• 대한임상검사과학회지
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• 제37권2호
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• pp.71-77
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• 2005

We experienced the specimen that contains a hemoglobin variant known as interference from HbAS in October 2003. It was the first case of Hb variants since Samsung Medical Center began conducting glycohemoglobin College of American Pathologists surveys in 1997. The purpose of this study is to share our experience with the specimen and promote the understanding of Hb variants & derivatives. We've performed cross checks to examine HbA1c by using two pieces of equipment; the TOSHOH G7 and BIO-RAD VARIANT-T(turbo), and Automatic High Performance Liquid Chromatography(HPLC) as an analytic measurement method. HPLC provides different fractional information of hemoglobin with a two-dimensional graph as well as numeric results. We have been performing a "Systematic Checking Process". Three specimen suspicious of Hb variants & derivatives were found through this process. College of American Pathologists notified that it is important for users to be aware of the limitation of their glycohemoglobin method to avoid reporting incorrect results due to interference from hemoglobin variants or hemoglobin adducts. Therefore, laboratory findings of Hb variants & derivatives are very important. The experience of qualified technicians with professional knowledge in Hb variants is the most important aspect in finding Hb variants. Korea is homogeneous in race and is not in an area with a higher finding rate of Hb variants. While 1,024 cases of Hb variants have been found in Japan, we do not have specific data on how many cases of Hb variants have been found in Korea. Considering Hb variant cases in Japan, which is geographically close to us, it is presumed that there must be various Hb variant cases in Korea. If domestic laboratories set a systemic protocol and build a network to share our experience in Hb variants, I expect the Korean Hb variants could also be listed on the world's Hb variant list.

• 간호행정학회지
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• 제2권1호
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• pp.125-139
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• 1996

Organizational commitment is characterized by a strong belief in and acceptance of the organization's goal and values ; a willingness to exert considerable effort on behalf of the organization ; a strong desire to maintain membership in the organization. The purpose of this study was to identify the variables which influence the organizational commitment and to test the relationship between the clinical nurses' organizational commitment and turnover intention. The subjects were 412 nurses who were working on general wards at three General Hospitals in Chounbuk. The data were collected by self-reporting questionnaire from Sept. 20 to Sept. 31, 1995. The instruments used in this study were Likert-type scale which were Organizational Commitment Scale by Mowday et al, and Turnover Intention Scale by Mobley et al. The questionnaire of organizational characteristics was made through reviewing literature. The data were analyzed by frequency, percentage, t-test, one-way ANOVA, Scheffe test, Pearson's correlation coefficient, and stepwise multiple regression with $SPSS-PC^+$ program. Major findings are as follows : 1. Mean scores for organizational commitment were 3.008 and turnover intention 3.167 on a 5 point scale. 2. Age and clinical experience were positively related to organizational commitment(r=.4806, p=.000; r=.4792, p=.000). 3. In the personal variables, hospital type(F=21.374, p=.000), education level(F=5.481, p=.001), position(F=30.867, P=.000), and marital status(t=-5.63, p=.000) of the nurses showed significant differences in organizational commitment. 4. The variables to the organizational characteristic were statistically significant in organizational commitment : formalization(r=.3458, p=.000), human-centered organizational characteristic(r=.4302, p=.000), performance- centered organizational characteristic(r=-.1502, p=.000), payment(r=.2234, p=.000), promotion(r=.2710, p=.000), benefit & service(r=.2325, p=.000), and resource inadequacy(r=-.2172, p=.000). 5. For the purpose of identifying the predicting variables in organizational commitment, stepwise multiple regression is conducted. The results show that age, human-centered organizational characteristic, formalization, hospital type, resource inadequacy, promotion, and benefit & service were significant variables and explained 46% of the variance. 6. Organizational commitment was significantly negatively correlated with turnover intention(r=-.6442, p=.000). As a result of stepwise multiple regression analysis, organizational commitment is the most powerful variable predicting turnover intention and explained 41.5% of the variance. In conclusion, this study shows that the higher the organizational commitment level, the lower the turnover intention. Therefore, for effective turnover management, it is important to improve the organizational commitment among clinical nurses. In order to enhance the organizational commitment by the clinical nurses, it will be useful to consider significant organizational characteristics variables identified in this study.

• 대한교통학회지
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• 제23권4호
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• pp.7-16
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• 2005

항공기 운항에서 이륙과 착륙단계는 가장 어려우며 많은 사고가 발생되는 위험한 과정이다. 이륙단계에서 발생될 수 있는 비상상황 가운데 가장 심각한 것은 이륙단념이다. 이륙단념 관련 사고의 대부분은 활주로 이탈사고로 연결되었는데 이와 관련하여 미국 NTSB는 사고발생의 주원인을 이륙이나 정지를 결심하는 시간지연으로 분석하였다. 본 연구는 이와 같은 이륙단념속도(시간)에 대한 조종사들의 인지도와 적합성을 검토하였는데, 먼저 현장에서 항공기를 운용하는 조종사를 대상으로 한 이륙단념 설문을 통하여 이와 관련된 인지여부를 비롯한 기초자료를 측정하였고, 그 후 무작위로 선정된 조종사를 대상으로 모의비행장치(Simulator)를 이용하여 이륙단념 상황을 부여하고 이에 따른 반응시간을 측정하여 현재 적용하는 기준과 비교하였다. 설문 결과, 일부 조종사들은 비행규정에 적용된 이륙단념의 기준과 현행 절차를 불만족스럽게 생각하고 있었다. 모의비행장치의 측정결과, 현장조종사의 이륙단념시간이 항공기 비행규정보다 1.5 초 더 소요되는 것으로 나타났으며 결국 현행 규정에 의한 Y1 속도에서 이륙단념을 하는 경우, 활주로 이탈로 이어질 가능성이 높은 것으로 분석되었다. 따라서 이륙단념 사고를 줄이기 위해서는 관련 규정에 대한 지속적인 교육이 필요하며, 실제로 안전한 이륙단념을 위하여 $V_1$ 속도를 6노트 줄여서 사용하여야 이륙단념에 대한 안전성이 확보될 것이다.

• Clinical and Experimental Pediatrics
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• 제51권10호
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• pp.1071-1076
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• 2008

목적: RSV 호흡기 바이러스 감염은 해마다 영유아에서 심한 호흡기 질환의 중요한 원인이 되고 있다. 이에 따라 최근 검사 방법이 간편하고 결과를 빨리 알 수 있는 면역 크로마토그래피법이 신속 항원 검사법으로서 소개되어 그 정확성과 임상에서의 유용성이 많이 연구되고 있으나 국내에서는 연구례가 드문 실정이다. 이에 저자들은 이 검사법의 정확성과 유용성을 평가하여 실질적인 검사법으로 정착시키고자 하였다. 방법: 2007년 4월부터 2008년 3월까지 발열, 기침, 천명, 호흡곤란, 빈호흡 등의 증상으로 외래 내원 및 입원치료를 받은 112명의 환아를 대상으로 비인두 가검물을 채취하여 RSV Respi-Strip과 효소 면역 측정법, RT-PCR(ASTEC)을 동시에 시행하였다. RT-PCR을 표준으로 하여 RespiStrip 과 EIA의 결과를 비교 분석하여 정확성과 유용성을 평가하였다. 결 과: RSV RespiStrip, RT-PCR, EIA에 양성을 보인 환아는 각각 42명, 45명, 39명 이었다. RespiStrip는 RT-PCR 검사법에 대하여 민감도 88%, 특이도 94%, 양성 예측도 90%, 음성 예측도는 92% 였으며 위양성률과 위음성률 그리고 일치도가 각각 5.9%, 11%, 83% 로 나왔다. EIA는 RT-PCR 검사법에 대하여 민감도 84%, 특이도 94%, 양성 예측도 90%, 음성 예측도 90%, 일치도 79% 로 나왔다. 결론: 신속 항원 검사가 비교적 민감도가 높으므로 RSV 감염의 선별 검사로서 적합하다고 생각한다. 외래 진료실에서 빠르고 경제적이며 간편하게 검사하여 조기에 적절한 치료를 함으로써 합병증을 예방할 수 있고 아울러 불필요한 항생제의 사용을 줄일 수 있다. 앞으로 이러한 신속검사가 실제 임상에서 많이 적용되리라 기대된다.

• 한국응용과학기술학회지
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• 제37권4호
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• pp.925-935
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• 2020

본 연구는 사업장 보건관리자의 우수한 보건관리 활동과 동기를 파악하여 추후 보건관리자의 활동에 대한 가이드를 제시하기 위한 연구이다. 본 연구는 5년 이상 동일한 사업장에 근무한 사업장 보건 관리자 21명을 대상으로 연구에 대한 동의를 얻은 후 반구조화된 설문지를 이메일로 보내 자료를 수집하였으며 응답한 내용을 질적 분석하였다. 본 연구 결과 17개의 범주와 3가지 주제가 도출되었다. 도출된 주제는 보건관리자로서의 보람과 성취감, 보건관리자로서의 어려웠던 부분, 어려움은 이렇게 해결하자 이었다. 보건관리자는 근로자가 마음을 열어주고, 생활을 변화시키기며, 감사해 하며, 새로운 분야를 개척하는 것에 보람과 성취감을 느낀다고 하였다. 반면, 예측할 수 없는 건강, 조직문화의 변화, 질병을 비밀화하는 것, 보건관리자 업무가 편하다고 생각하는 사람들에 대해 어려움을 느꼈다. 이러한 어려움을 극복하는 방법으로 근로자의 마음을 읽어주고, 스스로 알게 하며, 기존 프로그램을 활용하며, 가장 어려운 사람을 내 편으로 하며, 자신의 성과를 알리는 것이 필요하다고 하였다. 본 연구 결과를 통하여 보건관리자는 자신의 전문성을 갖추기 위하여 노력하고, 건강관리 성과를 지속적으로 알려 사업장의 정책결정자와 근로자들에게 보건관리의 중요성을 설득할 필요가 있다. 또한, 우수한 보건관리자의 성공전략을 적극적으로 벤치마킹해야 할 것이다.

• Nutrition Research and Practice
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• 제5권5호
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• pp.396-403
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• 2011

Ceramides (Cer) comprise the major constituent of sphingolipids in the epidermis and are known to play diverse roles in the outermost layers of the skin including water retention and provision of a physical barrier. In addition, they can be hydrolyzed into free sphingoid bases such as $C_{18}$ sphingosine (SO) and $C_{18}$ sphinganine (SA) or can be further metabolized to $C_{18}$ So-1-phosphate (S1P) and $C_{18}$ Sa-1-phosphate (Sa1P) in keratinocytes. The significance of ceramide metabolites emerged from studies reporting altered levels of SO and SA in skin disorders and the role of S1P and Sa1P as signaling lipids. However, the overall metabolism of sphingoid bases and their phosphates during keratinocyte differentiation remains not fully understood. Therefore, in this study, we analyzed these Cer metabolites in the process of keratinocyte differentiation. Three distinct keratinocyte differentiation stages were prepared using 0.07 mM calcium (Ca$^{2+}$) (proliferation stage), 1.2 mM Ca$^{2+}$ (early differentiation stage) in serum-free medium, or serum-containing medium with vitamin C (50 ${\mu}L$/mL) (late differentiation stage). Serum-containing medium was also used to determine whether vitamin C increases the concentrations of sphingoid bases and their phosphates. The production of sphingoid bases and their phosphates after hydrolysis by alkaline phosphatase was determined using high-performance liquid chromatography. Compared to cells treated with 0.07 mM Ca$^{2+}$, levels of SO, SA, S1P, and SA1P were not altered after treatment with 1.2 mM Ca$^{2+}$. However, in keratinocytes cultured in serum-containing medium with vitamin C, levels of SO, SA, S1P, and SA1P were dramatically higher than those in 0.07- and l.2-mM Ca$^{2+}$-treated cells; however, compared to serum-containing medium alone, vitamin C did not significantly enhance their production. Taken together, we demonstrate that late differentiation induced by vitamin C and serum was accompanied by dramatic increases in the concentration of sphingoid bases and their phosphates, although vitamin C alone had no effect on their production.

• 유통과학연구
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• 제10권12호
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• pp.35-43
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• 2012

Purpose - This study analyzes the effects of types of leadership on the employees of Italian restaurants, its efficacy, and organizational citizenship behavior, utilizing a causal assessment model. In this study, independent variables such as the type of leadership perceived in the manager or chef by an Italian restaurant's employees, and its efficacy were parameters, and the organizational citizenship behavior and organizational effectiveness were the variables representing the results in the hypothesis. The study aimed to draw implications by verifying the leadership via efficacy and the impact on organizational citizenship behavior of Italian restaurants. Research design, data, methodology - For the purpose of this analysis, specific questionnaire items were configured according to the theory and efficacy of the study. From a questionnaire used in organizational citizenship behavior comprising 22 questions, six were modified to suit the research purpose of this study. The configured questionnaire comprised 5 parts and 40 items. A Likert (Likert) 5-point scale was utilized to measure responses to the questionnaire items from the employees of an Italian restaurant in Seoul who participated in the survey. For data collection, 400 questionnaires were distributed, and 344 collected. Factor analysis and reliability verification were conducted using SPSS18.0 and AMOS18.0. A covariance structure analysis was conducted to test the research hypotheses. Results - Based on the results of the analyses, the summary and suggested implications of the research are as follows: The covariance structure analysis used to analyze the kind of effect transformational and transactional leadership styles in Italian restaurant employees had on self-efficacy, group-efficacy, and organizational citizenship behavior, indicated that among the characteristics of transformational leadership (such as, idealized influence, inspirational motivation, individual consideration, and intellectual stimulation), idealized influence and individual consideration had a positive influence on self-efficacy. Idealized influence, individual consideration, conditional reward, and management by exception also positively influenced self-efficacy and altruistic and conscientious behavior (organizational citizenship behavior). Conclusions - Results suggest that with regard to self-efficacy and group efficacy, managers in different departments and chefs should provide team members with a vision for the future, increase their confidence in their abilities, and build their trust in the organization. By evaluating employee performance and experiences, management can demonstrate leadership and encourage organizational citizenship behavior through enjoyable, voluntary participation. Transformational and transactional leadership is effective in group processes that include social-exchange relationships, self-efficacy and group efficacy, and organizational citizenship behavior. However, as this research study utilizes only self-reported data, it has several limitations, such as a vulnerability of errors caused by the various experiment types. A significant limitation of this study is the lack of potential for the duplication of results. The covariance structure analysis, however, provides complementation to limit the impact of errors from self-reporting studies. A future study can extend this research by utilizing different data collection methods.

• 산학경영연구
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• 제16권
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• pp.23-42
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• 2003

최근 세정환경의 변화로 납세자에 대한 서비스의 제공 등 많은 개혁을 시행하고 있으나 합리적이고 효율적인 세정을 위한 개혁조치는 납세자와 직접적으로 접촉하는 세무조사가 중심이 되며 이에 부합되는 공정하고 투명한 세무조사가 이루어지려면 세무조사와 관련한 제반절차의 합법성과 세무공무원의 전문성 및 투명성이 선행되어야 할 것이다. 본 연구에서는 효율적이고 합리적인 세무행정을 위하여 세무조사에 대한 선행연구와 각종 참고문헌을 통해 세무조사의 이론적 측면과 주요 국가의 세무조사제도 및 우리나라 세무조사세도의 개선방안은 다음과 같다. 첫째, 세무조사대상자 선정에 있어서 선정위원회(가칭)와 외부인사 등을 참여하는 제도를 법제화하여 객관성 있는 선정제도의 틀을 마련하여야 할 것이다. 또한 매년 초 공개한 선정기준에 의해 엄중한 세무조사를 실시하고, 연중 실시한 세무조사 결과 자료를 공개하고 피드백 시켜 익년 세무조사선정기준을 정하는데 활용하도록 한다. 둘째, 세무조사평가방법에서는 조사실적에 대한 통제제도의 개선, 정기조사 심사분석 개선, 평가제외 규정을 확대함으로써 세무조사요원들이 실적에 부담을 갖지 않고 정확하고 공정한 세무조사를 할 수 있게 하여야 한다. 세무조사 대상자 선정위원회에서 세무조사대상자를 선정하는 명확한 규정을 법제화함으로써 세무조사에 대한 인식이 바뀌게 될 것이고, 세무조사를 시행하는데 실적위주의 부담이 줄어들게 되면 조사위원들은 보다 편한 마음에서 정확한 세무조사를 시행할 수 있게 될 것이다.

• 대한지역사회영양학회지
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• 제8권4호
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• pp.603-609
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• 2003

This study examined the reproducibility of nutrient intakes estimated by the 24-hour recall method in a prospective cohort study (Longitudinal study of aging and health monitoring of Korean elderly) of middle-aged volunteer subjects (42 males and 49 females) in the Seoul area. The three-day 24-hour recall was administered twice at an interval of approximately 6 months. The first data were collected and a corrective procedure was performed by interviewing of the subjects and a trained dietitian. The second data were collected by mail from the subjects without the performance of any corrective procedure. The mean age of the subjects was 53.5 $\pm$ 9.6 for the males and 52.2 $\pm$ 8.9 for the females. The subjects who had above college education were 95% in the case of the males and 60% in the case of the females. The characteristics of the male subjects in this study were that they were highly educated and held professional jobs and were from the middle or upper class. Comparing the first and second 24-hour recall data, the second data showed relatively lower intakes of all nutrients, except vitamin A, vitamin Bi and cholesterol. There was no difference in the nutrients of the first and the second data with respect to vitamin A, vitamin B$_1$ and cholesterol in the males and calcium, iron, sodium, vitamin A, vitamin B$_1$, vitamin B$_2$ and cholesterol in the females. This data may indicate that the 24 hour retail method without a dietitian's help may result in lower reporting of the subject's intakes. The men had a tendency to remember less than the women. Pearson's correlation coefficients with unadjusted nutrient intakes values were ranged from 0.24 to 0.66. When energy intake was adjusted, there was a slight increase (from 0.26 to 0.71). Intra-class correlation coefficients with nutrient-unadjusted values ranged from 0.22 to 0.66, and the energy-adjusted values were ranged from 0.23 to 0.69. The weighted Kappa statistical values ranged from 0.10 to 0.40. On the average,46.3% of the subjects who were found in the lowest quartile of the nutrient intake levels based on the first 24-hour recall, were in the lowest quartile based on the second 24-hour recall. Therefore, there was a low reproducibility between the first and the second 24-hour recall. We should examine the factors influencing low reproducibility. Also, strategies should be developed to maximize the reliability of the assessment, with regard to portion-size training and telephone validation. (Korean J Community Nutrition 8(4) : 603∼609, 2003)

• 한국방사선학회논문지
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• 제12권2호
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• pp.217-223
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• 2018

본 연구는 유방종괴에서 횡탄성 초음파검사(SWE)의 진단 수행도를 알아보고, 조직검사 결과와 SWE에서 얻어지는 강성도와 비교하고자 하였다. 진단적 유방 초음파와 SWE를 2017년 6월부터 2017년 9월까지 유방 초음파 검사 상 종괴가 발견된 환자 157명을 대상으로 하였다. 157명의 병리학적 결과는 양성 92명(나이, $44.54{\pm}11.84$), 악성 65명(나이, $51.55{\pm}10.54$)으로 나타났다. 진단적 유방 초음파의 유방영상보고데이터체계(BI-RADS)에 따른 최종 평가, 조직검사 결과, 정량적 SWE 결과를 구하고 서로 비교하였다. 정량적 SWE 수치와 병리학적 결과에서 진단 특이도는 평균탄성값(Emean)에서 83.70%로 가장 높게 나왔으며, 민감도는 최소탄성값(Emin)에서 89.23%로 가장 높게 나타났다. 정량적 SWE값과 조직검사결과와는 통계학적으로 유의한 차이를 나타내었다.(p=0.000) 악성병변에서 최적의 절사값(cut-off value)은 민감도, 특이도가 높은 최대탄성값(Emax), 평균탄성값(Emean)에서 66.3 kPa, 63.7 kPa로 나타났으며 이는 다른 SWE 측정 수치들과 비교했을 때 가장 높은 진단 곡선 하 면적(area under the curve; AUC)값을 보였다.(p=0.000) 유방종괴에서 기존의 초음파에서 SWE를 추가적으로 시행하는 것은 진단 특이도를 높이고 불필요한 조직검사를 줄일 수 있다. 따라서 상기 분석법 및 기기를 이용하여 유방종괴를 분석하는 데에 도움을 받을 수 있게 될 것으로 기대한다.