Journal of Pharmaceutical Investigation

The Korean Society of Pharmaceutical Sciences and Technology (한국약제학회)
권호 표지

Dissolution Enhancement of Metoclopramide by Coprecipitation with Water-Soluble Carriers

수용성 담체와의 공침물 형성에 의한 메토클로프라미드의 용출 증가

  • Yong, Jae-Ick (College of Pharmacy, Sookmyung Women's University) ;
  • Jeong, Cha-Ok (College of Pharmacy, Sookmyung Women's University)
  • 용재익 (숙명여자대학교 약학대학) ;
  • 정차옥 (숙명여자대학교 약학대학)
  • Published : 1988.06.20
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Abstract

In order to increase the dissolution characteristics of relatively water-insoluble metoclopramide (MCP), coprecipitates of MCP with polyvinylpyrrolidone (PVP), polyethylene glycol (PEG) 1000, 4000 or 6000 were prepared in various drug to polymer ratios. The dissolution rate of MCP-PVP coprecipitate was greater than those of MCP alone, MCP-PVP physical mixture and MCP-PEG coprecipitates. The dissolution rate of MCP-PEG 6000 coprecipitate was greater than those of MCP-PEG 1000 and MCP-PEG 4000 coprecipitates. The dissolution half-lives $(T_{50%})$ for MCP alone and 1:5 (w/w) MCP-PEG 6000 coprecipitate were determined by the log-probit method at $37^{\circ}C$ and found to be 4.17 and 0.98 min, respectively.

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