• Title/Summary/Keyword: PPA

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New Thiazolo[3,2-b][1,2,4]triazole Derivatives : Useful Compounds for the Preparation of 7-Substituted Cephalosporins

  • Nam, Ghil-Soo;Lee, Jae-Chul;Chi, Dae-Yoon;Kim, Joong-Hyup
    • Bulletin of the Korean Chemical Society
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    • v.11 no.5
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    • pp.383-386
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    • 1990
  • We have synthesized several bicyclic heteroaromatic compounds with bridgehead nitrogen from N-amine salts of heteroaromatic amines. 2-Amino and 2-unsubstituted thiazolo[3,2-b][l,2,4]triazole derivatives 2a-b were prepared by the cyclization reaction from N-amine salts of aminothiazole-5-yl(N-methoxyimino)acetate with cyanogen bromide and formamidine acetic acid salt, respectively. 2-Methylthiazolo[3,2-b][1,2,4]triazole 2c was obtained from N-acetylated N-amine salt of aminothiazole-5-yl(N-methoxyimino)acetate by the cyclization reaction in the presence of polyphosphoric acid (PPA). 2-Substituted and 2-unsubstituted thiazole[3,2-b][1,2,4]triazole derivatives 2a-c were coupled with 7-aminocephalosporanic acid (7-ACA). Coupled cephalosporin derivatives 1a-c did not have good antibacterial activities in vitro.

Synthesis and COX-2 Inhibitory Activities of Rutaecarpine Homologues

  • Jung, He-Jin;Kim, Seung-Il;Chang, Hyeun-Wook;Jahng, Yurng-Dong
    • Proceedings of the PSK Conference
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    • 2003.04a
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    • pp.250.2-250.2
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    • 2003
  • A series of rutaecarpine homologues were prepared from 2,3-polymethylene-4(3H-quinazolinones in 4 steps [i) PhCHO/Ac$_2$O, ⅱ) O,$_3$ ⅲ) PhNHNH$_2$HCl, and ⅳ) PPA], in which dihedral angles of the two planar aromatic rings (indole and 4(3H)-quinazolinone) were controlled in a regular fashion. Their inhibitory activities on COX-1 and COX-2 were evaluated to show that the inhibitory activities were increased with the increase of the length of methylene unit while selectivities on COX-2 decreased leading a loss in trimethylene bridged system.

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Smart and Secure Point of Sale Framework with Threat Modeling and Formal Verification

  • Mona faraj Nasser alwahabi;Shaik Shakeel Ahamad
    • International Journal of Computer Science & Network Security
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    • v.24 no.6
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    • pp.41-48
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    • 2024
  • Existing PoS (Point of Sale) based payment frameworks are vulnerable as the Payment Application's integrity in the smart phone and PoS are compromised, vulnerable to reverse engineering attacks. In addition to these existing PoS (Point of Sale) based payment frameworks do not perform point-to-point encryption and do not ensure communication security. We propose a Smart and Secure PoS (SSPoS) Framework which overcomes these attacks. Our proposed SSPoS framework ensures point-to-point encryption (P2PE), Application hardening and Application wrapping. SSPoS framework overcomes repackaging attacks. SSPoS framework has very less communication and computation cost. SSPoS framework also addresses Heartbleed vulnerability. SSPoS protocol is successfully verified using Burrows-Abadi-Needham (BAN) logic, so it ensures all the security properties. SSPoS is threat modeled and implemented successfully.

Comparison of National Park Visitors' Recreational Experiences in terms of Awareness about the Presence of Wildlife and Wildlife Species (Asiatic black bear and Water Deer) (야생동물의 존재에 대한 인지 및 야생동물의 종류(곰과 고라니)에 따른 국립공원 방문객의 휴양경험 비교)

  • Kim, Sang-Mi;Choi, Sol-Ah;Kim, Sang-Oh
    • Korean Journal of Environment and Ecology
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    • v.29 no.4
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    • pp.615-625
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    • 2015
  • This study examined the effects of wildlife or wildlife species on national park visitors' perception of place attributes and recreational experiences. Data were collected from 502 users of Seongsamjae Rest area and Nogodan Shelter area in Jirisan National Park and 173 college students during May-June 2014 using survey questionnaire. Some simulated photographs of water deer and Asiatic black bears were used for the college student survey. Overall, awareness about wildlife inhabiting in Jirisan National Park (AW) was not related with one's perception of place attributes (PPA) (i.e., crowdedness, naturalness, safety) and types of visitors' recreational experiences. Respondents with higher awareness about the presence of Asiatic black bear (AABB), however, tended to perceive Jirisan National Park as a place that provides 'wild' or 'natural' recreational opportunities compared to those with lower AABB. Differences in PPA (i.e., crowdedness, naturalness, safety) and types of recreational experiences were also found to be influenced by wildlife species. Respondents exposed to bear or water deer tended to perceive their recreational experiences as more 'wild'. Existence of wildlife in Jirisan National Park had a positive effect on the quality of visitors' recreational experiences. Different wildlife species showed different levels of effectiveness to quality enhancement of recreational experience. Some practical implications of the study were discussed from a managerial point of view.

Development of COVID-19 Neutralizing Antibody (NAb) Detection Kits Using the S1 RBD Protein of SARS-CoV-2 (코로나 바이러스 감염증-19의 재조합 S1 RBD 단백질을 이용한 COVID-19 바이러스의 중화항체 검사 키트의 개발)

  • Choi, Dong Ok;Lee, Kang Moon
    • Korean Journal of Clinical Laboratory Science
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    • v.53 no.3
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    • pp.257-265
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    • 2021
  • The COVID-19 virus is a β-genus virus that causes infection by mediating the angiotensin convertible enzyme 2 (ACE2) receptor, which is distributed in large numbers in the human respiratory tract. The disease requires effective post-management of antibody production by complete healers and vaccinators because there is no perfect remedy for the virus infection. This study aimed to develop recombinant proteins specifically responsive to neutralizing antibodies in clinical specimens and use them to develop a rapid diagnostic kit to diagnose neutralizing antibodies quickly and conveniently against the COVID-19 virus and confirm the possibility of commercialization through a performance evaluation. Rapid diagnostic kits using COVID-19 S1 RBD recombinant proteins can be applied to rapid diagnostic kits, with positive percentage agreement (PPA) and negative percentage agreement (NPA) of 100% and 98.3%, respectively, compared to the U.S. FDA-approved ELISA kits. If the performance of the rapid diagnostic kit is improved and neutralizing antibodies can be analyzed quantitatively using quantitative analysis equipment, it can be used as important data to predict immunity to the COVID-19 virus and determine additional vaccinations.

A Study on the Improvement of Philippine Maritime Traffic Environment and Safety Management System (필리핀 해상 교통 환경과 안전 관리 시스템 개선에 관한 연구)

  • DIMAILIG, Orlando S.;KIM, Hong-Ryeol;RIM, Geung-Su
    • Journal of Fisheries and Marine Sciences Education
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    • v.29 no.1
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    • pp.31-39
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    • 2017
  • The paper presents the Philippine maritime condition, safety systems and navigational aids. It aims to uplift the maritime safety systems and infrastructures by studying the different strata of the industry, thereby emphasizing on the structures, weaknesses and opportunities. It presents the different maritime agencies involved and each responsibilities. Data from PPA demonstrate the statistics of increase in the cargo throughput, passenger, shipcalls and cargo-container handled in the year 2014. It also highlights the insufficiency of different navigational aids, VTMS, MBS and TSS placed in the whole archipelago. It gathers data of maritime accidents in 10-year period, 2006-2015, showing the most occurred accidents, casualties and areas these accidents happened. It includes the weather phenomena which contribute to the maritime movements and accidents incidence. The results show that systems and infrastructures that focus on the lack of improvement in technology and over-lapping functions of different agencies of government require development and upgrading.

The Modernization of Automatic Control facilities of Hydro Power Plant (수력발전소 자동제어설비의 현대화)

  • Kwon, O-Geuk;Kwon, Young-June;Song, Young-Cheol
    • Proceedings of the KIEE Conference
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    • 2008.07a
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    • pp.69-70
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    • 2008
  • Automatic control systems(AVR, Governor, Synchronizer) installed $1970{\sim}1980$ in K-water were considered to be rehabilitated around 2000. Moreover, Korea Power Exchange market system was changed from PPA (Power Purchase Agreement) to a bidding system. Therefore, depending on the power quality, the power provider could achieve additional profits. It is the excitation system and governor that have the functions of enhancing power necessities. During the 20 to 30 years of generator operation, there were many major and minor problems. Examples are SCR burnout (Andong: Excitation system), hunting (Imha: governor), field circuit breaker failure (Chungju 1st: excitation system), the rise of leakage current (Chungju 2nd: excitation system), power supply burnout (Chungju 2nd: governor). These are the typical examples of malfunction which hindered the generator operation and, consequently, diminished the profit of power business. In order to satisfy the needs of the power market and prevent malfunctions mentioned above, the rehabilitation of AVRs and governors were executed. A new system was made to have the flexibility of ancillary service (GF, AGC, etc.), PSS function. With user friendly HMI software, it is more convenient for the operator to fulfill suitable maintenance. It was possible to connect SCADA system by opening protocol of AVR, governor for the efficiency of operation and maintenance.

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Preparation and Effects of Acidic Cleaning Agents; for Aluminum (알루미늄용 산성세정제의 제조 및 세정효과)

  • Shim, Il-Woo;Jo, Hye-Jin;You, Hyuk-Jae;Wu, Jong-Pyo;Kim, Myung-Soo;Hahm, Hyun-Sik;Park, Hong-Soo;Baik, Woon-Phil
    • Journal of the Korean Applied Science and Technology
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    • v.21 no.4
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    • pp.306-312
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    • 2004
  • An acid cleaning agent (AACA) for aluminum was prepared by blending of sorbitol, n-octanoic acid, MJU-100A, Tetronix T-701, PPA-23, C8-83 and phosphoric acid. With the prepared AACA, degreasing, foam height, etching and derusting tests were carried out. As a result, AACA-4 and AACA-7 showed better cleaning ability than commercial acid cleaning agents.

Therapeutic Effect of Pipemidic Acid on OMPC (만성중이염에 대한 Pipemidic Acid의 치료효과)

  • 장인원;이종원;정종진;조용범;국태진;이정헌;염시경;김종욱;조재식
    • Proceedings of the KOR-BRONCHOESO Conference
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    • 1981.05a
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    • pp.39.2-39
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    • 1981
  • Recently, there has been many problems in the treatment of OMPC, because of inadequate and abuse of antibiotics, and resistant strain of pathogenic organisms to antibiotics. Authors studied on the culture and sensitivity of otorrhea obtained from 50 patients with OMPC, and evaluated the therapeutic effect of PPA, which is a new derivative of piromidic acid and active against gram (-) bacteria including pseudomonas aeruginosa as well as some gram (+) bacteria. We observed good therapeutic effect on OMPC with pseudomonas and other gram (-) bacteria, and considerable effect on OMPC with gram (+) bacteria.

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Numerical and Experimental Study to Improve Thermal Sensitivity and Flow Control Accuracy of Electronic Thermostat in the Engine for Hybrid Vehicle (하이브리드 자동차용 엔진 내부의 전자식 수온조절기의 감온성 및 유량제어 정확도 향상을 위한 수치 및 실험적 연구)

  • Jeong, Soo-Jin;Jeong, Jinwoo;Ha, Seungchan
    • Journal of ILASS-Korea
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    • v.26 no.3
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    • pp.135-141
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    • 2021
  • High-efficient HEV Engine cooling systems reflects variable coolant temperature because it can decrease the hydrodynamic frictional losses of lubricated engine parts in light duty conditions. In order to safely raise the operating temperature of passenger cars to a constant higher level, and thus optimize combustion and all accompanying factors, a new thermostat technology was developed : the electronically map-controlled thermostat. In this work, various crystalline plastics such as polyphthalamide (PPA) and polyphenylenesulfide (PPS) mixed with various glass fiber amounts were introduced into plastic fittings of automotive electronic controlled thermostat for the purpose of suppressing influx of coolant into the element and undesirable opening during hot soaking. Skirt was installed around element frame of automotive electronic controlled thermostat for improving thermal sensitivity in terms of response time, hysteresis and melting temperature. To validate the effectiveness and optimum shape of skirt, thermal sensitivity test and three-dimensional CFD simulation have been performed. As a consequence, important improvement in thermal sensitivity with less than 3℃ of maximum coolant temperature between opening and engine inlet was obtained.