• Journal of Nutrition and Health
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• v.43 no.5
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• pp.443-452
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• 2010

Elevated plasma concentration of total homocysteine (ptHcy) is known as an independent risk factor of cardiovascular disease (CVD) and oxidative stress is also commonly implicated in CVD. An association between ptHcy and oxidative stress has recently been suggested. The study objective is to examine the relationship between ptHcy and oxidative stress markers in 103 healthy college students (62 males and 41 females). Plasma levels of ptHcy, oxidative stress markers (conjugated diene, erythrocyte catalase, TRAP, lymphocyte DNA damage), antioxidant vitamins ($\alpha$-tocopherol, $\gamma$-tocopherol, carotenoids), and lipid parameters (total cholesterol, triglyceride, HDL cholesterol) were determined. The results show that the concentration of ptHcy was significantly higher in male subjects ($22.17\;{\pm}\;2.14\;{\mu}mole/L$) than in female subjects ($12.28\;{\pm}\;0.45\;{\mu}mole/L$). There was a negative association between ptHcy and plasma ${\beta}$-carotene in male subjects (p $lt; 0.05), but no correlation between ptHcy and other plasma antioxidant vitamin levels in either gender. However, there were the negative correlations between ptHcy and plasma ${\alpha}$-carotene or ${\beta}$-carotene, and a positive correlation between ptHcy and lymphocyte DNA damage. A significantly low level of ${\alpha}$-carotene or ${\beta}$-carotene was found in male subjects with elevated ptHcy (${\geq}\;15\;{\mu}mol/L$), as compared to those with lower plasma homocysteine. These study results confirmed the views on the association between plasma homocysteine and oxidative stress markers in humans and support the hypothesis that homocysteine promotes the oxidative environment by counteracting the antioxidant defense mechanism.

• Journal of Applied Biological Chemistry
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• v.63 no.4
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• pp.357-363
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• 2020

Oxidative stress caused by the overproduction of reactive oxygen species (ROS) is known as an etiology of neurodegenerative diseases. Populus tomentiglandulosa (PT), a member of the Salicaceae family, is widely grown in Korea and has been reported to exert protective effects on cerebral ischemia by attenuating of oxidative stress and neuronal damage. In the present study, we investigated the antioxidant activity and neuroprotective effects of an ethanol extract and four fractions [n-butanol, ethyl acetate (EtOAc), chloroform, and n-hexane] of PT under in vitro and cellular systems. The extract and four fractions of PT showed 1,1-diphenyl-2-picrylhydrazyl (DPPH), •OH, and O2- radical scavenging activities in a dose-dependent manner. In particular, the EtOAc fraction of PT had the strongest DPPH, •OH, and O2- radical scavenging activities among the extract and other fractions. Therefore, we further investigated the neuroprotective effect of the EtOAc fraction of PT against oxidative stress in H2O2-induced SH-SY5Y cells. Treatment with H2O2 significantly decreased cell viability and lactate dehydrogenase (LDH) release, and it also increased the ROS levels compared to the normal group. However, treatment with the EtOAc fraction of PT significantly increased cell viability. Moreover, the EtOAc fraction of PT-treated group significantly suppressed ROS production and LDH release compared to the H2O2-induced control group. In conclusion, our findings indicated that PT had in vitro antioxidant activity and neuroprotective effects against oxidative stress. Therefore, PT could be used as a natural agent for protection against oxidative stress.

• Journal of Magnetics
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• v.15 no.1
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• pp.12-16
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• 2010

Combined study of in-situ stress measurements and atomic force microscopy (AFM) revealed drastic stress relaxation in the CoCrPt and PS(styrene)-PVP(vinyl pyridine) polymer hybrid structure that was closely related to the growth structure of the film. We have observed not only no large initial growth stress at the initial stages of film growth but also twice smaller stress in magnitude with opposite sign in the CoCrPt/PS-PVP/Si sample. The microstructural studies using AFM at the various film growth stages revealed that the film growth structure plays an important role in the stress relaxation mechanism of CoCrPt films on a corrugated polymer surface.

• Journal of the Korean Institute of Telematics and Electronics A
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• v.32A no.6
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• pp.59-66
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• 1995

The hot electron induced effective channel length modulation (${\Delta}L_{H}$) and HEIP characteristics in PMOSFET's after bidirectional stress are presented. Trapped electron charges in gate oxide and lateral field are calculated from the gate current model, and ${\Delta}L_{H}$(${\Delta}L_{HD},\;{\Delta}L_{HS}$) is calculated using trapped electron charges and lateral field. It has been found that ${\Delta}I_{d}$and ${\Delta}L_{H}$ are more affected by the stress order (Forward-Reverse of Reverse or Reverse-Forward) than the stress direction, and they vary logarithmically with the stress time. In contrast, ${\Delta}V_{t}$ and ${\Delta}V_{pt}$ are more affected by the stress direction thatn the stress order. The correlation between ${\Delta}V_{pt}$ and the stress time can be explanined as the following polynomial functin: ${\Delta}V_{pt}$=AT$^{n}$. It has also been shown that PMOSFET degradation is related with the gate current and the effects of ${\Delta}V_{pt}$ is the most significant.

• Nutrition Research and Practice
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• v.16 no.2
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• pp.173-193
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• 2022

BACKGROUND/OBJECTIVES: Alzheimer's disease (AD) is one of the most representative neurodegenerative disease mainly caused by the excessive production of amyloid beta (Aβ). Several studies on the antioxidant activity and protective effects of Populus tomentiglandulosa (PT) against cerebral ischemia-induced neuronal damage have been reported. Based on this background, the present study investigated the protective effects of PT against cognitive impairment in AD. MATERIALS/METHODS: We orally administered PT (50 and 100 mg/kg/day) for 14 days in an Aβ_25-35-induced mouse model and conducted behavioral experiments to test cognitive ability. In addition, we evaluated the levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in serum and measured the production of lipid peroxide, nitric oxide (NO), and reactive oxygen species (ROS) in tissues. RESULTS: PT treatment improved the space perceptive ability in the T-maze test, object cognitive ability in the novel object recognition test, and spatial learning/long-term memory in the Morris water-maze test. Moreover, the levels of AST and ALT were not significantly different among the groups, indicating that PT did not show liver toxicity. Furthermore, administration of PT significantly inhibited the production of lipid peroxide, NO, and ROS in the brain, liver, and kidney, suggesting that PT protected against oxidative stress. CONCLUSIONS: Our study demonstrated that administration of PT improved Aβ_25-35-induced cognitive impairment by regulating oxidative stress. Therefore, we propose that PT could be used as a natural agent for AD improvement.

• Journal of Marine Life Science
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• v.7 no.2
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• pp.113-120
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• 2022

Despite concerns about the significant toxicity of copper pyrithione (CuPT) at environmental concentrations, effects of CuPT on benthic organisms have received little attention. Here, we analyzed the detrimental effects of CuPT at sublethal concentrations (1/50, 1/20, and 1/10 of the 96 h-LC50 value) for 14 days in the marine polychaete Perinereis aibuhitensis. Reduced burrowing activity and significantly decreased the acetylcholinesterase activity in response to relatively high concentrations of CuPT were identified as CuPT-triggered cholinergic inhibition. The lipid peroxidation marker, malondialdehyde levels were dose-dependently increased, whereas intracellular glutathione was depleted by relatively high concentrations. In the CuPT-treated polychaete, significant fluctuations in the enzymatic activities of the antioxidant defense system (catalase, superoxide dismutase, glutathione reductase, and glutathione peroxidase) were observed with significantly modulated glutathione 𝘚-transferase activity. These results indicate that even sublethal levels of CuPT would have detrimental effects on the health status of the marine polychaete.

• Journal of Korean Society for Atmospheric Environment
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• v.26 no.3
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• pp.253-264
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• 2010

This study investigates the relationship between daily mortality and heat stress in Seoul, using perceived temperatures (PT) derived from a heat budget model. During the summer season, observed PT intensity showed the biggest magnitude of summer heat stress from the middle 10 days of July to the first 10 days of August. The elderly (65 and above) were found to be the most vulnerable to heat stress. The threshold PT, with a significant increase in excess mortality, was $38^{\circ}C$. No time lagged effect was observed with summer heat stress, while a high correlation was observed between anomalies in PT and relative deviation of mortality. A comparison of the heat index and the discomfort index with excess mortality revealed that the discomfort index underestimated excess mortality, whereas the heat index could not appropriately explain the increase in excess mortality correlated with the increase in excess heat. In contrast, PT was found to be the weather element that best represents excess mortality due to heat stress, and is thus expected to serve as a more reliable forecast index of human biometeorology.

• Structural Engineering and Mechanics
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• v.65 no.2
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• pp.129-139
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• 2018

Post-tensioning (PT) tendons are commonly used for the assembly of modularized concrete members, and tension is applied to the tendons during construction to facilitate the integrated behavior of the members. However, the tension in a PT tendon decreases over time due to steel corrosion and concrete creep, and consequently, the stress on the anchor head that secures the PT tendon also diminishes. This study proposes an automatic detection system to identify tension reduction in a PT tendon using pulsed-eddy-current (PEC) measurement. An eddy-current sensor is installed on the surface of the steel anchor head. The sensor creates a pulsed excitation to the driving coil and measures the resulting PEC response using the pick-up coil. The basic premise is that the tension reduction of a PT tendon results in stress reduction on the anchor head surface and a change in the PEC intensity measured by the pick-up coil. Thus, PEC measurement is used to detect the reduction of the anchor head stress and consequently the reduction of the PT tendon force below a certain threshold value. The advantages of the proposed PEC-based tension-reduction-detection (PTRD) system are (1) a low-cost (< $ 30), low-power (< 2 Watts) sensor, (2) a short inspection time (< 10 seconds), (3) high reliability and (4) the potential for embedded sensing. A 3.3 m long full-scale monostrand PT tendon was used to evaluate the performance of the proposed PTRD system. The PT tendon was tensioned to 180 kN using a custom universal tensile machine, and the tension was decreased to 0 kN at 20 kN intervals. At each tension, the PEC responses were measured, and tension reduction was successfully detected.

• Atmosphere
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• v.18 no.2
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• pp.137-146
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• 2008

This study examines one thermal index, perceived temperature (PT), over the Korean Peninsula during 2007 summer. Heat/cold stress has been described using air temperature and humidity for warm seasons and air temperature and wind velocity in the cold conditions, while PT is based on a heat budget model of the human body that considers air temperature, humidity, wind velocity and radiation effect regardless of climates, regions and seasons. PT is higher about $4-5^{\circ}C$ than air temperature in the summer. Humidity increases PT, while wind tends to reduces PT possibly by evaporation of water vapor. The geographical distribution of summer PT indicates that the lowest PT happened in the east central region, with the appearance of the highest PT in the inland of southern region in Korea. Although the latitudinal trend shows that PT decreases northward, inland PT is higher than that of coastal region. Compared to the heat index or the discomfort index that considers air temperature and humidity, PT represents distinctive regional characteristics of thermal comfort. The distribution of PT shows that it may be a useful thermal index for the assessment of thermal comfort or stress region in the Korean Peninsula.

• Korean Journal of Materials Research
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• v.9 no.7
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• pp.735-739
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• 1999

In this study we investigated stress development and shrinkage of thickness for a single $PbTiO_3$(PT) layer prepared by sol-gel processing. Changes of microhardness for multideposited PT layers with temperatures are also monitored to understand the densification of thin films. Single PT layer shrank rapidly from room temperature to$ 220^{\circ}C$ yielding 83% of total shrinkage observed up to $500^{\circ}C$. A tensile stress of ~75MPa developed in an as-spun layer, and increased steadily beyond $130^{\circ}C$ until it reaches the maximum value of 147MPa at $250^{\circ}C$. The significant decrease of tensile stress in the film beyond $370^{\circ}C$ indicates that thermal expansion mismatch between the film and the substrate dominates the stress behavior in this temperature range. Microhardness of the multideposited coatings also increased rapidly above $300^{\circ}C$ regardless of the pyrolysis temperatures used. Large amount of perovskite phase formed in multideposited coatings after $550^{\circ}C$ may be due partly to enhanced homogeneous nucleation in the thicker coating.