• Journal of the Korea Society for Simulation
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• v.28 no.1
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• pp.99-107
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• 2019

Until now it has had the limitation of the target in the US JMEM to calculate the Pk with the existing method by our study. In this study, we focused on deriving a method to calculate the Pk of the actual targets except JMEM targets using ANN. We study the initial predictive model of ANN(Artificial Neural Network) from the targets data of the specification and the vulnerable area in the US JMEM(Joint Munitions Effectiveness Manuals), and calculate the actual targets vulnerable area by using this method. Finally, we propose a method to calculate the Pk by applying those data to the existing method of us.

• Journal of KIISE:Computing Practices and Letters
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• v.12 no.3
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• pp.170-182
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• 2006

Last few years have seen a rapid increase in research on ubiquitous computing. Ubiquitous computing is often touted as a technology that will make computing available to the user anywhere and anytime. One important problem to be addressed in building such a ubiquitous computing environment is how to manage services and deliver them to the user in an effective manner. This paper presents our model called Personal Kiosk(PK) as a way of solving the problem. PK is a model of ubiquitous service provisioning that enables the user to use desired services anytime and anywhere. The design and implementation of the current PK in the 'Local Area' setting with related technical issues are also presented. A location-sensing technique for indoor users and a personalized service provisioning based on user location and privileges are discussed in detail.

• The Korean Journal of Applied Statistics
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• v.12 no.1
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• pp.45-65
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• 1999

공정능력지구 $C_{pk}$는 제조공정이 제품을 제대로 생산하고 있는지를 평가하기 위하여 널리 사용되고 있는 측도이다. 최근까지 공정능력지수 $C_{pk}$에 관한 추정문제들이 만히 연구되었는 바, 대부분의 이러한 연구들은 공정분포가 정규분포임을 가정하였다. 하지만 실제 품질관리 현장의 공정으로부터 얻어지는 특성치들이 정규분포를 따르지 않는 경우가 많이 발생하며, 이를 감지하기가 어려울 수 있다. 따라서 본 논문에서는 공정능력지수 $C_{pk}$에 대한 바람직한 구간추정 방법을 제안하기 위하여 6가지 형태의 비모수적인 붓스트랩 신뢰구간을 설정하고 세 가지 공정분포에 대하여 다양하고 포괄적인 모의실험을 통하여 그 효율성에 관하여 비교연구를 하였다.

• Journal of Life Science
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• v.19 no.8
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• pp.1023-1032
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• 2009

Despite the fact that many cancer cells are sensitive to TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis, some cancer cells show either partial or complete resistance to TRAIL. Human leukemic K562 and CEM cells also show resistance to TRAIL-induced apoptosis. Novel molecular target and treatment strategies are required to overcome TRAIL resistance of human leukemia cells. Therefore, the purpose of this study was to target key anti-apoptotic molecules deciding TRAIL resistance for sensitization of TRAIL-resistant K562 and CEM cells, and to evaluate the effect of quercetin as a TRAIL sensitizer on these TRAIL-resistant cells. We found that quercetin acted in synergy with TRAIL to enhance TRAIL-induced apoptosis in K562 cells by inhibition of the DNA-PK/Akt signaling pathway, which leads to enhancement of TRAIL-mediated activation of caspases and concurrent cleavage of PARP and up-regulation of Bax. The findings suggest that the DNA-PK/Akt signaling pathway plays an essential role in regulating cells to escape from TRAIL-induced apoptosis, and quercetin could act in synergy with TRAIL to increase apoptosis by inhibition of the DNA-PK/Akt signaling pathway, which overcomes TRAIL-resistance of K562 and CEM cells. This study suggests that DNA-PK might interfere with TRAIL-induced apoptosis in human leukemic cells through activation of the Akt signaling pathway.

• Nuclear Medicine and Molecular Imaging
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• v.43 no.4
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• pp.337-343
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• 2009

Purpose: ((R)-1-(2-chlorophenyl)-N-1-[$^{11}$C]methyl-N(1-propyl)-3-isoquinoline carboxamide ((R)-PK11195) is a specific ligand for the peripheral type benzodiazepine receptor and a marker of activated microglia, used to measure inflammation in neurologic disorders. We report here that a direct and simple radiosynthesis of [$^{11}$C](R)-PK11195 in mild condition using NaH suspension in DMF and one-step loop method. Materials and Methods: (R)-N-Desmethyl-PK11195 (1 mg) in DMSO (0.1 mL) and NaH suspension in DMF (0.1 mL) were injected into a semi-prep HPLC loop. [$^{11}$C]methyl iodide was passed through HPLC loop at room temperature. Purification was performed using semi-preparative HPLC. Aliquots eluted at 11.3 min were collected and analyzed by analytical HPLC and mass spectrometer. Results: The labeling efficiency of [$^{11}$C](R)-PK11195 was 71.8$\pm$8.5%. The specific activity was 11.8:$\pm$6.4 GBq/$\mu$mol and radiochemical purity was higher than 99.2%. The mass spectrum of the product eluted at 11.3 min showed m/z peaks at 353.1 (M+1), indicating the mass and structure of (R)-PK11195. Conclusion: By the one-step loop method with the [$^{11}$C]CH3l automated synthesis module, [$^{11}C$](R)-PK11195 could be easily prepared in high radiochemical yield using NaH suspension in DMF.

• Journal of the Korea Society for Simulation
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• v.30 no.2
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• pp.23-31
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• 2021

Defense M&S(Modeling & Simulation) requires weapon effectiveness index which indicates Ph(Probability of hit) and Pk(Probability of kill) values on various impact and environmental conditions. The index is usually produced by JMEM(Joint Munition Effectiveness Manual) development process, which calculates Pk based on the impact condition and circular error probable. This approach requires experts to manually adjust the index to consider the environmental factors such as terrain, atmosphere, and obstacles. To reduce expert's involvement, this paper proposes a meta-model based method to produce weapon effectiveness index. The method considers the effects of environmental factors during calculating a munition's trajectory by utilizing high-resolution weapon system models. Based on the result of Monte-Carlo simulation, logistic regression model and Gaussian Process Regression(GPR) model is respectively developed to predict Ph and Pk values of unobserved conditions. The suggested method will help M&S users to produce weapon effectiveness index more efficiently.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2005.05a
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• pp.680-683
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• 2005

The wing component model for flutter analysis consisting of stiffness, mass, and aerodynamic model has been constructed based on the full airframe finite element model for 4-seat canard-type small aircraft. A study on wing flutter characteristics has been investigated based on the wing component model constructed using PK method in MSC/NASTRAN for flutter analysis. In addition, wing flutter mechanism for the aircraft under consideration has been analyzed based on the results of normal mode and flutter analysis.

• Proceedings of the Korean Information Science Society Conference
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• 2005.11b
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• pp.565-567
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• 2005

유비쿼터스 개념의 등장으로 사용자가 언제 어디서도 자신이 필요로 하는 서비스를 쉽게 이용할 수 있는 환경을 구축하기 위한 연구는 활발히 진행되고 있다. 이와 같은 유비쿼터스 환경의 서비스들의 대부분은 장소, 사물, 사람 등과 같은 물리공간의 개체가 가상공간인 서비스공간에 표현됨으로써 생성되고 사용자가 이를 통해 물리개체의 정보 및 그 개체에서 제공하는 기능을 편리하게 이용할 수 있게 하는 방향으로 연구 개발되고 있다. 하지만 유용한 서비스를 많이 만드는 것만으로 유비쿼터스 환경 구축되는 것은 아니다. 사용자를 위한 각종 서비스 수의 급격한 증가는 오히려 서비스 사용자나 제공/관리자가 이를 이용하고 관리하는데 혼란을 초래할 수 있다. 이를 방지하기위해서 사용자는 자신의 상황에 따라 유용하고 가용한 서비스를 선택적으로 제공받아 이용할 수 있어야 한다. 우리는 이런 이슈에 대한 해결 방안으로 "local area"에 존재하는 유비쿼터스 서비스를 효과적으로 지원하고 사용자가 이를 편리하게 이용할 수 있도록 하는 Personal Kiosk (PK) 시스템 및 기반구조를 설계 구현하였다. 본 논문에서는 local area PK 환경을 구축에 필요한 세부 이슈 중 특정 사용자의 환경정보를 기반으로 유용한 정보를 선택하는 방법을 제안하고 이를 기반으로 구현한 PK 시스템 및 기반구조를 소개한다.

• Journal of the Korean Society of Food Science and Nutrition
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• v.43 no.5
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• pp.668-674
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• 2014

The objective of the present study was to investigate the protective and free radical scavenging effects of conventionally and organically cultivated kale juices against oxidative damage in $LLC-PK_1$ cells. The DPPH, NO, $O_2{^-}$, and ${\cdot}OH$ radical scavenging activities of organically cultivated kale were higher than those of conventionally cultivated kale juice. Oxidative damage induced by AAPH (2,2'-azobis(2-amidinopropane) dihydrochloride), SNP (sodium nitroprusside), pyrogallol, and SIN-1 (3-morpholinosydnonimine) led to loss of cell viability and increased lipid peroxidation in LLC-PK1 cells, whereas treatment with vegetable juices, especially organically cultivated kale juices, significantly increased cell viability and inhibited lipid peroxidation in a dose-dependent manner (P<0.05). These results suggest that organically cultivated kale juices have protective roles against oxidative stress induced by free radicals.

• Journal of Life Science
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• v.7 no.2
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• pp.107-111
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• 1997

To remove dissolved $NH_{4}$$^{+}$ in the aquaculture system, one ammonia oxidizing bacterium, Nitrsomonas sp. PK1, was isolated from samples collected in many aquacultural place and sludges of waste water. The stationary phase of this atrain was reached after 9 days, and the maximum $NO_{2}$ production was shown from 3 days to 9 days. In the selective medium, 0.1% of glucose was the good carbon source for growth. However, the $NO_{2}$productivity was repressed by the addition of glucose to the medium. When $Zn^{++}$ ion was supplemented to the medium, growth and the $NO_{2}$ productivity was increased, 10mM of $ZnCl_{2}$ was the optimal concentration for growth and 1 mM of $ZnCl_{2}$ was the optimal concentration for the production of $NO_{2}$, respectively.