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http://dx.doi.org/10.5713/ajas.2007.1342

DdeI Polymorphism in Coding Region of Goat POU1F1 Gene and Its Association with Production Traits  

Lan, X.Y. (College of Animal Science and Technology, Northwest A & F University, Shaanxi Key Laboratory of Molecular Biology for Agriculture)
Pan, C.Y. (College of Animal Science and Technology, Northwest A & F University, Shaanxi Key Laboratory of Molecular Biology for Agriculture)
Chen, H. (College of Animal Science and Technology, Northwest A & F University, Shaanxi Key Laboratory of Molecular Biology for Agriculture)
Lei, C.Z. (College of Animal Science and Technology, Northwest A & F University, Shaanxi Key Laboratory of Molecular Biology for Agriculture)
Hua, L.S. (College of Animal Science and Technology, Northwest A & F University, Shaanxi Key Laboratory of Molecular Biology for Agriculture)
Yang, X.B. (College of Animal Science and Technology, Northwest A & F University, Shaanxi Key Laboratory of Molecular Biology for Agriculture)
Qiu, G.Y. (College of Animal Science and Technology, Northwest A & F University, Shaanxi Key Laboratory of Molecular Biology for Agriculture)
Zhang, R.F. (College of Animal Science and Technology, Northwest A & F University, Shaanxi Key Laboratory of Molecular Biology for Agriculture)
Lun, Y.Z. (Medical College, Dalian University)
Publication Information
Asian-Australasian Journal of Animal Sciences / v.20, no.9, 2007 , pp. 1342-1348 More about this Journal
Abstract
POU1F1 is a positive regulator for GH, PRL and TSH${\beta}$ and its mutations associate with production traits in ruminant animals. We described a DdeI PCR-RFLP method for detecting a silent allele in the goat POU1F1 gene: TCT (241Ser)>TCG (241Ser). Frequencies of $D_1$ allele varied from 0.600 to 1.000 in Chinese 801 goats. Significant associations of DdeI polymorphism with production traits were found in milk yield (*p<0.05), litter size (*p<0.05) and one-year-old weight (*p<0.05) between different genotypes. Individuals with genotype $D_1D_1$ had a superior performances when compared to those with genotype $D_1D_2$ (*p<0.05). Hence, the POU1F1 gene was suggested to the potential candidate gene for superior milk performance, reproduction trait and weight trait. Genotype $D_1D_1$, characterized by a DdeI PCR-RFLP detection, was recommended to geneticists and breeders as a molecular marker for better performance in the goat industry.
Keywords
Goat; POU1F1 Gene; Polymorphism; Association;
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1 Li, J. T., A. H. Wang, P. Chen, H. B. Li, C. S. Zhang and L. X. Du. 2006. Relationship between the Polymorphisms of 5'Regulation Region of Prolactin Gene and Milk Traits in Chinese Holstein Dairy Cows. Asian-Aust. J. Anim. Sci. 19(4):459-462   DOI
2 Dubeuf, J. P., P. Morand-Fehr, Rubino and R. Situation. 2004. changes and future of goat industry around the world. Small Rumin. Res. 51:165-173   DOI   ScienceOn
3 Yu, T. P., C. K. Tuggle, C. B. Schmitz and M. F. Rothschild. 1995. Association of PIT1 polymorphisms with growth and carcass traits in pigs. J. Anim. Sci. 73:1282-1288   DOI
4 Woollard, J., C. K. Tuggle and. F. A. Ponce de Leon. 2000. Rapid communication: Localization of POU1F1 to bovine, ovine, and caprine 1q21-22. J. Anim. Sci. 78:242-243   DOI
5 Zhao, Q., M. E. Davis and H. C. Hines. 2004. Associations of polymorphisms in the Pit-1 gene with growth and carcass traits in Angus beef cattle. J. Anim. Sci. 82(8):2229-2233   DOI
6 Zhou, L., Y. Y. Yang, Z. H. Li, L. J. Kong, G. D. Xing, H. S. Di and G. L. Wang. 2006. Detection and Characterization of PCRSSCP Markers of the Bovine Lactoferrin Gene for Clinical Mastitis. Asian-Aust. J. Anim. Sci. 19(10):1399-1403   DOI
7 Esley, M., J. Heizer, Douglas W. Raiford, Michael L. Raymer, Travis E. Doom, Robert V. Miller and Dan E. Krane. 2006. Amino Acid Cost and Codon-Usage Biases in 6 Prokaryotic Genomes: A Whole-Genome Analysis. Mole. Biol. Evol. 2399:1670-1680
8 Zhou, G. L., Q. Zhu, H. G. Jin and S. L. Guo. 2006. Genetic Variation of Growth Hormone Gene and Its Relationship with Milk Production Traits in China Holstein Cows. Asian-Aust. J. Anim. Sci. 19(3):315-318   과학기술학회마을   DOI
9 Renaville, R., N. Gengler, I. Parmentier, F. Mortiaux, S. Massart, C. Bertozzi, A. Burny and D. Portetelle. 1997b. Pit-1 gene HinfI RFLP and growth traits in double-muscled Belgian Blue Cattle. J. Anim. Sci. 75 (Suppl. 1):146 (Abstr.)
10 Boyazoglu, J., I. Hatziminaoglou and P. Morand-Fehr. 2005. The role of the goat in society: Past, present and perspectives for the future. Small Rumin. Res. 60:13-23   DOI   ScienceOn
11 Stancekov, K., D. Vasicek, D. Peskovicov, J. Bull and A. Kubek. 1999. Effect of genetic variability of the porcine pituitaryspecific transcription factor (PIT-1) on carcass traits in pigs. Anim. Genet. 30:313-315   DOI   ScienceOn
12 Li, S., III E. B. Crenshaw, E. J. Rawson, D. M. Simmons, L. W. Swanson and M. G. Rosenfeld. 1990. Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene Pit-1. Nature, 347:528-533   DOI   ScienceOn
13 Renaville, R., N. Gengler, E. Vrench, A. Prandi, S. Massart, C. Corradini, C. Bertozzi, F. Mortiaux, A. Burny and D. Portetelle. 1997a. Pit-1 gene polymorphism, milk yield, and conformation traits for Italian Holstein-Friesian bulls. J. Dairy Sci. 80:3431-3438   DOI   ScienceOn
14 Pfaffle, R. W., G. E. DiMattia, J. Parks, M. Brown, J. M. Wit, M. Jansen, N. H. Van der, J. L. Van den Brande, M. G. Rosenfel, H. A. Ingraham. 1992. Mutation of the POU-specific domain of Pit-1 and hypopituitarismwithout pituitary hypoplasia. Sci. 257:1118-1121   DOI   ScienceOn
15 Sambrook, J. and D. W. Russell. 2001. Molecular Cloning: A Laboratory Manual, vol. 3, third ed. Cold Spring Harbor Laboratory Press, New York
16 Reynau, R., A. Saveanu, A. Barlier, A. Enjalbert and T. Brue. 2004. Pituitary hormone deficiencies due to transcription factor gene alterations. Growth Hormone & IGF Research, 14(6):442-448   DOI   ScienceOn
17 Sun, H. S., L. L. Andersona, T. P. Yu, K. S. Kim, J. Klind and C. K. Tuggle. 2002. Neonatal Meishan pigs show POU1F1 genotype effects on plasma GH and PRL concentration. Anim. Rep. Sci. 69:223-237   DOI   ScienceOn
18 Coghlan, A. and K. H. Wolfe. 2000. Relationship of codon bias to mRNA concentration and protein length in Saccharomyces cerevisiae. Yeast, 16(12):1131-1145   DOI   ScienceOn
19 Archetti, M. 2004. Codon usage bias and mutation constraints reduce the level of error minimization of the genetic code. J. Mol. Evol. 59(2):258-266   DOI   ScienceOn
20 Bastos, E., I. Santos, I. H. Parentier, J. L. Castrillo, A. Cravador, M. Guedes-Pinto and R. Renaville. 2006. Ovis aries POU1F1 gene: cloning, characterization and polymorphism analysis. Genet. 126:303-314   DOI   ScienceOn
21 Kurland, C. G. 1991. Codon bias and gene expression FEBS Lett. 285(2):65-69
22 Lavner, Y. and D. Kotlar. 2005. Codon bias as a factor in regulating expression via translation rate in the human genome. Gene. 345:127-138   DOI   ScienceOn
23 Kim, J. Y., D. H. Yoon, B. L. Park, L. H. Kim, K. J. Na, J. G. Choi, C. Y. Cho, H. K. Lee, E. R. Chung, B. C. Sang, I. J. Cheong, S. J. Oh and H. D. Shin. 2005. Identification of Novel SNPs in Bovine Insulin-like Growth Factor Binding Protein-3 (IGFBP3) Gene. Asian-Aust. J. Anim. Sci. 18(1):3-7   과학기술학회마을   DOI
24 Jacobson, E. M., P. Li, A. Leon-del-Pio, M. G. Rosenfeld and A. K. Aggarwa. 1997. Structure of Pit-1 POU domain bound to DNA as dimer: unexpected arrangement and flexibility. Genes. Dev. 11:198-212   DOI   ScienceOn
25 Eyre-Walker, A. 1996. Synonymous codon bias is related to gene length in Escherichia coli: selection for translational accuracy? Mole. Biol. Evol. 13:864-872   DOI   ScienceOn
26 Liu, H., X. H. Wang, Y. F. Liu, X. B. Zhao, N. Li and C. X. Wu. 2006. Codon frequency influencing laying performance: Evidence from 3 SNP in chicken prolactin gene, 10(1):196-198 (Abstr.)