• Clinical and Experimental Pediatrics
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• v.61 no.7
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• pp.221-225
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• 2018

Purpose: Congenital hypothyroidism (CH) is the most common endocrine disorder in children. Thyroid hormone deprivation results not only in mental retardation but also growth retardation. This study investigates the final height (FH) in Korean patients with CH detected by newborn screening and examines factors that may affect the FH. Methods: The medical records of Korean CH patients (n=45) were reviewed. The FH was examined and target height (TH) was calculated based on mid-parental height. The FH z score (FHZ) and TH z score (THZ) were computed using the 2007 Korean National Growth Chart. The FHZ and THZ were compared with a Student t test. The impact of the etiology of CH (athyreosis, dyshormonogenesis, ectopic thyoid, hypoplastic thyroid), initial serum thyroid stimulating hormone (TSH) level, initial free thyroxine (T4) level, and time of therapy initiation based on FH was assessed. Results: The mean FHZ was $0.10{\pm}1.01$ for male patients and $-0.11{\pm}1.09$ for female patients. There were no significant differences between FHZ and THZ for both female (P=0.356) and male patients (P=0.237). No significant relationship was found between FH and the etiology of CH, initial TSH level, initial free T4 level, and the time of therapy initiation. Conclusion: Early intervention and satisfactory management do not appear to impede growth in Korean patients with CH. Thus, early detection and proper management of patients with CH detected by newborn screening program are necessary.

• Asian-Australasian Journal of Animal Sciences
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• v.23 no.8
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• pp.1089-1095
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• 2010

Four biological candidate genes, natural resistance associated macrophage protein 1 (SLC11A1 or NRAMP), prosaposin (PSAP), interferon Gamma (IFNG), and toll-like receptor 4 (TLR4), were examined to identify single nucleotide polymorphisms (SNP) and associations of the SNP with antibody response kinetics in hens. An $F_2$ population was produced by mating $G_0$ highly inbred (<99%) males of two MHC-congenic Fayoumi lines with highly inbred Leghorn hens. The $F_2$ hens (n = 158) were injected twice with SRBC and whole, fixed Brucella abortus (BA). Blood samples were obtained before each immunization, at 7 d after primary immunization, and at several time points after secondary immunization. Minimum titers (Ymin) and the time needed to reach them (Tmin), and maximum (Ymax) titers and the time needed to reach them (Tmax), were estimated from the seven post-secondary immunization titers using a nonlinear regression model. The $F_2$ hens were genotyped for the four candidate genes by using PCR-RFLP for one SNP per gene, which identified the parental allele. General linear models were used to test associations of SNP genotypes with antibody response parameters and BW measured at 4 ages. The IFNG SNP was highly significantly (p<0.0125) associated with primary response to SRBC, Tmin to BA, Ymin to BA, and 12-week BW. The current study demonstrated that the novel IFNG promoter SNP was associated with antibody kinetics for BA and SRBC in laying hens, and also with BW, suggesting that this cytokine may play a pivotal role in the relationship between immune function and growth.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.12
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• pp.4815-4821
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• 2014

Background: This study aimed to examine the relationship between respiratory health of Malaysian adolescents with secondhand smoke (SHS) exposure and smoke-free legislation (SFL) implementation. Materials and Methods: A total of 898 students from 21 schools across comprehensive- and partial-SFL states were recruited. SHS exposures and respiratory symptoms were assessed via questionnaire. Prenatal and postnatal SHS exposure information was obtained from parental-completed questionnaire. Results: The prevalence of respiratory symptoms was: 11.9% ever wheeze, 5.6% current wheeze, 22.3% exercise-induced wheeze, 12.4% nocturnal cough, and 13.1% self-reported asthma. SHS exposure was most frequently reported in restaurants. Hierarchical logistic regression indicates living in a comprehensive-SFL state was not associated with a lower risk of reporting asthma symptoms. SHS exposure in public transport was linked to increased risk for wheeze (Adjusted Odds Ratio (AOR) 16.6; 95%confidence interval (CI), 2.69-101.7) and current wheezing (AOR 24.6; 95%CI, 3.53-171.8). Conclusions: Adolescents continue to be exposed to SHS in a range of public venues in both comprehensive- and partial-SFL states. Respiratory symptoms are common among those reporting SHS exposure on public transportation. Non-compliance with SFL appears to be frequent in many venues across Malaysia and enforcement should be given priority in order to reduce exposure.

• Journal of the Korean Society of School Health
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• v.16 no.1
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• pp.91-104
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• 2003

The purpose of this study is primarily intended to examine the stress and physical, emotional and behavioral stress symptoms of elementary school students supply the basic data of intervention for children's health promotion. The subjects of this study were 616 students who were currently enrolled in 5th and 6th grade elementary school in Jeollabukdo ; 3 schools in J city and other 6 in 3 rural area. The data were collected by self-reported questionnaire from 3rd to 13th April 2002 and collected data were analyzed by SPSS WIN 8.0. The results of this study were as followings. 1. The mean score of stress that children experience was 2.73 and the most stressful factor was a friendship stress. The most frequently experienced stress were feel that a friends would leave them alone. 2. The mean score of stress symptom that children experience was 1.92 and the most stressful symptom was the emotion symptom. The most frequently experienced stressful symptom were feel fatigue of everyday. 3. General characteristics related to stress were showed significantly different according to sex(t=-3.243, p=.001) 4. General characteristics related to stress symptoms were showed significantly different according to sex(t=-2.268, p=.024), family circumstances(F=8.697, p=.000), academic scores(F=11.216, p=.000) and parental concerns on a child(t=-2.561, p=.011). 5. The relation between stress and stress symptoms showed a positive correlation, which was significant statistically(r=.453, p=.000). In conclusion, elementary school students experience various stresses and the stress symptoms have positive close connection with health problems. Therefore, to study the students stress and consequent symptoms further, it is recommended that we should subdivide and analyze the stressor and stress symptoms by proper areas. In the meantime, in order to promote children's health using the data in this study, we should develop the correlated program among individual, family, school and community while we are deeply concerned about and support children continuously.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.8 no.2
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• pp.287-297
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• 1997

Conduct disorder has been subclassified by the symptom characteristics of socialization, aggression, or age of onset. In ICD-10, ‘Conduct disorder confined to family context’ has been developed as a distinct subtype. Which delineates the conduct problems which take place only in the family and related situation. These authors experienced a case which presents a child who shows aggressive and violent behavior to his parent and brother, severe tamper tantrum and destructiveness only in family. By through history taking, observation and treatment after admission, we could find that insecure and ambivalent attachment between parent and child due to chronic neglect and abuse, and inconsistent parental behavior contribute to many behavioral and emotional problems of this child. We reviewed the relationship between conduct disorder and family pathology and treatment strategy for conduct disorder with family problems.

• Korean Journal of Childcare and Education
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• v.11 no.6
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• pp.79-96
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• 2015

The purpose of this study was to investigate the structural relationships between preschooler's temperament, externalizing behavior problems and mother's parenting competency. The 5th Panel Study of Korean Children by Korea Institute of Child Care and Education were analyzed in this study by using the structural model. The major findings are as follows, First, preschoolers' emotionality temperament were found to have a negative effect on mothers' parenting competency. Preschoolers' activity and sociability temperament had a positive influence on mothers' parenting competency. Second, preschoolers's emotionality temperament also had a direct impact on their externalizing problems behavior, otherwise preschoolers's activity and sociability temperament were unrelated to that. Third, mothers' parenting competency had a negative influence on preschoolers' externalizing problems behavior. Finally, mothers' parenting competency had mediating effects between preschoolers' temperament and their externalizing problems behavior. These findings suggest that parental education should be concerned about parenting competency based on the understanding of preschooler's temperament.

• Journal of The Korean Association For Science Education
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• v.21 no.5
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• pp.893-905
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• 2001

Korean students ranked the 3rd out of 32 participating countries in the first cycle of PISA(Programme for International Student Assessment) science field, which assessed 15-years-old students' scientific literacy. PISA developed several variables such as parents' socio-economic status, parents' educational attainment, family wealth, and cultural possession, to investigate the effects of background variables on scientific literacy. On the other hand, motivation and engagement in science study were not given much attention, partly because science was the minor area in the first cycle of PISA. Therefore, PISA Korea developed a series of variables to collect data on students' learning motives and out-of-school activities in science as a national option. The results are as followings. First, Korea was found to be one of the PISA participating countries with the scientific literacy achievement least influenced by parents' socio-economic status, family wealth, and parents' cultural possession. Second, the degree of achievement in scientific literacy according to parents' educational attainment was in a positive correlation, similar to the overall tendency of PISA. Third, the most crucial learning motive for Korean students was their desire to develop scientific thinking abilities or obtain science knowledge. On the other hand, choosing jobs in the field of science or parental expectation was the least important learning motive. In particular, the motive for scientific learning was found to have a positive relationship with the degree of scientific literacy achievement. Therefore, the higher the students achievement, the stronger the motive for scientific learning in order to develop their ability to think scientifically or acquire science knowledge. Fourth, Korean students were shown to participate very little in out-of-school scientific activities other than watching TV programs related to science. Whatever the activities may be, the more actively involved students are in out-of-school scientific activities, the higher their scientific literacy achievement. Fifth, Korean girls were rather passive compared to boys in all areas, including science learning motive and out-of-school scientific activities. The gender difference was especially more pronounced in out-of-school scientific activities with wider gaps in such activities as reading scientific books or articles and visiting science-related web sites.

• Korean Journal of Social Welfare
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• v.66 no.3
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• pp.297-319
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• 2014

This research seeks to clarify correlationship between satisfaction of visually impaired, hearing impaired and mentally disabled mothers and their burden of raising their children and whether communication between their children mediates their relationship. This research tries to set a standard performing method to alleviate burden of raising children and devise an effective parenting method. The study was done in cooperation with 13 welfare centers for the disabled in the Seoul area, 23 and performed 300 questionnaires were distributed. Hearing impaired person had answered by themselves, and visually impaired were provided with disability aid, by reading the questionnaire to them. 210 responses were collected, and 187 were used for final analysis. Analysis showed that burden of fostering showed a negative correlation between satisfaction as a mother and availability for communication. Moreover, communication with the children were shown to mediate the satisfaction as a parent and burden of raising the children. Thus, the goal is to reduce the burden of fostering for female disabled and increase their satisfaction as a parent as well as enhancing their communicational skills.

• Journal of the Korea Convergence Society
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• v.11 no.2
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• pp.261-269
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• 2020

The purpose of the study was to investigate the relationship among children's perception of parenting style, their social anxiety, aggression, and school adjustment. A total of 267 children(male 117, female 150) and 10 homeroom teachers participated. Each child completed questionnaires on perception of parenting style, and social anxiety. Children's aggression and school adjustment was measured by their homeroom teachers' reports. The results of the structural equation model showed that children's perception of parenting style high in rejection and control significantly influenced aggression as well as school adjustment, but didn't influence social anxiety. Both parenting style high in rejection and control and aggression had significant effect on school adjustment. Our results showed that parenting style high in rejection and control directly influenced school adjustment, and mediated by their aggression.

• Biotechnology and Bioprocess Engineering:BBE
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• v.6 no.5
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• pp.332-336
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• 2001

When parental Chinese hamster ovary (CHO) cell clones that are capable of producing thrombopoietin (TPO) were subjected to high methotrexate (MTX) concentrations, clonal variations in cell growth were apparent. In the clones that had no significant enhancement in specific TPO productivity (q$\_$Tpo/)when a higher level of MTX was administered, their growth was not depressed significantly nor their cell size changed significantly. On the other hand, those clones that showed a significant-enhancement in q$\_$Tpo/ at higher a MTX dosage, cell growth was depressed initially but recovered during successive sub-cultures. Furthermore, their cell size increased, which suggested that changes in cell size may be indicative of an enhanced q$\_$Tpo/. When the enhancement of the q$\_$Tpo/ of 9 clones after a high MTX dosage was plotted against the extent of the increase of their size, there was a linear correlation (γ$^2$=0.80, p<0.001, ANOVA), which suggested that an enhancement of q$\_$Tpo/ after high MTX administration can be measured by the increase in their cell size. Taken together, our data demonstrate that the selection of amplified CHO cell clones with enhanced q$\_$Tpo/ can be done upon their increased size and growth pattern. This facilitates the development of highly productive recombinant CHO cell lines.