Korean Journal of Schizophrenia Research (대한조현병학회지)

Korean Society for Schizophrenia Research (대한조현병학회)
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Comparison of Polygenic Risk for Schizophrenia between European and Korean Populations

유럽인 자료로 산출된 조현병 다유전자 위험도 점수의 한국인 조현병 환자를 대상으로 한 적용

  • Lee, Jinyoung (Department of Psychiatry, Sungkyunkwan University School of Medicine, Samsung Medical Center) ;
  • Lee, Dongbin (Department of Psychiatry, Sungkyunkwan University School of Medicine, Samsung Medical Center) ;
  • Cho, Eun Young (Samsung Biomedical Research Institute, Center for Clinical Medicine) ;
  • Baek, Ji Hyun (Department of Psychiatry, Sungkyunkwan University School of Medicine, Samsung Medical Center) ;
  • Hong, Kyung Sue (Department of Psychiatry, Sungkyunkwan University School of Medicine, Samsung Medical Center)
  • 이진영 (성균관대학교 의과대학 삼성서울병원 정신건강의학교실) ;
  • 이동빈 (성균관대학교 의과대학 삼성서울병원 정신건강의학교실) ;
  • 조은영 (삼성생명과학연구소 임상의학연구센터) ;
  • 백지현 (성균관대학교 의과대학 삼성서울병원 정신건강의학교실) ;
  • 홍경수 (성균관대학교 의과대학 삼성서울병원 정신건강의학교실)
  • Received : 2020.07.13
  • Accepted : 2020.09.15
  • Published : 2020.10.30
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Abstract

Objectives: This study aimed to explore whether common genetic variants that confer the risk of schizophrenia have similar effects between Korean and European ancestries using the polygenic risk score (PRS) analysis. Methods: Study subjects included 713 Korean patients with schizophrenia and 497 healthy controls. The Korea Biobank array was used for genotyping. Summary statistics of the most recent genome-wide association study (GWAS) of the European population were used as baseline data to calculate PRS. Logistic regression was conducted to determine the association between calculated PRS of European patients with schizophrenia and clinical diagnosis of schizophrenia in the Korean population. Results: Schizophrenia PRS was significantly higher in patients with schizophrenia than in healthy controls. The PRS at the p-value threshold of 0.5 best explained the variance of schizophrenia (R2=0.028, p=4.4×10-6). The association was significant after adjusting for age and sex (odds ratio=1.34, 95% confidence interval=1.19-1.51, p=1.1×10-6). The pattern of the association remained similar across different p-value thresholds (0.01-1). Conclusion: Schizophrenia PRS calculated using the European GWAS data showed a significant association with the clinical diagnosis of schizophrenia in the Korean population. Results suggest overlapping genetic risk variants between the two populations.

Keywords

Acknowledgement

이 연구는 정부(과학기술정보통신부)의 재원으로 한국연구재단의 지원을 받아 수행되었음(No. 2019R1A2C1005346).

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