• Korean Journal of Animal Reproduction
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• v.25 no.2
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• pp.155-162
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• 2001

These experiments were conducted to evaluate the effects of the administration of exogenous PG $F_{2{\alpha}}$ on hormone concentrations and follicular development in early postpartum(pp) Korean native goats. 1. Plasma PG $F_{2{\alpha}}$ concentrations in PG $F_{2{\alpha}}$ treated goals showed a gradual increase from a low on day 2 (GR-1 : 10 day-treatment group: 6.35$\pm$0.5 and GR-2; 4 day-treatment group: 0.22$\pm$0.2 pg/$m\ell$, respectively) to reach a peak of 21.18$\pm$1.6 or 4.21 $\pm$0.4 pg/$m\ell$ on day 4 after treatment of PG $F_{2{\alpha}}$. 2. Plasma PG $F_{2{\alpha}}$ concentrations in GR-1 goats averaged 9.08 $\pm$1.2 pg/$m\ell$ compared with 5.44$\pm$ 1.8 pg/$m\ell$ in GR-2 goats the day before treatment of PG $F_{2{\alpha}}$. Mean PG $F_{2{\alpha}}$ concentrations thereafter remained low during the treatment period but PG $F_{2{\alpha}}$ concentrations did not differ between the two group. 3. Plasma concentrations of estradiol-17 $\beta$ (E,) in PG $F_{2{\alpha}}$ - treated group were decreased gradually until 2 days after PG $F_{2{\alpha}}$ treatment but mean $E_2$ concentrations began to increase on 3 days and were Inaximal on the 4 days after treatment. 4. Plasma lulenizing hormone (LH) concentrations in PG $F_{2{\alpha}}$ - treated goats were slightly higher than in controls but mean LH concentrations did not differ between the two treatment groups. 5. Plasma prolactin (PRL) concentrations were suppressed in both GR-1(10 day-treatment group) and GR-2(4 day-treatment group) goats compared to saline controls but mean PRL concentrations remained lower in PG $F_{2{\alpha}}$ treated animals during post-treatment period. 6. The mean number of small and medium follicles present when PG $F_{2{\alpha}}$ was administrated was similar in all does but the increase in number of large follicles($\geq$4mm) tended to be higher in PG $F_{2{\alpha}}$ treated group than controls. These results suggest that concentrations of PG $F_{2{\alpha}}$ and estradiol-17$\beta$ were positively correlared with follicular diameter. We conclude that PG $F_{2{\alpha}}$ treatment stimulates follicular development similarly in both GR-1 and GR-2 group.

• Journal of Nutrition and Health
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• v.35 no.2
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• pp.192-200
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• 2002

Conjugated linoleic acid (CLA) is a collective term for positional and geometric isomers of octadecadienoic acid in which the double bonds are conjugated. CLA has anticancer activity in a variety of animal cancer models, and cis-9, trans-11 (c9t11) and trans-10, cis-12(t10c12) CLA are the most predominant isomers present in the synthetic preparations utilized in these animal studies. To compare the ability of c9t11, t10c12 and an isomeric mixture of CLA to inhibit TSU-Prl cell growth, cells were incubated in a serum-free medium with various concentrations of these fatty acids. The isomeric mixture inhibited cell growth in a dose-dependent manner (1-3 $\mu$M) with a 41 $\pm$ 1% inhibition observed at 3 $\mu$M concentration after 48 hours. T10c12 also inhibited cell proliferation in a dote-dependent manner, However, the efficacy and potency of this isomer was much greater than that of the isomeric mixture with a 49 $\pm$ 2% inhibition observed at 0.3 $\mu$M concentration after 48 hours. By contrast, c9t11 slightly increased cell proliferation. To determine whether the growth-inhibiting effect of CLA is related to the changes in production of insulin-like growth factors (IGF) and IGF-binding proteins (IGFBP) by these cells, serum-free conditioned media were collected. Immunoblot analysis of conditioned media using a monoclonal anti-IGF-II antibody showed that both the isomeric mixture and t10c12 inhibited secretion of both mature 7,500 Mr and higher Mr forms of pro IGF-II, whereas c9t11 had no effect. Ligand blot analysis with 125I-IGF-II revealed the presence of two types of IGFBPs : 24,000 Mr IGFBP-4 and 30,000 Mr IGFBP-6. The production of IGFBP-4 slightly decreased at the highest concentrations of the isomeric mixture and t10c12. These results indicate that CLA inhibits human prostate cancer cell growth, an effect largely due to the action of t10c12. The growth inhibition may result, at least in part, from decreased production of IGF-II and IGFBP-4 by these cells.

• Journal of the Korean Society of Marine Environment & Safety
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• v.27 no.7
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• pp.954-966
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• 2021

With regards to the marine spatial plannings of the world, the spaces are being managed through the integration of various uses and the establishment of systems and laws in the perspective of the utilization of spaces. In the perspective of policy establishment, the policy readiness level is applied to analyze the trends in the studies on South Korea's marine spatial plans. The scope of the study included analyzing marine spatial plan as a keyword in articles published over the period from 2010 to 2020. The methods of analysis included the analyses of the frequency of word appearance, word clouds, and appearance intensity, which were used to identify key issues. Five keywords that were related to the topics were identified, and were again used to identify the key themes. The core themes were changing in all phases, such as the principles development phase, institutionalization phase, policy verification phase. For future benefit, this requires more research in South Korean public organizations and universities.

• The Korean Journal of Physiology and Pharmacology
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• v.3 no.2
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• pp.215-222
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• 1999

Nonylphenol (NP) is a widespread environmental pollutant that has been shown to exert both toxic and estrogenic effects on mammalian cells. As the effects of NP on the reproductive system of adult male vertebrates are virtually unknown, we investigated not only the changes of reproductive hormone secretion in serum after chronic exposure to NP but also, in order to identify the site of its action, the reproductive hormone secretion in serum 48 hours after microinfusion of NP within hypothalamic preoptic area (POA). In the chronic exposure, the luteinizing hormone (LH), follicle stimulating hormone (FSH), and testosterone in serum were decreased but prolactin (PRL) concentrations were increased. The LH, FSH, and testosterone in serum were decreased through the direct infusion of NP into POA, while there was no difference in mean serum prolactin between NP and control groups. These observations suggest that NP as endocrine disruptor has modulatory effects on hypothalamo-pituitary-gonadal axis and that the site of action of NP could be hypothalamic POA.

• Journal of Applied Biological Chemistry
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• v.50 no.4
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• pp.249-253
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• 2007

Thirteen edible plants previously reported to show inhibitory activities on farnesyl protein transferase (FPTase) and phosphatase of the regenerating liver-3 (PRL-3) were evaluated for inhibitory activity on the proliferation of human umbilical vein endothelial cells (HUVECs). Four plant extracts, Oenothera erythrosepala, Perilla frutescens, Panicum miliaceum, and Quercus acutissima, significantly inhibited the proliferation of HUVECs induced by the basic fibroblast growth factor (bFGF) without cytotoxicity at 100 ${\mu}g/mL$. Myristica fragrans, Rosmarinus officinalis, and Syringa patula also showed inhibitory activity on the proliferation with only mild cytotoxicity.

• Korean Journal of Animal Reproduction
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• v.17 no.3
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• pp.209-220
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• 1993

This study was attempted to investigate the processes of regression of the corpus luteum and uterus after parturition in 2∼3 multiparous Korean native goats. The concentrations of LH, prolactin and progesterone in blood plasma of native goats were measured at 5 day intervals from 10 days prepartum to 35 days postpartum. The pregnancy corpus luteum from goats at Days(D) 1, 10, 20 and 30 days of postpartum were examined by light microscopy. Changes in the uterus fo goats were studies by macroscopic and light microscopic observations during the postpartum period. Mean concentrations of plasma LH were low after parturition and the levels of plasma LH were similar during late gestation and throughout the postpartum period. Mean plasma concentrations of prolactin were 0.30 0.06 and 0.38 0.13ng/ml at Day 5 and Day 10 prepartum, respectively, but PRL levels remained slightly high for 5 weeks after kidding. Mean levels of progesterone in plasma were 0.33 0.05ng/ml on Day 1 postpartum(P<0.01). Through light microscopic survey, pregnancy corpora lutea were quite degeneration by day 10 pospartum. Microscopic changes of CL regression consisted of cytoplasmic eosinophilia and vacuolation, and pyknosis and karyorrhexis of the nucleus of luteal cells. Vascular changes were distended at the periphery ofthe CL. From macroscopic measurements of the uterus, the uteri were returned to their initial non-pregnant stage within a period of 21 dyas after parturition. Following partuition the intercaruncular epithelium was reparied by 20 days. The uterine epithelium was partially recovered in the carucle by 30 days postpartum.

• The Journal of Korean Obstetrics and Gynecology
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• v.21 no.4
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• pp.1-16
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• 2008

Purpose: The purpose of this study is to investigate the effect of Boheo-tang (B) and Boheo-tang plus cervi pantotrichum cornu (B+CP) on lactation in postpartum C57BL/6N mice. Methods: Normal saline(control), Band B+CP (8mu l/g$) were administerd p.o. twice a day for 20 days. Lactating mammary gland tissues were examined through light microscope by the way of HE staining and immunohistochemical assay. Milk producing associated gene expression were accessed by RT-PCR. Results: In mammary gland, amount of adipose tissues were decreased in both Band B+CP treated group. And the ductal branches and alveolar tissues increased in both treated group. Immunoreactivity of prolactin receptors was increased both treated group, and immunoreactivity of oxytocin receptors was increased in the B+CP treated group. In both treated group, IGF-l mRNA expression was increased and TGF-$\beta$ mRNA expression was decreased. And PRL mRNA expression was increased in the B+CP treated group. PL-l mRNA expression was decreased in the B treated group but increased in the B+CP treated group. Conclusion: This study shows that treatment of Boheo-tang and Boheo-tang plus cervi pantotrichum cornu can improve postpartum lactation in C57BL/6N mice.

• International Journal of Computer Science & Network Security
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• v.21 no.3
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• pp.212-218
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• 2021

Low-power and Lossy Networks (LLNs) have become the common network infrastructure for a wide scope of Internet of Things (IoT) applications. For efficient routing in LLNs, IETF provides a standard solution, namely the IPv6 Routing Protocol for LLNs (RPL). It enables effective interconnectivity with IP networks and flexibly can meet the different application requirements of IoT deployments. However, it still suffers from different open issues, particularly in large-scale setups. These include the node unreachability problem which leads to increasing routing losses at RPL sink nodes. It is a result of the event of memory overflow at LLNs devices due to their limited hardware capabilities. Although this can be alleviated by the establishment of multi-sink topologies, RPL still lacks the support for effective load balancing among multiple sinks. In this paper, we address the need for an efficient multi-sink load balancing solution to enhance the performance of PRL in large-scale scenarios and alleviate the node unreachability problem. We propose a new RPL objective function, Multi-Sink Load Balancing Objective Function (MSLBOF), and introduce the Memory Utilization metrics. MSLBOF enables each RPL node to perform optimal sink selection in a way that insure better memory utilization and effective load balancing. Evaluation results demonstrate the efficiency of MSLBOF in decreasing packet loss and enhancing network stability, compared to MRHOF in standard RPL.

• Journal of the Korean Society for Nondestructive Testing
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• v.27 no.5
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• pp.442-448
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• 2007

The ultrasonic inspection system for the expansion/transition area of steam generator tube was successfully developed. Variety of artificial flaw and real track specimen was tested using the UT system to verify the performance of the system. All artificial flaws of which through-wall depth larger than 10% was clearly detected by UT system. Measurement results of through-wall depth of flaws larger than 20% had good linearity and reproducibility with 3.27 of standard deviation. Results of real crack specimen test suggested that the detection limit of real crack strongly depends on the track morphology. A potential for measurement of PRL(percentage of remaining ligament) was recognized by the real crack specimen test.

• Asian-Australasian Journal of Animal Sciences
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• v.20 no.9
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• pp.1342-1348
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• 2007

POU1F1 is a positive regulator for GH, PRL and TSH${\beta}$ and its mutations associate with production traits in ruminant animals. We described a DdeI PCR-RFLP method for detecting a silent allele in the goat POU1F1 gene: TCT (241Ser)>TCG (241Ser). Frequencies of $D_1$ allele varied from 0.600 to 1.000 in Chinese 801 goats. Significant associations of DdeI polymorphism with production traits were found in milk yield (*p<0.05), litter size (*p<0.05) and one-year-old weight (*p<0.05) between different genotypes. Individuals with genotype $D_1D_1$ had a superior performances when compared to those with genotype $D_1D_2$ (*p<0.05). Hence, the POU1F1 gene was suggested to the potential candidate gene for superior milk performance, reproduction trait and weight trait. Genotype $D_1D_1$, characterized by a DdeI PCR-RFLP detection, was recommended to geneticists and breeders as a molecular marker for better performance in the goat industry.