Ginsenoside Rb1 attenuates methamphetamine (METH)-induced neurotoxicity through the NR2B/ERK/CREB/BDNF signalings in vitro and in vivo models |
Yang, Genmeng
(NHC Key Laboratory of Drug Addiction Medicine, Kunming Medical University)
Li, Juan (School of Basic Medicine, Kunming Medical University) Peng, Yanxia (NHC Key Laboratory of Drug Addiction Medicine, Kunming Medical University) Shen, Baoyu (NHC Key Laboratory of Drug Addiction Medicine, Kunming Medical University) Li, Yuanyuan (NHC Key Laboratory of Drug Addiction Medicine, Kunming Medical University) Liu, Liu (NHC Key Laboratory of Drug Addiction Medicine, Kunming Medical University) Wang, Chan (NHC Key Laboratory of Drug Addiction Medicine, Kunming Medical University) Xu, Yue (NHC Key Laboratory of Drug Addiction Medicine, Kunming Medical University) Lin, Shucheng (NHC Key Laboratory of Drug Addiction Medicine, Kunming Medical University) Zhang, Shuwei (NHC Key Laboratory of Drug Addiction Medicine, Kunming Medical University) Tan, Yi (NHC Key Laboratory of Drug Addiction Medicine, Kunming Medical University) Zhang, Huijie (NHC Key Laboratory of Drug Addiction Medicine, Kunming Medical University) Zeng, Xiaofeng (NHC Key Laboratory of Drug Addiction Medicine, Kunming Medical University) Li, Qi (SDIVF R&D Centre) Lu, Gang (CUHK-SDU Joint Laboratory on Reproductive Genetics, School of Biomedical Sciences, the Chinese University of Hong Kong) |
1 | De Cesare D, et al. Rsk-2 activity is necessary for epidermal growth factor-induced phosphorylation of CREB protein and transcription of c-fos gene. Proc Natl Acad Sci U S A 1998;95(21):12202-7. DOI |
2 | Tymianski M, et al. Source specificity of early calcium neurotoxicity in cultured embryonic spinal neurons. J Neurosci 1993;13(5):2085-104. DOI |
3 | Li J, et al. Effect of rhynchophylline on conditioned place preference on expression of NR2B in methamphetamine-dependent mice. Biochem Biophys Res Commun 2014;452(3):695-700. DOI |
4 | Lin ZY, et al. Ginsenoside Rb1 selectively inhibits the activity of L-type voltage-gated calcium channels in cultured rat hippocampal neurons. Acta Pharmacol Sin 2012;33(4):438-44. DOI |
5 | Jiang S, Fang DF, Chen Y. Involvement of N-Methyl-D-Aspartic acid receptor and DL-alpha-amino-3-hydroxy-5- methyl-4-isoxazole propionic acid receptor in ginsenosides Rb1 and Rb3 against oxygen-glucose deprivation-induced injury in hippocampal slices from rat. Pharmacology 2018;101(3-4):133-9. DOI |
6 | Tian X, et al. Developmentally regulated role for Ras-GRFs in coupling NMDA glutamate receptors to Ras, Erk and CREB. EMBO J 2004;23(7):1567-75. DOI |
7 | Xing J, Ginty DD, Greenberg ME. Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase. Science 1996;273(5277):959-63. DOI |
8 | Grant KM, et al. Methamphetamine-associated psychosis. J Neuroimmune Pharmacol 2012;7(1):113-39. DOI |
9 | Prakash MD, et al. Methamphetamine: effects on the brain, gut and immune system. Pharmacol Res 2017;120:60-7. DOI |
10 | Courtney KE, Ray LA. Methamphetamine: an update on epidemiology, pharmacology, clinical phenomenology, and treatment literature. Drug Alcohol Depend 2014;143:11-21. DOI |
11 | Haddar M, et al. Inhibitory effects of Shati/Nat8l overexpression in the medial prefrontal cortex on methamphetamine-induced conditioned place preference in mice. Addict Biol 2019. |
12 | Liu Q, et al. Effects of co-administration of ketamine and ethanol on the dopamine system via the cortex-striatum circuitry. Life Sci 2017;179:1-8. DOI |
13 | Kohno M, et al. Midbrain functional connectivity and ventral striatal dopamine D2-type receptors: link to impulsivity in methamphetamine users. Mol Psychiatry 2016;21(11):1554-60. DOI |
14 | Ren W, et al. Time-dependent serum brain-derived neurotrophic factor decline during methamphetamine withdrawal. Medicine (Baltimore) 2016;95(5):e2604. DOI |
15 | Kirschmann EK, et al. Appetitive cue-evoked ERK signaling in the nucleus accumbens requires NMDA and D1 dopamine receptor activation and regulates CREB phosphorylation. Learn Mem 2014;21(11):606-15. DOI |
16 | Kim DJ, et al. High concentrations of plasma brain-derived neurotrophic factor in methamphetamine users. Neurosci Lett 2005;388(2):112-5. DOI |
17 | Pierce RC, Bari AA. The role of neurotrophic factors in psychostimulant-induced behavioral and neuronal plasticity. Rev Neurosci 2001;12(2):95-110. |
18 | Tian C, Murrin LC, Zheng JC. Mitochondrial fragmentation is involved in methamphetamine-induced cell death in rat hippocampal neural progenitor cells. PLoS One 2009;4(5):e5546. DOI |
19 | Foulkes NS, Sassone-Corsi P. Transcription factors coupled to the cAMP-signalling pathway. Biochim Biophys Acta 1996;1288(3):F101-21. |
20 | Mehrafza S, et al. Pharmacological evidence for lithium-induced neuroprotection against methamphetamine-induced neurodegeneration via Akt-1/GSK3 and CREB-BDNF signaling pathways. Iran J Basic Med Sci 2019;22(8):856-65. |
21 | Thompson PM, et al. Structural abnormalities in the brains of human subjects who use methamphetamine. J Neurosci 2004;24(26):6028-36. DOI |
22 | Schmidt HD, et al. Epigenetics and psychostimulant addiction. Cold Spring Harb Perspect Med 2013;3(3):a012047. |
23 | Carlezon Jr WA, Duman RS, Nestler EJ. The many faces of CREB. Trends Neurosci 2005;28(8):436-45. DOI |
24 | Olson VG, et al. Regulation of drug reward by cAMP response element-binding protein: evidence for two functionally distinct subregions of the ventral tegmental area. J Neurosci 2005;25(23):5553-62. DOI |
25 | Walters CL, Kuo YC, Blendy JA. Differential distribution of CREB in the mesolimbic dopamine reward pathway. J Neurochem 2003;87(5):1237-44. DOI |
26 | Wang B, et al. Methamphetamine modulates the production of interleukin-6 and tumor necrosis factor-alpha via the cAMP/PKA/CREB signaling pathway in lipopolysaccharide-activated microglia. Int Immunopharmacol 2018;56:168-78. DOI |
27 | Jiao D, et al. The role of the GABA system in amphetamine-type stimulant use disorders. Front Cell Neurosci 2015;9:162. DOI |
28 | Pereira FC, et al. Disruption of striatal glutamatergic/GABAergic homeostasis following acute methamphetamine in mice. Neurotoxicol Teratol 2012;34(5):522-9. DOI |
29 | Kokoshka JM, et al. Methamphetamine treatment rapidly inhibits serotonin, but not glutamate, transporters in rat brain. Brain Res 1998;799(1):78-83. DOI |
30 | O'Brien CP, Gardner EL. Critical assessment of how to study addiction and its treatment: human and non-human animal models. Pharmacol Ther 2005;108(1):18-58. DOI |
31 | Li MH, et al. Amphetamine and methamphetamine increase NMDAR-GluN2B synaptic currents in midbrain dopamine neurons. Neuropsychopharmacology 2017;42(7):1539-47. DOI |
32 | Sun L, et al. A selective D3 receptor antagonist YQA14 attenuates methamphetamine-induced behavioral sensitization and conditioned place preference in mice. Acta Pharmacol Sin 2016;37(2):157-65. DOI |
33 | Wang P, et al. Inhibition of autophagy is involved in the protective effects of ginsenoside Rb1 on spinal cord injury. Cell Mol Neurobiol 2018;38(3):679-90. DOI |
34 | Ahmed T, et al. Ginsenoside Rb1 as a neuroprotective agent: a review. Brain Res Bull 2016;125:30-43. DOI |
35 | Groenewegen HJ, et al. Organization of the projections from the subiculum to the ventral striatum in the rat. A study using anterograde transport of Phaseolus vulgaris leucoagglutinin. Neuroscience 1987;23(1):103-20. DOI |
36 | West AE, Griffith EC, Greenberg ME. Regulation of transcription factors by neuronal activity. Nat Rev Neurosci 2002;3(12):921-31. DOI |
37 | Peterson AB, Abel JM, Lynch WJ. Dose-dependent effects of wheel running on cocaine-seeking and prefrontal cortex Bdnf exon IV expression in rats. Psychopharmacology (Berl) 2014;231(7):1305-14. DOI |
38 | Pena-Bravo JI, et al. Methamphetamine self-administration elicits sex-related changes in postsynaptic glutamate transmission in the prefrontal cortex. eNeuro 2019;6(1). |
39 | Jia F, Mou L, Ge H. Protective effects of ginsenoside Rb1 on H2O2-induced oxidative injury in human endothelial cell line (EA.hy926) via miR-210. Int J Immunopathol Pharmacol 2019;33. 2058738419866021. |
40 | Li J, et al. Protective effects of ginsenoside Rb1 against blood-brain barrier damage induced by human immunodeficiency virus-1 Tat protein and methamphetamine in sprague-dawley rats. Am J Chin Med 2018;46(3):551-66. DOI |
41 | Wu Y, et al. Ginsenoside Rb1 improves leptin sensitivity in the prefrontal cortex in obese mice. CNS Neurosci Ther 2018;24(2):98-107. DOI |
42 | Nestler EJ. Historical review: molecular and cellular mechanisms of opiate and cocaine addiction. Trends Pharmacol Sci 2004;25(4):210-8. DOI |
43 | Huang M, et al. Thioredoxin-1 downregulation in the nucleus accumbens promotes methamphetamine-primed reinstatement in mice. Neuropharmacology 2018;139:117-23. DOI |
44 | Grace CE, et al. (+)-Methamphetamine increases corticosterone in plasma and BDNF in brain more than forced swim or isolation in neonatal rats. Synapse 2008;62(2):110-21. DOI |
45 | Kim HS, et al. Inhibition by ginsenosides Rb1 and Rg1 of methamphetamine-induced hyperactivity, conditioned place preference and postsynaptic dopamine receptor supersensitivity in mice. Gen Pharmacol 1998;30(5):783-9. DOI |
46 | Liao B, Newmark H, Zhou R. Neuroprotective effects of ginseng total saponin and ginsenosides Rb1 and Rg1 on spinal cord neurons in vitro. Exp Neurol 2002;173(2):224-34. DOI |
47 | Fu K, et al. Pseudoginsenoside-F11 inhibits methamphetamine-induced behaviors by regulating dopaminergic and GABAergic neurons in the nucleus accumbens. Psychopharmacology (Berl) 2016;233(5):831-40. DOI |
48 | Alshehri FS, et al. Effects of ceftriaxone on hydrocodone seeking behavior and glial glutamate transporters in P rats. Behav Brain Res 2018;347:368-76. DOI |
49 | Yang GM, et al. The potential role of PKA/CREB signaling pathway concerned with gastrodin administration on methamphetamine-induced conditioned place preference rats and SH-SY5Y cell line. Neurotox Res 2020. |
50 | Barria A, Malinow R. Subunit-specific NMDA receptor trafficking to synapses. Neuron 2002;35(2):345-53. DOI |
51 | Lu JM, et al. Ginsenoside Rb1 blocks ritonavir-induced oxidative stress and eNOS downregulation through activation of estrogen receptor-beta and upregulation of SOD in human endothelial cells. Int J Mol Sci 2019;20(2). |
52 | Hajheidari S, et al. Effects of prolonged abstinence from METH on the hippocampal BDNF levels, neuronal numbers and apoptosis in methamphetamine-sensitized rats. Neurosci Lett 2017;645:80-5. DOI |
53 | Ricoy UM, Martinez Jr JL. Local hippocampal methamphetamine-induced reinforcement. Front Behav Neurosci 2009;3:47. DOI |
54 | Kim S, et al. Inhibitory effect of ginsenosides on NMDA receptor-mediated signals in rat hippocampal neurons. Biochem Biophys Res Commun 2002;296(2):247-54. DOI |
55 | Zeng XF, et al. HIV-1 Tat and methamphetamine co-induced oxidative cellular injury is mitigated by N-acetylcysteine amide (NACA) through rectifying mTOR signaling. Toxicol Lett 2018;299:159-71. DOI |
56 | Brown TE, et al. A silent synapse-based mechanism for cocaine-induced locomotor sensitization. J Neurosci 2011;31(22):8163-74. DOI |