• Tuberculosis and Respiratory Diseases
• /
• v.74 no.6
• /
• pp.264-268
• /
• 2013

Background: Idiopathic pulmonary fibrosis (IPF) is a lethal pulmonary fibrotic disease. In general, the exaggerated activation of the coagulation cascade has been observed during initiation or maintenance of the fibrotic disease. In our recent study, immunohistochemical expression of protease-activated receptor-2 (PAR-2), which plays a key role in coagulation cascade, was observed in surgical specimen of IPF patients, and associated with poor clinical outcome. The aim of this study was to evaluate the overexpression of PAR-2 in inflammatory cells from peripheral blood and bronchoalveolar lavage fluid in IPF patients. Methods: From May 2011 to March 2012, IPF patients and controls were enrolled in Seoul National University Hospital. Peripheral blood and bronchoalveolar lavage fluid were collected for analysis of PAR-2 expression. Flow cytometry and reverse transcription polymerase chain reaction were used for PAR-2 receptor and mRNA assessment. Results: Twelve IPF patients and 14 controls were included in this study. Among them, flow cytometry analysis was conducted from 26 peripheral blood (patient group, 11; control group, 13) and 7 bronchoalveolar lavage fluid (patient group, 5; control group, 2). The expression of PAR-2 receptor was not different between patient and control groups (p=0.074). Among all 24 population, PAR-2 mRNA assessment was performed in 19 persons (patient group, 10; control group, 9). The mRNA expression of PAR-2 was not significant different (p=0.633). Conclusion: In IPF patients, PAR-2 receptor and mRNA expression were not different from control group.

• The Journal of the Acoustical Society of Korea
• /
• v.38 no.4
• /
• pp.443-449
• /
• 2019

To protect the patient's internal organs when a patient with cardiovascular disease occurs, it is important to reduce the elapsed time by providing emergency medical services. Decisions for conducting cardiopulmonary resuscitation are mainly made using the carotid palpation method, which directs the pulse of the carotid artery, which can diagnose the patient's condition according to one's own subject and cause cerebral blood flow to be blocked by excessive pressure in the carotid due to the weaken cardiopulmonary function. In this study, we developed a multimodal patch-type probe based on multi-channel ultrasound Doppler pairs and oxygen saturation measurement modules which can monitor cardiopulmonary functions. From the in-vivo experiments, the developed probe can be utilized as a novel tool that can increase the survival rate of cardiovascular disease patients by objectively monitoring the cardiopulmonary function of the patient quantitatively and promptly in an emergency situation.

• The Journal of the Society of Stroke on Korean Medicine
• /
• v.23 no.1
• /
• pp.41-54
• /
• 2022

Brady-arrhythmia is defined as an arrhythmia in which the heart rate slows to less than 60 beats per minute. Brady-arrhythmia reduces cardiac output and causes changes in blood flow. As a result, dizziness occurs because not only ischemia occurs in the central nervous system, but also blood flow in major organs decreases. The insertion of an artificial pacemaker is known as almost the only treatment alternative for patients with brady-arrhythmia with symptoms. This study reports a case of 85 year old male diagnosed with brady-arrhythmia complaining presyncope type of dizziness. The patient underwent complex Korean medicine treatments by herbal medicine, acupuncture and moxibustion. The daily average value of pulse rate, K-DHI score, NRS score and the patient's subjective expression of symptoms were used as evaluation tools. This study suggested a significant improvement in symptoms through complex Korean medicine treatments without the use of anti-arrhythmic drugs or insertion of an artificial pacemaker in the patient with brady-arrhythmia complaining dizziness.

• Journal of Institute of Control, Robotics and Systems
• /
• v.8 no.12
• /
• pp.1061-1065
• /
• 2002

Sensors need to be implanted to obtain necessary information for LVAS (Left Ventricular Assist System) operations. Size of the sensors can prevent them from being implanted in a patient and reliabilities of the sensors are questionable for a long term use. In this wort we utilize a developed pump model to estimate flow and pressure difference across the pump without implanted sensors and present a method to obtain the physiological variables as aorta pressure and left ventricle pressure from the pump model and pulsatility of flow estimate or pressure difference estimate. These estimated variables can be used for LVAS control as an index or indices.

• Journal of Industrial Technology
• /
• v.29 no.B
• /
• pp.107-113
• /
• 2009

For the environmental safety of the operating room and patient healthcare, the closed type rebreathing system is widely adopted. In order to reduce the anesthesia gas during surgery, the mixing ratio of anesthesia gas with breathing air should be precisely controlled. Generally, the breathing air passes through the vaporizer to mix the anesthesia gas, but there is a difficulty in controlling the mixing ratio precisely. In this paper, the stand-alone style vaporizer is designed and the operating characteristics are investigated. The vaporizer measures the temperature and pressure in the vaporizing chamber and chamber temperature is precisely controlled by proportional controlled heater. Exact quantity of anesthesia media is feeded by PID controlled peristaltic pump and vaporized gas is mixed with breathing air flow by PWM controlled solenoid valve. The experimental result shows that the vaporizer has an excellent command following performances that it can be applied to the low flow anesthesia system.

• Proceedings of the KIEE Conference
• /
• 2003.07d
• /
• pp.2492-2494
• /
• 2003

Urine analysis is one of the most important medical examination in the hospital. Not only the data for the ingredients of urine through chemical analysis, but also the data related to fluid dynamics, e.g., peak flow rate, average flow rate, may provide some useful information about patient's state of health. Therefore, we develop the portable system to measure and analyse fluid volume/flow rate in this study. This system can store and print the measured data during the pre-specified time interval, and provide some meaningful data related with fluid dynamics. We explain the method and the technical stuff to implement the system, and show the result.

• The Korean Journal of Pain
• /
• v.28 no.1
• /
• pp.57-60
• /
• 2015

Sphincter of Oddi dysfunction (SOD) is a syndrome of chronic biliary pain or recurrent pancreatitis due to the functional obstruction of the pancreaticobiliary flow. We report a case of spinal cord stimulation (SCS) for chronic abdominal pain due to SOD. The patient had a history of cholecystectomy and had suffered from chronic right upper quadrant abdominal pain. The patient had been diagnosed as having SOD. The patient was treated with opioid analgesics and nerve blocks, including a splanchnic nerve block. However, two years later, the pain became intractable. We implanted percutaneous SCS at the T5-7 level for this patient. Visual analog scale (VAS) scores for pain and the amount of opioid intake decreased. The patient was tracked for more than six months without significant complications. From our clinical case, SCS is an effective and alternative treatment option for SOD. Further studies and long-term follow-up are necessary to understand the effectiveness and the limitations of SCS on SOD.

• Korean Institute of Interior Design Journal
• /
• v.26 no.6
• /
• pp.71-80
• /
• 2017

The purpose of this study is identify the status of the ward of public hospital for integrated nursing care service. Integrated nursing care service has been expanding on a national scale from 2016 but most of public hospitals are currently unable to operate due to nursing shortage. In this study 8 wards of public hospital have been chosen and analyzed. The measure of space program and area distribution(patient area percentage, staff area percentage, circulation area percentage), nurses's walking distance(distance from ns to patient room, distance from ns to core) were calculated by depthmapX and autocad programs. The result of this study is as follows. Nurse's walking distance is more than 24m so the efficiency of nurse's patient care is reduced. The percentage of patient area in double-corridor is higher and the patient feels more comfortable but the Nurse's walking distance is longer and the accessibility is lowered. NS should be located in the center of the ward and close to the core but some wards are not composed of proper space-separation and flow of human trrafic is overlapped. This study may serve as basic research for the architectural plan for future integrated nursing care ward.

• Archives of Plastic Surgery
• /
• v.46 no.4
• /
• pp.381-385
• /
• 2019

Hypospadias is a congenital malformation of the male genitalia. The reconstructive objectives are to obtain voiding with laminar flow and satisfactory sexual function. Several urethroplasty techniques have been described, but for perineal or revisional cases no single technique has shown robust success. In this study, we describe the expanded use of intestinal flaps for urethral reconstruction and report a peculiar request from a patient to undergo peno-urethral separation after successful hypospadias repair with a free ileum flap. A 51-year-old male patient with perineal hypospadias underwent several urethral reconstructive procedures with poor outcomes. A free ileum flap was attempted as a substitute for the urethra. Following successful reconstruction, separation of the neo-urethra (ileum) from the penile body was performed to address the patient's sexual expectations. A free ileum flap proved to be a reliable urethral substitute in perineal hypospadias reconstruction, with a successful outcome. The peno-urethral separation with the creation of an "accessory penis," however peculiar, optimized the results in terms of both sexual and urinary function. Anatomical restoration of the urethra and patient-reported expectations are the key to successful hypospadias reconstructive procedures. Sexual function outcomes and the patient's perception of success should not be underestimated, even when urinary function has been restored.

• Journal of Biomedical Engineering Research
• /
• v.23 no.5
• /
• pp.391-395
• /
• 2002

Shunt valves used to treat patient with hydrocephalus were numerically simulated to investigate influence of pressure pulsation on their flow control characteristics. We modeled flow orifice through the shunt valve and imposed pulsating pressure and valve diaphragm movement to compute flow through the valve. The results of our study indicated that flow rates increased more than 40% by introducing pressure pulsation and diaphragm movement on the shunt valve. Our results demonstrate the pressure-flow control characteristics of shunt valves implanted above human brain may be quite different from those obtained by syringe pump test just after manufacture that induces uniform pressure.