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Malignant Retroperitoneal Paraganglioma in a Siberian Tiger  

Shin, Sang-Kyung (College of Veterinary Medicine, Chungbuk National University)
Park, Byung-Min (College of Veterinary Medicine, Chungbuk National University)
Youm, So-Young (College of Veterinary Medicine, Chungbuk National University)
Kim, Tae-Wang (College of Veterinary Medicine, Chungbuk National University)
Na, Ki-Jeong (College of Veterinary Medicine, Chungbuk National University)
Ahn, Byeong-Woo (College of Veterinary Medicine, Chungbuk National University)
Publication Information
Journal of Veterinary Clinics / v.28, no.5, 2011 , pp. 522-525 More about this Journal
Abstract
A 14 year old female Siberian tiger presented for postmortem examination. A large mass attached to sublumbar area was found to be circumscribing aorta with metastases to mesenteric lymph nodes, uterus, kidney, adrenal gland, lung and thymus. The tumor cells were arranged in clusters or nests separated by well-developed fibrovascular stroma. The individual cells were plump and polygonal with granular eosinophilic cytoplasms and had distinct cell borders. The tumor cells were positive for synaptophysin, chromogranin A and neuron-specific enolase, and negative for cytokeratins, S100 and glial fibrillary acidic protein. The primary tumor was diagnosed as a malignant retroperitoneal paraganglioma.
Keywords
Siberian tiger; paraganglioma; chromogranin A; neuron-specific enolase; synaptophysin;
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