• 제목/요약/키워드: POEMS syndrome

검색결과 7건 처리시간 0.02초

POEMS syndrome에서의 $^{18}F-FDG$ PET/CT 소견 ([ $^{18}F-FDG$ ] PET/CT in POEMS Syndrome)

  • 안영실;윤준기;홍선표;조철우;윤석남
    • Nuclear Medicine and Molecular Imaging
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    • 제41권1호
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    • pp.66-67
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    • 2007
  • POEMS syndrome is a rare disorder, also known as Crow-Fukase, PEP or Takatsuki syndrome. The acronym, POEMS, represents polyneuropathy, organomegaly, endocrinopathy, M protein and skin change. However, there are associated features not included in the acronym such as sclerotic bone lesions, Castleman disease, papilledema, thromobocytosis, peripheral edema, ascites, effusion, polycythemia, fatigue and clubbing. In most cases, osseous lesions in POEMS syndrome present as an isolated sclerotic deposit and that reveal as osteosclerotic myeloma. Several cases of $^{18}F-FDG$ PET in multiple myeloma involvements were reported, but there was no previous literature that reported FDG PET findings in POEMS syndrome. We describe here a 66-year-old patient with POEMS syndrome who underwent $^{18}F-FDG$ PET/CT image.

POEMS 증후군의 임상적, 전기생리학적 특성 (Clinical and Electrophysiological Features of the Patients with POEMS Syndrome)

  • 민주홍;홍윤호;이광우
    • Annals of Clinical Neurophysiology
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    • 제6권1호
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    • pp.14-19
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    • 2004
  • Backgrounds and objectives: POEMS (polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes) syndrome is the rare cause of polyneuropathy. Although the polyneuropathy is essential for the diagnosis of the disease, the pattern of electrodiagnostic abnormalities has not been characterized in detail. The purpose of this study was to elucidate the features of nerve conduction abnormalities in POEMS syndrome. Methods: We reviewed the medical records and nerve conduction studies (NCS) of 12 consecutive patients with POEMS. Results: A total of 68 motor and 46 sensory nerves were examined. Compound muscle action potentials (CMAPs) and sensory nerve action potentials were abnormally attenuated or not elicited in majority of motor and sensory nerves (80.88% in motor, and 82.6% in sensory nerves). Frequency of the nerves with no potential was significantly higher in lower limbs than in upper limbs (p<0.01 in both motor and sensory nerves), and CMAP amplitude was more reduced in lower limbs than in upper limbs (p<0.01). Conduction slowing was very frequently observed with 95% and 76% of motor and sensory nerves, respectively, having the abnormally reduced values of conduction velocity. Distal motor latencies were abnormally prolonged in 75% of motor nerves, and terminal latency indices were significantly higher in patients than in normal controls (p < 0.05). Conduction block was observed only in 5% of motor nerves. Conclusions: NCS in POEMS syndrome showed characteristic patterns, in which conduction abnormalities were more frequently and severely affected in the lower limbs, and more predominantly in the intermediate nerve segments than in the distal portions. The recognition of these characteristic patterns may be helpful in early diagnosis of polyneuropathy in POEMS syndrome.

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갑상선암 환자에서 골전이로 오인된 POEMS 증후군 (POEMS syndrome misdiagnosed as bone metastasis in a patient with thyroid cancer)

  • 백상아;류헌모;배성화;조윤영;김성규;김가영;김민근
    • Journal of Yeungnam Medical Science
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    • 제32권2호
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    • pp.122-126
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    • 2015
  • Polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome is a monoclonal plasma cell disorder. Patients with POEMS syndrome also have various clinical manifestations including generalized edema, pleural effusion, ascites, papilledema, and sclerotic bone lesions. These manifestations can lead to a misdiagnosis or delayed diagnosis. We recently experienced a 51-year-old male patient with POEMS syndrome whose sclerotic bone lesion was misdiagnosed as malignant bone metastasis of papillary thyroid carcinoma. We reassessed the patient and found polyneuropathy, hepatosplenomegaly, hypothyroidism, partial hypopituitarism, immunoglobulin G lambda-type monoclonal gammopathy, hypertrichosis, ascites, and multiple sclerotic bone lesions, all of which led us to a diagnosis of POEMS syndrome. Treatment with thalidomide and dexamethasone resulted in clinical and radiological improvement. The patient has remained in remission after peripheral blood stem cell transplantation.

POEMS 증후군 환자의 뇌혈관병증에 의한 뇌졸중 (Ischemic Stroke with Cerebral Vasculopathy in POEMS Syndrome)

  • 강성우;최보규;한희조;조수미;차지훈;남효석;허지회;김영대
    • 대한신경과학회지
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    • 제36권4호
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    • pp.350-353
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    • 2018
  • Ischemic stroke caused by the cerebral vasculopathy is a rare complication of polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome. We present a case of recurrent ischemic strokes caused by cerebral vasculopathy in a patient with POEMS syndrome. A 34-year-old man presented with gait disturbance and dizziness. Brain magnetic resonance imaging demonstrated acute ischemic stroke in the middle cerebral artery-anterior cerebral artery (MCA-ACA) border zones of bilateral hemispheres. Repeated angiographic studies showed progressive worsening of the left distal internal carotid artery, ACA, and MCA stenoses, along with sustained steno-occlusion of right MCA.

Immunoglobulin으로 호전된 POEMS 증후군의 다발성 신경병증 1예 (A Case of Polyneuropathy of the POEMS Syndrome Responsive to Intravenous Immunoglobulin)

  • 배상우;권준우;윤숙;장윤정;이창민;이근호;김재일
    • Annals of Clinical Neurophysiology
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    • 제5권2호
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    • pp.210-213
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    • 2003
  • POEMS syndrome is a multisystem disorder associated with polyneuropathy, organomegaly, endocrinopathy, a monoclonal protein(M-protein), and skin change. Recently we have had the opportunity to attend one patient with clinical features similar to this syndrome. He was a 46-year-old man who had a progressive polyneuropathy, swallowing difficulty, hepatosplenomegaly, hypothyroidism, IgA ${\lambda}type$ monoclonal gammapathy, specific skin change and ascites. His symptoms such as low extrimity pain and weakness, swallowing difficulty were improved by high-dose 7S-IgG. Thus, we report a case with a review of the literature.

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Paraproteinemic neuropathy

  • Pyun, So Young;Kim, Byung-Jo
    • Annals of Clinical Neurophysiology
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    • 제19권2호
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    • pp.79-92
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    • 2017
  • Paraproteinemia is caused by a proliferation of monoclonal plasma cells or B lymphocytes. Approximately 10% of idiopathic neuropathies are associated with paraproteinemia, where a certain paraprotein acts like an antibody targeted at constituents of myelin or axolemma in peripheral nerves. The relationship between paraproteinemia and peripheral neuropathy remains unclear despite this being of interest for a long time. Neurologists frequently find paraproteinemia during laboratory examinations of patients presenting with peripheral neuropathy, especially in the elderly. The possibility of a relationship with paraproteinemia should be considered in cases without an explainable cause. We review the causal association between paraproteinemia and neuropathy as well as clinical, laboratory, and electrophysiologic features, and the treatment options for paraproteinemic neuropathy.

새로운 매체문화시대의 글쓰기와 시조 (Writing and Sijo in new media culture age)

  • 정기철
    • 한국시조학회지:시조학논총
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    • 제22집
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    • pp.27-55
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    • 2005
  • 컴퓨터와 인터넷의 발달이 가져온 매체 변화는 시각매체 절대 우위의 문화를 형성하였다. 현대시. 시조 역시 '보는 시'로 급속하게 변화하면서 추상적 관념과 현학적 표현에 빠져 '그들만의 시'로 전락하고 말았다. 이러한 위기는 전통(Tradtion)을 무시하고 개인의 재능(Individual Talent)만능주의에 빠진 결과이다. 이제, 새로운 시조는 순수 자연과 인간의 몸이 전해주는 신화적$\cdot$역사적 목소리에 귀기울여야 한다. 즉, 생태학적 세계관으로의 과감한 전환과 우리말의 특성을 살린 표현 양식의 복원을 이루어야 한다. 민족의 일상적인 생활과 정신을 담아냈던 시조가 생태학적 세계관을 적극적으로 끌어안음으로써 컴퓨터매체 변화가 가져온 장점들, 즉 평등$\cdot$자유$\cdot$인권$\cdot$조화$\cdot$친환경의 가치를 극대화할 수 있다. 그리고 새로운 시조의 이 모든 변화는 시조의 전통적인 표현 형식 안에서 이루어지고 재창조되어야 한다. 시조의 미적 가치는 음성의 조화. 율격, 리듬 등 표현 형식에서 찾아야 할 것이다. 그래야만 분리와 단절을 기본 속성으로 하는 시각의 본성에서 빠져 나와 조화와 통합을 기본 속성으로 하는 청각의 본성으로 되돌아 올 수 있을 것이며, 적어도 시각과 청각, 문자문화와 음성문화가 균형을 이룰 수 있을 것이다. 그래야만 시각 매체 우위가 가져온 단절$\cdot$분리$\cdot$분열$\cdot$소외$\cdot$정신병적 증후군 등등의 현대사회의 병리 현상들을 극복할 수 있을 것이며, 동시에 현대시와 시조, 글쓰기의 병폐를 획기적으로 치료하여 진정한 행복과 발전을 이룰 수 있을 것이다.EX>$C_{27}$ brassinosteroids 생합성과정이 토마토의 활성형 brassinosteroid인 castasterone의 함량조절에 관여한다는 결과와 함께 토마토 이외의 식물들에 있어서도 $C_{27}$ brassinosteroids 생합성에 의한 활성형 $C_{28}$ brassino-steroid(s)의 함량조절에 일어나고 있음을 처음으로 밝힌 중요한 결과라 하겠다. 부세포가 잘 발달되어 있었다. 특히 PPF $99\;{\mu}mol\;m^{-2}s^{-1}$에서 환기횟수 $0.1 h^{-1}$는 부세포의 발달이 미흡하고 기공이 많이 열려 있는 상태인 반면 환기횟수 $4.9 h^{-1}$는 부세포가 잘 발달된 잎을 지니고 있었다.:PR30, KB50:PR50, PR100:KB0 처리구의 $1m^2$ 당 개체 수는 각각 16,600개, 6,700개, 4,900개, 3,300개, 12,400개였으며 총직립경 수는 각각 33,200개, 22,800개, 18,000개, 15,000개, 62,000개였다. 개체 수는 KB100:PR0처리구가 가장 높았고, 다음은 PR100:KB0처리구였으며 혼합처리구의 경우는 Kentucky bluegrass 혼합비 율이 높을수록 높았다. 총직립경 수는 PR100:KB0 처리구가 KB100:PR0 처리구보다 오히려 높았으며 혼합 처리구의 경우는 개체수와 비슷한 경향을 보였다. 혼합처리구의 경우 초종별 개체수의 비율은 KB80:PR20는 87:13, KB70:PR30는 78:22, KB50:PR50은 48:52의 비율로 나타났다. 조성시기의 기상과 피복율과의 상관관계 2001년 가을과 2002년 봄의 일일평균기온을 비교하여 보면 가을(9월,

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