• International Journal of Computer Science & Network Security
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• 제22권7호
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• pp.383-388
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• 2022

Many methods used for secret data steganography are based on least significant bit method, which is suffering from security and the embedded message can be easily hacked. In this paper research a proposed method of adding security issues will be introduced, a complex private key will be constructed, the contents of this key will depend on the results of secrete message segmentation. The proposed method will be implemented and the obtained experimental results will be compared with least significant method results to prove that the proposed method raises the image quality parameters.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2011년도 추계학술대회 논문집
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• pp.171-177
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• 2011

In this paper, a square simply supported panel flutter have been considered at high supersonic flow by using coupled fluid-structure (FSI) analysis that based on time domain method. The Reynolds-Average Navier Stokes (RANS) equation with Spalart-Allmaras turbulent model were applied for unsteady flow problems of panel flutter. A fully implicit time marching schemed based on the Newmark direct integration method is used for calculating the coupled aeroelastic governing equations of it. In addition, the SOL 145 solver of MSC.NASTRAN was used to investigate flutter velocity based on PK-method of Piston theory. Our numerical results indicated that there is a good agreement result between Piston Theory in MSC.NASTRAN and coupled fluid-structure analysis.

• International Journal of Computer Science & Network Security
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• 제21권12spc호
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• pp.648-656
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• 2021

Color digital images are used in many multimedia applications and in many vital applications. Some of these applications require excellent protection for these images because they are confidential or may contain confidential data. In this paper, a new method of data cryptography is introduced, tested, and implemented. It will be shown how this method will increase the security level and the throughput of the data cryptography process. The proposed method will use a secret image_key to generate necessary private keys for each byte of the data block. The proposed method will be compared with other standard methods of data cryptography to show how it will meet the requirements of excellent cryptography, by achieving the objectives: Confidentiality, Integrity, Non-repudiation, and Authentication.

• 대한수의학회지
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• 제36권4호
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• pp.845-858
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• 1996

The purpose of this study was to establish early diagnostic methods for the detection of Aujeszky's disease viral antigens and nucleic acid in nasal cells, and buffy coats from experimentally infected living pigs by a combination of immunocytochemistry, in situ hybridization with digoxigenin(DIG)-labled probe and electron microscopy. Forty days old piglets were inoculated intranasally with $10^{7.0}TCID_{50}$ of Aujeszky's disease virus (ADV, NYJ-1-87 strain). The viral antigens and nucleic acid of ADV were detected in nasal cells, and buffy coat for 20 days after inoculation by immunocytochemistry, in situ hybridization with DIG-labeled probe and electron microscopical method. The results were compared with conventional methods such as a porcine Aujeszky's disease serodiagnostic(PAD) kit, neutralization test(NT) and virus isolation. 1. The viral antigens, nucleic acids and capsids of ADV were detected in nasal cells, buffy coats from 3 days to 20 days after inoculation by immunocytochemistry, in situ hybridization with DIG-labeled probe and electron microscopy, respectively. 2. When viral antigens were detected by the immunocytochemical technique, a diffuse brown deposit was observed in the nucleus and cytoplasm of nasal cells, buffy coats and PK-15 cells under a microscope. 3. DIG-labeled DNA probe was prepared by amplification of conserved sequence of recombinant ADV-gp50 clone with polymerase chain reacction. When ADV-DNA was detected by ISH with DIG-labeled probe, purplish blue pigmentation were observed in the nuclei and cytoplasms of ADV-infected cells under a microscope. Positive signals were observed in nasal cells and in the buffy coat and PK-15 cells at the first day after inoculation. 4. Where ADV-capsids were detected by transmission electron microscopical method, aggregation of capsids was observed in the nuclei and cytoplasms of nasal cells, buffy coats and PK-15 cells. The results suggested that these methods were considered as the highly sensitive and reliable tools for rapid and confirmative diagnosis of Aujeszky's disease in living pigs.

• The Korean Journal of Physiology and Pharmacology
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• 제16권4호
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• pp.249-253
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• 2012

We analyzed the pharmacokinetics of C3G on data from twelve subjects, after 2-week multiple dosing of black bean (Phaseolus vulgaris, Cheongjakong-3-ho) seed coat extract, using the mixed effect analysis method (NONMEM, Ver. 6.2), as well as the conventional non-compartmental method. We also examined the safety and tolerability. The PK analysis used plasma concentrations of the C3G on day 1 and 14. There was no observed accumulation of C3G after 2-week multiple dosing of black bean seed coat extract. The typical point estimates of PK were CL (clearance)=3,420 l/h, V (volume)=7,280 L, Ka (absorption constant)=9.94 $h^{-1}$, ALAG (lag time)=0.217 h. The black bean seed coat extract was well tolerated and there were no serious adverse events. In this study, we confirmed that a significant amount of C3G was absorbed in human after given the black bean seed coat extract.

• Archives of Pharmacal Research
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• 제27권2호
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• pp.259-264
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• 2004

The purpose of the present study was to investigate the pharmacokinetics of PEG-hemoglobin SB 1, a modified bovine hemoglobin with polyethylene glycol, after its single and multiple administration in beagle dogs. For this purpose, the analytical method of free hemoglobin in the plasma was developed and validated. Excellent linearity ($r^2$=0.999) was observed in the calibration curve data, with the limit of quantification of 0.005 g/dL. The precision and the deviation of the theoretical values for accuracy were always within $\pm$15％ in both the between-and the within-day results. The method was tested by measuring the plasma concentrations following intravenous administration to beagle dogs and was shown to be suitable for pharmacokinetic studies. In a single dose study, the plasma half-life (t$_{1}$2/) increased and the total body clearance (Cl$_{t}$) decreased with the dose (i.e., 0.017 to 0.75 gHb/kg as PEG-hemoglobin SB1) in both sexes. The volume of distribution at steady-state (Vd$_{ss}$ ) showed no difference with the dose. In contrast, the values of t$_{1}$2/, CL$_{t}$ and the area under the plasma concentration-time curve (AUC) after the multiple dose were significantly different from those of the single dose administration. The values of t$_{1}$2/ in the multiple administration were about two times higher-than that of the single dose. As a result, t$_{1}$2/ of hemoglobin after the administration of PEG-hemoglobin SB1 was about 15-30 h, indicating the PEG modification of the hemoglobin lead to a prolongation of plasma concentration of the protein. Therefore, these observations suggested that the PEG modification of hemoglobin is potentially applicable in the hemoglobin-based therapeutics.tics.

• International Journal of Computer Science & Network Security
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• 제21권12spc호
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• pp.451-458
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• 2021

Providing a secure and effective way to protect confidential and private data is an urgent process, and accordingly, we will present in this research paper a new method, which is called multiple rounds variable block method (MRVB) which depends on the use of a colored image that is kept secret to generate needed work and round keys. This method can be used to encrypt-decrypt data using various lengths private key and data blocks with various sizes. The number of rounds also will be variable starting from one round. MRVB will be implemented and compared with the encryption-decryption standards DES and AES to show the improvements provided by the proposed method in increasing the security level and in increasing the throughput of the process of data cryptography. The generated private key contents will depend on the used image_key and on the selected number of rounds and the selected number of bytes in each block of data.

• 폴리머
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• 제38권4호
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• pp.464-470
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• 2014

A chemo-mechanical method was used to prepare lignin-containing cellulose nanofibrils(L-CNF) from unbleached woodpulps dispersed uniformly in an organic solvent. L-CNF/PLA composites were obtained by solvent casting method. The effects of L-CNF concentration on the composite performances were characterized by tensile test machine, contact angle machine, scanning electron microscope (SEM), and Fourier transform infrared spectroscopy (FTIR). The tensile test results indicated that the tensile strength and elongation-at-break increased by 50.6% and 31.8% compared with pure PLA. The contact angle of PLA composites decreased from $79.3^{\circ}$ to $68.9^{\circ}$. The FTIR analysis successfully showed that L-CNF had formed intermolecular hydrogen bonding with PLA matrix.

• 실천공학교육논문지
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• 제13권2호
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• pp.293-300
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• 2021

이 연구는 테크놀로지 교수 내용 지식(TPACK)에 대한 예비 교사의 인식을 측정하기 위해 실시되었다. 충청북도에 위치한 A대학교의 재학생 307명이 테크놀로지 교수 내용 지식(TPACK) 척도에 응답한 결과를 분석에 활용하였다. 분석 과정에서 IBM SPSS 21 프로그램을 사용하였으며, 독립표본 t검증, 일원변량분석, 중다회귀분석(Enter 방식)을 실시하였다. 연구 결과는 다음과 같다. 첫째, 성별에 따른 평균 차이 분석 결과, 교수 지식(PK), 교수 내용 지식(PCK), 테크놀로지 교수 지식(TPK), 테크놀로지 교수 내용 지식(TPACK)에서 여학생 평균이 남학생보다 높게 나타났다. 둘째, 학년별 평균 차이 분석 결과, 내용 지식(CK)의 경우 1학년, 3학년과 4학년의 평균이 2학년보다 통계적으로 유의한 수준에서 높게 나타났다. 셋째, 테크놀로지 교수 내용 지식(TPACK)에 대해 β값이 교수 지식(PK)은 .11, 교수 내용 지식(PCK)은 .11, 테크놀로지 교수 지식(TPK)은 .715로써 통계적으로 유의한 예측 변인으로 나타났다. 끝으로 연구 결과를 바탕으로 TPACK 실행 매뉴얼 및 워크북 개발과 다양한 테크놀로지 실습 기회 제공 등의 논의점을 제시하였다.

• Korean Journal of Acupuncture
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• 제36권2호
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• pp.93-103
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• 2019

Objectives : The aim of this study is to review the current trends in experimental studies on the acupuncture moxibustion treatment for visceral hypersensitivity. Methods : PubMed was searched for experimental studies about visceral hypersensitivity and acupuncture/moxibustion. Data were extracted and tabulated from the selected articles about experimental method, intervention, result and mechanism. Results : Total 23 articles were reviewed. Chronic visceral hypersensitivity animal model was applied in 17 studies (74%). Visceral hypersensitivity was measured by abdominal withdrawal reflex scoring or/and abdominal electromyogram. Acupoints like ST25, ST36, ST37, BL25, LI11, BL32 and PC6 were treated by electroacupuncture or moxibustion. All articles reported that electroacupuncture or moxibustion treatment is significantly effective in reducing visceral hypersensitivity. Treatment mechanisms were studied, related to mast cell, serotonin (5-HT) and receptor (5-HT3R and 5-HT4R), substance P (SP), vasoactive intestinal polypeptide (VIP), c-fos positive cell, corticotropin-releasing hormone (CRH), purinergic 2X (P2X)2, P2X3, P2X4, P2X7, N-methyl-D-aspartate (NMDA) receptor (NR1 and NR2B), prokinectin (PK) 1 and PK2. Conclusions : Evidences on acupuncture/moxibustion treatment for visceral hypersensitivity in animal studies warrant more research on effective acupoins, electro-acupuncture methods and treatment durations.