• Natural Product Sciences
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• v.21 no.2
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• pp.98-103
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• 2015

Pueraiae Radix (PR), Pueratia Folium (PF) and Sorbus commixta (SC) mixture, namely GS-SP (PR (1)/PF (2)/SC (0.5): v/v/v) was developed as hangover-relieving elixir and its effects on alcoholic metabolism have been investigated. The enzymatic activity of alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH) of GS-SP was shown higher than those of single treatment with PR, PL, SC, and the positive control group (YM-808). The survival rate of mouse liver cell line NCTC clone 1469 in the presence of acetaldehyde was 30.6, 22.2, and 8.7% at the GS-SP dosage level of 50, 100, and 200 μg/mL respectively. Different concentrations of 50, 100 and 200 mg/kg of GS-SP showed efficient activity for ADH and ALDH than YM-808 in rat fed with 25% ethanol. The levels of blood alcohol and acetaldehyde after oral administration of 200 mg/kg of GS-SP showed efficient activity of 11.7% and 37% than those of YM-808. These results have been supported to the potential for GS-SP to serve as an excellent potential in providing hangover relief and liver protection.

• IMMUNE NETWORK
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• v.23 no.2
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• pp.14.1-14.14
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• 2023

Immune status including the immune cells and cytokine profiles has been implicated in the development of endometriosis. In this study, we analyzed Th17 cells and IL-17A in peritoneal fluid (PF) and endometrial tissues of patients with (n=10) and without (n=26) endometriosis. Our study has shown increased Th17 cell population and IL-17A level in PF with endometriosis patients. To determine the roles of IL-17A and Th17 cells in the development of endometriosis, the effect of IL-17A, major cytokine of Th17, on endometrial cells isolated from endometriotic tissues was examined. Recombinant IL-17A promoted survival of endometrial cells accompanied by increased expression of anti-apoptotic genes, including Bcl-2 and MCL1, and the activation of ERK1/2 signaling. In addition, treatment of IL-17A to endometrial cells inhibited NK cell mediated cytotoxicity and induced HLA-G expression on endometrial cells. IL-17A also promoted migration of endometrial cells. Our data suggest that Th17 cells and IL-17A play critical roles in the development of endometriosis by promoting endometrial cell survival and conferring a resistance to NK cell cytotoxicity through the activation of ERK1/2 signaling. Targeting IL-17A has potential as a new strategy for the treatment of endometriosis.

• Textile Coloration and Finishing
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• v.27 no.1
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• pp.70-79
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• 2015

To establish the optimal conditions for the manufacture of high absortive cellulose film(CF) originated from Styela clava tunic(SCT), the physicochemical properties included absorption was measured in CFs prepared under the various conditions. The highest absorption was observed for SCT-CF20 prepared from the cellulose solution dissolved at $80^{\circ}C$ for 20min, although the filtration treatment did not induce any significance alteration. Also, the absorption was higher in SCT-CF20-F prepared by the freeze drying than SCT-CF20-N(ambient air drying) and SCT-CF20-H(heat drying). The addition of porogen($NaHCO_3$) induced an increase of absorption in SCT-CF20-PF relative to SCT-CF20-F, while the number of interconnected porous structures was enhanced in SCT-CF20-PF. Furthermore, a high level of SK-MEL-2 cells viability was observed in SCT-CF20-PN and SCT-CF20-PF cultured group. These results show that SCT-CF may have high absorption and biocompatibility when prepared from SCT cellulose solution dissolved at $80^{\circ}C$ for 20min after addition of porogen and then subjected to freeze drying.

• Tuberculosis and Respiratory Diseases
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• v.81 no.4
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• pp.319-329
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• 2018

Background: Bronchoalveolar lavage (BAL) is a necessary procedure for diagnosis of various lung diseases. High-flow nasal cannula (HFNC) oxygen delivery was recently introduced. This study aimed to investigate the safety and effectiveness of HFNC oxygen supply during BAL procedure in patients with acute respiratory failure (ARF). Methods: Patients who underwent BAL while using HFNC at a partial pressure of oxygen in arterial blood/fraction of inspired oxygen ($PaO_2/FiO_2$; PF) ratio of 300 or below among patients who had been admitted from March 2013 to May 2017 were retrospectively investigated. Results: Thirty-three BAL procedures were confirmed. Their baseline PF ratio was $166.1{\pm}46.7$. $FiO_2$ values before, during, and after BAL were $0.45{\pm}0.12$, $0.74{\pm}0.19$, and $0.57{\pm}0.14$, respectively. Flow (L/min) values before, during, and after BAL were $26.5{\pm}20.3$, $49.0{\pm}7.2$, and $40.8{\pm}14.2$, respectively. Both $FiO_2$ and flow during and after the procedure were significantly different from those before the procedure (both p<0.001). Oxygen saturation levels before, during, and after BAL measured by pulse oximeter were $94.8{\pm}2.9$, $94.6{\pm}3.5$, and $95.2{\pm}2.8%$, respectively. There were no significant differences in oxygen saturation among the three groups. Complications of BAL procedure included transient hypoxemia, hypotension, and fever. However, there was no endotracheal intubation within 24 hours. Baseline PF ratio in "without HFNC" group was significantly higher than that in "with HFNC" group. There were no differences in complications between the two groups. Conclusion: The use of HFNC during BAL procedure in ARF patients was effective and safe. However, there were no significant differences in oxygen saturation level and complications comparing "without HFNC" group in mild ARF. More studies are needed for moderate to severe ARF patients.

• Journal of Nutrition and Health
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• v.33 no.5
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• pp.517-523
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• 2000

The effect of dietary zinc deficiency and age on lipid peroxide level was investigaed in rats. Zinc level in serum and liver were also measured. Fifty Sprague-Dawly male rats aging 8 months(older rats) and 2 months(younger rats) were used as experimental animal. Zinc deficient diet(1.1ppm) and normal zinc diet(36.5ppm) were used as experimental diets. Rats in each age group were divided into zinc deficient(ZnDF), zinc pair-fed(ZnPF) and zinc ad-libitum(ZnAL) to remove the variances of food intake. After 4 weeks of experimetal period, rats were sacrificed. Thiobarbituric acid reactive substance(TBARS) levels in plasma and liver, lipofuscin and conjugated diene levels in liver were measured as lipid peroxide index. Food intakes of all groups were not different because zinc deficiency did not reduce food intake in ZnDF group. Younger rats gained weight continuously, while older rats lost weight in the begining of experiment and regained afterwards. In older rats, serum zinc level was decreaed while plasma TBARS. level was increased in ZnDF group. In younger rats, plasma TBARS concentration was increased in dietary zinc deficient rats although serum zinc concentration was not reduced. Liver zinc concentration was significantly higher in older rats comparing to younger rats. However, there was no difference among the three dietary groups. Liver TBARS level was not different by age or dietary zinc level. However it was tended to be higher in older rats. However there was no difference by the dietary zinc level. In both age groups, ZnDF group significantly increased plasma TBARS levels, which suggested dietary zinc deficiency could increase lipid peroxidation in part. Significantly higher levels of lipofuscin and conjugated diene in older rats suggested lipid peroxidation was accelerated by aging.

• Proceedings of the Acoustical Society of Korea Conference
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• autumn
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• pp.479-482
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• 2004

In this article we consider a single maneuvering target Tracking algorithm in the presence of missing measurements and high clutter environments for multi-sensor target tracking problem. The tracking algorithm is based on the Particle filtering method to predict and update target states. Proposed is the AMM-PF(Auxiliary Multiple Model Particle Filter)[2] method for maneuvering target tracking to improve performance in track estimate and maintenance with a high level of uncertainty. The algorithm we propose is compared to the Extended Kalman Filter(EKF). A simulation study is included.

• Journal of Power Electronics
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• v.12 no.4
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• pp.578-586
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• 2012

In this paper a single-phase Cascaded H-Bridge (CHB) inverter for photovoltaic (PV) applications is presented. Based on the presented mathematical analysis, a novel controller is introduced which adjusts the inverter power factor (PF) and manipulates the distribution of the reactive power between the cells to enhance the operating range of the CHB inverter. The adopted control strategy enables tracking of the maximum power point (MPP) of distinct PV strings and allows independent control of the dc-link voltages. The proposed controller also enables the inverter to operate under heavily unbalanced PV conditions. The performance of the CHB inverter and the proposed controllers are evaluated in the PSCAD/EMTDC environment. A seven-level CHB-based grid connected laboratory prototype is also utilized to verify the system performance.

• The Transactions of the Korean Institute of Electrical Engineers B
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• v.50 no.10
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• pp.530-535
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• 2001

Resonant-type electronic ballast for a metal halide discharge(MHD) lamp is proposed and implemented for 400W MHD lamp. HID lamps have good color rendition, long life and good focusing capability but they have flickers by acoustic resonance when driven at high frequency. A new control method is employed to remove acoustic resonance related instability in HID lamp. By using the amplitude modulation, a spread spectrum effect is employed on the ballast. The control loop of resonant inverter is analyzed and a current is designed. The ballast consists of a power factor controller, an half-bridge resonant inverter, a simple ignitor and an integrator with OP-amps. The experimental results show the good performance as PF 0.93, ballast loss 22W at output 400W and the conducted EMI level is below 60dBuV.

• Proceedings of the KIPE Conference
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• 2014.07a
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• pp.508-509
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• 2014

전력변환장치의 효율을 개선하기 위해 많은 연구가 이루어지고 있는 가운데, 본 논문에서는 3-레벨 인버터 중에서도 NPC 인버터와 T-타입 인버터를 사용한다. 각 인버터는 서로 다른 스위치 정격에 의해 손실 차이가 생기며, 또한 손실에 영향을 미치는 MI(Modulation Index), PF(Power Factor), 그리고 스위칭 주파수에 따라 손실의 크기가 좌우 되었다. 하지만 두 인버터는 각 구조의 특성상 NPC 의 경우 도통손실이 매우 크며, T-타입의 경우 스위칭 손실이 크게 나타난다는 모듈상의 한계가 있다. 본 논문에서는 인버터 구조에 따라 손실에 지배적으로 영향을 미치는 각 Device의 특성을 고려하여, 전력변환장치에서 발생되어지는 도통손실과 스위칭손실을 분석 하였다.

• Journal of the Korean Society for Aviation and Aeronautics
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• v.29 no.2
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• pp.47-54
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• 2021

Recently, the issue of maintaining pilot competency has emerged as one of the major challenges in the aviation industry due to irregular schedules and flight intervals caused by the global COVID-19. Therefore, a survey was conducted on airline pilots to determine how stressed they would be when returning to their flights after experiencing irregular schedules or long-term furloughs. The level of stress that pilots receive due to flight intervals was divided into periods, and correlation with general characteristics was identified to see what emotional burdens exist as the lengths of flight interval increased. As a result, burdened flight intervals and the Pilot Flying(PF) intervals were identified as a statistically significant variables. In the case of the Pilot Flying interval, the level of stress was confirmed to be worse as the flying interval was elongated, and in the case of the burdened flying interval, the tendency of the stress index were lower as the period increased. Through this study, pilots who experienced reduced flight times were found to be accompanied by considerable amount of emotional burden proportionate to the length of the interval period.