• 대한골관절종양학회지
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• 제13권2호
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• pp.130-134
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• 2007

부신경절종은 발생학적으로 신경 능선 세포로부터 기원하는 종양으로 두경부에서 가장 많이 발생하나 드물게 종격동, 후복막 등의 내장 기관에서도 생기며 대부분 양성 경과를 보인다. 그 중 흉요추부의 경막내에 발생한 경우는 매우 드물며, 경추나 흉추보다는 요추부에 대부분 발생한다고 보고되었다. 지금까지 흉요추부의 부신경절종이 보고된 예는 드물기에 저자들은 부신경절종이 흉요추부의 경막내 수막외에 발생한 1예를 경험하여, 자기 공명 영상 및 조직학적 특징과 그 치료 결과를 문헌 고찰과 함께 보고하고자 한다.

• Journal of Korean Neurosurgical Society
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• 제67권1호
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• pp.122-129
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• 2024

Paragangliomas are rare neuroendocrine tumors that are usually benign in nature. They may be either familial or sporadic in their occurrence. Numerous neuroendocrine tumors are collectively included under the umbrella of paragangliomas. Among them, carotid body tumors and glomus jugulare tumors are extremely rare. Thus, we present a rare case of 29-year-old male who was admitted with hearing difficulties and tinnitus in the left ear, with swelling on the left side of the neck. Based on clinical and radiological findings, a diagnosis of left-sided glomus jugulare with carotid body tumor was made. The patient underwent a two-stage surgery with an interval of approximately 2 months. Histopathology revealed a paraganglioma. Herein, we present the clinical features, imaging findings, management, and a brief review of literature on the classification, evaluation, and management of carotid body and glomus jugulare tumors. Paraganglioma is a slow-growing tumor. The synchronous occurrence of carotid body and glomus jugulare tumors is infrequent. Microsurgical resection remains the primary treatment modality. Therefore, our patient underwent two-stage surgery. The rarity of occurrence and the proximity and adherence to vital neurovascular structures have resulted in the treatment of paragangliomas remaining a challenge.

• 대한세포병리학회:학술대회논문집
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• 대한세포병리학회 1991년도 제5차 춘계학술대회 초록집
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• pp.14-15
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• 1991

• Tuberculosis and Respiratory Diseases
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• 제70권2호
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• pp.165-169
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• 2011

Pheochromocytomas are neuroendocrine tumors of chromaffin cell that originate in the paraganglia of the adrenal medulla. Approximately 10% of pheochromocytomas are found in the extra-adrenal paraganglia and are called paragangliomas. However, cases of middle mediastinal paragangliomas are very rare. In this case, the patient presented with a voice change and a headache. A middle mediastinal soft tissue mass with marked enhancement was detected on computed tomography of the chest. The 24-hour urine catecholamine level was markedly elevated. The middle mediastinal mass was biopsied via mediastinoscopy and the resulting immunohistochemical staining was compatible with a diagnosis of middle mediastinal paraganglioma. The mass was resected surgically and the symptoms were relieved.

• 한국임상수의학회지
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• 제33권4호
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• pp.187-193
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• 2016

A tyrosine kinase is an enzyme that can transfer a phosphate group from ATP to a protein in a cell. It functions as an "on" or "off" switch in many cellular functions. This study aims to show that the actions of growth factors associated with PDGFR-${\alpha}$, PDGFR-${\beta}$, VEGFR-2, c-KIT, and c-ABL, which are used in veterinary medicine, are expressed in canine intractable tumors. This study used archival cases of canine paraganglioma, gastrointestinal adenocarcinoma, hepatocellular carcinoma, and renal cell carcinoma. Tissues had been immunohistochemical analysis. The antibodies used were PDGFR-${\alpha}$, PDGFR-${\beta}$, c-kit, VEGFR-2, and c-Abl. PDGFR-${\alpha}$ was expressed only in HCC, and PDGFR-${\beta}$ was expressed in all tumors. VEGFR was also only expressed in HCC, and c-KIT has been expressed in HCC, paraganglioma, and small intestinal adenocarcinoma. c-Abl was expressed in all cancers, but was weakly expressed in paraganglioma, while more than moderately expressed in other tissues. In conclusion, this study investigated how TKIs used in human medicine can be applied to canine intractable tumors, through immunohistochemistry. The results indicate that there may be an application for TKIs in treating canine intractable tumors.

• 한국임상수의학회지
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• 제28권5호
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• pp.522-525
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• 2011

조직병리소견과 면역염색결과를 바탕으로 14년령 암컷 시베리아 호랑이의 복막뒤공간에서 발생한 악성부신경절종을 보고하였다. 부신경절종은 동물에서 드물게 발생하는 신경내분비종양으로 주로 자율신경계의 부신외신경절 세포로부터 발생한다. 원발종괴는 복막뒤공간에 요추의 배쪽면을 따라 장방향으로 부착되어 있었고, 장간막림프절, 신장, 자궁, 부신, 폐, 흉선으로 전이되었다. 종양세포는 다각형의 통통한 형태에 과립상의 호산성 세포질을 갖고 있었으며, 섬유혈관 기질에 의해 구획되어 집락(cluster) 또는 둥지(nest) 모양으로 배열된 전형적인 Zell-ballen 형태를 나타냈다. 면역염색에서 synaptophysin, chromogranin A, neuron-specific enolase에 특이적인 양성반응을 보였다. 본 증례는 시베리아 호랑이에서 발생한 악성후복막부신경절종이 전신으로 전이된 최초보고이다.

• 한국임상수의학회지
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• 제32권6호
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• pp.508-510
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• 2015

7살의 중성화된 수컷 보스턴테리어 개가 호흡곤란과 편측성 목부위 혹으로 내원하였다. 신체검사에서 왼쪽 아래턱밑 부위의 혹이 촉진되었다. 컴퓨터단층촬영 검사 결과 이 혹은 왼쪽 혀정맥 유래의 종양으로 의심되었다. 보호자의 거부로 치료가 진행되지 못했으며 내원 10일 후 호흡부전으로 폐사하였다. 부검에서 경계가 분명한 혹이 왼쪽 후두부위에서 확인되었으며 병리조직학적, 면역조직화학적 검사가 시행되었다. 컴퓨터단층촬영, 병리조직학적, 면역조직화학적 검사를 토대로 왼쪽 혀정맥에서 유래한 목부위 곁신경절종으로 최종진단되었다. 본 증례보고는 개에서 발생한 혀정맥 유래 목부위 곁신경절종의 임상적, 컴퓨터단층촬영, 병리조직학적 및 면역조직화학적 특징들을 잘 나타내고 있다.

• 대한세포병리학회:학술대회논문집
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• 대한세포병리학회 1992년도 제5차 추계학술대회 초록집
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• pp.20.2-20.2
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• 1992

• 대한두경부종양학회지
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• 제20권2호
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• pp.198-201
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• 2004

Neuroendocrine carcinomas are rare neoplasms of the hypopharynx. Neuroendocrine neoplasms are divided into four main types : carcinoid, atypical carcinoid, small cell carcinoma and paraganglioma. The diagnosis is primarily based on light microscopy and should be confirmed by immunohistochemical investigation. Small cell neuroendocrine carcinoma of the hypopharynx is extremely uncommon tumor and surgical results for this tumor have been disappointing. Chemotherapy and radiotherapy currently appear the most effective forms of therapy. We report our case of small cell neuroendocrine carcinoma of the hypopharynx with the brief review of literatures.

• 대한두경부종양학회지
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• 제3권1호
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• pp.79-83
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• 1987

Carotid body tumor is rare tumor in the neck. Among the pathologic conditions affecting paraganglionic tissue. the carotid body is most frequently involved. There are controversies in terms of natural history. biological behaviors, technique of excision, risks of the operation. Carotid angiography is the most valuable diagnostic aid and important for the planning of therapy. Definite treatment of carotid body tumor is surgical excision. Considerable degree of caution and vascular surgical armamentation are required because of its anatomical location and profuse vascularity. Surgical removal of this kind of paraganglioma must be predicated upon several factors such as tumor character. location. symptom, vascularity, and surgeon's ability.