• BMB Reports
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• v.47 no.8
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• pp.424-432
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• 2014

The defining feature of Parkinson's disease is a progressive and selective demise of dopaminergic neurons. A recent report on Parkinson's disease animal model demonstrates that poly (ADP-ribose) (PAR) dependent cell death, also named parthanatos, is accountable for selective dopaminergic neuronal loss. Parthanatos is a programmed necrotic cell death, characterized by PARP1 activation, apoptosis inducing factor (AIF) nuclear translocation, and large scale DNA fragmentation. Besides cell death regulation via interaction with AIF, PAR molecule mediates diverse cellular processes including genomic stability, cell division, transcription, epigenetic regulation, and stress granule formation. In this review, we will discuss the roles of PARP1 activation and PAR molecules in the pathological processes of Parkinson's disease. Potential interaction between PAR molecule and Parkinson's disease protein interactome are briefly introduced. Finally, we suggest promising points of therapeutic intervention in the pathological PAR signaling cascade to halt progression in Parkinson's disease.

• PNF and Movement
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• v.9 no.3
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• pp.31-39
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• 2011

Purpose : The purpose of this study was to evaluate the criterion-related validity of the Berg balance test between fallers and non-fallers in individuals with Parkinson's disease. Methods : Thirty-one patients were recruited for this study. Their initial diagnosis had been made on average $30.1{\pm}10.1$ years earlier. Score of Berg balance test showed significant correlations with indicators of motor functioning and daily living capacity. Berg balance test score was inversely associated with the unified Parkinson's disease rating scale-motor score, and Schwab and England activities of daily living rating scale. Results : In all 3 correlations, lower scores on the Berg balance test correlated with higher unified Parkinson's disease rating scale-motor scores. Results support the criterion-related validity of the Berg balance test. Conclusion : Our research results agree with other published research in suggesting that the Berg balance test may be used as a screening tool and ongoing assessment tool for patients with Parkinson's disease.

• PNF and Movement
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• v.18 no.1
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• pp.143-154
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• 2020

Purpose: This study aimed to investigate the current and future status of Parkinson's disease rehabilitation service in Busan. Methods: A literature search of domestic journals was conducted using the keywords "Parkinson's", "exercise", "rehabilitation", and "physical therapy". The chosen databases were Research Information Sharing Service (RISS), e-articles, and Korean studies Information Service System (KISS). International literature was searched in PubMed, Pedro, DOI, Publisher, CINAHL (EBSCOhost), and PsycINFO using the same combination of keywords. Results: The results of this study showed that 33 medical institutions provide Parkinson's disease rehabilitation service and five do not. Regarding the composition of Parkinson's disease rehabilitation teams, 15 medical institutions provide physical therapy, occupational therapy, and speech therapy as their rehabilitation program, 15 medical institutions provide physical therapy and occupational therapy, and three provide only physical therapy. The study found that muscle-strengthening, flexibility, endurance, and balance exercises were commonly provided in all 33 medical institutions for Parkinson's disease. Additional exercises were provided in only three medical institutions. The frequency was five times a week in 20 medical institutions. Conclusion: Medical institutions located in Busan provide a variety of Parkinson's disease rehabilitation services, not only in general hospitals but also in multiple medical institutions, although the composition of their Parkinson's disease rehabilitation teams and the frequency of treatment vary.

• Proceedings of the Korean Society of Applied Pharmacology
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• 2008.04a
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• pp.49-52
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• 2008

Parkinson's disease is characterized by motor disturbances and dopaminergic neurodegeneration. parkin and PINK1, two most critical Parkinson's disease-associated genes, have been intensively studied to address the underlying molecular pathogenesis of the disease, but our understanding still remains unclear. Through generation and characterization of Drosophila mutants for PINK1, we show that PINK1 is required for mitochondrial integrity and function in both indirect flight muscles and dopaminergic neurons. Surprisingly, we find that PINK1 mutants share striking phenotypic similarities with parkin mutants. Indeed, transgenic expression of parkin dramatically ameliorates all PINK1 loss-of-function phenotypes, but not vice versa, implicating that Parkin acts downstream of PINK1 in maintaining mitochondrial integrity and function in both muscles and dopaminergic neurons. With the establishment of the PINK1-Parkin pathway, we are trying to further investigate the detailed molecular relationship between PINK1 and Parkin using both mammalian dopaminergic neuronal cells for biochemical analysis and Drosophila model animal for genetic analysis. We believe that elucidating the molecular function of Parkinson's disease-associated genes will be of big help for the ultimate understanding of the pathogenic mechanism of this disease and also for the development of effective drugs for Parkinson's disease.

• The Journal of Korea CHUNA Manual Medicine
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• v.6 no.1
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• pp.127-135
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• 2005

Object : To discuss the Use of Chuna treatment in managing two patients with Parkinson's disease and/or Parkinson' syndrome Methods : This clinical study was carried out of 2 cases with confirmed by certified neurologist Parkinson's disease and/or Parkinson' syndrome. One case had been admitted from 2004.09.16 to 2004.09.24 and treated from 2004.09.26 to 2004.10.15 and the other case had been admitted from 2004.10.21 to 2004.11.06 and treated from 2004.11.08 to 2004.11.15 in the department of acupuncture and moxibustion of Ha-na oriental medical center. Results : There was significant improvement in condition of the two patients treated by Chuna treatment(upper cervical to promote CSF circulation) on Parkinson's disease or Parkinson' syndrome. Conclusion: In the case, we treated two patients of Parkinson's disease and/or Parkinson' syndrome. Chuna treatment efficiently relieved the symptoms including tremor and bradykinesia.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.19 no.6
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• pp.145-152
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• 2019

Parkinson's disease(PD) is one of the three major senile diseases and the incidence rate is increasing worldwide as the population ages. And as the disease progresses, time and economic costs increase, so it is important to understand the progress of the disease and to diagnose it early In this paper, we propose a method for pre-screening Parkinson's disease using a smartphone. The contents of the developed application are composed of tapping, tremor, spiral drawing, and gait based on Part III of the Unified Parkinson's Disease Rating Scale. This can be used to quantitatively diagnose Bradykinesia, Tremor and Postural Instability, which are known as motility symptoms of Parkinson's disease, and to monitor the progress of symptoms. This method is expected to be useful for the diagnosis and treatment of Parkinson's disease.

• Journal of Radiopharmaceuticals and Molecular Probes
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• v.9 no.1
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• pp.3-8
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• 2023

Parkinson's disease is a neurodegenerative disease caused by damage to brain neurons related to dopamine. Non-clinical animal models mainly used in Parkinson's disease research include drug-induced models of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 6-hydroxydopamine, and genetically modified transgenic animal models. Parkinson's diagnosis can be made using brain imaging of the substantia nigra-striatal dopamine system and using a radiotracer that specifically binds to the dopamine transporter. In this study, ¹⁸F-N-(3-fluoropropyl)-2β-carboxymethoxy-3β-(4-iodophenyl) nortropane was used to confirm the image evaluation cutoff between normal and parkinson's disease models, and to confirm model persistence over time. In addition, the efficacy of single or combined administration of clinically used therapeutic drugs in parkinson's animal models was evaluated. Image analysis was performed using the PMOD software. Converted to standardized uptake value, and analyzed by standardized uptake value ratio by dividing the average value of left striatum by the average value of right striatum obtained by applying positron emission tomography images to the atlas magnetic resonance template. The image cutoff of the normal and the parkinson's disease model was calculated as SUVR=0.829, and it was confirmed that it was maintained during the test period. In the three-drug combination administration group, the right and left striatum showed a high symmetry of more than 0.942 on average and recovered significantly. Images using ¹⁸F-N-(3-fluoropropyl)-2β-carboxymethoxy-3β-(4-iodophenyl) nortropane are thought to be able to diagnose and evaluate treatment efficacy of non-clinical Parkinson's disease.

• Journal of Acupuncture Research
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• v.22 no.4
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• pp.47-54
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• 2005

Objectives : In order to find Sasang constitutional therapies on Parkinson's disease and to make a fundamental basis for clinical application, this study was performed. Methods : We recruit thirty five person as the disease group and we test them by QSCCII. also, We estimate them by UPDRS scale. Results : In the distribution of sasang constitution among parkinson's disease patients and controls, we can know that in the distribution of sasang constitution among parkinson's disease patients, Taeumin has a large division. but we don't find out significantly difference statistically. In the distribution of UPDRS Std. score of sasang constitution, we find out significantly difference statistically. Conclusion : Unfortunately, we fail to lead significantly difference statistically in the sasang constitution among parkinson's disease patients and controls. But, in the distribution of UPDRS Std. score of sasang constitution, we fine out significantly difference statistically. Consequencely, it is necessary that further study on the theme in the more sample.

• Nuclear Medicine and Molecular Imaging
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• v.42 no.sup1
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• pp.177-180
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• 2008

Parkinson's disease is the second most common neurodegenerative disorder. It is slowly progressive disease that affects a small area of cells in the mid brain known as the substantia nigra. Gradual degeneration of these cells causes a reduction in a vital chemical known as dopamine. In the diagnosis of Parkinson's disease, it has difficulty in biopsy and limits in radiologic modalities. $^{18}F-FDG$ PET shows various findings from normal to diffuse decrement of FDG uptake. $^{18}F-FDG$ PET is expected to be a evaluation tool in the treatment of Parkinson's disease.

• The Journal of Internal Korean Medicine
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• v.39 no.2
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• pp.286-291
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• 2018

Objective: This clinical study aims to report the effect of acupuncture and moxibustion treatment in a patient with Parkinson's disease. Methods: The patient was treated with acupuncture totally eight times, which was applied at LU8, LR4, HT3, LR2, GV20, and GB20 and moxibustion at CV12, CV4. The effect of treatment was evaluated using the Unified Parkinson's Disease Rating Scale (UPDRS). Results: After treatment the patient's UPDRS scores improved from 78 to 29 points after 28 days, and the patient's symptoms of tremor also improved. Conclusions: The Korean medicine treatment of acupuncture might be effective for Parkinson's disease.