• Journal of Microbiology and Biotechnology
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• 제20권3호
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• pp.643-649
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• 2010

Evaluation of the primary etiologic agents that cause aseptic meningitis outbreaks may provide valuable information regarding the prevention and management of aseptic meningitis. In Korea, an outbreak of aseptic meningitis caused by echovirus type 30 (E30) occurred from May to October in 2008. In order to determine the etiologic agent, CSF and/or stool specimens from 140 children hospitalized for aseptic meningitis at Soonchunhyang University Cheonan Hospital between June and October of 2008 were tested for virus isolation and identification. E30 accounted for 61.7% (37 cases) and echovirus 6 accounted for 21.7% (13 cases) of all the human enteroviruses (HEVs) isolates (60 cases in total). For the molecular characterization of the isolates, the VP1 gene sequence of 18 Korean E30 isolates was compared pairwise using the MegAlign with 34 reference strains from the GenBank database. The pairwise comparison of the nucleotide sequences of the VP1 genes demonstrated that the sequences of the Korean strains differed from those of lineage groups A, B, C, D, E, F, and G. Reconstruction of the phylogenetic tree based on the complete VP1 nucleotide sequences resulted in a monophyletic tree, with eight clustered lineage groups. All Korean isolates were segregated from other lineage groups, thus suggesting that the Korean strains were a distinct lineage of E30, and a probable cause of this outbreak. This manuscript is the first report, to the best of our knowledge, of the molecular characteristics of E30 strains associated with an aseptic meningitis outbreak in Korea, and their respective phylogenetic relationships.

• Genomics & Informatics
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• 제11권3호
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• pp.135-141
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• 2013

Gene set analysis is a powerful tool for interpreting a genome-wide association study result and is gaining popularity these days. Comparison of the gene sets obtained for a variety of traits measured from a single genetic epidemiology dataset may give insights into the biological mechanisms underlying these traits. Based on the previously published single nucleotide polymorphism (SNP) genotype data on 8,842 individuals enrolled in the Korea Association Resource project, we performed a series of systematic genome-wide association analyses for 49 quantitative traits of basic epidemiological, anthropometric, or blood chemistry parameters. Each analysis result was subjected to subsequent gene set analyses based on Gene Ontology (GO) terms using gene set analysis software, GSA-SNP, identifying a set of GO terms significantly associated to each trait ($p_{corr}$ < 0.05). Pairwise comparison of the traits in terms of the semantic similarity in their GO sets revealed surprising cases where phenotypically uncorrelated traits showed high similarity in terms of biological pathways. For example, the pH level was related to 7 other traits that showed low phenotypic correlations with it. A literature survey implies that these traits may be regulated partly by common pathways that involve neuronal or nerve systems.

• Restorative Dentistry and Endodontics
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• 제40권2호
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• pp.143-148
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• 2015

Objectives: This study evaluated the maximum depth and percentage of irrigant penetration into dentinal tubules by passive ultrasonic irrigation (PUI). Materials and Methods: Thirty extracted human teeth were instrumented and divided into three groups. According to final irrigation regimen, 5.25% sodium hypochlorite (Group A, NaOCl), 2% chlorhexidine (Group B, CHX) and saline solution (Group C, control group) were applied with Irrisafe 20 tips (Acteon) and PUI. Irrigant was mixed with 0.1% rhodamine B. Sections at 2 mm, 5 mm, and 8 mm from the apex were examined with confocal laser scanning microscopy (CLSM). The percentage and maximum depth of irrigant penetration were measured. Kruskal-Wallis test and Mann-Whitney test were performed for overall comparison between groups at each level and for pairwise comparison, respectively. Within a group, Wilcoxon test was performed among different levels. p values less than 0.05 were considered significant. Results: In all groups, highest penetration depth and percentage of penetration were observed at the 8 mm level. At 2 mm level, Groups A and B had significantly greater depths and percentages in penetration than Group C (p < 0.05), but there were no significant differences between Groups A and B. At 5 mm level, penetration depths and percentage of penetration was not significantly different among the groups. Conclusions: NaOCl and CHX applied by PUI showed similar depth and percentage of penetration at all evaluated levels.

• 경영과학
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• 제27권1호
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• pp.1-16
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• 2010

According to appearance of a new competitive factor, as 'Green', Green Logistics becomes the important evaluation factor for many firms in emerging competitive environment. Despite this importance, the recognition level of Korean firms on Green Logistics lags behind that of leading companies in developed countries. In addition, the literature studies and practical strategies for systematic management control plans are very insufficient. In this paper, we establish decision making framework of Green Logistics by using ANP(analytic network process). Specifically, we suggest at first the overall concepts and issues of Green Logistics through literature studies. Next, we derive 6 clusters and 21 components forming the strategic green logistics, and then we conduct surveys for pairwise comparison of experts on Green Logistics and compute relative weights of the clusters, components and altanatives considering the feedback structure. We expect that the results of this study will be very helpful for managers to make strategic decisions.

• 수산경영론집
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• 제38권1호
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• pp.19-45
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• 2007

There have not been many studies which considered both quantitative and qualitative location factors on the issues of site selection problems for a fish farm. This study develops AHP(analytic hierarchy process) model to resolve site selection problem for a fish raising farm by using quantitative and qualitative factors. In order to evaluate the validity of the location factors found in the literature review, the study used advice from fish raising farmers and related academic experts. Four major factors have been selected as economic factors, social factors, natural environmental factors and infrastructures. An AHP structural diagram has developed by considering the factors and potential sites proposed for fish farming. Through the survey on the preference of factors and potential sites, pairwise comparison matrices have been estimated and used to calculated the relative weights of each potential site. The AHP model process shown in the study can be applied to resolve site selection problems for fish raising farmers.

• 한국수학사학회지
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• 제17권2호
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• pp.21-32
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• 2004

AHP는 수학적 이론이 간명하고 실제 적용이 용이하여 다양한 분야에서 폭 넓게 활용되고 있는 의사결정 기법이다. 본 연구에서는 AHP의 수학적 배경을 고찰하고, AHP가 수학교육의 목적인 실용성, 도야성, 심미성, 문화적 가치 등을 실천하고 있음을 논의하였다. 또한 이러한 논의를 통하여 수학 교육과 학습에 대한 하나의 대안을 제시하였다.

• 한국경영과학회:학술대회논문집
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• 한국경영과학회 2001년도 추계학술대회 논문집
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• pp.31-34
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• 2001

The customer unsatisfaction in the new products exists, though the most of enterprises using QFD. It is mainly caused by the failure of corrective determination of technical importance rating(TIR). To derive the technical importance rating, the impact of the fulfillment of design requirements on the satisfaction of customer requirements must first be quantified. This has been accomplished through the use of a 1-3-9 or a 1-5-9 scale and ignored the peak of the house of quality(HOQ). In this paper we suggested the methodology reflecting effectiveness among engineering characteristics and adjusting the relationship strength between customer attribute(CA) and engineering characteristic (EC), by using limit probability and PCMR(pairwise comparison and median rank). With using this method, the determination of TIR would be more suitable for the voice of customers objectively. Here negative correlation is ignored.

• 품질경영학회지
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• 제24권4호
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• pp.124-140
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• 1996

This study aims to deveop a methodology for measuring the level of service quality in the air transportation. To measure the level of service quality, the approach taken here deals with not only the facility factors but also qualitative factors such as comfort and convenience as the influencing elements for service quality. The contents of this study can be summarized as follows: (1) For the systematic developement and management of air service, service factors of the air transportation are classified by AHP(analytic hierarchy process). (2) In computing the weight of service factors, a pairwise comparison method in AHP is used. (3) This study will suggest a method of measuring the competitive level of air service, and a result of an empirical study appling the method developed.

• 산업공학
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• 제17권spc호
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• pp.1-10
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• 2004

The purpose of this paper is to reorganize cost adjustment factors of software development projects in estimating software development cost, and derive adjustment coefficients of application types and language types by analytical hierarchy process. We constructed a decision-making hierarchy of various criteria which determine the complexity of application types and language types, and conducted a survey on the pairwise comparison among alternatives. Finally, the cost adjustment coefficients of application types and language types were derived by analytic hierarchy process. This paper is the first study in which the analytic hierarchy process was applied to the field of estimating cost adjustment factors of software development projects.

• 한국경영과학회지
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• 제16권2호
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• pp.61-61
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• 1991

We propose a strategic R&D resource allocation and project selection model based on national R&D policy and objectives. First, contributions to R&D policy and objectives for each R&D area are evaluated by using analytical hierarchy process (AHP). Second, fuzzy Delphi are proposed to estimate R&D budget for each R&D area. Then, a project selection grid is also introduced to implement two-phased evaluation for R&D project selection. We also discuss how to improve the consistency in AHP and how to reduce the pairwise comparison in AHP. The proposed model enables the decision makers to allocate R&D budget, and to evaluate and select the R&D proposals based on both the contribution to national R&D policy and objectives, and the size of each R&D area concurrently