• The Korean Journal of Financial Management
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• v.11 no.1
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• pp.263-284
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• 1994

This study examines the monitoring effects of institutions, outside directors, and outside blockholders by seeing managers' selection of antitakeover measures. In this paper, we hypothesize that managers use antitakeover techniques to entrench themselves when they are not monitored closely. Consequently, we hypothesize that institutional ownership, outside membership on board of directors, outside directors ownership, and outside blockholder ownership are less in firms which adopt harmful antitakeover measures. This paper analyzes whether the degree of monitoring by institutions, outside directors, and outside blockholders influences managers' adoption of different types of takeover defenses. We find interesting empirical results. First, aggregate institutional ownership is positively correlated with the likelihood of antitakeover techniques adoption. This result implies that institutional investors are passive. Second, total and active blockholder owner-ship is higher at firms that do not propose any defensive tactics. passive blockholder owner-ship is highest at fair price firms but low at poison pills firms. Ownership concentration by outside investors increases monitoring and reduces agency problems. Thirid, outside board monitoring is ineffective.

• The KIPS Transactions:PartC
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• v.10C no.4
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• pp.441-446
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• 2003

Earlier efforts on optical access concentrated on the design of PONs for the collection and distribution portion of the access network. The PON architecture is very simple but it requires a MAC protocol for control of upstream traffic. The MAC protocol must support QoS (Quality of Service) administration function by various traffic class, efficient dynamic bandwidth assignment function, CDV (Ceil Delay Variation) minimization function etc. This paper proposes a dynamic bandwidth assignment algorithm of the MAC protocol for a broadband access network using an Ethernet Passive Optical Network supporting various traffic class. We compare our proposed with MDRR algorithm using simulation, and confirmed that our proposed Request-Counter algorithm produces shorter average cell delay.

• Journal of Oriental Neuropsychiatry
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• v.22 no.4
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• pp.185-199
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• 2011

In the present study, we assessed the effect of the PPA (Polygala japonica Houtt., Polygala tenuifolia WILLD. and Acorus gramineus SOLAND. mixed preparation), a traditional herbal prescription, on the learning and memory impairments induced by scopolamine. The cognition-enhancing effect of PPA was investigated using a passive avoidance test, Y-maze test and the Morris water maze test in mice. Drug-induced amnesia was induced by treating animals with scopolamine (1 mg/kg, i.p.). A single PPA (400 and 800 (mg/kg)) administration significantly reversed the scopolamine-induced cognitive impairments in the passive avoidance test (P<0.05). On the Y-maze test, PPA (400 and 800 (mg/kg)) also significantly reversed scopolamine-induced cognitive impairments in mice (P<0.05). PPA also improved escape latencies in training trials and increased swimming times and distances within the target zone of the Morris water maze (P<0.05). These results suggest that PPA attenuates amnesic state induced by scopolamine and that these Effect are mediated by enhancing the cholinergic dysfunction.

• Journal of Physiology & Pathology in Korean Medicine
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• v.31 no.5
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• pp.270-276
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• 2017

The aim of this study was to investigate the effects of the water extract of Albizziae Cortex (AC) on the learning and memory impairments. AC was administered to normal mouse and scopolamine-injected amnesia mouse model. Passive avoidance test, Y-maze test, and Morris water maze test were conducted to confirm the cognitive-enhancing activities of AC. Acetylcholinesterase (AChE) activity and acetylcholine (Ach) content were measured after oral administration of AC. On the passive avoidance test, AC (200 mg/kg) significantly increased latency time and recovered scopolamine-impaired learning and memory in mice. In addition, AC (200 mg/kg) reduced Exploration time in target quadrant and reversed the scopolamine-induced cognitive impairments in the Y-maze test. Moreover, AC (200 mg/kg) increased exploration time in target quadrant and improved scopolamine-reduced escape latencies in the Morris water maze test. These effects were presented by regulatory effects of AC on AChE activity and Ach content. Taken together, AC increases cognitive-enhancing activities and ameliorates scopolamine-induced learning and memory impairment. AC might be a potential agent for prevention and treatment of amnesia and dementia.

• Proceedings of the Korea Water Resources Association Conference
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• 2018.05a
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• pp.152-152
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• 2018

Soil moisture is a important factor in hydrologic analysis. So, if we have spatially distributed soil moisture data, it can help to study much research in a various field. Recently, there are a lot of satellite derived soil moisture data, and it can be served through web freely. Especially, NASA (National Aeronautics and Space Administration) launched the Soil Moisture Aperture Passive (SMAP) satellite for mapping global soil moisture on 31 January 2015. SMAP data have many advantages for study, for example, SMAP data has higher spatial resolution than other satellited derived data. However, becuase many satellited derived soil moisture data have a limitation to data accuracy, if we have ancillary materials for improving data accuracy, it can be used. So, in this study, after applying the alogorithm, which is data assimilation methods, applicability of satellite derived soil moisture data was analyzed. Among the various data assimilation methods, in this study, Model Output Statistics (MOS) technique was used for improving satellite derived soil moisture data. Model Output Statistics (MOS) is a type of statistical post-processing, a class of techniques used to improve numerical weather models' ability to forecast by relating model outputs to observational or additional model data.

• Parasites, Hosts and Diseases
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• v.31 no.3
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• pp.223-230
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• 1993

Monoclonal antibodies (Ub) against merozoites and sporozoites of the protozoan parasite Cryptosporidium pcnjum were examined for potential modulation of cryptosporidial infections in vivo by daily oral Ub administration to oocyst-inoculated neonatal mice. Monoclonal-treated neonatal mice were sacrified four and eight days post infection (pi) . Differences in infection rates were observed among the treatment groups at the p < 0.05 level. Suckling mice treated daily with orally administered mixtures of mAbs( ascitic fluids) showed significantly reduced parasite loads compared to control mice at flour and eight days pi, while suckling mice receiving mAb Cmg-3 alone showed signiacant differences only at 4 days Pi., suggesting that passive transfer of mAb may be of value in controlling cryptosporidial infections.

• Biomolecules & Therapeutics
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• v.17 no.3
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• pp.249-255
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• 2009

Forsythiaside is a polyphenolic constituent of the fruits of Forsythia suspense Vahl which are widely used as anti-inflammatory herbal raw materials in traditional Chinese medicine. In the present study, the authors assessed the effects of forsythiaside on learning and memory impairments induced by scopolamine using a passive avoidance and the Morris water maze tests in mice. Drug-induced amnesia was induced by scopolamine treatment (1 mg/kg, i.p.). Forsythiaside (10 mg/kg, p.o) administration significantly prevented scopolamine-induced step-through latency reduction in the passive avoidance test and scopolamine-induced increased escape latency in the Morris water maze test (p<0.05). Moreover, in an ex-vivo study, forsythiaside treatment (10 mg/kg, p.o) significantly reduced the increase of thiobarbituric acid reactive substance levels induced by scopolamine (p<0.05). Taken together, the present study suggests that forsythiaside could be useful for the treatment of cognitive impairment, and that its beneficial effects are mediated, in part, by its antioxidative properties.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.1
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• pp.753-759
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• 2020

A modified Chebyshev lowpass filter function with progressively diminishing ripples in the passband is proposed and analyzed in the frequency domain. Owing to the diminishing ripples, the passband magnitude characteristic of the proposed Chebyshev function has improved compared to the classical Chebyshev function. In addition, the phase characteristics of the proposed Chebyshev function were improved considerably compared to that of the Chebyshev function, and the time delay of the proposed function was much simpler and flatter. In addition, the proposed Chebyshev filter was realizable by the passive doubly terminated ladder network delivering maximum power transfer for the order n, even or odd, thus making themselves amenable to low-sensitivity active RC or switched capacitor filters through the simulation techniques. To verify the proposed Chebyshev filter characteristics, a 6th order passive doubly terminated ladder lowpass filter was designed and analyzed using the MATLAB and SPICE program. Thus, the proposed Chebyshev function can remove the drawbacks of the classical Chebyshev function and could be applicable to the design of a filter with an improved filter size, phase, and time delay characteristics for various signal processing.

• Toxicological Research
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• v.34 no.3
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• pp.183-189
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• 2018

Currently, injuries to customers due to health functional foods are annually increasing. To evaluate the antigenicity of Korean red ginseng mixture (KRGM), we tested for systemic anaphylactic shock and passive cutaneous anaphylaxis in guinea pigs. Based on a comparison of measured body weights, there were no changes in body weight for the KRGM treatment group compared with the control group. In the ovalbumin treated group, however, there was a statistically significant decrease in body weight. For the active systemic anaphylaxis test, after the induction, there were no symptoms that suggested anaphylactic shock in the control and KRGM treatment group. In the ovalbumin treated group, there were symptoms that suggested severe anaphylaxis, and those symptoms included restlessness, piloerection, tremor, rubbing or licking the nose, sneezing, coughing, hyperpnea, dyspnea, staggering gait, jumping, gasping and writhing, convulsion, side position and Cheyne-stokes respiration. All animals died within thirty minutes in the ovalbumin treated group. For the passive cutaneous anaphylaxis test in guinea pigs sensitized to KRGM, each anti-serum was diluted in a stepwise manner. This was followed by an intravenous injection of a mixture of KRGM and Evans blue. The results of the test showed that all the responses were negative in the control and the low-dose and high-dose administration groups. However, in the ovalbumin treated group, all the responses were positive. Based on the above results, there were no anaphylactic responses for up to 12 times the amount of human intake of KRGM in Hartley Guinea-pigs. The results suggest that KRGM is safe as measured by the systemic and local antigenicity in guinea pigs.

• Biomolecules & Therapeutics
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• v.22 no.1
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• pp.27-34
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• 2014

Curcumin is naturally occurring polyphenolic compound found in turmeric and has many pharmacological activities. The present study was undertaken to evaluate anti-allergic inflammatory activity of curcumin, and to investigate its inhibitory mechanisms in immunoglobulin E (IgE)/Ag-induced mouse bone marrow-derived mast cells (BMMCs) and in a mouse model of IgE/Ag-mediated passive systemic anaphylaxis (PSA). Curcumin inhibited cyclooxygenase-2 (COX-2) dependent prostaglandin $D_2$ ($PGD_2$) and 5-lipoxygenase (5-LO) dependent leukotriene $C_4$ ($LTC_4$) generation dose-dependently in BMMCs. To probe the mechanism involved, we assessed the effects of curcumin on the phosphorylation of Syk and its downstream signal molecules. Curcumin inhibited intracellular $Ca^{2+}$ influx via phospholipase $C{\gamma}1$ ($PLC{\gamma}1$) activation and the phosphorylation of mitogen-activated protein kinases (MAPKs) and the nuclear factor-${\kappa}B$ (NF-${\kappa}B$) pathway. Furthermore, the oral administration of curcumin significantly attenuated IgE/Ag-induced PSA, as determined by serum $LTC_4$, $PGD_2$, and histamine levels. Taken together, this study shows that curcumin offers a basis for drug development for the treatment of allergic inflammatory diseases.