• Title/Summary/Keyword: PRC

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Development of Linearly Interpolated PRC Regenerating Algorithm to Improve Navigation Solution using Multi-DGPS Reference Stations

  • Oh, Kyung-Ryoon;Kim, Jong-Chul;Nam, Gi-Wook
    • 제어로봇시스템학회:학술대회논문집
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    • 2004.08a
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    • pp.1618-1622
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    • 2004
  • In this paper, the linearly interpolated PRC(Pseudo Range Correction) regenerating algorithm was applied to improve the DGPS(Differential Global Positioning System) positioning accuracy at user's spot by using the various PRC information obtained from multi-DGPS reference stations. The PRC information of each GPS satellite is not varying rapidly; it is possible to assume that the variation of PRC information of each GPS satellite is linear. So the linearly interpolated PRC regenerating algorithm can be applied to improve the DGPS positioning accuracy at user's spot by using the various PRC information obtained from multi-DGPS reference stations. To test the performance of the linearly interpolated PRC regenerating algorithm, maritime DGPS reference stations' PRC data was used in RTCM format. 11 maritime DGPS reference stations are in service providing DGPS information to public since 1999. Two set of 3 DGPS reference stations are selected to compare the performance of the linearly interpolated PRC regenerating algorithm. The DGPS positioning accuracy was dramatically improved about 40%. Linearly interpolated PRC regenerating algorithm adopted multi-channel DGPS receiver will be developed in near future.

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Analysis of PRC regeneration algorithm performance in dynamic environment by using Multi-DGPS Signal (다중 DGPS 신호를 이용한 동적 환경에서의 PRC 재생성 알고리즘 성능분석)

  • Song Bok-Sub;Oh Kyung-Ryoon;Kim Jeong-Ho
    • The KIPS Transactions:PartA
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    • v.13A no.4 s.101
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    • pp.335-342
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    • 2006
  • As PRC linear interpolation algorithm is applied after analysed and verified in this paper, the unknown location of a user can be identified by using PRC information of multi-DGPS reference station. The PRC information of each GPS satellite is not varying rapidly, which makes it possible to assume that PRC information of each GPS satellite varies linearly. So, the PRC regeneration algorithm with linear interpolation can be applied to improve the accuracy of finding a user's location by using the various PRC information obtained from multi-DGPS reference station. The desirable PRC is made by the linear combination with the known position of multi-DGPS reference station and PRC values of a satellite using signals from multi-DGPS reference station. The RTK-GPS result was used as the reference. To test the performance of the linearly interpolated PRC regeneration algorithm, multi-channel DGPS beacon receiver was built to get a user's position more exactly by using PRC data of maritime DGPS reference station in RTCM format. At the end of this paper, the result of the quantitative analysis of the developed navigation algorithm performance is presented.

The role of EZH1 and EZH2 in development and cancer

  • Soo Hyun, Lee;Yingying, Li;Hanbyeol, Kim;Seounghyun, Eum;Kyumin, Park;Chul-Hwan, Lee
    • BMB Reports
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    • v.55 no.12
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    • pp.595-601
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    • 2022
  • Polycomb Repressive Complex 2 (PRC2) exhibits key roles in mammalian development through its temporospatial repression of gene expression. EZH1 or EZH2 is the catalytic subunit of PRC2 that mediates the mono-, di- and tri-methylation of histone H3 lysine 27 (H3K27me1/2/3), H3K27me2/me3 being a hallmark of facultative heterochromatin. PRC2 is a chromatin-modifying enzyme that is recruited to a limited number of "nucleation sites", spreads H3K27 methylation and fosters chromatin compaction. EZH1 and EZH2 exhibit differences in their expression patterns, levels of histone methyltransferase activity (HMT) in the context of PRC2, and DNA/nucleosome binding activity. This suggests that their roles in heterochromatin formation are disparate. Dysregulation of PRC2 activity leads to aberrant gene expression and is implicated in cancer and developmental diseases. In this review, we discuss the distinct function of PRC2/EZH1 and PRC2/EZH2 in the early and late developmental stages. We then discuss the cancers associated with PRC2/EZH1 and PRC2/EZH2.

A Cancer-specific Promoter for Gene Therapy of Lung Cancer, Protein Regulator of Cytokinesis 1 (PRC1) (폐암의 유전자 치료법을 위한 암특이적인 PRC1 프로모터)

  • Cho, Young-Hwa;Yun, Hye-Jin;Kwon, Hee-Chung;Kim, Hee-Jong;Cho, Sung-Ha;Kang, Bong-Su;Kim, Yeun-Ju;Seol, Won-Gi;Park, Kee-Rang
    • Journal of Life Science
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    • v.18 no.10
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    • pp.1395-1399
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    • 2008
  • We have recently reported the PRC1 promoter as a promoter candidate to control expression of transcriptionally targeted genes for breast cancer gene therapy. We tested whether the PRC1 promoter could be also applied for the lung cancer gene therapy. In the transient transfection assay with naked plasmids containing the luciferase fused to the PRC1 promoter, the promoter showed little activity in the normal lung cell line, MRC5. However, in the lung cancer A549 cells, PRC1 showed approximately 30-fold activation which was similar to the survivin promoter, the gene whose promoter has been already reportedas a candidate for the gene therapy of lung cancer. In viral systems, the PRC1 promoter showed approximately 75% and 66% of transcriptional activity compared to the CMV promoter in the adeno-associated virus (AAV) and the adenovirus (AV) systems, respectively. However, the PRC1 promoter in either AAV or AV showed approximately 20% activity compared to the CMV promoter in the normal lung cells. In addition, human lung tumor xenograft mice showed that the PRC1 promoter activity was as strong as the CMV activity in vivo. Taken together, these results suggested that PRC1 might be a potential promoter candidate for transcriptionally targeted lung cancer gene therapy.

Predict DGPS Algorithm using Machine Learning (기계학습을 통한 예측 DGPS 항법 알고리즘)

  • Kim, HongPyo;Jang, JinHyeok;Koo, SangHoon;Ahn, Jongsun;Heo, Moon-Beom;Sung, Sangkyung;Lee, Young Jae
    • Journal of Advanced Navigation Technology
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    • v.22 no.6
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    • pp.602-609
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    • 2018
  • Differential GPS (DGPS) is known as a positioning method using pseudo range correction (PRC) which is communicating between a refence receiver and moving receivers. In real world, a moving receiver loses communication with the reference receiver, resulting in loss of PRC real-time communication. In this paper, we assume that the transmission of the pseudo range correction isinterrupted in the middle of real-time positioning situations, in which calibration information is received in the DGPS method. Under the disconnected communication, we propose 'predict DGPS' that real-time virtual PRC model which is modeled by a machine learning algorithm with previously acquired PRC data from a reference receiver. To verify predict DGPS method, we compared and analyzed positioning solutions acquired from real PRC and the virtual PRC. In addition, we show that positioning using the DGPS prediction method on a real road can provide an improved positioning solution assuming a scenario in which PRC communication was cut off.

PRC Maritime Operational Capability and the Task for the ROK Military (중국군의 해양작전능력과 한국군의 과제)

  • Kim, Min-Seok
    • Strategy21
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    • s.33
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    • pp.65-112
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    • 2014
  • Recent trends show that the PRC has stepped aside its "army-centered approach" and placed greater emphasis on its Navy and Air Force for a wider range of operations, thereby reducing its ground force and harnessing its economic power and military technology into naval development. A quantitative growth of the PLA Navy itself is no surprise as this is not a recent phenomenon. Now is the time to pay closer attention to the level of PRC naval force's performance and the extent of its warfighting capacity in the maritime domain. It is also worth asking what China can do with its widening naval power foundation. In short, it is time to delve into several possible scenarios I which the PRC poses a real threat. With this in mind, in Section Two the paper seeks to observe the construction progress of PRC's naval power and its future prospects up to the year 2020, and categorize time frame according to its major force improvement trends. By analyzing qualitative improvements made over time, such as the scale of investment and the number of ships compared to increase in displacement (tonnage), this paper attempts to identify salient features in the construction of naval power. Chapter Three sets out performance evaluation on each type of PRC naval ships as well as capabilities of the Navy, Air Force, the Second Artillery (i.e., strategic missile forces) and satellites that could support maritime warfare. Finall, the concluding chapter estimates the PRC's maritime warfighting capability as anticipated in respective conflict scenarios, and considers its impact on the Korean Peninsula and proposes the directions ROK should steer in response. First of all, since the 1980s the PRC navy has undergone transitions as the focus of its military strategic outlook shifted from ground warfare to maritime warfare, and within 30 years of its effort to construct naval power while greatly reducing the size of its ground forces, the PRC has succeeded in building its naval power next to the U.S.'s in the world in terms of number, with acquisition of an aircraft carrier, Chinese-version of the Aegis, submarines and so on. The PRC also enjoys great potentials to qualitatively develop its forces such as indigenous aircraft carriers, next-generation strategic submarines, next-generation destroyers and so forth, which is possible because the PRC has accumulated its independent production capabilities in the process of its 30-year-long efforts. Secondly, one could argue that ROK still has its chances of coping with the PRC in naval power since, despite its continuous efforts, many estimate that the PRC naval force is roughly ten or more years behind that of superpowers such as the U.S., on areas including radar detection capability, EW capability, C4I and data-link systems, doctrines on force employment as well as tactics, and such gap cannot be easily overcome. The most probable scenarios involving the PRC in sea areas surrounding the Korean Peninsula are: first, upon the outbreak of war in the peninsula, the PRC may pursue military intervention through sea, thereby undermining efforts of the ROK-U.S. combined operations; second, ROK-PRC or PRC-Japan conflicts over maritime jurisdiction or ownership over the Senkaku/Diaoyu islands could inflict damage to ROK territorial sovereignty or economic gains. The PRC would likely attempt to resolve the conflict employing blitzkrieg tactics before U.S. forces arrive on the scene, while at the same time delaying and denying access of the incoming U.S. forces. If this proves unattainable, the PRC could take a course of action adopting "long-term attrition warfare," thus weakening its enemy's sustainability. All in all, thiss paper makes three proposals on how the ROK should respond. First, modern warfare as well as the emergent future warfare demonstrates that the center stage of battle is no longer the domestic territory, but rather further away into the sea and space. In this respect, the ROKN should take advantage of the distinct feature of battle space on the peninsula, which is surrounded by the seas, and obtain capabilities to intercept more than 50 percent of the enemy's ballistic missiles, including those of North Korea. In tandem with this capacity, employment of a large scale of UAV/F Carrier for Kill Chain operations should enhance effectiveness. This is because conditions are more favorable to defend from sea, on matters concerning accuracy rates against enemy targets, minimized threat of friendly damage, and cost effectiveness. Second, to maintain readiness for a North Korean crisis where timely deployment of US forces is not possible, the ROKN ought to obtain capabilities to hold the enemy attack at bay while deterring PRC naval intervention. It is also argued that ROKN should strengthen its power so as to protect national interests in the seas surrounding the peninsula without support from the USN, should ROK-PRC or ROK-Japan conflict arise concerning maritime jurisprudence. Third, the ROK should fortify infrastructures for independent construction of naval power and expand its R&D efforts, and for this purpose, the ROK should make the most of the advantages stemming from the ROK-U.S. alliance inducing active support from the United States. The rationale behind this argument is that while it is strategically effective to rely on alliance or jump on the bandwagon, the ultimate goal is always to acquire an independent response capability as much as possible.

Polycomb-Mediated Gene Silencing in Arabidopsis thaliana

  • Kim, Dong-Hwan;Sung, Sibum
    • Molecules and Cells
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    • v.37 no.12
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    • pp.841-850
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    • 2014
  • Polycomb group (PcG) proteins are conserved chromatin regulators involved in the control of key developmental programs in eukaryotes. They collectively provide the transcriptional memory unique to each cell identity by maintaining transcriptional states of developmental genes. PcG proteins form multi-protein complexes, known as Polycomb repressive complex 1 (PRC1) and Polycomb repressive complex 2 (PRC2). PRC1 and PRC2 contribute to the stable gene silencing in part through catalyzing covalent histone modifications. Components of PRC1 and PRC2 are well conserved from plants to animals. PcG-mediated gene silencing has been extensively investigated in efforts to understand molecular mechanisms underlying developmental programs in eukaryotes. Here, we describe our current knowledge on PcG-mediated gene repression which dictates developmental programs by dynamic layers of regulatory activities, with an emphasis given to the model plant Arabidopsis thaliana.

The Effects of Puerariae Radix Catechins Administration on Liver Function in Carbon Tetrachloride-Treated Rats (사염화탄소를 투여한 흰쥐에 있어서의 간 기능에 미치는 칡 카테킨의 효과)

  • 이치호;한석현;김종배;민상기
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.24 no.5
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    • pp.713-719
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    • 1995
  • These studies were carried out to investigate the effects of Puerariae radix catechins(PRC) administration on the biochemical parameters of liver function in liver of carbon tetrachloride(CCl4)-treated rats. Thirty six healthy Sprague-Dawley rats weighing about 120g were used for this experiment and divided intot he following 3 groups : normal control group(NCON), $CCl_4$ control group(CCON), PRC treated group(PRC). Fifty percent $CCl_4$ in oil was administered(I.P.) by 2ml per kg body weight two times a week for 3 weeks. PRC treated groups were administered orally at the leaves of 1% per day in distilled water for 8 weeks. Lipid hydroperoxides were analyzed by using chemiluminescence-high performance liquid chromatography(CL-HPLC) method as a phosphatidylcholine hydroperoxide value(PCOOH) in liver tissues. $CCl_4$ treatment significantly(p<0.05) resulted in an increase in GPT & GOT activities and liver hydroperoxide values comparing with those of the untreated control, while administration of PRC to the $CCl_4-treated$ rats significantly(p<0.001) decreased GPT & GOT activities and liver hydroperoxide value. Their ultrastructual changes of hepatocellular organelles were shown to clarify the morphologic nature of protective effects of PRC on hepatocytic injuries. $CCl_4$ treatment observed to change the ultrastructual nature of outer membrane of hepatocytes. However, the hepatic changes on PRC treatment to $CCl_4$ group was not found. PRC administration may inhibit the formatiion of liver lipid hydroperoxides in vivo and were very effective in recovering the liver function in $CCl_4-treated$ rats.

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Development of Removal Techniques for PRC Outlier & Noise to Improve NDGPS Accuracy (국토해양부 NDGPS 정확도 향상을 위한 의사거리 보정치의 이상점 및 노이즈 제거기법 개발)

  • Kim, Koon-Tack;Kim, Hye-In;Park, Kwan-Dong
    • Journal of Korean Society for Geospatial Information Science
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    • v.19 no.2
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    • pp.63-73
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    • 2011
  • The Pseudorange Corrections (PRC), which are used in DGPS as calibration messages, can contain outliers, noise, and anomalies, and these abnormal events are unpredictable. When those irregular PRC are used, the positioning error gets higher. In this paper, we propose a strategy of detecting and correcting outliers, noise, and anomalies by modeling the changing pattern of PRC through polynomial curve fitting techniques. To validate our strategy, we compared positioning errors obtained without PRC calibation with those with PRC calibration. As a result, we found that our algorithm performs very well; the horizontal RMS error was 3.84 m before the correction and 1.49 m after the correction.