• Journal of Korean Society for Geospatial Information Science
• /
• v.19 no.3
• /
• pp.33-40
• /
• 2011

This paper presents the prediction and evaluation of landslide using LRA(logistic regression analysis) and ANN (Artificial Neural Network) methods. In order to assess the landslide, we selected Sarabong, Byeoldobong area and Mt. Song-ak in Jeju Island. Five factors which affect the landslide were selected as: slope angle, elevation, porosity, dry density, permeability. So as to predict and evaluate the landslide, firstly the weight value of each factor was analyzed by LRA(logistic regression analysis) and ANN(Artificial Neural Network) methods. Then we got two prediction maps using AcrView software through GIS(Geographic Information System) method. The comparative analysis reveals that the slope angle and porosity play important roles in landslide. Prediction map generated by LRA method is more accurate than ANN method in Jeju. From the prediction map, we found that the most dangerous area is distributed around the road and path.

• Journal of Korean Society of Water and Wastewater
• /
• v.31 no.4
• /
• pp.303-310
• /
• 2017

Pressure retarded osmosis(PRO) has attracted much attention as potential technology to reduce the overall energy consumption for reverse osmosis(RO) desalination. The RO/PRO hybrid process is considered as the most logical next step for future desalination. The PRO process aims to harness the osmotic energy difference of two aqueous solutions separated by a semipermeable membrane. By using the concentrated water(RO brine) discharged from existing RO plants, the PRO process can effectively exploit a greater salinity gradient to reduce the energy cost of processing concentrated water. However, in order to use RO brine as the draw solution, PRO membrane must have high water flux and enough mechanical strength to withstand the high operational pressure. This study investigates the development of a thin film composite PRO membrane and spiral wound module for high power density. Also, the influence of membrane backing layer on the overall power density was studied using the characteristic factors of PRO membranes. Finally, the performance test of an 8-inch spiral wound module was carried out under various operating conditions(i.e. hydraulic pressure, flow rate, temperature). As the flow rate and temperature increased under the same hydraulic pressure, the PRO performance increased due to the growth of water permeability coefficient and osmotic pressure. For a high performance PRO system, in order to optimize the operating conditions, it is highly recommended that the flow pressure be minimized while the flow rate is maintained at a high level.

• The Journal of Korean Medicine
• /
• v.19 no.2
• /
• pp.485-501
• /
• 1998

Cortex Mori (Moros alba L.), the root bark of mulberry tree has been used as an autiphlogistic, diuretic and expectorant in herval medicine. Recently, a few papers reported that phenolic extract of Cortex Mori had the hypotensive, hypoglycemic, antiviral and anticancer effects, and hot water extract of Cortex Mori(CM) had inhibitory effect on the degranulation and histamine release from activated mast cells. These previous studies suggest a possibility that CM has an antidotal activity against inflammation which was mediated mainly by macrophage-secreting inflammatory factors. This study was performed to evaluate the influences of CM on carrageenan-induced edema in vivo and release of inflammatory mediators such as NO, TNF and IL-1 by macrophages stimulated with LPS or $IFN-{\gamma}$ in vitro. Subcutaneous injections of carrageenan into the mouse paw rapidly induced local edema by increasing vascular permeability, but single intraperitoneal injection of CM extract at 30 minutes before carrageenan suppressed the development of edema. NO and TNF production from macrophage stimulated by LPS or $IFN-{\gamma}$ were significantly suppressed, especially TNF secretion by up to 3-4 folds. LPS stimulated IL-1 production was also inhibited, but not significantly. Cell viability assay verified that the inhibition was not due to general cell toxicity. These results suggest that reduction of NO, TNF and IL-1 production may be one of the means by which CM prevent inflammation associated diseases.

• Journal of Pharmaceutical Investigation
• /
• v.32 no.1
• /
• pp.21-26
• /
• 2002

The primary culture of human nasal epithelial cell monolayer was performed on a Transwell. The effect of various factors on the tight junction formation was observed in order to develop an in vitro experimental system for nasal transport studies. Human nasal epithelial cells, collected from human normal inferior turbinates, were plated onto diverse inserts. After 4 days, media of the apical surface was removed for air-liquid interface (ALI) culture. Morphological characteristics was observed by transmission electron microscopy (TEM). A polyester membrane of $0.4\;{\mu}m$ pore size was determined as the most effective insert based on the change in the transepithelial electric resistance (TEER) value as well as the $^{14}C-mannitol$ transport study. The ALI method was effective in developing the tight junction as observed in the further increase in the TEER value and reduction in the permeability coefficient $(P_{app})$ of $^{14}C-mannitol$ transport. Results of the transport study of a model drug, budesonide, showed that the primary culture system developed in this study could be further developed and applied for in vitro nasal transport studies.

• Journal of Pharmaceutical Investigation
• /
• v.30 no.4
• /
• pp.247-252
• /
• 2000

The advantages of transdermal administration are avoiding hepatic first pass effect, minimizing inter- and intra-patient variation, maintaining steady-state plasma level to provide long-term therapy from a single dose, and allowing a rapid termination of drug input. Clenbuterol, a selective ${\beta}_2-adrenergic$ receptor stimulant, has been introduced as a potent bronchodilator for patients with bronchial asthma, chronic obstructive bronchial disease. For the development of transdermal systems containing clenbuterol, two limiting factors - long lag time and low flux - must be overcome. In this study, we attempted to select optimal formulation for preparation of clenbuterol patch using hairless mouse skin and flow-through diffusion cell. The flux of clenbuterol increased as the percent of clenbuterol dose dependently in the concentration range of 5-15%. Based on this result, we fixed the concentration of clenbuterol as 15%. The effect of various penetration enhancers on percutaneous absorption of clenbuterol through hairless mouse skin was investigated. Labrafil was the most effective enhancer, which increased the permeability of clenbuterol approximately 4-fold compared with the control without penetration enhancer. Optimal enhancer concentration was 3%. The effect of various adhesives on penetration of clenbuterol was also investigated. Among the adhesives studied, MA-31 was the most effective adhesive. Furthermore, the clenbuterol patch composed of 15% clenbuterol, 3% Labrafil and 82% MA-31, which gave most excellent penetration of drug in in vitro penetration study, maintained therapeutic plasma levels in in vivo study using S.D. rats. These studies demonstrated a good feasibility of clenbuterol administration through the intact skin using a transdermal patch, and show a possibility of the development of clenbuterol patches.

• Journal of the Korea Furniture Society
• /
• v.28 no.3
• /
• pp.248-258
• /
• 2017

A study was carried out to observe the 1% aqueous safranine solution flow speed in longitudinal and radial directions of softwood Thuja orientalis L., diffuse-porous wood Gmelina arborea Roxb., and ring-porous wood Phellodendron amurense Rupr., Longitudinal flow was considered from bottom to top while the radial flow was considered from bark to pith directions. In radial direction, ray cells and in longitudinal direction tracheids, vessel and wood fiber were considered for the measurement of liquid penetration speed at less than 12% moisture contents(MC). The variation of penetration speed for different species was observed and the reasons behind for this variation were explored. The highest radial penetration depth was found in ray parenchyma of T. orientalis but the lowest one was found in ray parenchyma of P. amurense. The average liquid penetration depth in longitudinal trachied of T. orientalis was found the highest among all the other cells. The penetration depth in fiber of G. arborea was found the lowest among the other longitudinal cells. It was found that cell dimension and also meniscus angle of safranine solution with cell walls were the prime factors for the variation of liquid flow speed in wood. Vessel was found to facilitate prime role in longitudinal penetration for hardwood species. The penetration depth in vessel of G. arborea was found highest among all vessels. Anatomical features like ray parenchyma cell length and diameter, end-wall pits number were found also responsible fluid flow differences. Initially liquid penetration speed was high and the nit gradually decreased in an uneven rate. Liquid flow was captured via video and the penetration depths in those cells were measured. It was found that even in presence of abundant rays in hardwood species, penetration depth of liquid in radial direction of softwood species was found high. Herein the ray length, lumen area, end wall pit diameter determined the radial permeability. On the other hand, vessel and fiber structure affected the longitudinal flow of liquids. Following a go-stop-go cycle, the penetration speed of a liquid decreased over time.

• Magazine of the Korean Society of Agricultural Engineers
• /
• v.35 no.2
• /
• pp.43-56
• /
• 1993

The laboratory tests are performed on how the liquefaction potential of the sea dike structures on the saturated sand or silty sand seabed could be affected due to earthquake before and after construction results are given as follows ; 1. Earthquake damages to sea dike structures consist of lateral deformation, settlement, minor abnormality of the structures and differential settlement of embankments, etc. It is known that severe disasters due to this type of damages are not much documented. Because of its high relative cost of the preventive measures against this type of damages, the designing engineer has much freedom for the play of judgement and ingenuity in the selection of the construction methods, that is, by comparing the cost of the preventive design cost at a design stage to reconstruction cost after minor failure. 2. The factors controlling the liquefaction potential of the hydraulic fill structure are magnitude of earthquake(max. surface velocity), N-value(relative density), gradation, consistency(plastic limit), classification of soil(G & vs), ground water level, compaction method, volumetric shear stress and strain, effective confining stress, and primary consolidation. 3. The probability of liquefaction can be evaluated by the simple method based on SPT and CPT test results or the precise method based on laboratory test results. For sandy or silty sand seabed of the concerned area of this study, it is said that evaluation of liquefaction potential can be done by the one-dimensional analysis using some geotechnical parameters of soil such as Ip, Υt' gradation, N-value, OCR and classification of soils. 4. Based on above mentioned analysis, safety factor of liquefaction potential on the sea bed at the given site is Fs =0.84 when M = 5.23 or amax= 0.12g. With sea dike structures H = 42.5m and 35.5m on the same site Fs= 3.M~2.08 and Fs = 1.74~1.31 are obtained, respectively. local liquefaction can be expected at the toe of the sea dike constructed with hydraulic fill because of lack of constrained effective stress of the area.

• Journal of the Korean Institute of Gas
• /
• v.21 no.3
• /
• pp.61-69
• /
• 2017

The commercial development of unconventional gas is pursued in North America because it is more feasible owing to the technology required to improve productivity. Shale reservoir have low permeability and gas production can be carried out through cracks generated by hydraulic fracturing. The decline rate during the initial production period is high, but very low latter on, there are significant variations from the initial production behavior. Therefore, in the prediction of the production rate using deterministic decline curve analysis(DCA), it is not possible to consider the uncertainty in the production behavior. In this study, production rate of the Eagle Ford shale is predicted by Arps Hyperbolic and Modified SEPD. To minimize the uncertainty in predicting the Estimated Ultimate Recovery(EUR), Monte Carlo simulation is used to multi-wells analysis. Also, kernel density function is applied to determine probability distribution of decline curve factors without any assumption.

• Journal of the Korean Geographical Society
• /
• v.38 no.6
• /
• pp.935-948
• /
• 2003

The State Soil Geographic (STATSGO) database is a valuable source for assessment of soil properties at a state level. Using GIS techniques, eight physical soil properties were extracted from the database, including available water capacity, clay content, soil depth, slope, depth to water table, drainage, texture, and permeability. The influences of these soil properties on drought severity, which was estimated by NDVI departures from normal, were determined over western-central Kansas. Study results showed that seven soil properties had significant relationships with drought severity with correlation coefficients, ranging from -0.89 to 0.85. Thermal emission signals from the Moderate Resolution Imaging Spectroradiometer (MODIS) had a significant relationship with drought severity expressed by NDVI departure from normal and represented spatial progression of drought over time well. High thermal signals, indicating high soil moisture deficit, emerged in the western region and their spatial distribution changed over time. Different sets of soil factors influenced drought severity among early-drying and late-drying areas.

• Journal of the Korean Geotechnical Society
• /
• v.33 no.2
• /
• pp.35-47
• /
• 2017

Thermal behavior of soils is mainly focused on thermal conduction, and the study of natural convection is very limited. Increase of soil temperature causes natural convection due to buoyancy from density change of pore water. The limitations of the analysis using fluid dynamics for natural convection in the porous media is discussed and a new numerical analysis is presented for natural convection in porous media using THM governing equations fully coupled in the macroscopic view. Numerical experiments for thermal probe show increase in the uncertainty of thermal conductivity estimated without considering natural convection, and suggest appropriate experimental procedures to minimize errors between analytical model and numerical results. Burial of submarine power cable should not exceed the temperature changes of $2^{\circ}C$ at the depth of 0.2 m under the seabed, but numerical analysis for high permeable ground exceeds this criterion. Temperature and THM properties of the seafloor are important design factors for the burial of power cable, and in this case effects of natural convection should be considered. Especially, in the presence of heat sources in soils with high permeability, natural convection due to the variation of density of pore water should be considered as an important heat transfer mechanism.