• 한국전자파학회논문지
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• 제17권12호
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• pp.1240-1248
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• 2006

본 논문에서는 유도 결합 구조를 응용하여 등방향 방사 특성에 근접하고 기 상용화된 태그 칩과의 임피던스 매칭과 제작이 용이한 UHF(911 MHz) 대역 RFID 태그 안테나를 설계 제작하였다. 제안된 안테나는 $40{\times}46mm\;(0.12{\times}0.14{\lambda})$의 크기를 가지고 수직 입사의 경우에 최대 RCS가 $-18.5dBm^2$이며, 3 dB RCS 대역폭이 9 MHz(1%)이다. 태그 칩과 안테나 임피던스가 단락 상태일 때의 RCS가 방향에 따라 최대 $-16.9dBm^2$, 최소 $-21.4dBm^2$로 4.5 dB의 차이를 보여, 기존 다이폴 형태의 안테나가 가지는 입사파의 방향에 따른 문제점을 대폭 개선하였다. 또한 설계된 안테나를 제작하여 입사파 각도에 따른 RCS를 측정하였고, 시뮬레이션 결과와 유사함을 확인하였다.

• 한국생물정보학회:학술대회논문집
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• 한국생물정보시스템생물학회 2000년도 International Symposium on Bioinformatics
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• pp.13-16
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• 2000

Microorganisms have been widely employed for the production of useful bioproducts including primary metabolites such as ethanol, succinic acid, acetone and butanol, secondary metabolites represented by antibiotics, proteins, polysaccharides, lipids and many others. Since these products can be obtained in small quantities under natural condition, mutation and selection processes have been employed for the improvement of strains. Recently, metabolic engineering strategies have been employed for more efficient production of these bioproducts. Metabolic engineering can be defined as purposeful modification of cellular metabolic pathways by introducing new pathways, deleting or modifying the existing pathways for the enhanced production of a desired product or modified/new product, degradation of xenobiotics, and utilization of inexpensive raw materials. Metabolic flux analysis and metabolic control analysis along with recombinant DNA techniques are three important components in designing optimized metabolic pathways, This powerful technology is being further improved by the genomics, proteomics, metabolomics and bioinformatics. Complete genome sequences are providing us with the possibility of addressing complex biological questions including metabolic control, regulation and flux. In silico analysis of microbial metabolic pathways is possible from the completed genome sequences. Transcriptome analysis by employing ONA chip allows us to examine the global pattern of gene expression at mRNA level. Two dimensional gel electrophoresis of cellular proteins can be used to examine the global proteome content, which provides us with the information on gene expression at protein level. Bioinformatics can help us to understand the results obtained with these new techniques, and further provides us with a wide range of information contained in the genome sequences. The strategies taken in our lab for the production of pharmaceutical proteins, polyhydroxyalkanoate (a family of completely biodegradable polymer), succinic acid and me chemicals by employing metabolic engineering powered by genomics, proteomics, metabolomics and bioinformatics will be presented.

• 대한기계학회논문집B
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• 제25권10호
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• pp.1392-1399
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• 2001

The flow fields inside a molten Zn pot of continuous hot-chip galvanizing process were investigated experimentally. With varying several parameters including the strip speed Vs, flow rate Q of induction heater. scrapper location and baffle configuration, instantaneous velocity fields were measured using a PIV velocity field measurement technique. Inside the strip region, counter-clockwise rotating flow is dominant. The general flow pattern inside the strip region is nearly not influenced by the strip speed Vs, flow rate Q and the scrapper location. In the exit region, the flow separated from the moving strip due to the existence of a stabilizing roll ascends to the free surface, for the cases of no scrapper and scrapper detached form the roll. On the other hand, the ascending flow to the free surface is decreased, as the flow rate Q of induction heater increases. By installing a baffle around the uprising strip, the flow moving up to the stabilizing roll decreases. In addition, B-type baffle is better than A-type baffle in reducing speed of flow around the stabilizing rolls. However, the flow ascended to the free surface is largely influenced by changing the flow rate Q, and the scrapper location, irrespective of the baffle type.

• 동의생리병리학회지
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• 제19권4호
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• pp.913-921
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• 2005

In this study, we investigated gene expression patterns induced by Ailanthus altissima extract and compared it with Gleevec, a well-known anti-leukemia drug, in K562 chromic leukemia cells. Ailanthus altissima extract(100 ug/ml) and Gleevec(50 ug/ml) were treated to cells for 1h, 2h, 4h, and 16h and total RNA was extracted. Gene expressions were evaluated using cDMA microarray, in which 24,000 genes were spotted. Hierarchical clustering analysis showed that expression of genes included in two clusters were increased or decreased time dependently by both Ailanthus altissima extract and Gleevec. Genes included in another cluster were induced by Ailanthus altissima extract but not by Gleevec. In biological process analysis, expression of genes involved in apoptosis, growth arrest and DNA-damage were increased, but genes stimulating cell cycle were decreased. This study provides comprehensive comparison of the patterns of gene expression changes induced by Ailanthus altissima extract and Gleevec in K-562 leukemia cells.

• Molecular & Cellular Toxicology
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• 제1권4호
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• pp.275-280
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• 2005

Carbon tetrachloride ($CCl_4$) is well known hepatotoxicant. Its overdose cause severe centrilobular hepatic necrosis in human and experimental animals. We administered $CCl_{4}$ at low (0.2 mL/kg p.o.) and high (2 mL/kg p.o.) doses to mice. Mice were sacrificed at 24 h after administration. We evaluated liver toxicity by serum AST and ALT level and by microscopic observation. Using cDNA chip, we conducted gene expression analysis in liver. Mean serum activities of the hepatocellular leakage enzymes, ALT and AST, were significantly increased compare to control, respectively, in the low and high dose groups. H&E evaluation of stained liver sections revealed $CCl_{4}-related$ histopathological findings in mice. Moderate centrilobular hepatocellular necrosis was present in all $CCl_{4}$ treated mice. We found that gene expression pattern was very similar between low and high dose group. However, some stress related genes were differently expressed. These results could be a molecular signature for the degree of liver injury. Our data suggest that the degree of severity could be figure out by gene expression profiling.

• JSTS:Journal of Semiconductor Technology and Science
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• 제4권2호
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• pp.100-105
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• 2004

The influencing factors on the OPC (optical proximity correction) results are quantitatively analyzed using OPCed L/S patterns. ${\sigma}$ values of proximity variations are measured to be 9.3 nm and 15.2 nm for PR-A and PR-B, respectively. The effect of post exposure bake condition is assessed. 16.2 nm and 13.8 nm of variations are observed. Proximity variations of 11.6 nm and 15.2 nm are measured by changing the illumination condition. In order not to seriously deteriorate the OPC, these factors should be fixed after the OPC rules are extracted. Proximity variations of 11.4, 13.9, and 15.2 nm are observed for the mask mean-to-targets of 0, 2 and 4 nm, respectively. The decrease the OPC grid size from 1 nm to 0.5 nm enhances the correction resolution and the OCV is reduced from 14.6 nm to 11.4 nm. The enhancement amount of proximity variations are 9.2 nm corresponding to 39% improvement. The critical dimension (CD) uniformity improvement for adopting the small grid size is confirmed by measuring the CD uniformity on real SRAM pattern. CD uniformities are measured 9.9 nm and 8.7 nm for grid size of 1 nm and 0.5 nm, respectively. 22% improvement of the CD uniformity is achieved. The decrease of OPC grid size is shown to improve not only the proximity correction, but also the uniformity.

• 전기학회논문지
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• 제64권3호
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• pp.458-464
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• 2015

This paper proposes a portable 3-D scanning technique using a laser pointer. 3-D scanning is a process that acquires surface information from an 3-D object. There have been many studies on 3-D scanning. The methods of 3-D scanning are summarized into some methods based on multiple cameras, line lasers, and light pattern recognition. However, those methods has major disadvantages of their high cost and big size for portable appliances such as smartphones and digital cameras. In this paper, a 3-D scanning system using a low-cost and small-sized laser pointer are introduced to solve the problems. To do so, we propose a 3-D localization technique for a laser point. The proposed method consists of two main parts; one is a fast recognition of input images to obtain 2-D information of a point laser and the other is calibration based on the least-squares technique to calculate the 3-D information overall. To verified our method, we carry out experiments. It is proved that the proposed method provides 3-D surface information although the system is constructed by extremely low-cost parts such a chip laser pointer, compared to existing methods. Also, the method can be implemented in small-size; thus, it is enough to use in mobile devices such as smartphones.

• 한국전자파학회논문지
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• 제25권6호
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• pp.628-636
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• 2014

본 논문은 재밍 대응 위성 항법 장치의 5소자 평면 배열 안테나 설계에 대해 기술한다. GPS $L_1/L_2$ 대역에서 공진하는 적층 구조의 패치 안테나 설계를 제안한다. 제안된 안테나는 광대역 및 원형 편파 특성을 구현하기 위해 칩 커플러를 이용한 이중 급전을 사용한다. 배열안테나 측정 결과, 중앙안테나의 전면 방향 이득은 $L_1$과 $L_2$ 대역에서 각각 1.10 dBic, 0.37 dBic, 측면안테나는 $L_1$과 $L_2$ 대역에서 0.99 dBic, -0.57 dBic를 갖는다. 고각 $30^{\circ}$에서 방위각의 이득은 중앙안테나 $L_1$과 $L_2$ 대역에서 평균 -2.08 dBic, -5.33 dBic의 측정 결과를 갖는다. 측면안테나는 $L_1$과 $L_2$ 대역에서 평균 -0.40 dBic, -2.09 dBic의 측정 결과를 갖는다. 제안된 5소자 평면 배열 안테나는 GPS 재밍 대응 장치에 적합함을 확인한다.

• 디자인학연구
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• 제15권3호
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• pp.29-38
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• 2002

최근 모바일 휴대폰을 이용한 서비스 종류는 기하급수적으로 증가하고 있다. 또한 잦은 휴대폰 기기의 교체와 통신 서비스 회선의 변경으로 인하여 사용자들은 그 어느 때보다도 모바일 서비스 이용에 어려움을 겪고 있다고 할 수 있다. 그러나 정작 도움을 주어야 하는 매뉴얼은 휴대폰 사용 상황의 특성상 큰 도움을 주지 못하고 있는 실정이다. 모바일 휴대폰에는 1) 휴대폰 기기 자체기능, 2) 인터넷 서비스 기능, 및 3) 통신회선 자체 서비스 기능 등이 혼재되어 있고, 주로 이동 중에 사용되므로, 매뉴얼 이용 공간과 사용자 기능습득의 공간이 일치하기 힘들다는 점이 두드러진다. 따라서 바람직한 모바일 휴대폰의 사용자 매뉴얼은 모바일 휴대폰 시스템 자체 내에서 포괄적으로 포함하는 것이 바람직한 모델이다. 본 연구는 이러한 시스템 자체 내에서 활용될 수 있는 사용자 매뉴얼의 가능성에 주목하고, 1) 전자 매뉴얼의 정보 표현 방식과 그에 대한 사용자의 반응을 조사하고, 2) 사용자의 정보습득 패턴을 분석하여 3) 시각적 단서(Visual Cue)의 제공이 사용자 매뉴얼 사용의 편의성을 향상시킴을 발견하여 이를 모바일 핸드폰에 활용하기 위한 가이드라인을 개발함을 그 목적으로 하였다.

• Journal of Animal Science and Technology
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• 제56권7호
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• pp.23.1-23.7
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• 2014

Background: Scanning of the genome for selection signatures between breeds may play important role in understanding the underlie causes for observable phenotypic variations. The discovery of high density single nucleotide polymorphisms (SNPs) provide a useful starting point to perform genome-wide scan in pig populations in order to identify loci/candidate genes underlie phenotypic variation in pig breeds and facilitate genetic improvement programs. However, prior to this study genomic region under selection in commercially selected Berkshire and Korean native pig breeds has never been detected using high density SNP markers. To this end, we have genotyped 45 animals using Porcine SNP60 chip to detect selection signatures in the genome of the two breeds by using the $F_{ST}$ approach. Results: In the comparison of Berkshire and KNP breeds using the FDIST approach, a total of 1108 outlier loci (3.48%) were significantly different from zero at 99% confidence level with 870 of the outlier SNPs displaying high level of genetic differentiation ($F_{ST}{\geq}0.490$). The identified candidate genes were involved in a wide array of biological processes and molecular functions. Results revealed that 19 candidate genes were enriched in phosphate metabolism (GO: 0006796; ADCK1, ACYP1, CAMK2D, CDK13, CDK13, ERN1, GALK2, INPP1; MAK, MAP2K5, MAP3K1, MAPK14, P14KB, PIK3C3, PRKC1, PTPRK, RNASEL, THBS1, BRAF, VRK1). We have identified a set of candidate genes under selection and have known to be involved in growth, size and pork quality (CART, AGL, CF7L2, MAP2K5, DLK1, GLI3, CA3 and MC3R), ear morphology and size (HMGA2 and SOX5) stress response (ATF2, MSRB3, TMTC3 and SCAF8) and immune response (HCST and RYR1). Conclusions: Some of the genes may be used to facilitate genetic improvement programs. Our results also provide insights for better understanding of the process and influence of breed development on the pattern of genetic variations.