• Title/Summary/Keyword: PEG(polyethylene glycol)

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Performance and characterization of PEG400 modified PVC ultrafiltration membrane

  • Aryanti, P.T.P.;Yustiana, R.;Purnama, R.E.D.;Wenten, I.G.
    • Membrane and Water Treatment
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    • v.6 no.5
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    • pp.379-392
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    • 2015
  • Polyvinyl chloride (PVC) ultrafiltration membrane was prepared by blending 12 wt.% of PVC in N, N-dimethylacetimide (DMAc) with polyethylene glycol 400 (PEG400) as an additive. The influence of PEG400 concentration on the PVC membrane morphology, permeability, fouling and rejection were investigated. Fouling and rejection of the PVC membrane were characterized by dextran T-100 filtration. The results showed that membrane water flux was increased up to $682Lm^{-2}h^{-1}$ when 28 wt.% of PEG400 was added into the PVC membrane solution. The best membrane performance with a low fouling and a high selectivity was achieved by adding 12 wt.% concentration of PEG400, which resulted in 90% rejection of dextran and 90% of flux recovery ratio. At further addition of PEG400 concentration, irreversible fouling was starting to increase. A 90% of irreversible fouling was formed in the PVC membrane when more than 22 wt.% of PEG400 is added.

A Study of Dewatering Phenomena of Potato Slice Cytorrhysed by High Molecules (고분자 용액의 세포 압착 현상에 의한 감자 절편의 탈수 현상에 관한 연구)

  • Choi, Dong-Won;Shin, Hae-Hun;Kim, Jong-Geu
    • The Korean Journal of Food And Nutrition
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    • v.19 no.4
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    • pp.358-365
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    • 2006
  • To study simultaneous water and solute transport kinetics during soaking in concentrated solution, the influence of the concentration and molecular weight of the solute(polyethylene glycol(PEG) and NaCl) in the soaking solution and the temperature on the water loss and solute gain rates were observed by using a model vegetable tissue(potato). When potato slices$(4cm{\times}4cm{\times}0.1cm)$ soaked in 60% PEG solutions, the water loss rate of the early phase decreased with increasing of the molecular weight of PEG from 200 to 6,000, while the final water loss increased with increasing the molecular weight of PEG and it reached to 80%. The cell wall of potato tissue was permeable to NaCl and PEGs of which average molecular weight is smaller than 400 but it was not permeable to PEG 600 and larger molecules. PEG which has average molecular weight below 600 induced plasmolysis and those above 600 induced cytorrhysis. The water loss rate of potato sample soaked in smaller molecular weight PEG solution was faster than those soaked in higher molecular weight PEG solution before cytorrhysis happened. The water loss rate was reversed after cytorrhysis happened. The volume change of potato within the first 60 minutes was larger in low molecular PEG solution but the final ratio of decreasing volume was larger in high molecular PEG solutions. In PEG 200 solution, the potato tissue was slightly shrinked without shape change. However, in PEG 4,000 solution, volume of potato was reduced significantly and potato tissue was twisted.

Feeding Acacia saligna to Sheep and Goats with or without the Addition of Urea or Polyethylene Glycol

  • Krebs, G.L.;Howard, D.M.;Dods, K.
    • Asian-Australasian Journal of Animal Sciences
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    • v.20 no.10
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    • pp.1551-1556
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    • 2007
  • The objective of the research was to investigate the effect of polyethylene glycol (PEG) or urea supplementation in sheep and goats fed a basal diet of Acacia saligna and wheat straw. The 3 dietary treatments were: (1) Control: ad libitum A. saligna+ 400 g/d wheat straw (95% DM) (basal diet); (2) Basal diet+50 g/d PEG 4000; and (3) Basal diet+1% (on a DM basis) urea sprayed onto the straw and A. saligna 30 min prior to feeding. All animals maintained live weight, regardless of the dietary treatment. All sheep readily consumed the A. saligna in preference to straw. In sheep both DMD and OMD were higher (p<0.05) where PEG was included in the diet compared to the other two treatments. Contrary to findings by other researchers there was no significant difference in DMI, DMD or OMD between sheep and goats in corresponding treatment groups. All animals were in positive N balance. For both sheep and goats, rumen ammonia concentrations were increased with the use of either urea or PEG. In these groups the maximum ammonia concentrations exceeded 50 mg/L, considered the minimum required to maximise microbial growth. This threshold, however, was exceeded only for a period of 8-11 h. Of those measured, rumen ammonia levels were generally the highest at 4 h post feeding. None of the measurements of rumen ammonia for the control group approached 50 mg/L. It is unclear how and why feed intake and live weight were maintained when rumen ammonia levels were often sub-optimal.

Design and Pharmaceutical Evaluation of Biphenyl Dimethyl Dicarboxylate Elastic Capsules (비페닐디메칠디카르복실레이트 연질캅셀제의 설계 및 제제학적 평가)

  • 전인구;곽혜선;문지현
    • Biomolecules & Therapeutics
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    • v.4 no.4
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    • pp.419-427
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    • 1996
  • To solubilize practically insoluble biphenyl dimethyl dicarboxylate (DDB), which has been used for the treatment of chronic hepatitis as tablets or hard capsules, the solubilities of DDB in various hydrophilic, oily and hydrocarbon vehicles, and aqueous surfactant solutions were measured by high performance liquid chromatography. It was found that, among the vehicles studied, polyethylene glycol (PEG) 300 revealed the best solvency, and the solubility reached 17.6 mg/ml at 37$^{\circ}C$. The addition of glycyrrhizic acid ammonium salt (GAA) to DDB-PEG 300 solution (5-20 mg/g) inhibited the formation of precipitates, and at the concentration of 10 mg/g, any precipitaction was not observed even after 2 years at 4$^{\circ}C$. Furthermore, GAA markedly enhanced the permeation of DDB through the rabbit duodenal mucosa in a concentration dependent manner. The addition of copolyvidone (ca. 1.0%) to DDB-GAA-PEG 300 system (1 : 0.5 97.5 w/w) was most effective in preventing the considerable precipitation of DDB-PEG 300 solution (7.5 mg/750 mg) when mixed with water of 300-900 ml at 37$^{\circ}C$. GAA showed a synergistic effect in the prevention of precipitate formation. This finding suggests that this DDB formulation may form less precipitation when DDB soft capsules disintegrate and diffuse into the gastrointestinal fluid, resulting in improving the bioavailability Dissolution rate of DDB (7.5 mg) from sort elastic capsules of DDB-GAA-PEG 300 system was rapid. The supersaturation state was maintained for 2 hr at the concentration of 7.35$\pm$3.3 mg in 900 ml of water without precipitation. The total amount of DDB dissolved from this new formulation was 5.3 and 6.1 times higher, when compared to marketed DDB tablets (25 mg) and capsules (7.5 mg), respectively.

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A Study on the bioactive surface modification of PEEK intervertebral fusion cage using various coating techniques (다양한 코팅 처리에 의한 PEEK 추간체유합보형재의 생체 활성 표면에 관한 연구)

  • Su-Bin Noh;Su-Zy Park;Mun-Hwan Lee
    • Journal of the Korean institute of surface engineering
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    • v.56 no.4
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    • pp.273-282
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    • 2023
  • In this study, the surface of Polyetheretherketone (PEEK) disks was modified to have a hydrophilic surface by applying a coating of Polyethylene glycol (PEG), Hyaluronic acid(HA), and Poly-Dopamine(PDA). The investigation aimed to examine whether the coated surfaces showed enhanced bioactivity for orthopedic applications compared to the pure PEEK. The microstructure, surface characteristics, and wettability of PEEK coated with PEG, HA, and PDA were analyzed using scanning electron microscopy(SEM), FT-IR spectrophotometer, Roughness Measurement System, Micro-Vickers, and Contact angle measurement. The mechanical properties were analyzed using a tensile testing machine, while the MTT assay for cell activity was analyzed using a microplate reader to measure optical density. According to the SEM and FT-IR results, the composition and crystal structure of PEG, HA and PDA coated surface were verified. Also, roughness, hardness, and contact angle were all improved in the coating group compared to the pure PEEK. We checked the HepG2 cell proliferation by using MTT assay on 7th days. In MTT assay results, HepG2 cell proliferation was increased with time, at 7 days, cell viability on discs coated with PDA was significantly higher than pure PEEK, PEG, HA coated group. PDA coated PEEK exhibited the highest surface roughness, hardness, contact angle, and cell activity. The mechanical properties were not affected by the presence of the coating.

Vacuum Casting of Mn-Zn Ferrite Powders Prepared by Alcoholic Dehydration Method (알콜탈수법에 의해 제조된 Mn-Zn Ferrite 미분체의 진공주입성형)

  • 이경직;이대희;김창현;이창섭;이석기;이병교
    • Journal of the Korean Ceramic Society
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    • v.34 no.11
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    • pp.1107-1112
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    • 1997
  • Mn-Zn ferrite powders prepared by an alcoholic dehydration method. Vacuum casting, a kind of wet forming process was examined with this powders. As binders, polyethylene glycol and polyvinyl alcohol were used. In order to estimate this conditions, fracture morphology, densities of green and sintered bodies and the microstructure were observed. High density and homogeneous microstructure in sintered bodies were obtained in the case of 0.1 wt% PEG or 0.5 wt% PVA.

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Encapsulation of Plasmid DNA in Liposomes: Preparation and Characterization

  • Park, Hyo-Min;Lee, Hwa-Jeong
    • Proceedings of the PSK Conference
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    • 2003.04a
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    • pp.300.2-300.2
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    • 2003
  • Unlike cationic liposome/DNA complexes, neutralliposomes containing plasmid DNA are stable in blood and does not selectively entrapped in the lung. The objective of this study was to construct neutral liposomes containing plasmid DNA with optimal encapsulation efficiency. Plasmid DNA (pGL2 clone 753,-6 kb) was encapsulated by the freeze/thawing method into liposomes composed of 1-palmitoyl-2-oleyl-sn-glycerol-3-phosphocholine(POPC), didodecyldimethylammonium bromide(DDAB), distaroylphosphatidyl-ethanolamine polyethylene glycol 2000(DSPE-PEG 2000) and DSPE-PEG 2000-maleimide. (omitted)

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Phase-Separation Properties of Poly(Ethylene Glycol) had Dextran Solutions In Microfluidic Device (미세 유체장치 내에서 Poly(Ethylene Glycol)과 Dextran 용액의 상 형성 특성 연구)

  • Choi, Joo-Hyung;Chang, Woo-Jin;Lee, Sang-Woo
    • Journal of Biomedical Engineering Research
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    • v.28 no.2
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    • pp.244-249
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    • 2007
  • Fluidic conditions for the separation of phases were surveyed in a microfluidic aqueous two-phase extraction system. The infusion ratio between polyethylene glycol (PEG) and dextran solution defines the concentrations of each polymer in micro-channel, which determine the phase-separation. The appropriate ratio between PEG (M.W. 8000, 10%, w/v) and dextran T500 (M.W. 500000, 5%, w/v) in order to perform the separation of phases of both polymers was observed as changing the mixed ratio of both polymers. Based on the fluidic conditions, stable two-phase solutions were obtained within 4% to 8% and 3% to 1% of PEG and dextran, respectively. In addition, the characteristics of the two-phase were discussed. The separation technique studied in the paper can be applied for the implementation of a lab-on-a chip which can detect various biological entities such cells, bacterium, and virus in an integrated manner using built in a biosensor inside the chip.

Dissolution Enhancement of Metoclopramide by Coprecipitation with Water-Soluble Carriers (수용성 담체와의 공침물 형성에 의한 메토클로프라미드의 용출 증가)

  • Yong, Jae-Ick;Jeong, Cha-Ok
    • Journal of Pharmaceutical Investigation
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    • v.18 no.2
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    • pp.43-47
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    • 1988
  • In order to increase the dissolution characteristics of relatively water-insoluble metoclopramide (MCP), coprecipitates of MCP with polyvinylpyrrolidone (PVP), polyethylene glycol (PEG) 1000, 4000 or 6000 were prepared in various drug to polymer ratios. The dissolution rate of MCP-PVP coprecipitate was greater than those of MCP alone, MCP-PVP physical mixture and MCP-PEG coprecipitates. The dissolution rate of MCP-PEG 6000 coprecipitate was greater than those of MCP-PEG 1000 and MCP-PEG 4000 coprecipitates. The dissolution half-lives $(T_{50%})$ for MCP alone and 1:5 (w/w) MCP-PEG 6000 coprecipitate were determined by the log-probit method at $37^{\circ}C$ and found to be 4.17 and 0.98 min, respectively.

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Performance of PEG on immobilization of zero valent metallic particles on PVDF membrane for nitrate removal

  • Chan, Yi Shee;Chan, Mieow Kee;Ngien, Su Kong;Chew, Sho Yin;Teng, Yong Kang
    • Membrane and Water Treatment
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    • v.9 no.1
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    • pp.1-7
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    • 2018
  • The principal objective of this study is to investigate the effect of Polyethylene Glycol (PEG) crosslinking in Polyvinylidene Fluoride (PVDF) in immobilization of Fe and bimetallic Fe/Cu and Cu/Fe zero valent particles on the membrane and its efficiency on removal of nitrate in wastewater. PVDF/PEG polymer solution of three weight compositions was prepared to manipulate the viscosity of the polymer. PEG crosslinking was indirectly controlled by the viscosity of the polymer solution. In this study, PEG was used as a modifier of PVDF membrane as well as a cross-linker for the immobilization of the zero valent particles. The result demonstrates improvement in immobilization of metallic particles with the increase in crosslinking of PEG. Nitrate removal efficiency increases too.