• Journal of Information Processing Systems
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• 제13권6호
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• pp.1554-1574
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• 2017

This paper introduces a new type of determining factor for Pseudo Random Strings (PRS). This classification depends upon a mathematical property called Finite Induction (FI). FI is similar to a Markov Model in that it presents a model of the sequence under consideration and determines the generating rules for this sequence. If these rules obey certain criteria, then we call the sequence generating these rules FI a PRS. We also consider the relationship of these kinds of PRS's to Good/deBruijn graphs and Linear Feedback Shift Registers (LFSR). We show that binary sequences from these special graphs have the FI property. We also show how such FI PRS's can be generated without consideration of the Hamiltonian cycles of the Good/deBruijn graphs. The FI PRS's also have maximum Shannon entropy, while sequences from LFSR's do not, nor are such sequences FI random.

• Genomics & Informatics
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• 제19권4호
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• pp.36.1-36.11
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• 2021

Predicting individual traits and diseases from genetic variants is critical to fulfilling the promise of personalized medicine. The genetic variants from genome-wide association studies (GWAS), including variants well below GWAS significance, can be aggregated into highly significant predictions across a wide range of complex traits and diseases. The recent arrival of large-sample public biobanks enables highly accurate polygenic predictions based on genetic variants across the whole genome. Various statistical methodologies and diverse computational tools have been introduced and developed to computed the polygenic risk score (PRS) more accurately. However, many researchers utilize PRS tools without a thorough understanding of the underlying model and how to specify the parameters for the best performance. It is advantageous to study the statistical models implemented in computational tools for PRS estimation and the formulas of parameters to be specified. Here, we review a variety of recent statistical methodologies and computational tools for PRS computation.

• Imaging Science in Dentistry
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• 제49권4호
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• pp.323-329
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• 2019

Pierre Robin sequence (PRS) is characterized by the triad of micrognathia, glossoptosis, and airway obstruction. PRS does not have a single pathogenesis, but rather is associated with multiple syndromes. This report presents the case of a 35-year-old woman with PRS and scoliosis. Among the syndromes related to PRS, cerebro-costo-mandibular syndrome (CCMS), which is characterized by posterior rib gap defects and vertebral anomalies, was suspected in this patient. However, no posterior rib gap defect was detected on radiological examinations. Although over 80 cases of CCMS have been reported to date, few cases of PRS with scoliosis alone have been reported. Therefore, this report demonstrated the clinical, radiological, and cephalometric characteristics of an adult patient with PRS and scoliosis, but without rib anomalies.

• 정보관리학회지
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• 제39권4호
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• pp.159-189
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• 2022

본 연구는 인류의 자산이자 중요기록물인 세계기록유산의 홍보활동을 활성화하기 위한 초기 연구로, 국내 세계기록유산의 웹사이트를 통한 온라인 홍보현황을 파악하고 개선방안을 제안하였다. 세계기록유산의 홍보의 의미를 정의하고 문헌연구를 통해 현황 분석을 위한 기준을 도출하였다. 홍보활동 분석영역을 홍보내용, 홍보유형, 홍보매체으로 나누고 세부 홍보항목과 내용을 설정하였다. 도출된 분석기준을 바탕으로 국내 세계기록유산을 소장 관리하고 있으며 온라인홍보 활동을 수행하고 있는 11개 기관의 21개 웹사이트를 분석하였다. 분석 결과 내용을 바탕으로 첫째, 세계기록유산의 홍보내용에는 보존가치와 활용가치가 상호 강조되어야 하며 둘째, 이용자 세분화를 통한 홍보가 이루어져야 하며 셋째, 관련 기록유산을 통합하거나 연결하는 시스템 및 서비스 구축하여 기록유산에 대한 이용자의 접근성을 높여야 하며 끝으로, 세계기록유산 홍보 관련 지침 또는 매뉴얼을 마련해야 할 것을 개선방안으로 제언하였다.

• Clinical and Experimental Pediatrics
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• 제52권5호
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• pp.603-606
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• 2009

Pierre Robin sequence (PRS)는 소악증, 구개열, 설하수 및 고궁구개 등의 기형을 합병한 선천성 질환으로, 수유 장애 및 호흡 곤란 소견을 보이는 증후군이다. PRS과 관련된 염색체 핵형 분석 결과가 보고되면서, 유전학적 관련성이 제시되어 왔으나, 아직까지 명확히 규명되지 않은 상태이다. 이에 저자들은 PRS 환아에서 처음으로 핵형 46, XX, dup(8)(p21.3p23.1)를 보인 환아를 경험하고, 전염색체탐색자 분석을 통해 중복된 물질이 8번 염색체임을 확인하였으며, PRS와 8번 삼염색체성과의 관련성을 보고하는 바이다.

• Clinical and Experimental Reproductive Medicine
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• 제22권2호
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• pp.183-189
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• 1995

In human IVF-ET, the development and morphology of the embryo have been known to affect implantation and pregnancy rates(PRs). Recently, pregnancy has been reported to related to the embryos with thick zona-pellucida, high levels of fragmentation, poor blastomere development and zona hardening. Although the mechanism of implantation is unclear, it is thought that the hatching process precedes implantation and that the hatching is related to implantation and PRs. This study was carried out to investigate the effect of assisted hatching(AHA) on the improvement of PRs in human IVF-ET. The results were as follows; 1. The PRs of the AHA group (40.8%) was significantly higher than that of control group(27.2%)(P<0.01). 2. According to the age of patients, the PRs of control and AHA groups were 33.9%(20/59), 44,4%(12/27) in <30 yrs, 26.1%(30/115), 38.3%(18/47) in 31-35 yrs, 22.4%(13/58), 41.4%(12/29) in >36 yrs, respectively. 3. According to the factors of infertility in AHA group, unexplained(immunologic factor) (40.0%) and male factors(41.9%) were higher than female(tubal obstruction, endometriosis, adhesion) factor (28.9%). As a result, it is suggested that AHA technique improve the PRs in poor prognosis patients. It is concluded that AHA method can be used to improve the PRs in human lVF-ET.

• 대한조현병학회지
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• 제23권2호
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• pp.65-70
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• 2020

Objectives: This study aimed to explore whether common genetic variants that confer the risk of schizophrenia have similar effects between Korean and European ancestries using the polygenic risk score (PRS) analysis. Methods: Study subjects included 713 Korean patients with schizophrenia and 497 healthy controls. The Korea Biobank array was used for genotyping. Summary statistics of the most recent genome-wide association study (GWAS) of the European population were used as baseline data to calculate PRS. Logistic regression was conducted to determine the association between calculated PRS of European patients with schizophrenia and clinical diagnosis of schizophrenia in the Korean population. Results: Schizophrenia PRS was significantly higher in patients with schizophrenia than in healthy controls. The PRS at the p-value threshold of 0.5 best explained the variance of schizophrenia (R²=0.028, p=4.4×10^-6). The association was significant after adjusting for age and sex (odds ratio=1.34, 95% confidence interval=1.19-1.51, p=1.1×10^-6). The pattern of the association remained similar across different p-value thresholds (0.01-1). Conclusion: Schizophrenia PRS calculated using the European GWAS data showed a significant association with the clinical diagnosis of schizophrenia in the Korean population. Results suggest overlapping genetic risk variants between the two populations.

• Korean Journal of Radiology
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• 제21권7호
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• pp.829-837
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• 2020

Objective: The aim of this study was to investigate the prognostic value of the maximum standardized uptake value (SUV_max) measured while restaging with F-18 fluorodeoxyglucose (¹⁸F-FDG) positron emission tomography/computed tomography (PET/CT) to predict the 3-year post-recurrence survival (PRS) in patients with recurrent gastric cancer after curative surgical resection. Materials and Methods: In total, 47 patients with recurrent gastric cancer after curative resection who underwent restaging with ¹⁸F-FDG PET/CT were included. For the semiquantitative analysis, SUV_max was measured over the visually discernable ¹⁸F-FDG-avid recurrent lesions. Cox proportional-hazards regression models were used to predict the 3-year PRS. Differences in 3-year PRS were assessed with the Kaplan-Meier analysis. Results: Thirty-nine of the 47 patients (83%) expired within 3 years after recurrence in the median follow-up period of 30.3 months. In the multivariate analysis, SUV_max (p = 0.012), weight loss (p = 0.025), and neutrophil count (p = 0.006) were significant prognostic factors for 3-year PRS. The Kaplan-Meier curves demonstrated significantly poor 3-year PRS in patients with SUV_max > 5.1 than in those with SUV_max ≤ 5.1 (3-year PRS rate, 3.5% vs. 38.9%, p < 0.001). Conclusion: High SUV_max on restaging with ¹⁸F-FDG PET/CT is a poor prognostic factor for 3-year PRS. It may strengthen the role of ¹⁸F-FDG PET/CT in further stratifying the prognosis of recurrent gastric cancer.

• Journal of electromagnetic engineering and science
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• 제17권4호
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• pp.241-243
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• 2017

In this paper, we have presented an equation for estimating the gain of a Fabry-Perot cavity (FPC) antenna with a finite dimension. When an FPC antenna has an infinite dimension and its height is half of a wavelength, the maximum gain of that FPC antenna can be obtained theoretically. If the FPC antenna does not have a dimension sufficient for multiple reflections between a partially reflective surface (PRS) and the ground, its gain must be less than that of an FPC antenna that has an infinite dimension. In addition, the gain of an FPC antenna increases as the dimension of a PRS increases and becomes saturated from a specific dimension. The specific dimension where the gain starts to saturate also gets larger as the reflection magnitude of the PRS becomes closer to one. Thus, it would be convenient to have a gain equation when considering the dimension of an FPC antenna in order to estimate the exact gain of the FPC antenna with a specific dimension. A gain versus the dimension of the FPC antenna for various reflection magnitudes of PRS has been simulated, and the modified gain equation is produced through the curve fitting of the full-wave simulation results. The resulting empirical gain equation of an FPC antenna whose PRS dimension is larger than $1.5{\lambda}_0$ has been obtained.

• 한국통신학회:학술대회논문집
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• 한국통신학회 1984년도 추계학술발표회논문집
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• pp.70-73
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• 1984

By generalizing the concept of nonlinear switching filter, a transmission scheme for the PRS system is constructed. A hardware implementation of the transmission system is presented and its relations with the conventional system are measured. Our system provides the same speed as the traditional PRS system for a bandlimited channel, but has smaller ISI, Timing-jitter and maximum overshoot. Hence this technique improves speed-tolerance and power of the PRS system.