• Nutrition Research and Practice
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• 제7권5호
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• pp.393-399
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• 2013

Asian populations are thought to receive significant health benefits from traditional diets rich in soybeans due to high isoflavone contents. However, available epidemiologic data only weakly support this hypothesis. The present study was carried out to assess the pharmacokinetics of isoflavones in South Korean women after ingestion of soy-based foods. Twenty-six healthy female volunteers (20-30 y old) consumed three different soy products (i.e., isogen, soymilk, and fermented soybeans) with different aglycone/glucoside ratios. Plasma and urine isoflavone concentrations were measured by high-performance liquid chromatography (HPLC) after ingestion of one of the soy products. Pharmacokinetic parameters were determined using the WinNonlin program. The area under the curve (AUC) for plasma daidzein levels of the soymilk group ($2,101{\pm}352ng{\cdot}h/mL$) was significantly smaller than those of the isogen ($2,628{\pm}573ng{\cdot}h/mL$) and fermented soybean ($2,593{\pm}465ng{\cdot}h/mL$) groups. The maximum plasma concentration ($C_{max}$) of daidzein for the soymilk group ($231{\pm}44$ ng/mL) was significantly higher than those of the isogen ($160{\pm}32$ ng/mL) and fermented soybean ($195{\pm}35$ ng/mL) groups. The half-lives of daidzein and genistein in the soymilk group (5.9 and 5.6 h, respectively) were significantly shorter than those in the individuals given isogen (9.6 and 8.5 h, respectively) or fermented soybean (9.5 and 8.2 h, respectively). The urinary recovery rates of daidzein and genistein were 42% and 17% for the isogen group, 46% and 23% for the fermented soybean group, and 33% and 22% for the soymilk group. In conclusion, our data indicated that soy products containing high levels of isoflavone aglycone are more effective for maintaining plasma isoflavone concentrations. Additional dose-response, durational, and interventional studies are required to evaluate the ability of soy-based foods to increase the bioavailability of isoflavones that positively affect human health.

• Journal of Nutrition and Health
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• 제36권5호
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• pp.528-535
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• 2003

The purposes of this study were: 1) to investigate the operational and financial characteristics of contract-managed high school food services in Seoul, 2) to analyze the financial performance of high school food services 3) to develop guidelines for meal pricing and facilities investment costs. From Oct to Nov 2001, questionnaires were mailed to 249 high schools that were managed by contract food service companies. A 40.2％ response rate was recorded. The results of this study were as follows: 1. Student enrollment in high schools run by contract-managed food services was 1,518, with a 68.5％ participation rate in the school lunch program. The average meal price was 2,141 won. 2. Based on the income statement analysis, average total sales were 410,440,504 won and average net profit was 16,098,558 won. 3. The optimum food cost per meal was 1,200-1,300 won per meal, calculating using the methods of conversion factor, RDA (Recommended Daily Allowance), and nutrient exchange unit. 4. Guidelines for meal pricing were developed using the modified actual pricing method based on facilities investment cost, number of meals and food cost. The ratio of labor cost, general management expenses and ordinary profit were adopted from the schools with liability. The food cost, depreciation and interest cost were calculated based on unit meal. 5. The guideline for facilities investment was developed based on the number of meals, meal price and food cost. The guideline included the maximum facilities investment cost paid by the contract food service management company. (Korean J Nutrition 36(5): 528∼535, 2003)

• 한국추진공학회지
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• 제14권5호
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• pp.32-44
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• 2010

고체 추진기관 노즐의 2차원 열반응 및 삭마 해석 코드를 활용하여 노즐 부품의 숯 및 삭마현상을 연구하였다. Arrhenius 식을 이용한 내부 열분해 모델 상수는 TGA(열중량분석기) 실험으로 얻었다. 탄소와 $H_2O$, $CO_2$의 산화반응에 의한 화학적 삭마는 Zvyagin이 제안한 삭마모델 과 반응속도 상수를 이용하여 해석을 수행하였다. 삭마에 의한 경계조건 및 격자 이동은 상용해석 프로그램인 MSC-Marc-ATAS에서 적용되는 Rezoning-remeshing 기법을 사용하였다. 해석된 숯 및 삭마 두께는 연소시험 결과 값과 최대 20% 오차를 보였다. 향후 열방호 시스템의 성능을 모사하기 위하여 내부 온도 및 열유속을 실시간 측정하면 3차원 FEM 통합 열구조 해석에 적용될 것으로 기대된다.

• 센서학회지
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• 제1권1호
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• pp.43-51
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• 1992

본 연구에서는 물체의 열전도 특성을 감지하여 임의의 대기온도에서도 열전도가 다른 몇가지 물체의 재질을 식별할 수 있는 센서에 대해 연구하였다. 임의의 대기온도에서 센서의 온도 값을 계산하기 위해 3차 Spline 보간식을 적용하여 계산된 센서의 온도에 따라 재질을 식별하는데, 실측된 온도와 비교하였을 경우 매우 잘 일치하였다. 열전도 특성을 이용한 물체의 재질인식용 능동센서를 설계하였으며 C 언어를 이용한 물체의 재질 식별 프로그램을 개발하였다. 동일한 대기 온도상에서의 재질별 온도응답특성을 조사하였으며 대기온도변화에 따른 재질별 온도응답특성을 조사하였으며, 대기온도 변화에 따라 3 비교점의 온도는 거의 직선적으로 변화하고 평행상태를 유지함을 알 수 있었다.

• 한국임상약학회지
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• 제28권1호
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• pp.30-39
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• 2018

Background: Clinical Pharmacy Practice Experience (CPPE) is an important curriculum that offers students patient-centered disease prevention and treatment with evidence-based optimal pharmacotherapy for better clinical outcomes. However, few studies have evaluated the perception of pharmacy students regarding CPPE in tertiary and secondary hospitals. This study aimed to evaluate the perception of pharmacy students regarding the learning program of CPPE. Methods: The survey questionnaire consisted of 15 self-administered questions regarding pharmacy practices, barriers, and improvement of practical training. Fourteen institutional pharmacies located in seven regions responded to a survey questionnaire from March 1 to June 30, 2017. The participants were pharmacy students doing clerkship in a hospital setting. Results: The response rate was 73.6%. Thirty-five participants (22.4%) had used a hospital library, but 121 (77.6%) had never used the library for drug information resources. Eighty-one (50.0%) responded that clinical knowledge and drug information was the most beneficial practice. Thirty-seven (31.1%) respondents in the tertiary hospitals and 19 (46.3%) in the secondary hospitals answered that they were filling prescriptions during the daily break. On the other hand, 72 respondents (60.5%) in the tertiary hospitals and 17 (41.5%) in the secondary hospitals did literature research to prepare for presentation. Conclusion: More students in secondary hospitals continue to fill prescriptions during the daily break, as compared to those in tertiary hospitals. Therefore, the authors suggest self-directed learning to improve clinical performance and each institution considers offering onsite or online library service to improve evidence-based CPPE for pharmacy school students.

• Steel and Composite Structures
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• 제26권3호
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• pp.329-345
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• 2018

This paper systematically investigated the mechanical performance of the weak-axis cover-plate connection, including a beam end monotonic loading test and a column top cyclic loading test, and a series of parametric studies for exterior and interior joints under cyclic loading using a nonlinear finite element analysis program ABAQUS, focusing on the influences of the shape of top cover-plate, the length and thickness of the cover-plate, the thickness of the skin plate, and the steel material grade. Results showed that the strains at both edges of the beam flange were greater than the middle's, thus it is necessary to take some technical methods to ensure the construction quality of the beam flange groove weld. The plastic rotation of the exterior joint can satisfy the requirement of FEMA-267 (1995) of 0.03 rad, while only one side connection of interior joint satisfied ANSI/AISC 341-10 under the column top cyclic loading. Changing the shape or the thickness or the length of the cover-plate did not significantly affect the mechanical behaviors of frame joints no matter in exterior joints or interior joints. The length and thickness of the cover-plate recommended by FEMA 267 (1995) is also suitable to the weak-axis cover-plate joint. The minimum skin plate thickness and a design procedure for the weak-axis cover-plate connections were proposed finally.

• Earthquakes and Structures
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• 제19권5호
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• pp.347-359
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• 2020

The Mega-Sub Controlled Structure System (MSCSS), an innovative vibration passive control system for building structures, is improved by adding lead rubber bearings (LRBs) on top of the substructure. For the new system, a genetic algorithm is used to optimize the dynamic parameters and distributions of dampers and LRBs. The program uses various seismic performance indicators as optimization objectives, and corresponding results are compared. It is found that the optimization procedure for maximizing the energy dissipation ratio yields the best solutions, and optimized models have consistent seismic performances under different earthquakes. Seismic performances of optimized MSCSS models with and without LRBs, as well as the traditional Mega-Sub Structure model, are evaluated and compared under El Centro wave, Taft wave and 20 other artificial waves. In both elastic and plastic analysis, the model with LRBs shows significantly smaller story drift and horizontal acceleration than those of the other two models, and fewer plastic hinges are developed during severe earthquakes. Energy analysis also shows that LRBs installed in proper locations increase the deformation and energy dissipation of dampers, thereby significantly reduce the kinetic, potential, and hysteretic energy in the structure. However, LRBs do not have to be mounted on all the additional columns. It is also demonstrated that LRBs at unfavorable locations can decrease the energy dissipation for dampers. After LRBs are installed, the optimal damping coefficient and the optimal damping exponent of dampers are reduced to produce the best damping effect.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2006년도 춘계학술대회 논문집
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• pp.107-108
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• 2006

This paper shows the design optimization of the paper feeding mechanism under dynamic behavior by using commercial codes of RecurDyn/MTT2D and RecurDyn/AutoDesign which are developed by functionBay, Inc. A virtual mockup for dynamics analysis of the paper feeding mechanism is build on RecurDyn/MTT2D and is simulated. Flexible paper is represented as a series of rigid bars connected by revolute joints and rotational spring dampers. Paper is fed by a contact and friction mechanism on rollers or guides. The slip of the paper and nip force of rollers are measured to estimate the system performance. After a simulation, these performances are automatically send to RecurDyn/AutoDesign which is a sequential approximate optimization tool based on the response surface modeling. RecurDyn/AutoDesign makes the approximate objective function and computes the optimized design points of the design variables and gives them to analysis tool. And then the simulation is repeated with the updated design variables. These processes are repeated until finding a tolerable design optimization. In this paper, a paper feeding mechanism is introduced and it is optimized with the proposed algorithms.

• The Plant Pathology Journal
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• 제30권3호
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• pp.261-268
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• 2014

This work was conducted to identify mungbean genotypes showing yield stability and resistance to mungbean yellow mosaic virus (MYMV) disease. Sixteen genotypes were evaluated in a randomized complete block design with two replications for two years (2011 and 2012) at three locations (Gazipur, Ishurdi and Madaripur) of the Bangladesh Agricultural Research Institute. An analysis of variance exhibited significant effects of genotype (G), environment (E), and genotype ${\times}$ environment ($G{\times}E$) on grain yield. Among eight agronomic characters, the principal component 1 (PC1) was always higher than the PC2. Considering $G{\times}E$ interaction, BM6 was the best genotype at all three locations in both years. Based on grain yield and stability performance, BM6 ranked first while the worst performing genotypes were BM1 and G10. Based on discrimination and representation, Gazipur was identified as an ideal environment for these mungbeans. Relationship between soil-plant analysis developments (SPAD) value was positive with yield but negative with MYMV severity. BM6, G1 and G2 were considered as promising sources of resistance for low disease score and stable response across the environments. The environment proved to have an influence on MYMV infection under natural infestation. A positive correlation was observed between disease score and the temperature under natural growing condition.

• 한국지반공학회:학술대회논문집
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• 한국지반공학회 2008년도 추계 학술발표회
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• pp.1404-1414
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• 2008

In the mechanistic-empirical trackbed design of railways, the resilient modulus is the key input parameter. This study focused on the resilient modulus prediction model, which is the functions of mean effective principal stress and axial strain, for three types of railroad trackbed materials such as crushed stone, weathered soil, and crushed-rock soil mixture. The model is composed with the maximum Young's modulus and nonlinear values for higher strain in parallel with dynamic shear modulus. The maximum values is modeled by model parameters, $A_E$ and the power of mean effective principal stress, $n_E$. The nonlinear portion is represented by modified hyperbolic model, with the model parameters of reference strain, ${\varepsilon}_r$ and curvature coefficient, a. To assess the performance of the prediction models proposed herein, the elastic response of a test trackbed near PyeongTaek, Korea was evaluated using a 3-D nonlinear elastic computer program (GEOTRACK) and compared with measured elastic vertical displacement during the passages of freight and passenger trains. The material types of sub-ballasts are crushed stone and weathered granite soil, respectively. The calculated vertical displacements within the sub-ballasts are within the order of 0.6mm, and agree well with measured values with the reasonable margin. The prediction models are thus concluded to work properly in the preliminary investigation.