• Geomechanics and Engineering
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• v.12 no.3
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• pp.541-560
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• 2017

In this research, experimental and numerical simulations were adopted to investigate the effects of ligament angle on compressive strength and failure mode of rock-like material specimens containing two non-coplanar filled fissures under uniaxial compression. The experimental results show that with the increase of ligament angle, the compressive strength decreases to a nadir at the ligament angle of $60^{\circ}$, before increasing to the maximum at the ligament angle of $120^{\circ}$, while the elastic modulus is not obviously related to the ligament angle. The shear coalescence type easily occurred when ${\alpha}$ < ${\beta}$, although having the same degree difference between the angle of ligament and fissure. Numerical simulations using $PFC^{2D}$ were performed for flawed specimens under uniaxial compression, and the results are in good consistency with the experimental results. By analyzing the crack evolution process and parallel bond force field of rock-like material specimen containing two non-coplanar filled fissures, we can conclude that the coalescence and propagation of crack are mainly derived from parallel bond force, and the crack initiation and propagation also affect the distribution of parallel bond force. Finally, the displacement vectors in ligament region were used to identify the type of coalescence, and the results coincided with that obtained by analyzing parallel bond force field. These experimental and numerical results are expected to improve the understanding of the mechanism of flawed rock engineering structures.

• Tunnel and Underground Space
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• v.7 no.4
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• pp.267-273
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• 1997

Rock fragmentation with plasma blasting technique has advantageous properties in contrast to the conventional blasting method in controlling of flying rocks and ground vibrations, when residents are complaining or surrounding structures stay in protection from blasting operations. The experiences show in urban construction works that the plasma blasting is the most possible method to prevent damages and minimize adverse environmnetal impacts. The fragmentation energy level is evaluated by numerical simulation using PFC-2D for various drill hole pattern and tested accordingly to get the feasibility. The energy output of plasma blasting system has been improved to a level of 1 MJ, which can break a 2~3 ㎥ granite boulder or 1.5 m height bench face. Measurements are carried out to get the ground vibration level and propagation equation, so that the control of the blasting operations can be performed more precisely and safely.

• Proceedings of the Korean Society for Rock Mechanics Conference
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• 2011.09a
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• pp.3-21
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• 2011

Laboratory experiments and numerical simulations using Particle Flow Code (PFC2D) were performed to study the effects of joint separation and joint overlapping on the full failure behavior of rock bridges under direct shear loading. Through numerical direct shear tests, the failure process is visually observed and the failure patterns are achieved with reasonable conformity with the experimental results. The simulation results clearly showed that cracks developed during the test were predominantly tension cracks. It was deduced that the failure pattern was mostly influenced by both of the joint separation and joint overlapping while the shear strength is closely related to the failure pattern and its failure mechanism. The studies revealed that shear strength of rock bridges are increased with increasing in the joint separation. Also, it was observed that for a fixed cross sectional area of rock bridges, shear strength of overlapped joints are less than the shear strength of non-overlapped joints.

• Journal of the Korea Concrete Institute
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• v.20 no.2
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• pp.147-156
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• 2008

In an uniaxial compressive test of a concrete standard specimen (150$\times$300 mm) the crack initiation and extension with the stress increase are the major reason of the failure, which is similar to the breakage of the particle bonding in the simulation by using particle bonded model, especially particle flow code in 3 dimensions (PFC3D) developed by Itasca Consulting Group Inc. That is the main motive to study the possibility of an uniaxial compressive strength test simulation. It is important to investigate the relationship between the micro-parameters and the macro-properties because the 3-dimensional particle bonded model uses the spherical particles to analyze the physical phenomena. Contact bonded model used herein has eight micro-parameters and there are five macro-properties; Young's modulus, Poisson's ratio, uniaxial compressive strength and the crack initiation stress and the ratio concerning the crack propagation with the stress. To simulate the compressive test we made quantitative relationships between the micro-parameters and the macro-properties by using the fractional factorial design and various sensitivity analyses including regression analysis, which result in the good agreement with the previous studies. Also, the stress-stain curve and the crack distribution over the specimen given by PFC3D showed the mechanical behavior of the concrete standard specimen under the uniaxial compression. It is concluded that the particle bonded model can be a good tool for the analyzing the mechanical behavior of concrete under the uniaxial compressive load.

• Explosives and Blasting
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• v.22 no.1
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• pp.33-43
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• 2004

In this study, a comparison was made between the resulting behaviors of scaled model test and particle flow analysis for blasting demolition of a reinforced concrete structure. For the test and analysis, a progressive failure of a five-story structure was considered. The dimension analysis was carried out to properly scale down the real structure into the laboratory size. The test model was made of the mixture of gypsum, sand and water along with soldering lead to analogy reinforcing steel bars. The ratio of mixing components was chosen to best represent the scaled down strength and deformation modulus. The columns and girders of the structure were precasted in the laboratory and assembled right before the blasting test. The numerical analysis of the blasting demolition was carried out using PFC2D (Particle Flow Analysis 2-Dimension by Itasca). The results of the blasting of concrete lahmen structure showed roughly identical demolition behavior between scaled model test and numerical test. For the blasting of the reinforced concrete structure, the results were more identical and closer to the real demolition behavior, since the demolition behavior was better represented in this case due to the increased tensile strength of the component.

• The Journal of Engineering Geology
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• v.27 no.2
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• pp.133-141
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• 2017

In this study, filter conditions by difference in grading between core material and filter material used for dam construction was applied as evaluation condition for surrounding ground conditions near excavation site in a bid to identify the risk of land subsidence resulting from the erosion of soil particles. To that end, filter conditions proposed for the test was evaluated and the risk of land subsidence depending on grain size conditions was also evaluated using the filter conditions developed by COE. Consequently, evaluation diagram that can be used to determine the risk of land subsidence using grain size conditions obtained from ground investigation data was developed, which is expected to help evaluate the possibility of land subsidence depending on changes to the stratum. To simulate the particle flow process, PFC3D program was used. It's not only intended to determine the land subsidence pattern caused by falling ground water level but also predict and evaluate the land subsidence caused by soil erosion using grain size condition which can be verified by numerical analysis approach.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1993.04a
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• pp.141-141
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• 1993

말징버섯 Calvatia craniformis의 culture broth 40 liter를 여과하여 얻은 균사채를 열수 추출하여 진한 갈색 건조분말(Fr. A) 13.1g을 분리하였다. Fr. A에 대하여 DEAE-cellulose ion chromatography를 시행하여 중성분획인 흰색 분말 (Fr. B) 2.50g을, 산성분획인 갈색 분말 (Fr. C) 3.50g을 각각 분리하였다. Fr. B 500mg에 대하여 Sepharose CL-4B gel filtration chromatography를 시행하여 흰색분말 Fr. D(Calvatan) 350mg을 분리하였다. Calvatan 350mg에 대하여 Con A-Sepharose 4B affinity chromatography를 적용하여 미흡착 분획인 Fr. F($\alpha$-form)와 흡착 분획인 Fr. E ($\beta$-form)로 정제하였다. 항암작용의 기전을 구명하고자 마우스에 대하여 면역학적 실험을 시행하였다. macrophage의 활성에 대한 영향을 조사하였던 바, 투여군의 활성화된 macrophage에 의해 유리되는 superoxide anion의 양은 대조군에 비해 1.4배 증가하였고 Calvatan 투여군의 용혈반 형성세포(PFC)는 대조군에 비해 3.1배 증가하였다. 화학 분석에 의해, Calvatan은 다당체 87.2%, 단백질 1.8% 및 hexosamine 1.3%로 구성되어 있었다. 따라서 항암성 분획들은 protein-bound polysaccharide임을 알 수 있었다. 또한 각 분획의 다당체를 구성하고 있는 단당류는 glucose, galactose, mannose 및 xylose 였으며 단백질 부분은 16종의 아미노산으로 구성되어 있었다. IR 스펙트럼은 3300-3400 $cm^{－1}$에서 0-H stretching frequency, 2900 $cm^{－1}$ 에서 C-H stretching frequency, 1630 $cm^{－1}$ 에서 C-0 stretching frequency. 1000-1100 $cm^{－1}$에서 C-H 및 C-0 bending frequency를 나타내는 다당체의 전형적인 특성을 보여주었다.을 보여주었다.

• Journal of Ginseng Research
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• v.46 no.3
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• pp.426-434
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• 2022

Aim: This study investigates the effects of ginsenoside Rb1 (GsRb1) on methamphetamine (METH)-induced toxicity in SH-SY5Y neuroblastoma cells and METH-induced conditioned place preference (CPP) in adult Sprague-Dawley rats. It also examines whether GsRb1 can regulate these effects through the NR2B/ERK/CREB/BDNF signaling pathways. Methods: SH-SY5Y cells were pretreated with GsRb1 (20 mM and 40 mM) for 1 h, followed by METH treatment (2 mM) for 24 h. Rats were treated with METH (2 mg/kg) or saline on alternating days for 10 days to allow CPP to be examined. GsRb1 (5, 10, and 20 mg/kg) was injected intraperitoneally 1 h before METH or saline. Western blot was used to examine the protein expression of NR2B, ERK, P-ERK, CREB, P-CREB, and BDNF in the SH-SY5Y cells and the rats' hippocampus, nucleus accumbens (NAc), and prefrontal cortex (PFC). Results: METH dose-dependently reduced the viability of SH-SY5Y cells. Pretreatment of cells with 40 µM of GsRb1 increased cell viability and reduced the expression of METH-induced NR2B, p-ERK, p-CREB and BDNF. GsRb1 also attenuated the expression of METH CPP in a dose-dependent manner in rats. Further, GsRb1 dose-dependently reduced the expression of METH-induced NR2B, p-ERK, p-CREB, and BDNF in the PFC, hippocampus, and NAc of rats. Conclusion: GsRb1 regulated METH-induced neurotoxicity in vitro and METH-induced CPP through the NR2B/ERK/CREB/BDNF regulatory pathway. GsRb1 could be a therapeutic target for treating METH-induced neurotoxicity or METH addiction.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.36 no.1
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• pp.143-149
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• 2016

This study evaluated the shear behavior of geogrid reinforced ballast material using a large scale direct shear test and discrete element method (DEM) based on PFC 3D program. The direct shear test was conducted on ballast materials that have different particle size distributions. Whereas the test results revealed that the shear strength generally increased with the larger particle size of ballast material without geogrid reinforcement, the shear behavior of ballast material was found to change pertaining to the relationship between particle size distribution and geogrid rib size. Generally, it is deemed the effectiveness of reinforcement can be achieved when the rib size is two times greater than average particle size. A numerical analysis based on DEM was conducted to verify the test results. The geogrid modeling was successfully completed by calibration process along with sensitivity analysis to have actual tensile strength provided by manufacturer. With a given geogrid model, the parametric evaluation was further carried out to examine the interactive behavior between geogrid and ballast material. Consequently, it was found that the effectiveness zone of geogrid reinforcement generated within a specific depth.

• The Transactions of the Korean Institute of Power Electronics
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• v.6 no.6
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• pp.572-581
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• 2001

A heat pipe heat sink device which is to evacuate maximum heat of about 1800W from a powersemiconductor was designed and manufactured One set of cooling device os composed of an Aluminum block (130${\times}$160${\times}$35mm) 4 PFC heat pipes $(d_0 22.23mm)$ and 126 Aluminium fins (250${\times}$58${\times}$0.8mm) Experimental data obtained at a power of 1~2kW revealed that the total thermal resistance of the device varied 0.02~0.018$^{\circ}C$/W along with increasing air velocity from 2m/s to 3 m/s. The result represented a good satisfaction of requirement condition to maintain temperature rise of semiconductor lowe that $40^{\circ}C$ at 1800W and air velocity of 3 m/s Some important resistance such as convective resistances at both fins and heat pipes showed good agreement between mathematical predictions and measurement data.