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Determining the Required Vitamin D Level for Bone Health Based on Bone Turnover Markers

  • Ismail, Tuan Salwani Tuan;Muda, Bayani Che;Rosdi, Roznie Aida Mohd;Zainuddin, Azalina;Isa, Salbiah;Mustapaha, Zulkarnain
    • Korean Journal of Clinical Laboratory Science
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    • v.49 no.4
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    • pp.337-344
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    • 2017
  • To date, no clear threshold that has been established for defining an adequate store of vitamin D for bone health. Therefore, this study aims to determine the required level of vitamin D to maintain a healthy skeleton based on bone remodelling process among healthy adult population. This was a cross sectional study, involving a healthy adult population in Kota Bharu, Malaysia, aged 18~50 years. We measured serum 25(OH)D (vitamin D), serum parathyroid hormone (PTH), serum C-terminal telopeptide of type 1 collagen (CTX), and Procollagen 1 Intact N-Terminal (P1NP) in 120 healthy adults selected via multi stage sampling (64 males, 56 females) from 6 subdistricts in Kota Bharu. The mean level of 25(OH)D was 23.50 (${\pm}8.74$) nmol/L. There was a significant difference of the vitamin D level between genders ($26.81{\pm}8.3nmol/L$ vs $19.72{\pm}7.68nmol/L$ in males and females respectively) (p value<0.001). More than 50% of female subjects had 25(OH)D less than 20 nmol/L, while only 20.3% of male subjects had 25(OH)D below 20 nmol/L. Based on the LOESS plot, the bone turnover markers showed a plateauing result, at the 25(OH)D level of 35 nmol/L for CTX and 20 nmol/L for P1NP. Contrastingly, PTH showed a step rise in the 25(OH)D level of 20 nmol/L. Based on the LOESS plot for CTX, P1NP and PTH versus 25(OH)D, level of vitamin D between 20 to 35 nmol/L is recommended to maintain healthy skeleton.

The investigation of a new fast timing system based on DRS4 waveform sampling system

  • Zhang, Xiuling;Du, Chengming;Chen, Jinda;Yang, Herun;kong, Jie;Yang, Haibo;Ma, Peng;Shi, Guozhu;Duan, limin;Hu, Zhengguo
    • Nuclear Engineering and Technology
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    • v.51 no.2
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    • pp.432-438
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    • 2019
  • In the study of nuclear structure, the fast timing technique can be used to measure the lifetime of excited states. In the paper, we have developed a new fast timing system, which is made up of two $LaBr_3:Ce$ detectors and a set of waveform sampling system. The sampling system based on domino ring sampler version 4 chip (DRS4) can digitize and store the waveform information of detector signal, with a smaller volume and higher timing accuracy, and the waveform data are performed by means of digital waveform analysis methods. The coincidence time resolution of the fast timing system for two annihilation 511 keV ${\gamma}$ photon is 200ps (FWHM), the energy resolution is 3.5%@511 keV, and the energy linear response in the large dynamic range is perfect. Meanwhile, to verify the fast timing performance of the system, the $^{152}Gd-2_1^+$ state form ${\beta}^+$ decay of $^{152}Eu$ source is measured. The measured lifetime is $45.3({\pm}5.0)ps$, very close to the value of the National Nuclear Data Center (NNDC: $46.2({\pm}3.9)ps$). The experimental results indicate that the fast timing system is capable of measuring the lifetime of dozens of ps. Therefore, the system can be widely used in the research of the fast timing technology.

The Effects of DTBNP on Intracellular $Ca^{2+}$ Signaling in Cultured Bovine Aortic Endothelial Cells

  • Park, Sung-Jin;Kim, Byung-Joo;Zhu, Mei-Hong;So, In-Suk;Kim, Ki-Whan
    • The Korean Journal of Physiology and Pharmacology
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    • v.9 no.6
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    • pp.341-346
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    • 2005
  • The mechanism underlying oxidant-induced intracellular $Ca^{2+}$ ($[Ca^{2+}]_i$) increase was studied in cultured bovine aortic endothelial cells (BAECs) using fura-2 AM. In the presence of 2 mM extracellular $Ca^{2+}$, the application of DTBNP ($20{\mu}M$), a membrane-permeable oxidant, caused an increase in $[Ca^{2+}]_i$, and DTT (2 mM) as a reductant completely reversed the effect of DTBNP. The $[Ca^{2+}]_i$ increase induced by DTBNP was also observed in an extracellular $Ca^{2+}$-free/2 mM EGTA solution, indicating the release of $Ca^{2+}$ from intracellular store(s). After endoplasmic reticulum was depleted by an $IP_3$-generating agonist, ATP ($30{\mu}M$) or an ER $Ca^{2+}$ pump inhibitor, thapsigargin ($1{\mu}M$), DTBNP-stressed BAECs showed an increase of $[Ca^{2+}]_i$ in $Ca^{2+}$-free/2 mM EGTA solution. Ratio-differences before and after the application of DTBNP after pretreatment with ATP or thapsigargin were $0.42{\pm}0.15$ and $0.49{\pm}0.07$, respectively (n=7), which are significantly reduced, compared to the control value of $0.72{\pm}0.07$ in a $Ca^{2+}$-free/2 mM EGTA solution. After the protonophore CCCP ($10{\mu}M$) challenge to release mitochondrial $Ca^{2+}$, the similar result was obtained. Ratio-difference before and after the application of DTBNP after pretreatment with CCCP was $0.46{\pm}0.09$ (n=7). Simultaneous application of thapsigargin and CCCP completely abolished the DTBNP-induced $[Ca^{2+}]_i$ increase. The above results together indicate that the increase of $[Ca^{2+}]_i$ by DTBNP resulted from the release of $Ca^{2+}$ from both endoplasmic reticulum and mitochondria.

Real Time Monitoring of Energy Efficiency Operation Indicator on Merchant Ships

  • Barro, Ronald Dela Cruz;Kim, Jun-Seong;Lee, Don-Chool
    • Journal of Advanced Marine Engineering and Technology
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    • v.35 no.3
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    • pp.301-308
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    • 2011
  • International Maritime Organization (IMO) proposed the Energy Efficiency Operation Indicator (EEOI) in 2005 and the Energy Efficiency Design Index (EEDI) in 2008 so as to address emission concern and regulation. Likewise, Ship Energy Efficiency Management Plan (SEEMP) and Greenhouse Gas (GHG) monitoring and management are also becoming an issue lately. This paper introduces the energy efficiency design index (operation indicator) monitoring system (EDiMS) software can continuously monitor $CO_2$, $NO_x$, $SO_x$, and PM values emitted from ship. The accurate inventory of ships GHG can be obtained from base of emission result during the engine shop test trial and the actual monitoring of shaft power and ship speed. In addition, the ability to store all exhaust emission and engine operation data can be applied as the useful tool of the inventory work of air pollution and ship energy management plan for the mitigation or reduction of ship emissions.

A study of Weaning Practice and Propositions about processed baby foods - Focused on the Seoul and Kyunggi area- (서울 및 경기일부 지역의 이유실시 현황과 이유식 개발에 대한 기대치 조사)

  • 전주혜;손경희;이영미
    • Korean journal of food and cookery science
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    • v.9 no.3
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    • pp.239-246
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    • 1993
  • A study was designed to assess the current status of weaning practice and to serve as a guideline of a processed baby foods through the an in-depth survey focused on the Seoul and Kyunggi area. 16.I% mothers surveyed were breast-fed and 54.6% were formula-fed. They mostly wanted to obtain information about processed bady foods and the adequate amount and weaning method of bady foods and showed deep interest in recipe of weaning foods. The average score of weaning knowledge which is counted by mothers'responses was IS.S and was significantly high in the high-educated group. The average Period when those surveved began weaning was $4.3\pm1.8$months and hight-educated mothers began weaning earlier than low-educated group. 77.O% mothers prepared weaning foods at home. The most popular recipe were gruel with meats and vegetables(52.6%) and they usually used mashed or grinded fruits(69.7%). 36.6% of the mothers surveyed used processed baby foods on sale once a day on the ground that such a small package is very convinient to carry. The processed baby foods which the mothers wanted to develope was the already-cooked type and to be able store at room temperature.

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Comparison of Preference for Convenience and Dietary Attitude in College Students by Sex in Seoul and Kyunggi-do Area (일부 남.녀 대학생들의 편의식에 대한 기호도와 식태도에 관한 비교)

  • Im, Yeong-Suk;Park, Hye-Ryeon;Han, Gwi-Jeong
    • Journal of the Korean Dietetic Association
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    • v.11 no.1
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    • pp.11-20
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    • 2005
  • This study was conducted to investigate preference for convenience food and dietary attitude in college students in Seoul and Kyunggi-do area. This study used a questionnaires as instrument tool. Thequestionnaire consisted of socio-demographic characteristics of the subjects, the valuation of preference for convenience, the concern of nutrition, and the dietary attitude. The subject were 199 males and 137 females. The mean age of subjects was 22.4$\pm$2.3year. The results have been summarized as follows Male students preferred more convenience food than females. Male students liked chicken, ice cream, ramyeon, pizza·hamburgerandfemalestudentslikedchicken,pizza, ice cream, ramyeon·hamburger. The kinds of convenience foods for a substitute meal were ramyeon, hamburger, bread, potato in male group and female group had frequently ramyeon, hamburger, bread, rice cake for a substitute meal. Male students were more likely to eat ramyeon (p<0.01) and purchased sabalmyeon The subjects used to purchase sabalmyeon as main convenience food at convenient store The score of preference for convenience food in male group was higher than female group. The score of attitude toward balanced diet in female group was higher than male group(p<0.01). In scores of concern for nutrition information, balanced diet, and nutrition knowledge, Female group had higher scores of concern for nutrition information, balanced diet, and nutrition knowledge than that of male group (p<0.01).There was no significant difference in the degree of preference for packing types, however, Male group tended to prefer more micro wave type than female group. The persons to affect the consumption of convenience food were friends. There was no significant difference in the time of purchase convenience food, however, Male tended to purchase convenience food at the time of snack than female group. As a results, proper nutritional education and qualitative development of convenience food are required in order to improve the consuming attitude of consumers and their preference for convenience food.

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A Study of Legibility by Monitor Letter Color with an Eye Tracker (아이트래커를 이용한 모니터 글자 색상에 따른 가독성에 대한 연구)

  • Kim, Ha-Rim;Kim, Soo-Hyun;Shin, Dong-Min;Jeong, Hee-Young;Kim, Young-Gil;Kim, Tae-Hong;Seo, Jae-Myoung;Jeong, Ju-Hyun
    • Journal of Korean Ophthalmic Optics Society
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    • v.19 no.2
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    • pp.279-284
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    • 2014
  • Purpose: This study will be a basic research providing data which can reduce eye strain using monitor and electric media by measuring legibility of text color on monitor. Methods: Total experimental subjects who don't have color anomaly and best corrected visual acuity was over 1.0 were 50 and their mean age was $22.83{\pm}1.47$. Reading speed test were carried out with 163 words and subjects who could read over 123 words were selected for legibility examination. Monitor background color was white and letter colors were black, blue, red, and yellow for the legibility examination. Results: In case of text color of black, blue, red, and yellow, Event duration(sec) was measured to 41.89, 42.89, 45.32, and 56.28, respevtively, and reading error (number) was measured to 1.94, 2.74, 3.36, and 5.14. Average of fixation duration(sec) was measured to 0.25, 0.26, 0.27, and 0.32. Conclusions: In this paper, event Duration, reading error and average of fixation duration which can measure the legibility was reduced in a sequence of black blue, red, and yellow.

PARTIAL REPLACEMENT OF GRASS SILAGE WITH WHOLE-CROP CEREAL SILAGE FOR GROWING BEEF CATTLE

  • Raza, S.H.;Rowlinson, P.
    • Asian-Australasian Journal of Animal Sciences
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    • v.8 no.3
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    • pp.281-287
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    • 1995
  • A study was conducted to investigate the effect of different inclusion levels of urea treated whole-crop wheat silage (UWCWS) in grass silage based rations on the performance of growing beef cattle. The winter wheat (variety, Riband) was harvested (in the summer of 1991) at a dry matter proportion of 520 g/kg and treated with feed grade urea at the rate of 37 kg/tonne crop dry matter and preserved in a heavy duty plastic bag using a silo press. The urea treated whole crop wheat silage (UWCWS) was mixed with grass silage to replace 0.00 (S100), 0.33 (S33) and 0.67 (S67) parts of the forage dry matter and fed ad libitum in a cross over design to 18 Simmental X Holstein Friesian growing beef animals. Two energy sources {one high in starch, rolled barley (RB) and one high in digestible fibre, sugar beet pulp (SBP)} were fed to supply sufficient energy for the efficient use of nitrogen by the rumen micro-organisms. The data on DMIF (dry matter intake of forage), TDMI (total dry matter intake), DLWG (daily live weight gain), FCR (feed conversion ratio) were recorded and faecal samples were collected to determine the digestibility coefficients. Results revealed that with the inclusion of UWCW in the animals' diets the DMI of the forage was significantly increased (p < 0.05). The highest DMIF was found in the treatment "S33" ($6.28{\pm}0.25kg$) where 67% of the silage dry matter was replaced with the UWCW and the lowest value for DMIF was observed in the control treatment ($5.03{\pm}0.23kg$). The DLWG did not differ significantly between the treatments. However, treatment "S100" showed a trend towards a superior DLWG. Feed conversion ratio in the control treatment differed significantly from "S67" and "S33". The addition of the UWCW in the animals' diet resulted in the lower FCR There was no effect of type of energy supplement on any aspect of performance either overall or in interaction with grass silage: UWCWS ratio. The regression and correlation coefficients for DMIF (r = 5.22 + 0.0184x*), DLWG (r = $1.04-0.00086x^{NS}$) and FCR (r = 4.78 = 0.022x*) on the inclusion of UWCW in the diet were calculated. The effect of the inclusion of UWCW on the overall digestibility coefficients was significant (p < 0.05). The addition of the UWCWS in the diet decreased the digestibility of the DM, OM, ADF and NFE but effect on the protein digestibility was non significant. The results of present study suggests that a DLWG slightly over 1 kg can be achieved with UWCW during the store period (period in which animal performance targets are low especially during winter) and the prediction of ME was overestimated as the high intake of DM did not reflect in improved animal performance.

Modified Atmosphere Packaging of Minimally Processed Cut Garlic (최소가공된 절단 마늘의 환경기체조절포장)

  • Kwon, Min-Ji;Shin, Yong-Jae;Lee, Dong-Sun;An, Duck-Soon
    • KOREAN JOURNAL OF PACKAGING SCIENCE & TECHNOLOGY
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    • v.17 no.1
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    • pp.13-17
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    • 2011
  • There is a need in food industry to store minimally processed garlic for long time to have it be used just at the time of demand for final product processing. Optimal modified atmosphere packaging is expected to slow down the quality change extending its storage life. In order to find optimal packaging conditions, plastic films of different gas permeability properties (low density polyethylene (LDPE) $30{\mu}m$, polyolefin $50{\mu}m$ (PD 900), polyolefin $20{\mu}m$ (PD 941)) were used for packaging 400 g of minimally processed garlic. Perforated LDPE packages were prepared as control. The packaged products were stored at $1{\pm}1^{\circ}C$ for 52 days. Package treatments were compared in weight loss, decay, surface color, hardness and soluble solid content. While control package had normal atmosphere of air, LDPE, PD 900 and PD 941 packages attained internal concentration of $O_2$ 4.6% / $CO_2$ 12%, $O_2$ 0.9% / $CO_2$ 21% and $O_2$ 0.5% / $CO_2$ 13% after 45 days, respectively. Control packaging had rapid weight loss with high mold decay and great surface color change in 45 days. In PD 900 film packages of lowest gas permeability, the fresh-cut garlic could be stored without mold decay for 52 days. Except control packaging, there were no significant differences in surface color, hardness and soluble solid content among package treatments.

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IoT Based Real-Time Indoor Air Quality Monitoring Platform for a Ventilation System (청정환기장치 최적제어를 위한 IoT 기반 실시간 공기질 모니터링 플랫폼 구현)

  • Uprety, Sudan Prasad;Kim, Yoosin
    • Journal of Internet Computing and Services
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    • v.21 no.6
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    • pp.95-104
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    • 2020
  • In this paper, we propose the real time indoor air quality monitoring and controlling platform on cloud using IoT sensor data such as PM10, PM2.5, CO2, VOCs, temperature, and humidity which has direct or indirect impact to indoor air quality. The system is connected to air ventilator to manage and optimize the indoor air quality. The proposed system has three main parts; First, IoT data collection service to measure, and collect indoor air quality in real time from IoT sensor network, Second, Big data processing pipeline to process and store the collected data on cloud platform and Finally, Big data analysis and visualization service to give real time insight of indoor air quality on mobile and web application. For the implication of the proposed system, IoT sensor kits are installed on three different public day care center where the indoor pollution can cause serious impact to the health and education of growing kids. Analyzed results are visualized on mobile and web application. The impact of ventilation system to indoor air quality is tested statistically and the result shows the proper optimization of indoor air quality.