Tuberculosis and Respiratory Diseases

The Korean Academy of Tuberculosis and Respiratory Diseases (대한결핵및호흡기학회)
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CT Radiologic Findings in Patients with Tuberculous Destroyed Lung and Correlation with Lung Function

결핵성 파괴폐의 흉부 전산화단층촬영 소견 및 폐기능과의 상관관계

  • Chae, Jin-Nyeong (Departments of Internal Medicine, Keimyung University School of Medicine) ;
  • Jung, Chi-Young (Departments of Internal Medicine, Keimyung University School of Medicine) ;
  • Shim, Sang-Woo (Departments of Internal Medicine, Keimyung University School of Medicine) ;
  • Rho, Byung-Hak (Departments of Radiology, Keimyung University School of Medicine) ;
  • Jeon, Young-June (Departments of Internal Medicine, Keimyung University School of Medicine)
  • 채진녕 (계명대학교 의과대학 내과학교실) ;
  • 정치영 (계명대학교 의과대학 내과학교실) ;
  • 심상우 (계명대학교 의과대학 내과학교실) ;
  • 노병학 (계명대학교 의과대학 영상의학교실) ;
  • 전영준 (계명대학교 의과대학 내과학교실)
  • Received : 2011.07.07
  • Accepted : 2011.08.12
  • Published : 2011.09.30
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Abstract

Background: A tuberculous destroyed lung is sequelae of pulmonary tuberculosis and causes various respiratory symptoms and pulmonary dysfunction. The patients with a tuberculous destroyed lung account for a significant portion of those with chronic lung disease in Korea. However, few reports can be found in the literature. We investigated the computed tomography (CT) findings in a tuberculous destroyed lung and the correlation with lung function. Methods: A retrospective analysis was carried out for 44 patients who were diagnosed with a tuberculous destroyed lung at the Keimyung University Dongsan Hospital between January 2004 and December 2009. Results: A chest CT scan showed various thoracic sequelae of tuberculosis. In lung parenchymal lesions, there were cicatrization atelectasis in 37 cases (84.1%) and emphysema in 13 cases. Bronchiectasis (n=39, 88.6%) was most commonly found in airway lesions. The mean number of destroyed bronchopulmonary segments was 7.7 (range, 4~14). The most common injured segment was the apicoposterior segment of the left upper lobe (n=36, 81.8%). In the pulmonary function test, obstructive ventilatory defects were observed in 31 cases (70.5%), followed by a mixed (n=7) and restrictive ventilatory defect (n=5). The number of destroyed bronchopulmonary segments showed a significant negative correlation with forced vital capacity (FVC), % predicted (r=-0.379, p=0.001) and forced expiratory volume in one second ($FEV_1$), % predicted (r=-0.349, p=0.020). After adjustment for age and smoking status (pack-years), the number of destroyed segments also showed a significant negative correlation with FVC, % predicted (B=-0.070, p=0.014) and $FEV_1$, % predicted (B=-0.050, p=0.022). Conclusion: Tuberculous destroyed lungs commonly showed obstructive ventilatory defects, possibly due to bronchiectasis and emphysema. There was negative correlation between the extent of destruction and lung function.

Keywords

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