• The Korean Journal of Pain
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• 제30권2호
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• pp.126-133
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• 2017

Background: There are many mechanisms in which stress can lead to weight gain thus high a BMI. The endocrine and inflammatory pathway can directly increase abdominal adiposity. Another way in which stress leads to weight gain is through changes in health behaviors. The study aimed to investigate the prevalence of musculoskeletal disorders (MSDs) among healthy students of Ahlia University, and to determine the relationship between the development of MSDs and academic stressors and body mass index. Methods: Self-administered questionnaires were distributed to 94 students aged 18-26 years who were enrolled at various Ahlia University colleges and met other inclusion criteria. The students responded to the standardized Nordic musculoskeletal questionnaire and the modified College Student Stress Inventory regarding musculoskeletal symptoms and academic stressors. Height and weight measurements were also obtained to determine body mass index. Results: A total of 77.66% reported MSDs in one or more body part, with the prevalence being higher among women than among men. The 7-day prevalence of MSDs severe enough to interfere with activities of daily living was 60.64%, and 44.68% by female and male students, respectively. There was a significant relationship between academic stress and MSDs in the neck, shoulders, lower back, and hips, while the relationship between MSDs, and body mass index, academic stress, and grade point average was not significant. Conclusions: The prevalence of MSDs among Ahlia University students was found to be high. Apart from the positive correlation between academic stress and MSDs in certain body parts, other correlations were not significant.

• Journal of Ginseng Research
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• 제45권6호
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• pp.706-716
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• 2021

Background: Irritable bowel syndrome (IBS), the most common functional gastrointestinal disorder, is characterized by chronic abdominal pain and bowel habit changes. Although diverse complicated etiologies are involved in its pathogenesis, a dysregulated gut-brain axis may be an important factor. Red ginseng (RG), a traditional herbal medicine, is proven to have anti-inflammatory effects and improve brain function; however, these effects have not been investigated in IBS. Methods: Three-day intracolonic zymosan injections were used to induce post-infectious human IBS-like symptoms in mice. The animals were randomized to receive either phosphate-buffered saline (CG) or RG (30/100/300 mg/kg) for 10 days. Amitriptyline and sulfasalazine were used as positive controls. Macroscopic scoring was performed on day 4. Visceral pain and anxiety-like behaviors were assessed by colorectal distension and elevated plus maze and open field tests, respectively, on day 10. Next-generation sequencing of gut microbiota was performed, and biomarkers involved in gut-brain axis responses were analyzed. Results: Compared to CG, RG significantly decreased the macroscopic score, frequency of visceral pain, and anxiety-like behavior in the IBS mice. These effects were comparable to those after sulfasalazine and amitriptyline treatments. Moreover, RG significantly increased the proliferation of beneficial microbes, including Lactobacillus johnsonii, Lactobacillus reuteri, and Parabacteroides goldsteinii. RG significantly suppressed expression of IL-1β and c-fos in the gut and prefrontal cortex, respectively. Further, it restored the plasma levels of corticosterone to within the normal range, accompanied by an increase in adrenocorticotropic hormone. Conclusion: RG may be a potential therapeutic option for the management of human IBS.

• 대한간호학회지
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• 제22권3호
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• pp.297-315
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• 1992

Caring has been identified as the essence and unifying domin of nursing(Leininger). Many nurses believe that the art of nursing is comprised of actions that are predominantly caring in nature. Although caring has been the traditional ideology of nurses, it is only now beginning to emerge as the central construct for the development of nut sing research, theory and practice. The problem addressed by this study was to identify how hospitalized children and their nurses express the meaning of caring, how they think nurses should care for children and to describe their experiences of being cared for. The purpose was to provide theoretical understanding of caring as perceived in Korea to contribute to the development of Korean nursing knowledge. The subjects were 76 hospitalized children admitted to pediatric units in five teaching hospitals and 66 nurses who were caring for these children. In this descriptive study, data were collected from Nov 11, 1991 to Jan 30, 1992 by interviews and an open-ended questionnaire and analysed by van Kaam's method. Caring themes perceived by the children and their nurses were classified into eight categories, -helping, comfort, love, warmth(only by children), recovery from illness, health maintenance (only by nurses), presence, nurturance and responsibility. Ideal caring behaviors perceived by the children and their nurses were six categories, -to give help, provide comfort, give love, stay with, treat warmly and aid recovery. Subcategories of giving help were promptness and competence, detailed explanations and support and encouragement. Other subcategories of giving help reported only by nurses were individualizing care, recognizing needs and providing a familiar enviornment. Subcategories of maintaining comfort were making comfortable, alleviating pain ; one subcategory reported only by children was consolating. A subcategory of giving love was concern, two subcategories reported only by nurses were compassion and respect. Subcategories of staying with were playing with and touching : only nurses reported empathy, Subcategories of treating warmly were tenderness and kindness. In the experience of caring, there were 4 categories, -to give help, stay with, show concern and provide comfort. Both the hospitalized children and their nurses had experienced caring primarily from their mothers. Mothers' caring behaviors were direct, personal, basic, supportive nursing acts. On the other hand, nurses caring behaviors were task oriented skilled procedures and medically delegated acts. This study contributes understanding of the complexity of caring, more specifically the meaning and experience of caring and ideal caring behaviors. Research may be able to move into verification when instruments are developed to measure the complexity of caring beliefs, values and behaviors in Korea and other cultural settings.

• 정신신체의학
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• 제6권2호
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• pp.210-220
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• 1998

The relationships between emotion, stress and gastro-intestinal dysfunction were briefly reviewed. Until now, several kinds of theories on about pathophysiology, such as motility dysfunction, changes of pain perception on the lumen, dysregulations on the central nervous system associated with psychosocial factors were reported. However, none of those factors could'nt give any clues for the causes of the functional bowel disorders. For understanding the meaning of the symptoms and for the treatment approach, clinicians should give attention to the comprehensive point of view, i.e., not only biological but also psychological aspects of the patients with non-organic bowel dysfunctions. Giving warm and kind explanations to the patient about symptom formation and progression and understanding the patient's illness behaviors, and good and strong doctor-patient relationship is essentials for the treatment.

• 대한물리치료과학회지
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• 제10권2호
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• pp.163-172
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• 2003

Background and Purpose. Physical therapists are at risk for work-related musculoskeletal disorders (WMSDs). Little understand the characteristics of work in physical therapist or the effort they take to prevent injury. The purpose of this study was to investigate the characteristics of work in physical therapist and the efforts for prevent injury Subjects. Standardized questionnaire was administered to 103 physical therapist in Pusan association. Methods. An questionnaire was given to each subject. Questions investigated the characteristics of work in physical therapist, efforts and caring of injury prevention. Chi-square Test used to assess the association of general characteristics with the characteristics of work in physical therapist. AVONA and T-test used to assess the association of efforts of prevent injury in independent variable Results. Physical therapist was reported a higher prevalence of WMSDs in most body areas. These attributes sometimes resulted in behaviors that contributed to the development of their WMSDs.

• 한국가정과교육학회지
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• 제28권4호
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• pp.79-95
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• 2016

본 연구는 청소년들에게 사이버 공간이 중요한 환경으로 자리매김하면서 또래 괴롭힘에서 사이버 불링이 눈에 띄게 급증하고 있으므로, 중학생들의 사이버 불링 목격 실태와 목격 후 어떠한 행동을 보이는지를 파악하며, 중학생의 공감 능력이 목격 후 행동 유형에 영향을 미치는지 탐색하고자 하였다. 이를 위해 경기도 11개 지역에 소재한 중학교의 총 595명 중학생을 설문조사하였다. 연구 결과는 다음과 같다. 첫째, 전체 응답자의 61.2%가 다섯 가지 사이버 불링 상황을 목격한 적이 있다고 응답하였으며, 사이버 비방을 가장 흔히 목격하였고 유포, 왕따, 성추행, 갈취 순으로 목격한 것으로 나타났다. 사이버 불링을 목격한 주변인은 방관 행동, 방어 행동, 동조 행동, 역할 없음 순의 행동 유형을 보였으며 이러한 행동 유형은 성별, 학년, 부모 관계 만족도, 사이버 불링 목격 정도, 사이버 불링 가해 경험에 따라 유의한 차이를 보였다. 둘째, 정서적 측면의 공감 능력인 '공감적 관심'과 '개인적 고통'이 사이버 불링 주변인의 행동 유형에 영향을 미치는 것으로 나타났다. 이상의 연구 결과를 바탕으로 한 가정교과에서의 시사점은 첫째, 응답자의 약 2/3 정도가 사이버 불링 상황을 목격한 것으로 나타나 사이버 불링의 심각성에 대한 이해의 폭을 확장시킬 필요성을 제기하였다. 특히 사이버 비방, 유포, 왕따, 갈취, 성추행 등의 사이버 불링 상황을 다양하게 목격하고 있다는 사실을 통해 청소년들이 당면하고 있는 구체적인 문제 상황을 환기시켰다. 또한 사이버 불링을 목격한 주변인의 행동 유형 분포가 성별, 학년, 부모와의 관계 만족도, 사이버 불링 목격 정도, 사이버 불링 가해 경험에 따라 차이를 보이는 것으로 나타나 사이버 불링을 예방하기 위해 청소년 개인 뿐 아니라 가족 및 사이버 환경에서의 교육이 다각도로 필요함을 시사한다. 둘째, 사이버 불링 상황을 목격한 주변인이 피해자를 방어하기 위해서는 정서적인 공감 능력이 중요하지만, 불안이나 긴장과 같은 부정적 공감 정서는 방어 행동을 저해한다는 사실을 확인함으로써 정서적인 공감 교육은 감정 조절 교육과 함께 이루어질 필요가 있음을 시사한다.

• Journal of Korean Neurosurgical Society
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• 제61권2호
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• pp.186-193
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• 2018

Objective : The purpose of this study was to evaluate pain-related behaviors after bilateral C2 root resection and change in pain patterns in the suboccipital region in rats. Methods : Male Sprague-Dawley rats were randomly assigned to three groups (n=25/group); $n{\ddot{a}}ive$, sham, and C2 resection. Three, 7, 10, and 14 days after surgery, cold allodynia was assessed using $20{\mu}L$ of 99.7% acetone. c-Fos and c-Jun were immunohistochemically stained to evaluate activation of dorsal horn gray matter in C2 segments of the spinal cord 2 hours, 1 day, 7 days, and 14 days after surgery. Results : Three days after surgery, the response to acetone in the sham group was significantly greater than in the $n{\ddot{a}}ive$ group, and this significant difference between the $n{\ddot{a}}ive$ and sham groups was maintained throughout the experimental period (p<0.05 at 3, 7, 10, and 14 days). Seven, 10, and 14 days after surgery, the C2 root resection group exhibited a significantly greater response to acetone than the $n{\ddot{a}}ive$ group (p<0.05), and both the sham and C2 resection groups exhibited significantly greater responses to acetone compared with 3 days after surgery. No significant difference in cold allodynia was observed between the sham and C2 root resection groups throughout the experimental period. Two hours after surgery, both the sham and C2 root resection groups exhibited significant increases in c-Fos- and c-Jun-positive neurons compared with the naive group (p=0.0021 and p=0.0358 for the sham group, and p=0.0135 and p=0.014 for the C2 root resection group, respectively). One day after surgery, both the sham and C2 root resection groups exhibited significant decreases in c-Fos -positive neurons compared with two hours after surgery (p=0.0169 and p=0.0123, respectively), and these significant decreases in c-Fos immunoreactivity were maintained in both the sham and C2 root resection groups 7 and 14 days after surgery. The sham and C2 root resection groups presented a tendency toward a decrease in c-Jun-positive neurons 1, 7, and 14 days after surgery, but the decrease did not reach statistical significance. Conclusion : We found no significant difference in cold allodynia and the early expression of c-Fos and c-Jun between the sham and C2 resection groups. Our results may support the routine resection of the C2 nerve root for posterior C1-2 fusion, but, further studies are needed.

• The Korean Journal of Pain
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• 제12권1호
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• pp.1-7
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• 1999

Background: To study the role of spinal alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors in pain behaviors caused by mild burn, we examined the effect of intrathecal administered ACEA 2085, which has been recently characterized as a high potency competitive AMPA receptor antagonist, on the thermal hyperalgesia state induced by mild burn. Methods: A thermal injury was induced by applying the left hind paw to a thermal surface ($52.5^{\circ}C$) for 45 sec. Thermal escape latency of the hind paw was determined using an underglass thermal stimulus. Thirty min after thermal injury, the paw withdrawal latency (PWL) in injured paw of all groups fell from 10~12 sec to 5~7 sec. At that time, ACEA 2085 (0.01~0.1 mcg) and 6-cyano-7-nitroquinoxalinedione (CNQX, 1~30 mcg) were injected through intrathecal heters in rats with mild burn injury on the right hindpaw. And then, PWL were measured in the both hindpaw every 30 minutes for about three hours. Results: The intrathecal injection of ACEA 2085 produced a dose dependent reversal of the hyperalgesia in the right hindpaw and more potent than CNQX, but had no effect upon the response latency of the normal left hind paw even at the largest doses. All effects were observed at doses that had no significant effect upon motor function. Conclusions: Intrathecal ACEA 2085, highly selective AMPA receptor antagonist produce a dose- dependent reversal of the thermal hyperalgesia evoked mild burn injury. These results suggested that spinal AMPA receptor play an important role in the hyperalgesia induced by mild burn injury.

• 치위생과학회지
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• 제16권3호
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• pp.242-248
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• 2016

이 연구는 일부 아동들을 대상으로 일상생활구강영향지수와 구강건강관련행태, 구강건강상태를 조사하였으며, 일상생활구강영향지수에 영향을 미치는 요인을 파악하고, 서로간의 연관성을 알아보고자 2012년 3월부터 5월까지 인천광역시와 천안시 소재 일부 학교 아동 200명을 대상으로 설문조사를 하였다. 그 중 설문조사가 완료된 175명을 최종 분석대상으로 하여 SPSS WIN 20.0 프로그램을 이용하여 분석한 후 다음과 같은 결과를 얻었다. 일반적 특성과 C-OIDP 불편경험 항목 수, 구강건강관련 행태와 C-OIDP 불편경험 항목 수는 통계적으로 유의한 차이가 없었다(p>0.05). 그리고 C-OIDP 불편 경험 항목 수가 많을수록 충전유치치면과(p=0.024), 우식경험유치치면이 많고(p=0.049), 구강 내 전체충전치면과(p=0.021) 구강내 전체우식경험치면 역시 많은 것으로 나타났다(p=0.047). 이것은 객관적인 구강건강상태와 주관적 지표인 C-OIDP가 서로 관련성이 있음을 보여준다. C-OIDP 여덟 항목 중 영향빈도가 높은 것은 식사하기, 치아 닦기, 웃기 순이었으며, 구강 내 전체 우식경험치면수가 많고, 지난 한 달간 잇몸 통증을 경험한 대상자에서 C-OIDP 항목점수가 높았다. 이것은 C-OIDP가 우식과 치주 상태와 관련이 있음을 보여주는 것이다. 이 연구는 주관적 구강건강지표와 실제 구강건강과의 관련성을 본 연구로서 매우 의미 있는 연구이며, 앞으로 C-OIDP에 영향을 미치는 다양한 요인에 대한 연구가 필요할 것으로 생각된다.

• 치위생과학회지
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• 제15권4호
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• pp.424-429
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• 2015

본 연구는 trtiptolide의 안면부 통증 조절효과를 평가하기 위하여 포르말린으로 유도된 실험동물의 안면부 통증모델에서 말초와 중추로 투여한 trtiptolide의 농도별 차이를 확인하였고, 다음과 같은 결과를 얻었다. 먼저, 안면부 피하로 triptolide 투여 후 포르말린 주입군에서 포르말린 주입 후 11~45분에 발생하는 2차 통증행위반응은 25, $50{\mu}g/50{\mu}l$의 각 농도에 따라 $179.17{\pm}15.36$회, $114.33{\pm}16.65$회로 나타났고 $299.00{\pm}28.14$회로 나타난 포르말린 주입군과 비교시 통증행위반응이 유의하게 경감되었다. 시간의 경과에 따른 변화에서 $50{\mu}g/50{\mu}l$의 투여군에서 포르말린 주입 후 20분, 30분에 통증행위반응이 포르말린군과 비교하여 유의하게 감소되었음을 확인하였다. 안면부 피하로 투여한 triptolide는 포르말린으로 유도된 통증행위반응을 감소시킴으로써 안면부 통증조절효과를 나타내었다. 다음으로, 소뇌연수조 내로 triptolide 투여 후 포르말린 주군에서 2차 통증행위반응은 $1{\mu}g/10{\mu}l$의 $134.00{\pm}23.03$회로 나타났고, $289.50{\pm}44.30$회로 나타난 포르말린군과 비교 시 통증행위 반응이 경감되었다. 시간의 경과에 따른 변화에서, $1{\mu}g/10{\mu}l$의 triptolide 투여군에서 포르말린 주입 후 25~40분에 통증행위반응이 감소되었음을 확인하였다. 소뇌연수조로 투여한 triptolide는 포르말린으로 유도된 통증행위반응을 감소시킴으로써 안면부 통증조절효과를 나타내었다. 이상의 결과는, triptolide는 구강 및 턱관절 등을 포함하는 안면부 통증 조절의 예방 및 치료에 있어 활용 가능한 천연대체 약물로 제시될 수 있을 것으로 생각된다.