the isolation of compounds from S. plebeia extract using RP-HPLC. The isolates were determined to be caffeic acid (1), 6-hydroxyluteolin 7-O-β-D-glucoside (2), eudebeiolide B (3), (R)-rosmarinic acid (4), homoplantaginin (5), eudebeiolide D (6), plebeiolide C (7), salpleflavone (8), eupafolin (9) and hispidulin (10) based on the spectroscopic evidence.

• 유통과학연구
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• 제18권8호
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• pp.55-64
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• 2020

Purpose: This paper addresses issues that concern business-to-business marketing, namely informational justice in the supply chain or organizations. As previously reported by other studies, there is information asymmetry in organizations. The present study explores and addresses this in the medical industry, aiming to investigate how informational justice relates to information quality or logistics performance in the medical industry. This study also suggests a method for development of informational justice in medicine-related fields. Design, methodology, approach: The hypothesis and model were developed through a review of the literature. To this end, we surveyed 293 valid survey samples collected from occupational pharmacists and used structural equation modelling for analysis. Findings: The results of the empirical analysis of the hypotheses showed that symmetric sharing of information between pharmacists and employees of pharmaceutical companies has a positive effect on the perceived quality. Moreover, the results showed that quality information has a positive impact on logistics performance, whereas informational justice does not. Conclusions, implications: If information and explanations are exchanged fairly, information and logistics performance-as well as operational expenses-will be enhanced. Furthermore, our study has immense implications outside of academic applications since it suggests practical solutions to government and medical industry employees.

• The Journal of Asian Finance, Economics and Business
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• 제7권2호
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• pp.119-129
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• 2020

The main purpose of this study is to examine the impact of intellectual capital disclosure (ICD) on firm performance in the pharmaceutical and chemical industry of Bangladesh. In this study, 21 listed pharmaceutical and chemical companies have been selected as sample for 2016 and 2017. This study used the intellectual capital disclosure index developed by Rahman, Sobhan, and Islam. Return on assets and return on equity have been used as the proxy variable of firm performance. In this study, content analysis is performed to assess the level of disclosure regarding intellectual capital and pooled cross-sectional analysis is used to assess the relationship between ICD and firm performance. The study has found a positive and significant relationship between ICD and firm performance. Besides, an in-depth analysis of this study shows that all the components of ICD namely internal capital disclosure, external capital disclosure, and human capital disclosure are also positively and significantly associated with firm performance. The study suggests the development of an intellectual capital disclosure framework by the regulatory authority for mandatory compliance. This will improve the quality and quantity of ICD in the annual reports. Besides, firms should more emphasize on ICD which will help to improve their performance.

• 융합경영연구
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• 제11권1호
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• pp.31-44
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• 2023

Purpose: This study aims to figure out the characteristics of corporate life cycle and resource input in terms of the sustainability diagnosis of pharmaceutical companies in Korea. Research design, data, and methodology: Using the Gompertz model under the assumption that companies have finite resources, this study tries quantitative interpretation of life cycle and resource input pattern for longevity companies with 25 years of experience among 158 pharmaceutical companies listed on Korean stock market based on maturity of revenue. Results: The study found revenue maturity through Gompertz model was statistically correlated with enterprise value. According to the life cycle analysis, more than 95% of 59 pharmaceutical companies were in the growth and maturity phase and have an average life cycle of 88 years and an average remaining life of 52 years. Regarding maturity profile of resource input, maturity of employees was generally high more than 60% and this meant there was jobless growth in Korean pharmaceutical industry. Conclusion: This study demonstrated there is a high statistical correlation between the maturity of a company's resource input and its revenue and enterprise value. It is believed that these results could be utilized as a basis for high fidelity function that predict revenue and enterprise value based on resource input information.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제15권5호
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• pp.1630-1648
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• 2021

Owing to the unprecedented COVID-19 pandemic, the pharmaceutical industry has attracted considerable attention, spurred by the widespread expectation of vaccine development. In this study, we collect relevant topics from news articles related to COVID-19 and explore their links with two South Korean pharmaceutical indices, the Drug and Medicine index of the Korea Composite Stock Price Index (KOSPI) and the Korean Securities Dealers Automated Quotations (KOSDAQ) Pharmaceutical index. We use generalized Dirichlet-multinomial regression (g-DMR) to reveal the dynamic topic distributions over metadata of index values. The results of our analysis, obtained using g-DMR, reveal that a greater focus on specific news topics has a significant relationship with fluctuations in the indices. We also provide practical and theoretical implications based on this analysis.

• 생명과학회지
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• 제20권12호
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• pp.1807-1811
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• 2010

갈조류에서 에스트로겐 활성소재를 평가하기 위하여 in vitro 검출시스템을 사용하여 에스트로겐 효과를 가지는 분획을 검증하였다. 각각의 갈조류의 분획물들은 에탄올 추출로부터 물, 헥산, 부탄올 그리고 메탄올의 용매를 이용한 분획과정을 통해 제조하였다. 갈조류들의 수층 분획물에서 가장 높은 에스트로겐 활성을 보였다. 미역과 다시마의 수층 분획물들은 $500\;{\mu}g/ml$의 농도에서 $10^{-7}\;M$의 표준물질($17{\beta}$-estradiol)과 비슷한 활성을 보였으며, 곰피와 돌자반의 수층 분획물들은 $500\;{\mu}g/ml$의 농도에서 $10^{-8}\;M$의 표준물질보다 높은 활성을 보였다. 이 연구의 결과로 갈조류인 미역, 다시마, 곰피 및 돌자반의 수층 분획물에 에스트로겐 대체 작용을 할 수 있는 성분이 포함되어 있는 것을 확인하였으며, 이를 이용하여 폐경기 장애를 예방할 수 있는 에스트로겐 활성소재의 개발이 가능할 것으로 기대된다.

• 한국콘텐츠학회논문지
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• 제21권11호
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• pp.361-374
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• 2021

본 연구의 목적은 혁신형제약기업 인증 기업을 대상으로, 기술혁신활동에 대한 효율성과 생산성을 분석하여 경쟁력을 진단하고 강화 방안을 도출하는 것이다. 이를 위해 38개 혁신형제약기업에 대한 2017~2019년 동안의 투입(연구개발비, 종업원 수) 및 산출(매출, 영업이익, 특허) 데이터를 수집하여, DEA, Tobit 및 MPI를 실시하였다. 그 결과 첫째, 혁신형제약기업의 DEA 결과는 규모의 효율성을 보여주는 CCR 모형 값과 내부 운영 효율성을 나타내는 BCC 모형 값 간에 차이가 있었다. 둘째, 효율성은 기업의 특성에 따라 다르지 않았다. 셋째, Tobit 모형은 보유특허수가 효율성에 긍정적인 영향을 미치는 것으로 나타났다. 넷째, 전체 MPI는 0.89로, 이는 TECI가 3%p 감소하고 TCI가 4%p 증가한 것으로 해석할 수 있다. 본 연구의 결과는 비효율의 원인을 규명하고 목표값을 제시하여 효율성 향상을 위한 대응전략을 위한 의사결정 자료로 활용할 수 있다.