• Title/Summary/Keyword: PM32

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Pharmacokinetic Modeling of Reversible Interconversion between Prednisolone and Prednisone (가역적상호대사과정 모델을 이용한 Prednisolone과 Prednisone의 약동학적 분석)

  • Shin, Jae-Gook;Yoon, Young-Ran;Cha, In-June;Jang, In-Jin;Lee, Kyung-Hoon;Shin, Sang-Goo
    • The Korean Journal of Pharmacology
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    • v.32 no.2
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    • pp.269-281
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    • 1996
  • Pharmacokinetics of prednisolone and prednisone undergoing reversible interconversion were analyzed from the model including this metabolic process. Blood samples were drawn serially upto 12 hours after I,V. bolus injection of 1 mg/kg prednisolone sodium phosphate and prednisone into 8 dogs as a crossover manner. Plasma concentrations of those two steroids were simultaneously measured with the method of HPLC. After injection, plasma concentrations of administered prednisolone and prednisone were declined with a biexponential pattern and their metabolic partner was rapidly formed. Plasma concentrations of those metaboite were decayed in parallel with their parent steroids throught the elimination phase. Apparent clearances of prednisolone and prednisone were $11.1{\pm}2.0\;ml/min/kg$ and $45.9{\pm}6.4\;ml/min/kg$, and they were underestimated by 29.4% and 33.6% compared to their real clearances$(15.7{\pm}4.4\;and\;69.2{\pm}17.7\;ml/min/kg)$ estimated using reversible interconversion model. Apparent volume of distribution of prednisolone$(1.32{\pm}0.43\;L/kg)$ and prednisone$(4.81{\pm}2.75\;L/kg)$ were overestimated by 53.5 and 52.7% and were compared to the real volumes $(0.86{\pm}0.30\;and\;3.15{\pm}2.13\;L/kg)$. Mean residence time of prednisolone$(2.0{\pm}0.61\;h)$ and prednisone$(1.74{\pm}0.74\;h)$ were much longer than the real sojourn time$(0.93{\pm}0.26\;and\;0.88{\pm}0.54\;h)$. Essential clearances In the reversible interconversion were greater as following orders: $Cl_{21}$(44.3 ml/min/kg) > $Cl_{20}$(24.2 ml/min/kg) > $Cl_{12}$ (7.9 ml/min/kg) > $Cl_{10}$(7.8 ml/min/kg). Estimated mean values of RF, EE, $%X^1_{ss}$ and $RHO^2_1$ were $0.31{\pm}0.10$, $1.49{\pm}0.23$, $69.3{\pm}16.7%$ and $0.65{\pm}0.10$, respectively. These results suggested that true pharmacokinetic parameters estimated from the model including reversible interconversion were significantly different from the apparent parameters estimated from the conventional mamillary model, and disposition of these two steroids seemed to be well explained by the model including reversible interconversion.

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A Study of Q$_P^{-1}$ and Q$_S^{-1}$ Based on Data of 9 Stations in the Crust of the Southeastern Korea Using Extended Coda Normalization Method (확장 Coda 규격화 방법에 의한 한국남동부 지각의 Q$_P^{-1}$, Q$_S^{-1}$연구)

  • Chung, Tae-Woong;Sato, Haruo;Lee, Kie-Hwa
    • Journal of the Korean earth science society
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    • v.22 no.6
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    • pp.500-511
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    • 2001
  • For the southeastern Korea aound the Yangsan fault we measured Q$_P^{-1}$ and Q$_S^{-1}$ simultaneously by using the extended coda-normalization method for seismograms registered at 9 stations deployed by KIGAM. We analyzed 707 seismograms of local earthquakes that occurred between December 1994 and February 2000. From seismograms, bandpass filtered traces were made by applying Butterworth filter with frequency-bands of 1${\sim}$2, 2${\sim}$4, 4${\sim}$8, 8${\sim}$16 and 16${\sim}$32 Hz. Estimated Q$_P^{-1}$ and Q$_S^{-1}$ values decrease from (7${\pm}$2)${\times}$10$^{-3}$ and (5${\pm}$4)${\times}$10$^{-4}$ at 1.5 Hz to (5${\pm}$4)${\times}$10$^{-3}$ and (5${\pm}$2)${\times}$10$^{-4}$ at 24 Hz, respectively. By fitting a power-law frequency dependent to estimated values over the whole stations, we obtained 0.009 (${\pm}$0.003)f$^{-1.05({\pm}0.14)$ for Q$_P^{-1}$ and 0.004 (${\pm}$0.001)f$^{-0.75({\pm}0.14)$) for Q$_S^{-1}$, where f is frequency in Hz.

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The Difference of Left Atrial Volume Index : Can It Predict the Occurrence of Atrial Fibrillation after Radiofrequency Ablation of Atrial Flutter?

  • Kim, Ung;Kim, Young-Jo;Kang, Sang-Wook;Song, In-Wook;Jo, Jung-Hwan;Lee, Sang-Hee;Hong, Geu-Ru;Park, Jong-Seon;Shin, Dong-Gu
    • Journal of Yeungnam Medical Science
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    • v.24 no.2
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    • pp.197-205
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    • 2007
  • Background : The occurrence of atrial fibrillation after ablation of atrial flutter is clinically important. We investigated variables predicting this evolution in ablated patients without a previous atrial fibrillation history. Materials and Methods : Thirty-six patients (Male=28) who were diagnosed as atrial flutter without previous atrial fibrillation history were enrolled in this study. Group 1 (n=11) was defined as those who developed atrial fibrillation after atrial flutter ablation during 1 year follow-up. Group 2 (n=25) was defined as those who has not occurred atrial fibrillation during same follow-up term. Echocardiogram was performed to all patients. We measured left atrial size, left ventricle end diastolic and systolic dimension, ejection fraction and left atrial volume index before and after ablation of atrial flutter. The differences of each variables were compared and analyzed between two groups. Results : The preablation left ventricular ejection fraction (preLVEF) and postablation left ventricular ejection fraction (postLVEF) are $54{\pm}14%$, $56{\pm}13%$ in group 1 and $47{\pm}16%$, $52{\pm}13%$ in group 2. The differences between each two groups are statistically insignificant ($2.2{\pm}1.5$ in group 1 vs $5.4{\pm}9.8$ in group 2, p=0.53). The preablation left atrial size (preLA) and postablation left atrial size (postLA) are $40{\pm}4mm$, $41{\pm}4mm$ in group1 and $44{\pm}8mm$, $41{\pm}4mm$ in group 2. The atrial sizes of both groups were increased but, the differences of left atrial size between two groups before and after flutter ablation were statistically insignificant ($0.6{\pm}0.9mm$ in group 1 vs $-3.8{\pm}7.4mm$ in group 2, p=0.149). The left atrial volume index before flutter ablation was significantly reduced in group 1 than group 2 ($32{\pm}10mm^3/m^2$, $35{\pm}10mm^3/m^2$ in group 1 and $32{\pm}10mm^3/m^2$, $29{\pm}8mm^3/m^2$ in group 2, p<0.05). Conclusion : The difference between left atrial volume index before and after atrial flutter ablation is the robust predictor of occurrence of atrial fibrillation after atrial flutter ablation without previous atrial fibrillation.

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The Study of Isokinetic Exercise Test of Trunk Rotation of 20's Male College Students (20대 남자대학생의 몸통회전에 대한 등속성운동 검사에 관한 연구)

  • Choi, Byung-Ok
    • The Journal of Korean Academy of Orthopedic Manual Physical Therapy
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    • v.12 no.2
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    • pp.21-25
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    • 2006
  • Objective: The purposes of this study are to provide fundamental data and a rehabilitation program in physical therapy. It has been operated by 30 male college students for lumbar isokinetic exercises. Method : Subjects have been carried out in an experiment by Biodex system operating isokinetic torso rotation. This performance was activated by left rotation after right rotation repeatedly. Results: 1. The mean peak torques at $60^{\circ}$/sec were $95.6{\pm}20.62$ (Rt) and $93.84{\pm}18.41$ (Lt). 2. The mean peak torques/body weight at $60^{\circ}$/sec were $69.28{\pm}28.31$ (Rt) and $67.07{\pm}27.04$ (Lt). 3. The total works in right side at $60^{\circ}$/sec and $180^{\circ}$/sec were $492.21{\pm}92.37$, $1294.97{\pm}278.96$ and in left side at $60^{\circ}$/sec and $180^{\circ}$/sec were $515.78{\pm}109.47$, $1443.74{\pm}329.67$. 4. The work to body weight ratio at $60^{\circ}$/sec was $78.30{\pm}32.37$ (Rt) and $79.93{\pm}37.30$ (Lt). 5. The average powers in right side at $60^{\circ}$/sec and $180^{\circ}$/sec were $76.75{\pm}16.69$, $117.19{\pm}29.94$ and in left side at $60^{\circ}$/sec and $180^{\circ}$/sec were $78.54{\pm}18.58$, $125.39{\pm}32.90$. 6. The work fatigue at $180^{\circ}$/sec was $21.76{\pm}14.82$ (Rt) and $19.66{\pm}26.23$ (Lt). Conclusion: In right side and left side, there was no significant difference in peak torque. peak torque/body weight, work to body-weight ratio, average power of trunk rotators at $60^{\circ}$/sec(p<0.05). However there was a significant difference in the total work of trunk rotators at $60^{\circ}$/sec(p>0.05). Also there was a significant difference in the average of trunk rotators at $180^{\circ}$/sec(p>0.05).

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The effect of Park Golf exercise on body composition and sleep of the elderly (파크골프운동이 노인의 신체구성 및 수면에 미치는 영향)

  • Choe, Myouung-Ja
    • The Journal of the Korea institute of electronic communication sciences
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    • v.7 no.6
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    • pp.1529-1536
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    • 2012
  • The purpose of this study is the investigation of park golf exercise impact on body composition and sleep. Measuring body composition was using multi-frequency impedance meter (Inbody720) for the Weight,% Body Fat, BMI, WHR. And there was using Oh,jinju(1998) as a measurement tool for sleep. Looking at changes in body composition, In the experimental groups, before the experiment body weight $60.56{\pm}6.25kg$, BMI $25.40{\pm}12.4kg/m^2$, %BodyFat $36.46{\pm}4.67%$, WHR $0.93{\pm}0.17$, after 12weeks, weight $58.3{\pm}7.16kg$, BMI $24.28{\pm}2.32kg/m^2$, %BodyFat $35.1{\pm}3.02%$, WHR $0.92{\pm}0.16$ as a significant decrease(p <.05) have appeared. After conducting an exercise program, experimental sleep score increased from 42.03 to 47.43 (increased 5.37) and control group increased from 42.48 to 43.4(increased 0.94). Between the two groups were statistically significant differences. In this study, performed 12weeks of the park golf exercise has a positive effect on body composition and sleep of the elderly.

The Quality Characteristics of Curcuma longa L powder Sulgitteok (강황분말 설기떡의 품질 특성)

  • Lee, Myung-Ho;Jeon, Soon-Ju;Kim, Sun-Kyung;Park, Hyang-Suk;Choi, Young-Sim
    • Culinary science and hospitality research
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    • v.17 no.5
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    • pp.184-192
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    • 2011
  • This study aims to provide preliminary data to popularize Sulgitteok with optimum mix proportion of Curcuma longa L. powder by conducting moisture content, color values, texture and quantitative descriptive evaluations on Sulgitteok with 0 to 2.4% of Curcuma longa L. powder. The chemical composition of Curcuma longa L. powder was $12.6{\pm}0.21%$ of moisture, $1.8{\pm}0.12%$ of protein, $1.0{\pm}0.00%$ of fat, $1.3{\pm}0.01%$ of ash, and that of rice flour was $11.7{\pm}0.17%$ of moisture, $7.6{\pm}0.32%$ of protein, $2.1{\pm}0.01%$ of fat, $1.6{\pm}0.01%$ of ash. As the content of Curcuma longa L. powder increased, L-values significantly decreased while a-value and b-value significantly increased. The hardness of the texture characteristics significantly increased with increasing the amount of Curcuma longa L. powder(p<0.05). As for gumminess, cohesiveness, and chewiness, there was no significant difference(p<0.05) depending on the amount of Curcuma longa L. powder. The quantitative descriptive analysis of the color, flavor, moistness and chewiness of Sulgitteok showed that one with 0.8% of Curcuma longa L. powder was evaluated the highest.

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Web Structure of the Wasp Spider, Argiope bruennichi, Depending on Micro-Habitat Characteristics (미소서식지 특성에 따른 긴호랑거미 (Argiope bruennichi)의 웹 구조 분석)

  • Kim, Kil-Won;Kim, Duk-Rae;Jin, Woo-Young
    • Journal of Wetlands Research
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    • v.12 no.1
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    • pp.41-49
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    • 2010
  • Web building of the spider is an investment behavior for prey foraging with genetic constraint. Individual's decision-making on the web construction depends on diverse environmental variables. This study investigated web structure of the wasp spider, Argiope bruennichi, to compare individual's behaviors in dry field and in wet field. We measured 35 web structures in dry field (Chunma-San, Incheon) showing relatively low humidity (46.4%) and luxuriant herbage, and 13 web structures in the wet rice field (73.9%; Taean-Gun, Chungnam). Comparing to the wet field the individuals in the dry field invested significantly more silk: $32.5{\pm}12.8$ number of silk spirals used in the dry field vs. $16.9{\pm}5.4$ in the wet field. The web area of the dry field was greater than that of the wet field: $976{\pm}643cm^2$ vs. $532{\pm}254cm^2$. The web height, distance between the ground and the center of the web, appeared higher in the dry field than in the wet field: $71.4{\pm}39.6cm$ vs. $49.6{\pm}31.2cm$. Also the web constructed in the dry field showed longer stabilimentum than the web of the wet field: $18.8{\pm}3.4cm$ vs. $3.9{\pm}3.2cm$. The perpendicular inclination and the inclination to East-West of the web showed no difference between the two fields. This study suggests that adult females of A. bruennichi could modulate its construction behavior depending on the micro-habitat factors.

한국 재래닭의 난형에 관한 연구

  • 상병돈;최철환;김학규;나재천;김상호;장병귀;서옥석;이상진
    • Proceedings of the Korea Society of Poultry Science Conference
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    • 2004.11a
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    • pp.99-100
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    • 2004
  • The observed means and standard divisions of the egg shape per generation in korean native chickens were as follow. The egg major axis, the egg miner axis and the egg shape index were 53.0$\pm$0.6~55.6$\pm$0.8 mm, 39.1$\pm$0.8~40.9$\pm$0.2 mm and 72.7$\pm$1.5~75.9$\pm$0.5 mm. The regression coefficients were -0.02~0.20 mm, 0.10~0.52 mm and 0.19~1.00 mm respectively.

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A Comparison of Clinical Evaluation for the Management of Primary Spontaneous Pneumothorax Using the Video-Assisted Thoracic Surgery and Mid-Axillary Thoracotomy (원발성 자연기흉의 폐기포절제술시 정중액와개흉술과 비디오흉강경수술의 임상적 비교)

  • 서성구
    • Journal of Chest Surgery
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    • v.28 no.5
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    • pp.471-474
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    • 1995
  • A total of 20 patients underwent bullectomy in the spontaneous pneumothorax between October 1993 and August 1994. The patients were divided into two groups: Control group; the patients who received with mid-axillary approach[n=10 , Experimental group; the patients who received with video-assisted thoracic surgery [n = 10 . The results were as follows; 1. The total sex distribution was male predominence [M :F=6:1 . Mean age of control group was 31.6$\pm$ 10.1 age and experimental group was 24.3$\pm$ 5.5 age. 2. The operative times were 117.0 $\pm$ 32.6min in control group and 102.5$\pm$ 38.4min in experimental group [not significant . 3. The indwelling period of postoperative chest tube and hospital stay were 4.5$\pm$ 2.6 days and 8.3 $\pm$ 1.8 days in control group, $1.5\pm$ 0.5 days and 3.1 $\pm$ 0.3 days in experimental group[p=0.0018, < 0.0001 . 4. In control group, injection times of pain-killer were 1.7$\pm$ 0.7 times/day at operative day and 0.4$\pm$ 0.6times/day at postoperative 1 day. In experimental group, there were 0.3$\pm$ 0.7times/day at operative day and 0.1 $\pm$ 0.3times/day at postoperative 1 day[p=O.O002 at operative day, not significant at postoperative 1 day .

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A study on job preference type, academic ability and academic performance of dental hygiene department student (일부 치위생과 학생의 직업선호도 유형 및 학업능력과 학업성취도에 관한 연구)

  • Lee, Jung-Hwa;Kim, Ji-Hwa
    • Journal of Korean society of Dental Hygiene
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    • v.10 no.1
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    • pp.173-183
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    • 2010
  • Objectives : The purpose of this study was to provide basic materials for defining educational direction of dental hygiene department and establishing the instruction to improve direction consulting and academic effect of dental hygiene department student. Methods : The researcher surveyed the relation among job aptitude, academic ability and academic performance by selecting 131 dental hygiene department students of P university as study targets. Results : For high school classifications, direction searches and academic abilities of dental hygiene department students of P university, it was found that classical high school was 68.7% and vocational high school was 31.3%. For job aptitude, social type was 58.0% and artistic type was 26.0% so they were usual. For academic ability, interpersonal relation($12.78{\pm}1.34$), music/rhythm was($12.32{\pm}1.09$) and natural($12.32{\pm}1.00$) showed high scores in order over the first, the second and the third field and language/vocabulary(22.6%) and music/rhythm(21.6%) was the next. For academic performance depending on high school classification, job aptitude and academic ability, there was a significant difference in high school classification by classical high school($86.55{\pm}8.21$) and vocational high school($85.34{\pm}11.31$)(p<0.05) and there was also a significant difference in job aptitude by social type($85.45{\pm}9.42$) and artistic type($88.41{\pm}6.93$)(p<0.05). In the mutual relation between academic ability and academic performance, the high academic ability score in the first field was led to the high score in the second and the third field, showing significant mutual relation(p<0.00). Conclusions : This research has been accomplished by college students of dental hygeine department, so you have to consider before generalizing these results. Therefore it is required to research more, likewise using a comparison with other students or it should be conducted by general people.