• Title/Summary/Keyword: Pernicious anemia

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A clinical case study of Pernicious Anemia patinet who had performed total gastroectomy (각절제충(胃切除衝)을 시행(施行)한 이후(以後) 발생(發生)한 소양인(少陽人) 악성빈혈(惡性貧血) 환자(患者)의 치험 1례)

  • Kim, Jeong-Ho;Song, Jeong-Mo;Shin, Dong-Yoon
    • Journal of Sasang Constitutional Medicine
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    • v.15 no.2
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    • pp.89-93
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    • 2003
  • Pernicious anemia is a pathologic state due to lack of Vit.B12 or folic acid. Pernicious anemia is due to metabolic disorder including poor absorption of stomach through gastroectomy. We experienced a 76 year old male patient diagnosed as pernicious anemia for perfomed total gastroectomy. Herbal medicine that we had was mainly treated and several remarkable changes have been showed. This is a clinical report of that patient.

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Gastric Adenocarcinoma in Patient with Pernicious Anemia: A Case Report (악성 빈혈환자에서 발병한 위암 1예 보고)

  • Kim, Byung-Soo;Kim, Jong-Won;Lee, In-Kyu;Kim, Dong-Chul;Kim, Woo Ho;Lee, Hyuk-Joon;Yang, Han-Kwang
    • Journal of Gastric Cancer
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    • v.7 no.1
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    • pp.38-41
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    • 2007
  • Increased risk of gastric cancer has been reported in patients with chronic atrophic gastritis that develops in conjunction with pernicious anemia. We report here a case of a gastric adenocarcinoma associated with pernicious anemia. A 40-year-old female patient had been diagnosed with anemia 6 years earlier at a local hospital. One month ago, she visited our hospital for aggravated dizziness and newly developed epigastric soreness. Her blood hemoglobin level was 4.2 g/dl, and a gastroscopic work-up for anemia discovered a 2.5-cm-sized, slightly elevated mucosal lesion at the anterior wall of the high body in the stomach. The biopsy of this lesion revealed a moderately-differentiated adenocarcinoma. She underwent a total gastrectomy with a Roux en Y esophagojejunostomy with D2 lymph node dissection. The final stage of the gastric carcinoma was identified as T1N0M0. Based on this experience, we recommend that a follow-up gastroscopy be performed in patients with pernicious anemia with atrophic gastritis because of the increased risk of gastric cancer in patients with pernicious anemia.

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A Case of Lymphocytic Interstitial Pneumonia (Lymphocγtic Interstitial Pneumonia 1예)

  • Suh, Yo-Ahn;Kim, Sang-It;Kim, Dae-Han;Kwak, Jin-Young;Lee, Jae-Cheol;Baek, Hee-Jong;Chung, Jin-Haeng
    • Tuberculosis and Respiratory Diseases
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    • v.51 no.4
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    • pp.390-394
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    • 2001
  • Lymphocytic interstitial pneumonia(LIP) is characterized by a massive infiltration of the interstitium of the lung by mature lymphocytes, plasma cells and reticuloendothelial cells. LIP may be associated with autoimmune diseases including Sj$\check{o}$grens syndrome, SLE, myasthenia gravis, pernicious anemia, autoimmune hemolytic anemia, and HIV or an EB virus infection. There is a possibility of LIP progressing to a pulmonary or systemic lymphoma. The therapeutic response to corticosteroids and/or immunosuppressive drugs varies. Here we report a case of LIP that was diagnosed by an open lung biopsy and clonality study. The patient was a 36 year-old man without autoimmune disease or HIV infection. He was admitted as a result of severe hypoxemia showing $PaO_2$ of 48.3mmHg. The patient was treated with corticosteroids after the diagnosis and had fully recovered without a sequalae or relapse.

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Hemopoietic Effects of Rhizoma Rehmanniae Preparata on Cyclophosphamide-Induced Pernicious Anemia in Rats (Cyclophosphamide로 Rat에 유도된 악성빈혈에 대한 숙지황의 증(蒸)수에 따른 치료효능에 관한 연구)

  • Ha, Chang-Su;Sung, Hyun-Jea;Zee, Ok-Pyo;Ma, Jin-Yeul
    • Korean Journal of Pharmacognosy
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    • v.31 no.3
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    • pp.325-334
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    • 2000
  • Rhizoma Rehmanniae Preparata is a Chinese herbal tonic. The hemopoietic effects of Rhizoma Rehmanniae Preparata(4-time steamed Jihwang, 4-time steamed double dose Jihwang, 8-time steamed Jihwang, 8-time steamed double dose Jihwang) were examined using in vitro rat(SD) model. Cyclophosphamide(150 mg/kg) was injected into experimental groups and control group to induce bone marrow suppression. Oral administration of Rhizoma Rehmanniae Preparata suppressed hormone levels of $T_4\;and\;T_3$. Reticulocyte count was increased by the bone marrow suppression.

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Vitiligo in a Patient with Systemic Lupus Erythematosus: A Case Report (전신홍반루푸스 환자에서 병발한 백반증 1예)

  • Kwon, Hyoung Il;Oh, Eui Hyun;Jung, Yun Do;Ko, Joo Yeon
    • Korean journal of dermatology
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    • v.56 no.10
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    • pp.620-623
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    • 2018
  • Vitiligo is a multifactorial disorder. Neural, biochemical, and autoimmune mechanisms have been hypothetically suggested as etiopathological contributors to this condition. Autoimmunity focuses primarily on genetic factors and the association between vitiligo and other autoimmune disorders including autoimmune thyroid disease, rheumatoid arthritis, psoriasis, type 1 diabetes, pernicious anemia, and Addison's disease. We describe a 35-year-old man with systemic lupus erythematosus who developed concurrent vitiligo and discoid lupus erythematosus suggesting the possible autoimmune association between these 2 different diseases.

Hemopoietic Effects of Deer Blood on Cyclophosphamide Induced Pernicious Anemia (녹혈이 Cyclophosphamide로 유도된 악성빈혈의 조혈기능 촉진에 미치는 영향)

  • Hong, Soon-Bok;Kim, Eun-Hae;Ma, Jin-Yeul;Eun, Young-Ah;Kim, Han-Seob;Park, Kap-Joo
    • Korean Journal of Pharmacognosy
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    • v.29 no.4
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    • pp.283-292
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    • 1998
  • The hemopoietic effects of deer blood (whole blood, blood cell, plasma, respectively) were examined using in vivo rat model. Experimental animals (Sprague-Dawley rat, male, 200 g) were divided into negative control group (injection of saline), positive control group (injection of Sipjeondaebotang) experimental groups (injection of whole blood, blood cell, plasma) and healthy control group. Cyclophosphamide(150mg/kg) was injected into experimental groups, negative and positive control group to induce bone marrow supression. After 8 days, freez dried deer blood (whole blood, blood cell, plasma respectively) and Sipjeondaebotang of 200 mg/kg in dose was administered orally into experimental groups and positive control group, once a day for 3 days (A group) and once a day for 12 days (B group) respectively. And then body weight and organ weight, biochemical profile (ALB, GOT, GPT, PRO, CRE), hematological values (WBC, RBC, HGB, HCT, MCV, MCH, MCHC, PLT) and CBC differentiation (Neutro, Lymph, Mono, Reticulo) were carried out. Finally, platelets were specially increased in the plasma treated A group and reticulocytes were specially increased in the plasma treated B group.

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