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Poly (ADP-ribose) in the pathogenesis of Parkinson's disease

  • Lee, Yunjong (Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, the Johns Hopkins University School of Medicine) ;
  • Kang, Ho Chul (Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, the Johns Hopkins University School of Medicine) ;
  • Lee, Byoung Dae (Neurodegeneration Control Research Center, Department of Neuroscience, Kyung Hee University) ;
  • Lee, Yun-Il (Well Aging Research Center, Samsung Advanced Institute of Technology (SAIT)) ;
  • Kim, Young Pil (Department of Bio-Engineering, Life Science RD Center, Sinil Pharmaceutical Co.) ;
  • Shin, Joo-Ho (Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, the Johns Hopkins University School of Medicine)
  • Received : 2014.05.27
  • Published : 2014.08.31
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Abstract

The defining feature of Parkinson's disease is a progressive and selective demise of dopaminergic neurons. A recent report on Parkinson's disease animal model demonstrates that poly (ADP-ribose) (PAR) dependent cell death, also named parthanatos, is accountable for selective dopaminergic neuronal loss. Parthanatos is a programmed necrotic cell death, characterized by PARP1 activation, apoptosis inducing factor (AIF) nuclear translocation, and large scale DNA fragmentation. Besides cell death regulation via interaction with AIF, PAR molecule mediates diverse cellular processes including genomic stability, cell division, transcription, epigenetic regulation, and stress granule formation. In this review, we will discuss the roles of PARP1 activation and PAR molecules in the pathological processes of Parkinson's disease. Potential interaction between PAR molecule and Parkinson's disease protein interactome are briefly introduced. Finally, we suggest promising points of therapeutic intervention in the pathological PAR signaling cascade to halt progression in Parkinson's disease.

Keywords

References

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