• Transactions of the Korean Society of Automotive Engineers
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• v.13 no.5
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• pp.163-170
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• 2005

Urban transit is a complex system that is combined electrically and mechanically, it is necessary to construct maintenance system for securing safety accompanying high-speed driving and maintaining promptly. Expert system is a computer program which uses numerical or non-numerical domain-specific knowledge to solve problems. In this research, we intend to develop the expert system which diagnose failure causes quickly and display measures. For the development of expert system, standardization of failure code classification system and creation of BOM(Bill Of Materials) have been first performed. Through the analysis of failure history and maintenance manuals, knowledge base has been constructed. Also, for retrieving the procedure of failure diagnosis and repair linking with the knowledge base, we have built RBR(Rule Based Reasoning) engine by pattern matching technique and CBR(Case Based Reasoning) engine by similarity search method. This system has been developed based on web to maximize the accessibility.

• Korean Journal of Construction Engineering and Management
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• v.16 no.2
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• pp.21-28
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• 2015

Construction defects are major components that result in cost overruns and schedule delays in construction projects. There have been extensive research efforts to investigate the cause of defects. However, little effort has been devoted to analyze correlation among various reasons of construction defects while a defect is not usually an outcome of a single cause, but rather occurs when several interrelated causes combine. Based on this recognition, this paper analyzes 831 nonconformity reports collected from 30 construction projects in Korea from 2011 to 2014. The correlation analysis revealed that a significant portion of construction defects occurred in the procurement and construction phase and as the pattern of function defect and installation defect. Triggered by human error, defective material and faulty method, these defects are treated by conccession, repair, rework that can significantly lower the cost and schedule performance. This paper is significant in terms of providing a theoretical basis for analyzing correlation among various reasons of construction defects and quantitative measures for establishing effective defect prevention strategies.

• Molecules and Cells
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• v.38 no.11
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• pp.925-935
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• 2015

DNA methylation is a well-characterized epigenetic modification that plays central roles in mammalian development, genomic imprinting, X-chromosome inactivation and silencing of retrotransposon elements. Aberrant DNA methylation pattern is a characteristic feature of cancers and associated with abnormal expression of oncogenes, tumor suppressor genes or repair genes. Ten-eleven-translocation (TET) proteins are recently characterized dioxygenases that catalyze progressive oxidation of 5-methylcytosine to produce 5-hydroxymethylcytosine and further oxidized derivatives. These oxidized methylcytosines not only potentiate DNA demethylation but also behave as independent epigenetic modifications per se. The expression or activity of TET proteins and DNA hydroxymethylation are highly dysregulated in a wide range of cancers including hematologic and non-hematologic malignancies, and accumulating evidence points TET proteins as a novel tumor suppressor in cancers. Here we review DNA demethylation-dependent and -independent functions of TET proteins. We also describe diverse TET loss-of-function mutations that are recurrently found in myeloid and lymphoid malignancies and their potential roles in hematopoietic transformation. We discuss consequences of the deficiency of individual Tet genes and potential compensation between different Tet members in mice. Possible mechanisms underlying facilitated oncogenic transformation of TET-deficient hematopoietic cells are also described. Lastly, we address non-mutational mechanisms that lead to suppression or inactivation of TET proteins in cancers. Strategies to restore normal 5mC oxidation status in cancers by targeting TET proteins may provide new avenues to expedite the development of promising anti-cancer agents.

• Korean Journal of Microbiology
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• v.38 no.2
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• pp.96-102
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• 2002

The S-phase checkpoint mechanisms response to DNA damage or inhibition of DNA replication for maintenance of genetic stability in eukaryotic cells. These roles include cell cycle control arrest at S-phase and Iranscriptional induction of repair genes. To characterize the defects of dpbll mutant for both these responses, we examined the over-expression effect of DPBll gene, the sensitivity to HU, MMS, and the transcriptional pattern by DNA damage agent for RNRS mRNA. RNRS transcript is induced in response to a wide variety of agents that either damage D7A directly through chemical modification or induce stress by blocking DNA synthesis. As results, dpbll-1 cells are sensitive to DNA damage agents and the level of RNR3 mRNA is reduced approximately 40% than wild type cells. Moreover, we found the same results in dpb2-1 cells. Therefore, we propose that DPB2 and DPBll act as a sensor of replication that coordinates the transcriptional and cell cycle responses to replication blocks.

• Journal of Microbiology
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• v.43 no.6
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• pp.516-522
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• 2005

The phosphorylation of C-terminal domain (CTD) of Rpb1p, the largest subunit of RNA polymerase II plays an important role in transcription and the coupling of various cellular events to transcription. In this study, its role in DNA damage response is closely examined in Saccharomyces cerevisiae, focusing specifically on several transcription factors that mediate or respond to the phosphorylation of the CTD. CTDK-1, the pol II CTD kinase, FCP1, the CTD phosphatase, ESS1, the CTD phosphorylation dependent cis-trans isomerase, and RSP5, the phosphorylation dependent pol II ubiquitinating enzyme, were chosen for the study. We determined that the CTD phosphorylation of CTD, which occurred predominantly at serine 2 within a heptapeptide repeat, was enhanced in response to a variety of sources of DNA damage. This modification was shown to be mediated by CTDK-1. Although mutations in ESS1 or FCP1 caused cells to become quite sensitive to DNA damage, the characteristic pattern of CTD phosphorylation remained unaltered, thereby implying that ESS1 and FCP1 play roles downstream of CTD phosphorylation in response to DNA damage. Our data suggest that the location or extent of CTD phosphorylation might be altered in response to DNA damage, and that the modified CTD, ESS1, and FCP1 all contribute to cellular survival in such conditions.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 2015.10a
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• pp.322-323
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• 2015

Traditional rotation type large beacon was characterized by frequent failure, long repair time and high cost etc. These problems are caused by traditional light sources(metal halide lamps or tungsten halogen lamps). In order to solve these problems, IALA standards-based(efficiency and reliability) large LED beacon technologies are needed. we developed by applying a LED. The object of the this project, to design a reflective optics and the high power LED lighting engine module. And to develop a rotational speed control system for controlling flash pattern of beacon. As a result, to develop of LED beacon for landfall mark that distance to reach the light 20NM to 27NM.

• Proceedings of the SAREK Conference
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• 2007.11a
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• pp.459-465
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• 2007

This study was conducted to calculate the LCC of a apartment complex with a type of heating system, district heating and cogeneration system. For the purpose of analyzing LCC according to size of apartment complex, 500, 1,500 and 4,000 houses of model apartment selected. This research performs design of heating system and the life cycle cost analysis including an initial cost, energy cost, maintenance and operation cost, replacement cost and renovation cost during the project period(15years). According to the calculated results, 1) Initial cost of cogeneration system with 500, 1500 and 4000 houses is higher than district heating system each of 20%, 13%, 12%. 2) In case of cogeneration system, the payback period by electric generation is 5.21, 4.92 and 4.47 years and saving cost was calculated 29 billion won, 94 billion won and 262 billion won after payback period. 3) Cogeneration system LCC was 1.12, 1.07 and 1.06 times larger than district system with the size of apartment complex. According to the case of this study district heating system is more efficient than cogeneration system in terms of the reduction of LCC. 4) Gas Engine Co-generation System is more efficient than other systems because it can collect progressive part from electric charge progressive stage system. However, the efficiency is decreasing because of raising of fuel bills(LNG) and lowering of power rate for house use. Especially the engine is foreign-made so the cost of maintenance and repair is high and the technical expert is short. 5) District heating is also affected by fuel bills so we should improve energy efficiency through recovering of waste heat(incineration heat, etc.). Also, we should supply district cooling on the pattern of heat using of let the temperature high in winter and low in summer.

• Archives of Plastic Surgery
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• v.34 no.4
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• pp.485-489
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• 2007

Purpose: The basic vascular anatomy and versatility of the anterolateral thigh flap was reported firstly by Song in 1984 and then by Zhang who introduced the reverse flow pattern of this flap. In this case, the authors reviewed various articles and their experiences with the distally based anterolateral thigh flap and applied it for coverage of bone-exposed wound occurred at the distal of the disarticulated knee stump. We consequently reported the reliability and resourcefulness of this flap in the difficult and limited situation. Methods: A 67-year-old-man who had suffered from arteriosclerotic obliterans inevitably underwent the disarticulation at knee joint due to clinical deterioration. He presented to our clinic with soft tissue necrosis and bone exposure at the stump. We debrided the wound and conducted the distally based anterolateral thigh island flap by transecting proximal portion of descending branch of the lateral circumflex femoral artery and the $14{\times}10cm$ sized flap was transferred to cover the defect. The pedicle measured 14 cm in length with pivot point 7 cm above the patella. Results: The postoperative course was mainly uneventful except early venous congestion for 4 days and subsequent partial skin loss. The wound was healed by secondary intension and no other sequelae had been observed during follow-up period of 12 months. Conclusion: Despite the presence of various reconstructive choices, the distally based anterolateral thigh island flap can be designed to repair soft tissue defects around the knee region, providing its reliable blood supply and long pedicle length, especially in the challenging cases.

• Journal of Convergence for Information Technology
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• v.11 no.2
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• pp.201-210
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• 2021

This study was carried out to investigate the Fagopyrum esculentum (F. esculentum) extracts and vitexin are as the results of microarray, cell proliferation, cell wound recovery, cell cycle, microphage pattern and protein analysis for damage improvement caused by UVB-induced damage. Microarray results showed that UVB-induced increase in DRAM1, Atg2a and Atg13 genes was reduced in F. esculentum ethanol extract and vitexin. Cell proliferation, wound repair, cell cycle, and microphage patterns were improved in F. esculentum ethanol extract and vitexin, while buckwheat ethanol extract and vitexin decreased in both DRAM1, Beclin-1, and LC3 I/II in the vitexin treatment group and p-mTOR and survivin were all increased in protein analysis. It is thought that it can recover to normal and control autophagy, one of the causes of cell aging caused by UVB, to inhibit and regenerate cell death. F. esculentum ethanol extract and vitexin can be used as a functional cosmetic ingredient.

• Journal of the Society of Disaster Information
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• v.18 no.2
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• pp.290-305
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• 2022

Purpose: Currently, port facility informatization technology is focused on the planning and design phases, so the necessity of research and technology development on the port facility maintenance system based on life cycle-level information is emphasized. Method: Based on the maintenance history data of port facilities and facility operation information, from the perspective of the life cycle of port facilities, the system is configured to enable maintenance decisions for port facilities through analysis of aging patterns, performance degradation prediction models, and risk analysis and proposed a method of expressing information. Result: A function was developed to simultaneously display the SOC performance evaluation and the comprehensive performance evaluation developed in this study, so that mid-to long-term maintenance and reinforcement and facility expansion can be applied and comparatively judged. Conclusion: The integrated port performance system developed in this study induces and supports the risk minimization of port facility management by proactively promoting appropriate repair and reinforcement measures through historical and operational information on port facilities.