• Asian Pacific Journal of Cancer Prevention
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• 제16권8호
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• pp.3493-3498
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• 2015

Objective: To assess associations between codon 72 polymorphisms (Pro or B and Arg or b alleles) of the TP53 gene and lung cancer risk among Bangladeshis. Materials and Methods: The distribution of the BB, Bb, and bb genotypes and the frequencies of the B and b alleles were determined by PCR-RFLP method using DNA extracted from leucocytes of 50 confirmed lung cancer patients and 50 age-matched controls and the data were analysed. Results: The ratio of BB, Bb, and bb genotypes were in Hardy-Weinberg equilibrium except for the male patients (${\chi}2=4.6$). The B allele is overrepresented among all patients (OR=2.0, p=0.02) and the female patients (OR=4.1, $p{\leq}0.01$) compared to the controls. The BB/bb ratio was also higher among the patients (OR=3.0, p=0.03). The relative risk of cancer for having BB over bb genotype was 1.8 (p=0.04) but no effect was observed for the Bb genotype. The B allele was overrepresented among patients with adenocarcinomas (OR=2.4, $p{\leq}0.01$) and squamous cell carcinomas (OR=2.7, $p{\leq}0.01$) over the controls but the difference was not significant for those with small cell lung carcinomas (OR=1.1, p=0.66). The B allele was overrepresented among patients age 50 or younger (OR=2.7, $p{\leq}0.01$), but not for older patients (OR=1.7, p=0.07), and among smokers compared to the controls (OR=1.8-10.0, $p{\leq}0.01-0.03$). However, no correlation between increasing pack-years and lung cancer was observed. Conclusions: The Pro/Pro (BB) genotype and the B allele are risk factors for lung cancer among Bangladeshis, particularly for people under age 50, women and smokers.

• Asian Pacific Journal of Cancer Prevention
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• 제13권5호
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• pp.2311-2314
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• 2012

Genetic polymorphisms of uridine diphosphate-glucuronosyltransferases 1A6 (UGT1A6) and 1A7 (UGT1A7) may lead to genetic instability and colorectal cancer carcinogenesis. Our objective was to measure the interaction between polymorphisms of these repair genes and tobacco smoking in colorectal cancer (CRC). A total of 68 individuals with CRC and 112 non-cancer controls were divided into non-smoker and smoker groups according to pack-years of smoking. Genetic polymorphisms of UGT1A6 and UGT1A7 were examined using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). We found a weak association of UGT1A6 polymorphisms with CRC risk (crude odds ratio [OR], 1.65;95% confidence interval [95% CI], 0.9-3.1, P=0.107; adjusted OR 1.95%, 95% CI 1.0-3.8, P=0.051). The ORs for the UGT1A7 polymorphisms were statistically significant (crude OR: 26.40, 95% CI: 3.5-198.4, P=0.001; adjusted OR: 21.52, 95% CI: 2.8-164.1, P=0.003). The joint effect of tobacco exposure and UGTIA6 polymorphisms was significantly associated with colorectal cancer risk in non-smokers (crude OR, 2.11; 95% CI, 0.9-5.0, P=0.092; adjusted OR 2.63, 95% CI, 1.0-6.7, P=0.042). In conclusion, our findings suggest that UGT1A6 and UGT1A7 gene polymorphisms are associated with CRC risk in the Japanese population. In particualr, UGT1A6 polymorphisms may strongly increase CRC risk through the formation of carcinogens not associated with smoking.

• Journal of Nutrition and Health
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• 제44권5호
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• pp.366-377
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• 2011

Glutathione S-transferase (GST) is a multigene family of phase II detoxifying enzymes that metabolize a wide range of exogenous and endogenous electrophilic compounds. GSTM1 and GSTT1 gene polymorphisms may account for inter-individual variability in coping with oxidative stress. We investigated the relationships between the level of lymphocyte DNA and antioxidative parameters and the effect on GST genotypes. GSTM1 and GSTT1 were characterized in 301 young healthy Korean adults and compared with oxidative stress parameters such as the level of lymphocyte DNA, plasma antioxidant vitamins, and erythrocyte antioxidant enzymes in smokers and non smokers. GST genotype, degree of DNA damage in lymphocytes, erythrocyte activities of superoxide dismutase, catalase, and glutathione peroxidase (GSH-Px), and plasma concentrations of total radical-trapping antioxidant potential (TRAP), vitamin C, ${\alpha}$- and ${\gamma}$-tocopherol, ${\alpha}$- and ${\beta}$-carotene, and cryptoxanthin were analyzed. Lymphocyte DNA damage assessed by the comet assay was higher in smokers than that in non-smokers, but the levels of plasma vitamin C, ${\beta}$-carotene, TRAP, erythrocyte catalase, and GSH-Px were lower than those of non-smokers (p < 0.05). Lymphocyte DNA damage was higher in subjects with the GSTM1- or GSTT1-present genotype than those with the GSTM1-present or GSTT1- genotype. No difference in erythrocyte antioxidant enzyme activities, plasma TRAP, or vitamin levels was observed in subjects with the GSTM1 or GSTT1 genotypes, except ${\beta}$-carotene. Significant negative correlations were observed between lymphocyte DNA damage and plasma levels of TRAP and erythrocyte activities of catalase and GSH-Px after adjusting for smoking pack-years. Negative correlations were observed between plasma vitamin C and lymphocyte DNA damage only in individuals with the GSTM1-present or GSTT1- genotype. The interesting finding was the significant positive correlations between lymphocyte DNA damage and plasma levels of ${\alpha}$-carotene, ${\beta}$-carotene, and cryptoxanthin. In conclusion, the GSTM1- and GSTT1-present genotypes as well as smoking aggravated antioxidant status through lymphocyte DNA damage. This finding confirms that GST polymorphisms could be important determinants of antioxidant status in young smoking and non-smoking adults. Consequently, the protective effect of supplemental antioxidants on DNA damage in individuals carrying the GSTM1- or GSTT1-present genotypes might show significantly higher values than expected.

• 대한예방한의학회지
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• 제1권1호
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• pp.126-136
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• 1997

To procide basic data for improvement of oriental medical care system, the questionnaire interview was carried out with community peoples, over 20 years old, selected randomly in Seoul, Pusan, Taegu and Taejon err. from 10th Mar. to 20th Apr. 1996. The result were summarized as follows: 1. In the general characteristics of subjects, the highest portion of each part was 52.4% of male, 22.4% of thirties, 37.1% of college graduates, 19.1% of married, 30.6% of town dwellers, 63.3% of muddle social class, 26.6% of housewife, 19.3% of student, 16.6% officer and 11.6% of professional technician. 2. The portion of subjects agree to open oriental clinic in western medicine hospital was 60.0%, that of disagreement was 20.1%, Among 60.0% of agreement group, the high rate was showed in female, fifties, middle school graduates, unemployed, middle social level. 3. The rate of positive responses in system of a herb specialist was 64.7%, that of negative responses was 11.6%. Among positive responses, the groups of high rate were male. twenties, above college graduates, student, middle-high social level and city dwellers. 4. In the question whether a pack of herb medicine should be included in medical insurance or not, the rate of agreement was 74.3%, that of disagreement was 4.1%. Amount agreement subjects, the high rate was showed in male, young age, high educated, city dwellers, professional technician middle social class. 5. In the cost of oriental medical care, the portion was divided by 70.3% of expensiveness,25.6% of moderate, 4.1% of low price. among 70.3% of high price, the high rate was in female, forties, agrolivestock-fishery, and town dwellers. 6. In the question what the herb doctor should do for the improvement of oriental medicine, the highest rate was 54.2% in further study. The next was 23.0% in need of western medical and 9.1% in no complain in present situation. Among 54.2% of further study, the high rate was showed in male, forties, high school graduate, profession technician, high social level, christian, married and city dwellers. 7. About institution of oriental care, 86.8% of subjects answered to need of improvement, 8.0% of them replied no problem as present. Amount 86.8% of subjects, the high rate was showed in male, twenties, above college graduate, sales, singles, high social level and city dwellers. 8. About necessity of western medical care instrument in oriental medical hospital, the rate of sightly need was 47.5%, inevitably need was 37.7%, no need was 6.3%, the Positive subjects were showed high rate in male, officer, singer, the younger age, the higher educated, better social level and city dwellers. These results might be useful information for establishing of oriental medical care policies, which open oriental medical clinic in western medical hospital, equip western medical care instrument in oriental medical hospital, improve oriental medical care instrument carry out a herb specialist system, balance the resonable medical care cost and effort for further study & research on oriental medicine to satisfy increasing need of oriental medicine.

• Tuberculosis and Respiratory Diseases
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• 제71권3호
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• pp.202-209
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• 2011

Background: A tuberculous destroyed lung is sequelae of pulmonary tuberculosis and causes various respiratory symptoms and pulmonary dysfunction. The patients with a tuberculous destroyed lung account for a significant portion of those with chronic lung disease in Korea. However, few reports can be found in the literature. We investigated the computed tomography (CT) findings in a tuberculous destroyed lung and the correlation with lung function. Methods: A retrospective analysis was carried out for 44 patients who were diagnosed with a tuberculous destroyed lung at the Keimyung University Dongsan Hospital between January 2004 and December 2009. Results: A chest CT scan showed various thoracic sequelae of tuberculosis. In lung parenchymal lesions, there were cicatrization atelectasis in 37 cases (84.1%) and emphysema in 13 cases. Bronchiectasis (n=39, 88.6%) was most commonly found in airway lesions. The mean number of destroyed bronchopulmonary segments was 7.7 (range, 4~14). The most common injured segment was the apicoposterior segment of the left upper lobe (n=36, 81.8%). In the pulmonary function test, obstructive ventilatory defects were observed in 31 cases (70.5%), followed by a mixed (n=7) and restrictive ventilatory defect (n=5). The number of destroyed bronchopulmonary segments showed a significant negative correlation with forced vital capacity (FVC), % predicted (r=-0.379, p=0.001) and forced expiratory volume in one second ($FEV_1$), % predicted (r=-0.349, p=0.020). After adjustment for age and smoking status (pack-years), the number of destroyed segments also showed a significant negative correlation with FVC, % predicted (B=-0.070, p=0.014) and $FEV_1$, % predicted (B=-0.050, p=0.022). Conclusion: Tuberculous destroyed lungs commonly showed obstructive ventilatory defects, possibly due to bronchiectasis and emphysema. There was negative correlation between the extent of destruction and lung function.

• 산업융합연구
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• 제18권1호
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• pp.45-52
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• 2020

본 연구는 국내에서 판매되고 있는 담뱃갑 흡연 '담뱃갑경고그림'이 흡연자의 금연효과에 미치는 영향을 조사하여 향후 금연 및 건강관련 보건자료의 기초로 사용할 목적으로 시행된 서술적 조사연구이다. 이를 위해 인터넷 네이버 웹상에서 20세 이상 성인 남녀 500명을 대상으로 네이버 폼 설문지를 이용해 블러그와 카페 등을 이용하여 2018년 10월1부터 10일간 조사하여 응답이 미흡한 설문지를 제외하고 500부를 본 연구에 사용하였다. 분석된 데이터는 SPSS WIN20.0을 이용한 요인 분석, T-검정 및 상관관계를 분석하였다. 주요 연구 결과는 첫째, 인체해 유해한 담뱃갑 경고 그림이 금연효과에 가장 큰 영향을 미친 것으로 나타났다. 둘째, 금연효과는 담뱃갑 경고그림에 대한 설문 전 의식과 가장 높은 상관관계를 보였다. 이는 '담뱃갑 경고그림'이 흡연자에게는 가장 민감한 부분으로 받아들여지고 있음을 나타낸다. 본 논문의 결과를 토대로 담뱃갑 경고 그림의 다양화와 경고그림의 정기적인 교체 등은 금연 본능을 억제시키는 기전으로 작동함에 따라 향후 금연예방의 실천적 방안을 제안 할 수 있는 유용한 기초자료를 제공할 것으로 기대된다. 따라서 흡연경고 그림은 언론이나 매체를 통해 널리 홍보하여 국민들에게 금연을 실행하는데 긍정적인 영향을 미치며, 나아가 국민들의 건강 증진을 위한 보건정책의 기초자료로 활용될 것으로 사료된다.

• 한국콘텐츠학회논문지
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• 제12권11호
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• pp.258-266
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• 2012

본 연구는 일부 대학생들의 흡연행태와 흡연자와 비흡연자 간의 흡연에 대한 인식과 구강건강관리행태를 알아보고자 경상북도, 대구광역시, 강원도에 위치한 4년제 대학교에 재학 중인 대학생 260명을 대상으로 흡연에 대한 인식과 구강건강관리행태에 대해 조사한 결과 다음과 같은 결론을 얻었다. 1. 흡연자의 하루 평균 흡연량은 반 갑 미만이, 흡연기간은 1년~3년 미만이 가장 높았으며, 흡연을 시작하게 된 동기는 호기심과 주변 권유가 가장 높았고, 흡연이유는 스트레스 해소, 습관적 순으로 나타났다. 2. 흡연유무에 따른 구강건강관리행태 중 1회 잇솔질 시간, 정기적 치과 내원, 최근 치과 내원시기, 치과 방문 목적, 스켈링 및 구강보건교육 경험에서 유의한 차이가 있었다. 3. 흡연유무에 따른 구강건강에 대한 인식 중 주관적 구강건강상태에서 유의한 차이가 있었다. 4. 흡연유무에 따른 흡연에 대한 인식 중 담배, 한 두 개피 정도의 담배, 식후의 담배 및 간접흡연이 건강에 미치는 영향에 대한 인식에서 유의한 차이가 있었다. 이상의 결과로 미루어 볼 때 흡연자는 비흡연자에 비해 구강건강관리행태 및 구강건강에 대한 인식, 흡연에 대한 인식이 부족하므로, 대학생들을 위한 금연교육과 구강보건교육 프로그램 개발의 활성화가 필요하다고 사료된다.

• 대한물리치료과학회지
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• 제1권2호
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• pp.275-287
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• 1994

본 연구는 일부 중소도시지역 노인들의 우울증 및 인지기능장애의 정도를 분석하기 위해 1944년 8월 29일부터 9월 9일까지 경상북도 안동시 소재 43개 경로당 중 10개 시설에 거주하고 있는 노인의 전체 237명 중 150명을 대상으로 분석 하였는데, 그 결과는 다음과 같다. 1. 우울증의 항목별 평균값의 순위는 자기학대가 2.97점으로 1위, 성욕감퇴가 2.91점으로 2위, 절망감이 2.89점으로 3위 였다. 2. 성별에 따른 인지기능장애의 점수는 여자의 20.66점이 남자의 23.18점 보다 통계적으로 유의하게 낮았다(P<0.01). 3.교육수준과 인지기능장애에서 무학군이 20.41점으로 유학군의 23.05점 보다 유의하게 낮았다(P<0.01). 4. 결혼상태와 인지장애는 홀로사는 경우가 20.75점으로 배우자가 있는 경우의 22.87점 보다 유의하게 낮았다(P<0.01). 5. 일상생활활동 능력의 수준과 인지장애는 3단계(23.67점), 2단계(23.57점), 1단계(20.55점)로 내려갈수록 유의하게 낮은 점수였다(P<0.001). 6. 만성질환과 인지장애에서 질환을 가진군이 21.02점으로 가지고 있지않는 군의 22.52점 보다 유의하게 낮았다(P<0.05). 7. 성별과 우울증의 점수는 여성이 42.17점으로 41.10점인 남성 보다 유의하게 높은 우울점수를 보였으나 통계적 차이는 없었다. 8. 교육수준과 우울점수에서 무학군이 44.27점으로 유학군의 39.74점 보다 유의하게 높았다(P<0.05). 9. 흡연상태와 우울점수는 하루에 한갑이상의 흡연자 47.22점은 비흡연자의 40.34점 보다 높게 나타났다(P<0.05). 10. 신체이상유무와 우울점수는 가진경우가 44.22점으로 가지지 않은 경우의 40.46점 보다 유의하게 높았다(P<0.05). 11. 일상생활 활동능력의 수준과 우울점수는 3, 2, 1단계로 내려갈 수록 27.67, 38.41, 43.68점으로 높은 점수를 보였다(P<0.001). 12. 만성질환의 유무와 우울점수에서는 질환을 가진 군의 43.78점은 가지지않은 군의 37.63점 보다 높은 우울점수를 보였다(P<0.001). 이상의 본 연구결과에 의하면 연령이 높은 여성노인 이면서 교육을 받지못하고 수동적인 일상생활활동의 유지 및 만성질환을 가진 노인들일수록 인지기능장애와 우울증이 높음을 알 수 있다. 이러한 변수들이 직접적인 원인이라고는 할 수 없으며 단지 노인들의 복지정책에 참조사항이며 향후 이런 변수들을 중심으로한 전향적이고 인과적인 역학조사가 요구된다.

• The Journal of Korean Physical Therapy
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• 제16권1호
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• pp.157-182
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• 2004

The purpose of this study was to evaluate effects of lumbar stabilizing exercise on the functional recovery and the range of motion of low back pain patients. The subjects were consisted of sixty patients who had non specific chronic low back pain(32 females. 28 males; mean aged 37.3) from 19 to 65 years of age(mean age : 37.3). All subjects randomly assigned to the lumbar stabilizing exercise group, the modalities treatment group, the manual treatment group. Lumbar stabilizing exercise group received manual treatment with lumbar stabilizing exercise for 30minutes, modalities treatment group received hot pack used thermal therapy for 20minutes and ICT used electrical therapy for 20minutes and US or MWD used deep thermal therapy for 15minutes, manual treatment group received modalities treatment with therapeutic massage for 10minutes and joint mobilization or manipulation for 10minutes per day and three times a week during 4 weeks period. The Multilevel Roland-Morris Disability Questionnaire(MR-MDQ) was used to measure functional disability level. Visual Analogue Scale(VAS) was used to measure subjective pain level. Remodified Schober test(RST) was used to measure forward flexion range of motion of lumbar segment. Finger-to-Floor test(F-T-FT) was used to measure forward flexion range of motion of full spine of low back pain patients. All measurements of each patients were measured at pre-treatment and 4 week post-treatment. The results of this study were summarized as follows : 1. The MR-MDQ of lumbar stabilizing exercise group, modalities treatment group, and manual treatment group was significantly reduced between pre-treatment and post-treatment(p<.05). 2. The VAS of lumbar stabilizing exercise group, modalities treatment group, and manual treatment group was significantly reduced between pre-treatment and post-treatment(p<.05). 3. The RST of lumbar stabilizing exercise group, modalities treatment group, and manual treatment group was significantly reduced between pre-treatment and post-treatment(p<.05). 4. The F-T-FT of lumbar stabilizing exercise group, modalities treatment group, and manual treatment group was significantly reduced between pre-treatment and post-treatment(p<.05). 5. The results of analyzed effects of MR-MDQ, RST, F-T-FT were significantly reduced (p<.05), but VAS wasn't significantly reduced(p>.05) between treatment type of lumbar stabilizing exercise group and modalities treatment group and manual treatment group according to pre-treatment and post-treatment. 6. The results of LSD post-hoc to find difference between treatment type of lumbar stabilizing exercise group and modalities treatment group and manual treatment group according to pre-treatment and post-treatment that MR-MDQ was significantly reduced stabilizing exercise group than modalities treatment group(p<.05), and VAS wasn't significantly reduced all treatment group(p>.05), and RST was significantly reduced stabilizing exercise group than modalities treatment group(p<.05), and F-T-FT was significantly reduced stabilizing exercise group than modalities treatment group and manual treatment group (p<.05).

• 한국전자거래학회지
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• 제26권3호
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• pp.1-20
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• 2021

코로나19 대유행으로 세계경제포럼에서 그레이트 리셋이 논의되면서 제4차산업혁명의 동력인 인공지능도 조명을 받고 있다. 그러나 인공지능 분야의 기업 연구는 아직도 희소하다. 2000년 이후 관련 연구는 기존 기업에 어떻게 인공지능을 적용하여 가치를 창출할 것인가에 초점이 맞춰져 있으며, 신생기업들이 어떻게 기회를 포착하고 기존 사업자들 사이에 진입하여 새로운 가치를 창출하는지에 대한 연구는 거의 찾아볼 수 없다. 이에 본 연구는 소프트웨어의 세부 분야인 인공지능 기반 신생기업들이 기존 소프트웨어 산업과 어떻게 다른 혁신패턴을 갖는가라는 연구 질문을 가지고 다층적 접근론의 종합적 틀을 활용하여 신생 기업들의 사례를 분석하였다. 대상 기업들은 창업 7년 내 의료, 금융, 마케팅/광고, 유통, 제조 분야에서 의도적으로 표집된 머신러닝 모델링 전문 신생 기업들로 벤처기업 인증을 받은 고성장 기업들이다. 분석 결과 기존 소프트웨어 기업들은 전사적 통합 관점의 프로세스 혁신을 이루어냈다면, 이들만의 혁신 패턴은 기존의 프로세스들을 잘게 해체하여 자동화나 가치창출이 어려웠던 단위 프로세스들을 식별해 내고 데이터 기반으로 자동화, 최적화하여 새로운 가치를 제공하고 있다는 것이다. 이 연구의 기여는 통합적인 다층적 접근론의 틀의 유효성을 검증하면서 인공지능 기반 신생 기업들의 탄생과 그들의 혁신 패턴을 제시했다는 데에 있다. 한편 기업 실무적, 정부 정책적 함의를 정리하면, 데이터를 기반으로 혁신을 이끌어내기 때문에 신생 기업일지라도 데이터 관련 규제 등에 대한 제도 대응 역량이 강조되며, 정부는 관련 제도의 불확실성을 제거하고 구체화하여 예측가능하고 유연한 사업 환경을 마련할 필요가 있다.