• Molecules and Cells
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• 제40권1호
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• pp.66-72
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• 2017

Pathological hypertrophy of the heart is closely associated with endoplasmic reticulum stress (ERS), leading to maladaptations such as myocardial fibrosis, induction of apoptosis, and cardiac dysfunctions. Salubrinal is a known selective inhibitor of protein phosphatase 1 (PP1) complex involving dephosphorylation of phospho-eukaryotic translation initiation factor 2 subunit $(p-eIF2)-{\alpha}$, the key signaling process in the ERS pathway. In this study, the effects of salubrinal were examined on cardiac hypertrophy using the mouse model of transverse aortic constriction (TAC) and cell model of neonatal rat ventricular myocytes (NRVMs). Treatment of TAC-induced mice with salubrinal ($0.5mg{\cdot}kg^{-1}{\cdot}day^{-1}$) alleviated cardiac hypertrophy and tissue fibrosis. Salubrinal also alleviated hypertrophic growth in endothelin 1 (ET1)-treated NRVMs. Therefore, the present results suggest that salubrinal may be a potentially efficacious drug for treating pathological cardiac remodeling.

• 한국IT서비스학회지
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• 제16권1호
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• pp.73-82
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• 2017

Recently in-memory data stream processing has been actively applied to various subjects such as query processing, OLAP, data mining, i.e., frequent item sets, association rules, clustering. However, finding regular periodic patterns of events in an infinite data stream gets less attention. Most researches about finding periods use autocorrelation functions to find certain changes in periodic patterns, not period itself. And they usually find periodic patterns in time-series databases, not in data streams. Literally a period means the length or era of time that some phenomenon recur in a certain time interval. However in real applications a data set indeed evolves with tiny differences as time elapses. This kind of a period is called as a pseudo-period. This paper proposes a new scheme called FPMH (Finding Periods using Multiple Hash functions) algorithm to find such a set of pseudo-periods over a data stream based on multiple hash functions. According to the type of pseudo period, this paper categorizes FPMH into three, FPMH-E, FPMH-PC, FPMH-PP. To maximize the performance of the algorithm in the data stream environment and to keep most recent periodic patterns in memory, we applied decay mechanism to FPMH algorithms. FPMH algorithm minimizes the usage of memory as well as processing time with acceptable accuracy.

• Advances in materials Research
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• 제12권2호
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• pp.119-131
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• 2023

The development of sustainable composites materials, from recycled polymeric materials and waste from the wood industry and stone processing, allows reducing the volume of these by-products, minimizing impacts on health and the environment. Nowadays, Polypropylene (PP) is the most recycled polymer in industry, while the furniture industry has increasingly used timber felled from sustainable forest plantations as a eucalypt. The powder tailing from the ornamental stone extraction and processing industry is commonly disposed of in the environment without previous treatment. Thus, the technological option for the development of composite materials presents itself as a sustainable alternative for processing and manufacturing industries, enabling the development of new materials with special technical features. The results showed that powder granite particles may be incorporated into the polypropylene matrix associated with short eucalyptus fibres forming green hybrid composites with potential application in structural engineering, such as transport and civil construction industries.

• 대한수학회보
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• 제30권2호
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• pp.179-185
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• 1993

In this article S is a topologically complete subspace of $R^{1}$i.e., the relativized topology on S may be metrized so as to make S complete. B(S) is the Borel .sigma.-field of S. For .GAMMA. one takes a set of measurable monotone (increasing or dereasing) functions on S into itself. Make the assumption of pp. There exists $x_{0}$ and a positive integer $n_{0}$ such that (Fig.) It is then shown that there exists a unique inveriant probability to which $p^{(n)}$ (x,dy) converges exponentially fast in a metric (stronger than the Kolmogorov distance); this convergence is uniform for all x .mem. S. This generalizes an earlier result of Bhattacharya and Lee (1988) who considered monotone nondecreasing maps on S.

• 한국수학교육학회지시리즈D:수학교육연구
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• 제14권3호
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• pp.211-218
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• 2010

It is a truism that mathematics is about relations (cf. [Halford, G. S. (1999). The properties of representations used in higher cognitive processes: Developmental implications. In: Sigel, I. E. (Ed.), The Development of Mental Representation: Theories and Applications (pp. 147-168). Mahwah, New Jersey: Erlbaum]). In this article we are considering few problems related to the Viviani's and Routh's Theorems. All Problems are connected by the relation which exists between the distances of the point inside the triangle to it sides. We show how reasoning about the relations could lead the student's problem solving process and give easy to understand solutions of the problems. Among the problems being considered are the proof of the Converse to Viviani's Theorem, the formulas for areas of all figures formed by the sides of triangle and its cevians.

• 대한수학회보
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• 제26권2호
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• pp.109-114
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• 1989

This paper deals with the classifying spaces of finite groups. To any finite group G we associate a space BG with the property that .pi.$_{1}$(BG)=G, .pi.$_{i}$ (BG)=0 for i>1. BG is called the classifying space of G. Consider the problem of finding a stable splitting BG= $X_{1}$$^{V}$ $X_{1}$$^{V}$..$^{V}$ $X_{n}$ localized at pp. Ideally the $X_{i}$ 's are indecomposable, thus displaying the homotopy type of BG in the simplest terms. Such a decomposition naturally splits $H^{*}$(BG). The main purpose of this paper is to give the classification theorem in stable homotopy theory for groups with periodic cohomology i.e. cyclic Sylow p-subgroups for p an odd prime and to calculate some universal stable element. In this paper, all cohomology groups are with Z/p-coefficients and p is an odd prime.prime.

• 대한수학회보
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• 제25권2호
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• pp.175-178
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• 1988

Let .SIGMA. be a smooth compact manifold without boundary having the same homotopy type as a sphere, which is called a homotopy sphere. Supose a group G acts smoothly on .SIGMA. with the fixed point set .SIGMA.$^{G}$ consists of two isolated fixed points p and q. In this case, tangent spaces $T_{p}$ .SIGMA. and $T_{q}$ .SIGMA. at isolated fixed points, as isotropy representations of G are called Smith equivalent. Moreover .SIGMA. is called a supporting homotopy sphere of Smith equivalent representations $T_{p}$ .SIGMA. and $T_{q}$ .SIGMA.. The study on Smith equivalence has rich history, and for this we refer the reader to [P] or [Su]. The following question of pp.A.Smith [S] motivates the study on Smith equivalence.e.

• 대한수학회보
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• 제32권2호
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• pp.303-308
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• 1995

We consider a torus T, that is, a compact surface with genus 1 and $\Omega = D^2 \times S^1$ topologically with $\partial\Omega = T$, where $D^2$ is the open unit disk and $S^1$ is the unit circle. Let $\omega = (x,y)$ denote the generic point on T. For a smooth immersion $u : T \to R^3$, we define the Dirichlet functional by $$ E(u) = \frac{2}{1} \int_{T} $\mid$\nabla u$\mid$^2 d\omega $$ and the volume functional by $$ V(u) = \frac{3}{1} \int_{T} u \cdot u_x \Lambda u_y d\omege $$.

• 대한수학회보
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• 제20권1호
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• pp.31-36
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• 1983

Let R be a commutative ring with 1, and A a unitary commutative R-algebra. By a derivation module of A, we mean a pair (M, d), where M is an A-module and d: A.rarw.M and R-derivation, i.e., d is an R-linear mapping such that d(ab)=a)db)+b(da). A derivation module homomorphism f:(M,d).rarw.(N, .delta.) is an A-homomorphism f:M.rarw.N such that f.d=.delta.. A derivation module of A, (U, d), there exists a unique derivation module homomorphism f:(U, d).rarw.(M,.delta.). In fact, a universal derivation module of A exists in the category of derivation modules of A, and is unique up to unique derivation module isomorphisms [2, pp. 101]. When (U,d) is a universal derivation module of R-algebra A, the A-module U is denoted by U(A/R). For out convenience, U(A/R) will also be called a universal derivation module of A, and d the R-derivation corresponding to U(A/R).

• 지능정보연구
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• 제3권1호
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• pp.69-81
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• 1997

In this paper, first we propose an architecture of fuzzy neural networks with triangular fuzzy weights. The proposed fuzzy neural network can handle fuzzy input vectors. In both cases, outputs from the fuzzy network are fuzzy vectors. The input-output relation of each unit of the fuzzy neural network is defined by the extention principle of Zadeh. Also we define a cost function for the level sets(i. e., $\alpha$-cuts)of fuzzy outputs and fuzzy targets. Then we derive a learning algorithm from the cost function for adjusting three parameters of each triangular fuzzy weight. Finally, we illustrate our a, pp.oach by computer simulation examples.