• The Sea:JOURNAL OF THE KOREAN SOCIETY OF OCEANOGRAPHY
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• v.7 no.4
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• pp.2221-2221
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• 2002

The first laboratory culture of host-parasite system of Prorocentrum minimum- Amoebophrya sp. was established by single cell isolation method. Here, we report the life cycle stages of the parasitic dinoflagellate. Amoebophrya sp. of the red tide dinoflagellate P. minimum as observed by light and epifluorescence microscopy. Infections developed inside the nucleus of P. minimum. The trophont developed to occupy almost all the intracellular space of the host at its late stage. The fully developed trophont finally ruptured through the host cell. “Vermiform stage”, the free-swimming extracellular lift cycle stage is followed by another stage for the sudden release of many individual dinospores. Our laboratory strain of the host-parasite system for P. minimum, a causative species fur the huge red tides in spring and summer in Korean coastal waters, could be a useful living material for the in situ biological control of harmful algal blooms.

• The Sea:JOURNAL OF THE KOREAN SOCIETY OF OCEANOGRAPHY
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• v.7 no.4
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• pp.221-225
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• 2002

The first laboratory culture of host-parasite system of Prorocentrum minimum- Amoebophrya sp. was established by single cell isolation method. Here, we report the life cycle stages of the parasitic dinoflagellate. Amoebophrya sp. of the red tide dinoflagellate P. minimum as observed by light and epifluorescence microscopy. Infections developed inside the nucleus of P. minimum. The trophont developed to occupy almost all the intracellular space of the host at its late stage. The fully developed trophont finally ruptured through the host cell. “Vermiform stage”, the free-swimming extracellular lift cycle stage is followed by another stage for the sudden release of many individual dinospores. Our laboratory strain of the host-parasite system for P. minimum, a causative species fur the huge red tides in spring and summer in Korean coastal waters, could be a useful living material for the in situ biological control of harmful algal blooms.

• The Sea:JOURNAL OF THE KOREAN SOCIETY OF OCEANOGRAPHY
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• v.23 no.1
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• pp.20-31
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• 2018

Marine parasitoid Amoebophrya infects and kills various bloom-forming dinoflagellates and strongly influences the harmful algal bloom dynamics. We investigated the effect of temperature on survival, infectivity, generation time of the parasite from the parasitoid Amoebophrya sp. and the harmful dinoflagellate host Akashiwo sanguinea system. Temperature had a significant effect on the parasite generation time and infectivity. While the lower temperature ($15^{\circ}C$) arrested parasite intracellular development and infectivity, resulting in the longer generation time ($115{\pm}0.1h$), the higher temperatures ($25^{\circ}C$ and $20^{\circ}C$) accelerated the parasite development, with the generation times of $58{\pm}0.1h$ and $83{\pm}0.1h$, respectively. Parasite prevalence (percent of host infected) was $71.5{\pm}0.30%$, $54.3{\pm}1.68%$, and $29.6{\pm}1.42%$ at $25^{\circ}C$, $20^{\circ}C$, and $15^{\circ}C$, respectively. These results suggest that biological control by parasitism on A. sanguinea bloom would not be highly effective during low water temperature season. Further, water temperature would be an important factor of bottom-up controls for the host-parasite population dynamics.

• Journal of Aquaculture
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• v.19 no.1
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• pp.19-24
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• 2006

The objective of this study was to develop an efficient control method for the Alella macrotrachelus parasitic cultured black porgy, Acanthopagrus schlegeli utilizing the superior osmoregulatory ability of the host fish. The average number of the parasites on a fish was 5 worms (all female), which were attached to the cartilage of gill filament by their bulla. Morphologically, the parasite was tripartite with each length of $1822.1{\pm}521.5{\mu}m$ for the trunk $1825.0{\pm}495.8{\mu}m$ for the cephalothorax, and $134.2{\pm}43.1$ for the bulla. In histological observations, it was found that the female parasite took gill lamellae. Damage and loss of gill lamellae by the parasite caused hemorrhage and anemia in the fish. All parasites died within 48 hours by osmotic shock of freshwater or $5{\sim}15\%_{\circ}$ seawater treatment. These results suggest that Alella macrotrachelus could be controled by hyposmotic treatment.

• Parasites, Hosts and Diseases
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• v.56 no.5
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• pp.401-408
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• 2018

Korea is successfully controlled intestinal parasitic infections owing to economic development and high health consciousness. The Division of Vectors and Parasitic Diseases (formerly the Division of Malaria and Parasitology) is in the Center for Laboratory Control of Infectious Diseases of the Korea Centers for Disease Control and Prevention. It has been the governmental agency responsible for controlling and leading scientific research on parasitic diseases. The Division of Vectors and Parasitic Diseases has conducted and funded basic research and disseminated the research results to various medical fields, ultimately promoting public health in Korea. Among the noteworthy achievements of this division are the national surveillance of healthcare-associated parasitic infections, prevention and control for parasitic infections, and the elimination of lymphatic filariasis from Korea. On a broader scale, the division's research programs and academic supports were influential in preventing and treating infectious parasitic diseases through public policies and laws. In this review, we summarize the past and present role of the Division of Vectors and Parasitic Diseases in preventing and treating infectious parasitic diseases in Korea.

• Parasites, Hosts and Diseases
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• v.60 no.5
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• pp.317-325
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• 2022

Hypoxia-inducible factor-1 alpha (HIF-1α) is one of the master regulators of immune and metabolic cellular functions. HIF-1α, a transcriptional factor whose activity is closely related to oxygen levels, is a target for understanding infectious disease control. Several studies have demonstrated that HIF-1α plays an important role during the infectious process, while its role in relation to parasite virulence has not been addressed. In this work, we studied the expression levels of HIF-1α and related angiogenic vascular endothelial growth factor A (VEGF-A) in human macrophages infected with promastigotes of hypo- or hyper-virulent Leishmania major human isolates. L. major parasites readily subverted host macrophage functions for their survival and induced local oxygen consumption at the site of infection. In contrast to hypo-virulent parasites that induce high HIF-1α expression levels, hyper-virulent L. major reduced HIF-1α expression in macrophages under normoxic or hypoxic conditions, and consequently impeded the expression of VEGF-A mRNA. HIF-1α may play a key role during control of disease chronicity, severity, or outcome.

• Journal of fish pathology
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• v.23 no.1
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• pp.119-122
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• 2010

Mortality and gill lesions in snakehead, Channa argus (body length range, 20.3-22.2 cm) reared in a aqua-farm in Busan, Korea, were associated with a dense bloom of Apiosoma-like ciliate, Order Petrichida. The size of parasite was $48.83{\pm}7.75{\mu}m{\times}14.29{\pm}2.66{\mu}m$. Histological examination revealed that a severe edema and collapse of the gill tissue were observed in a number of samples of snakehead. The mechanism of gill damage was likely due to physical irritation by the parasite. It is believed that this is the first report of Apiosoma-like ciliate in cultured fish in Korea.

• Parasites, Hosts and Diseases
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• v.41 no.1
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• pp.1-16
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• 2003

Neospora caninum is a coccidian parasite of animals. It is a major pathogen for cattle and dogs and it occasionally causes clinical infections in horses, goats, sheep, and deer. Domestic dogs are the only known definitive hosts for N. caninum. It is one of the most efficiently transmitted parasite of cattle and up to 90% of cattle in some herds are infected. Transplacental transmission is considered the major route of transmission of N. caninum in cattle. Neospora caninum is a major cause of abortion in cattle in many countries. To elicit protective immunity against abortion in cows that already harbor a latent infection is a major problem. This paper reviews information on biology, diagnosis, epidemiology and control of neosporosis in animals.

• Parasites, Hosts and Diseases
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• v.51 no.1
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• pp.43-49
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• 2013

Three species of tapeworms infect humans in their adult stage (Taenia solium, Taenia saginata and Taenia asiatica). The 3 are flat, opaque white or yellowish, and exceptional long segmented parasites, measuring 1 to 12 m in their adult stage. In this review, the development of the knowledge regarding the first species, mainly focused on understanding how the larval stage or cysticercus is transmitted to humans, is described. The second species is a cosmopolitan parasite that only causes taeniosis and not cysticercosis; therefore, it will not be included. Information on the third species, which is presently being produced, since this species was recognized as such only at the end of the 20th century, will be discussed at the end of this review.

• Parasites, Hosts and Diseases
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• v.55 no.5
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• pp.465-472
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• 2017

Recent trends of malaria in Thailand illustrate an increasing proportion of Plasmodium vivax, indicating the importance of P. vivax as a major causative agent of malaria. P. vivax malaria is usually considered a benign disease so the knowledge of this parasite has been limited, especially the genetic diversity and genetic structure of isolates from different endemic areas. The aim of this study was to examine the population genetics and structure of P. vivax isolates from 4 provinces with different malaria endemic settings in Thailand using 6 microsatellite markers. Total 234 blood samples from P. vivax mono-infected patients were collected. Strong genetic diversity was observed across all study sites; the expected heterozygosity values ranged from 0.5871 to 0.9033. Genetic variability in this study divided P. vivax population into 3 clusters; first was P. vivax isolates from Mae Hong Son and Kanchanaburi Provinces located on the western part of Thailand; second, Yala isolates from the south; and third, Chanthaburi isolates from the east. P. vivax isolates from patients having parasite clearance time (PCT) longer than 24 hr after the first dose of chloroquine treatment had higher diversity when compared with those having PCT within 24 hr. This study revealed a clear evidence of different population structure of P. vivax from different malaria endemic areas of Thailand. The findings provide beneficial information to malaria control programme as it is a useful tool to track the source of infections and current malaria control efforts.