• 대한약침학회지
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• 제22권2호
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• pp.90-94
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• 2019

Objectives: Paclitaxel (PTX) as an anticancer drug used against solid cancers, possesses adverse reactions such as neuropathic pain which has confined its use. PTX-induced neuropathic pain is mediated via activation of oxidative stress. Berberine (BER), an isoquinoline phytochemical found in several plants, exerts strong antioxidant and painkilling properties. In the current study, we aimed to evaluate pain-relieving effect of BER in a mouse model of PTX-induced neuropathic pain. Methods: This study was done using 42 male albino mice that were randomly divided into 6 groups (n = 7) as follow: Sham-operated (not treated with PTX), negative control group (PTX-treated mice receiving normal saline), BER 5, 10, and 20 mg/kg (PTX-treated mice receiving BER) and positive control group (PTX-treated mice receiving imipramine 10 mg/kg). Neuropathic pain was induced by intraperitoneal administration of four doses of PTX (2 mg/kg/day) on days 1, 3, 5 and 7. Then, on day 7, hot plate test was done to assess latency to heat to measure possible anti-neuropathic pain effect of BER. Results: Four doses of PTX 2 mg/kg/day induced neuropathy that was reduced by BER at all time-points (i.e. 0, 30, 60, 90 and 120 min) after injection (P < 0.001 in comparison to control). The statistical analysis of data showed significant differences between groups (P < 0.001 in comparison to negative control), at 30, 60, 90 and 120 min after injection of BER 5, 10 and 20 mg/kg; in other words, 30, 60, 90 and 120 min after BER administration, neuropathic pain was significantly reduced as compared to normal saline-treated mice. Conclusion: Altogether, our results showed that PTX could induce neuropathic pain as reflected by hyperalgesia and BER could alleviate PTX-induced thermal hyperalgesia.

• 대한예방한의학회지
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• 제23권1호
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• pp.61-72
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• 2019

Introduction : The aim of this study was to investigate menstrual pattern according to Mibyeong Index(MBI) and compare Mibyeong symptom score according to severity of menstrual pain. Mibyeong Index was designed to measure inconvenience and resilience of subject's complains including four physical symptoms(fatigue, pain, low sleep quality, indigestion) and mental distress including anxiety, anger, depression. Method : We used the clinical data of Korean medicine Date Center(KDC) for subjects who participated in the study of 'Clinical research for collecting of clinical cases based on the personal type of Mibyeng' conducted in Seoul, from June 26, 2015 to June 26, 2017. A total of 566 fertile women aged 30 to 50 who completed the questionnaires were included in this study. In this study, we used items of Mibyeong Index and the menstrual pattern by self-report questionnaires. The date were analyzed through Kruskal Wallis test, Pearson's chi-square test, and one-way ANOVA using SPSS statistics 19.0. Results : Mibyeong status was significantly associated with severity of menstrual pain(p<0.001), worst day of menstrual pain(p<0.05), and type of menstrual pain(low back pain, nausea, depression, and none (respectively, p<0.05)). In addition, The 7-subtype score (fatigue (p<0.001), pain(p<0.001), low sleep quality(p<0.001), indigestion(p<0.001), anxiety(p<0.05), anger(p<0.05) and depression(p<0.05)) of Mibyeong index and total score of Mibyeong Index (p<0.001) showed significant difference for severity of menstrual pain. Conclusion : This result indicates that a close relationship between Mibyeong status and severity of menstrual pain. Further studies are needed but, we hope that this results will be used as the basic data to improve mibyeong status through health care to alleviate dysmenorrhea.

• 한국엔터테인먼트산업학회논문지
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• 제14권7호
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• pp.469-476
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• 2020

본 연구는 등받이 유무에 따른 하지 운동프로그램이 허리통증이 있는 대학생에게 미치는 영향을 알아 보기 위해 균형능력, KODI, VAS 검사를 이용하였다. 광주광역시 소재 K대학교 학생 32명을 대상으로 4주간 탄력밴드를 이용한 하지 운동프로그램을 진행하였으며 등받이의 유무에 따른 집단 별 16명씩 무작위로 선정하여 진행하였다. 균형능력과 KODI 점수에서는 집단과 시간에 의한 상호작용이 없는 것으로 나타난 반면 VAS 점수에서는 집단과 시간에 의한 상호작용이 나타났다. 또한 두 집단 모두 중재 후에 균형능력, KODI, VAS 점수에서 유의하게 증가하였다. 따라서 등받이 유무와 상관없이 의자에 앉아서 시행하는 하지운동 프로그램이 오랜시간 앉아서 생활하며 허리통증이 있는 학생과 직장인에게 일상에서 쉽게 할 수 있는 운동 프로그램으로 적용하는 것이 필요할 것으로 생각된다.

• 정신신체의학
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• 제10권1호
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• pp.18-26
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• 2002

연구목적: 본 연구의 목적은 만성요통 환자에서 스트레스지각 및 통증지각과 대응전략 간의 관계를 알아보고자 하는데 있다. 본 연구에는 만성요통 환자 80명과 정상대조군 100명이 참여하였다. 방법: 스트레스인자 및 스트레스반응에 대한 지각은 각각 스트레스인자 지각척도 (Global Assessment of Recent Stress Scale) 및 스트레스반응 척도(Stress Response Inventory)를, 대응전략 및 통증지각은 각각 대응척도(The Way of Coping-revised) 및 통증지각척도(Pain Discomfort Scale)를 이용하여 평가하였다. 결과: 만성요통환자들이 정상대조군보다 일 및 직장, 대인관계, 대인관계의 변화, 질병 및 상해에 관련된 스트레스인자 지각점수, 전체 스트레스인자지각 정수가 각각 유의하게 더 높았다. 스트레스반응점수에서는 피로점수가 정상대조군보다 환자군에서 유의하게 더 높았으나, 통증지각에서는 양군 간에 유의한 차이를 보이지 않았다. 대응전략에서는 환자군이 정상대조군에 비해 계획적 문제해결 및 긍정적 재평가를 더 많이 사용하였다. 환자군에서 통증지각은 전체 스트레스반응 점수, 질병 및 상해에 관련한 스트레스인자지각 점수와 각각 유의한 양상관성을 보였다. 도피 회피 점수는 연령과 유의한 음상관성을, 거리감두기 및 도피-회피 점수는 유의한 양상관성을 보였다. 한편 책임수용은 여자가 남자보다 더 유의하게 많이 사용하였다. 그러나 대응전략과 스트레스인자지각 및 스트레스반응 통증지각 간에는 각각 유의한 상관성을 보이지 않았다. 결론: 이상의 결과들은 만성요통환자들이 정상인에 비해 스트레스인자에 대한 지각이 더 높으나, 더 적극적인 대응을 하고 있음을 시사한다. 또한 환자군에서 사용하는 대응전략은 스트레스인자지각, 스트레스반응, 통증지각과 연관성을 보이지 않는 반면 사회인구학적 특정들과 연광성이 높음을 시사한다.

• 방송공학회논문지
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• 제15권5호
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• pp.607-616
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• 2010

현재까지 제안된 3차원 시각피로 측정 방법은 측정의 타당도가 결여되어 있고 시각피로의 복합적인 특성을 제대로 파악해 내지 못 하는 단점이 있다. 본 연구의 목적은 3차원 시각피로의 구성요인을 분석하고 안정적으로 타당하게 주관적인 시각피로를 측정하는 방법을 제안하는 것이다. 연구결과는 다음과 같이 요약된다. 첫째, 시각피로가 네 개의 독립적인 하위요인(시각적 스트레스, 안구 통증, 신체 통증, 상 흐림 요인)으로 구성되어 있음을 규명하였고, 둘째, 네 개의 요인으로 구성되어 있는 3차원 시각피로를 측정할 수 있는 29개의 문항을 개발하였으며, 셋째, 시각피로에 영향을 미칠 것으로 기대되는 시청시간과 양안시차의 조작이 개발된 측정 방법을 이용하여 측정된 시각피로에 실제로 영향을 미침을 확인하였다. 이와 같은 결과는 본 연구에서 제안하는 시각피로 측정 방법이 3차원 시각피로를 타당하게 측정함을 시사한다.

• 대한물리의학회지
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• 제1권1호
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• pp.13-21
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• 2006

Purpose : The main purpose of this study was to investigate the influence of muscle strengthening exercise on balance ability of knee osteoarthritis. The subject were consisted of 30 women patients with knee osteoarthritis. Method : The strengthening exercise group with modality treatment. The strengthening exercise for 40 minutes per day and three times a week during 6 weeks period. Short Form McGill Pain Questionnaire(SFMPQ) was used to measure patient's pain level. Patient Specific Functional Scale(PSFS) was used to measure patient's functional disability level. BPM was used to measure sway area. Global Perceived Effect Scale(GPES) was used to measure recovery or worse of patient's condition. Results : 1. SFMPQ was muscle strengthening exercise showed significantly decreased more than before treatment(p<.05). 2. PSFS was muscle strengthening exercise showed significantly increased more than before treatment (p<.05). 3. Sway area was muscle strengthening exercise showed significantly limited area more than before treatment(p<.05). 4. GPES was muscle strengthening exercise showed significantly increased more than before treatment(p<.05). Conclusion : This study will be used as exercise method of patient with osteoarhtritis.

• 대한전기학회논문지:시스템및제어부문D
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• 제52권11호
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• pp.657-661
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• 2003

In this paper, we designed a portable digital pressure algometer which not only can measure the pain level objectively and quantitatively, but also is able to do RF communication. This system consists of pressure sensor for pain measurement, analog signal analysis, digital hardware based on PIC16C73B, RF communication and display. To evaluate the performance of the developed system, we measured pressure threshold using commercial analog PA(Pressure Algometer) and the proposed system, and then evaluated the correlation and confidence. Using linear regression analysis, standard deviation of 0.1731 and R-square value of 99.3% were obtained. In conclusion, the above results showed good performance and its usability in measuring the pain clinically.

• 한방재활의학과학회지
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• 제23권4호
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• pp.95-115
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• 2013

Objectives The aim of this review is to provide fundamental data for low back pain scales which can be used in clinical trial. Methods We investigated the latest studies on chronic low back pain via PubMed. And we also investigated domestic studies through "http://oasis.kiom.re.kr". 95 research papers were analyzed. Scales were classified into pain scale, function scale, generic health status scale and psychological scale. Results 1) According to foreign clinical studies, Visual Analog Scale (VAS) and Numerical Rating Scale (NRS) were used 18 times as pain scale. Oswestry Disability Index (ODI) was used 20 times as function scale, Roland-Morris Disability Questionnaire (RMDQ) was 17, and Hannover Functional Ability Questionnaire (HFAQ) was used 3 times. 36-item Short Form Health Survey (SF-36) was used 13 times as generic health status scale, Euroqol-5 Dimentions Questionnaire (EQ-5D) was 11, and 12-item Short Form Health Survey (SF-12) was used 3 times. Fear-Avoidance Beliefs Questionnaire (FABQ) was used 9 times as psychological scale, Pain Catastrophizing Scale (PCS) and Tampa Scale for Kinesiophobia (TSK-R) both were used 3 times. 2) According to domestic clinical studies, VAS was used 37 times as pain scale, NRS was 11, and Short Form McGill Pain Questionnaire (SF-MPQ) was used 6 times. ODI was used 30 times as function scale, RMDQ was 2 times only. SF-36 was used once as generic health status scale and Beck's Depression Inventory (BDI) was used 3 times as psychological scale. Conclusions We recommend VAS or NRS as a measure to evaluate pain, and ODI as a measure to evaluate functional disability. And we also recommend SF-36 or SF-12 and EQ-5D as a measure to evaluate generic health status. Finally, we recommend FABQ for use in measuring psychological scale.

• 대한물리의학회지
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• 제12권3호
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• pp.23-32
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• 2017

PURPOSE: Flexibility and range of motion are very important factors in sports performance, rehabilitation, and musculoskeletal pain. The purpose of this study was to measure the effects of cupping therapy on flexibility, muscle activity, and pain threshold of hamstring muscle compared to passive stretching in healthy subjects. METHODS: Thirty healthy subjects were randomly assigned in a crossover design to cupping therapy and passive stretching. Subjects were tested to compare their effects according to the intervention such as Passive range of motion (PROM) (straight leg raising) and active range of motion (AROM). And algometer (pain) testing and MVC assessment using EMG were performed as dependent variables. RESULTS: The cupping therapy group and passive stretching group showed significant differences in all variables including PROM (p=.00, p=.00), AROM (p=.00, p=.03), Pain Threshold (p=.03, p=.08), Semitendinosus MVC (p=.01, p=.00), and Biceps femoris MVC (p=.01, p=.16). There were no significant differences between the two groups in all variables. CONCLUSION: These findings of this study suggested that cupping therapy has as much positive effect on flexibility, pain threshold, and muscle contraction as passive stretching. Also, it is more convenient and easier to work on patients than passive stretching. Therefore, cupping therapy should be considered as another option to treat range of motion, pain, and muscle activity in the clinical field.

• 성인간호학회지
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• 제13권1호
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• pp.159-170
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• 2001

The purpose of this pilot study was to identify the effects of hand moxibustion therapy to decrease pain and relieve coldness of the body in women who had a hysterectomy. The conceptual framework of this study was derived from Ying-Yang, Khi and other corresponding theories. The data were collected from February to May 1997. A Graphic Rating scale was used to measure the degree of pain and Digital Infrared Thermographic Imaging(D.I.T.I) was used to examine the degree of coldness. The subjects were women who resided in Seoul and had a hysterectomy within five years. An experimental group was composed of five women who received moxibustion and a control group was composed of five who did not. The research procedure began with having both the experimental group and control group describe their general characteristics and the degree of pain they perceived. Then, Digital Infrared Thermographic Imaging(D.I.T.I) was conducted. Moxibustion was only given to the experimental group on both hands twice every day for a total of five weeks. Their perception of pain and D.I.T.I were examined weekly. The control group received no therapy. After finishing therapy, the perception of pain and D.I.T.I for both groups were also measured. According to this study, moxibustion therapy resulted in a change of body temperature on the right shoulder joint(p=0.00074), abdomen(p= 0.0047), waist(p=0.0068) and hands(p=0.0317) respectively. Also, the study results showed significant decrease (p=0.0001) in pain over time and significant improvement over body coldness.