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http://dx.doi.org/10.4062/biomolther.2009.17.3.249

Forsythiaside, a Constituent of the Fruits of Forsythia suspense, Ameliorates Scopolamine-Induced Memory Impairment in Mice  

Kim, Sun-Ho (Department of Life and Nanopharmaceutical Sciences)
Kim, Dong-Hyun (Department of Life and Nanopharmaceutical Sciences)
Choi, Ji-Joung (College of Pharmacy, Yeungnam University)
Lee, Jong-Gu (College of Pharmacy, Yeungnam University)
Lee, Choong-Ho (College of Pharmacy, Yeungnam University)
Park, Se-Jin (Department of Life and Nanopharmaceutical Sciences)
Jung, Won-Yong (Department of Life and Nanopharmaceutical Sciences)
Park, Dong-Hyun (Department of Life and Nanopharmaceutical Sciences)
Ko, Kwang-Ho (Department of Pharmacology, College of Pharmacy, Seoul National University)
Lee, Seung-Ho (College of Pharmacy, Yeungnam University)
Ryu, Jong-Hoon (Department of Life and Nanopharmaceutical Sciences)
Publication Information
Biomolecules & Therapeutics / v.17, no.3, 2009 , pp. 249-255 More about this Journal
Abstract
Forsythiaside is a polyphenolic constituent of the fruits of Forsythia suspense Vahl which are widely used as anti-inflammatory herbal raw materials in traditional Chinese medicine. In the present study, the authors assessed the effects of forsythiaside on learning and memory impairments induced by scopolamine using a passive avoidance and the Morris water maze tests in mice. Drug-induced amnesia was induced by scopolamine treatment (1 mg/kg, i.p.). Forsythiaside (10 mg/kg, p.o) administration significantly prevented scopolamine-induced step-through latency reduction in the passive avoidance test and scopolamine-induced increased escape latency in the Morris water maze test (p<0.05). Moreover, in an ex-vivo study, forsythiaside treatment (10 mg/kg, p.o) significantly reduced the increase of thiobarbituric acid reactive substance levels induced by scopolamine (p<0.05). Taken together, the present study suggests that forsythiaside could be useful for the treatment of cognitive impairment, and that its beneficial effects are mediated, in part, by its antioxidative properties.
Keywords
Forsythiaside; Memory; Passive avoidance task; Morris water maze task; Antioxidant;
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