• Journal of the Computational Structural Engineering Institute of Korea
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• v.26 no.4
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• pp.223-231
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• 2013

This paper presents a time-domain Gauss-Newton full-waveform inversion method for the material profile reconstruction in heterogeneous semi-infinite solid media. To implement the inverse problem in a finite computational domain, perfectly-matchedlayers( PMLs) are introduced as wave-absorbing boundaries within which the domain's wave velocity profile is to be reconstructed. The inverse problem is formulated in a partial-differential-equations(PDE)-constrained optimization framework, where a least-squares misfit between measured and calculated surface responses is minimized under the constraint of PML-endowed wave equations. A Gauss-Newton-Krylov optimization algorithm is utilized to iteratively update the unknown wave velocity profile with the aid of a specialized regularization scheme. Through a series of one-dimensional examples, the solution of the Gauss-Newton inversion was close enough to the target profile, and showed superior convergence behavior with reduced wall-clock time of implementation compared to a conventional inversion using Fletcher-Reeves optimization algorithm.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.26 no.4
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• pp.213-221
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• 2013

This paper introduces a mesh continuation scheme for a one-dimensional inverse medium problem to reconstruct the spatial distribution of elastic wave velocities in heterogeneous semi-infinite solid domains. To formulate the inverse problem, perfectly-matched-layers(PMLs) are introduced as wave-absorbing boundaries that surround the finite computational domain truncated from the originally semi-infinite extent. To tackle the inverse problem in the PML-truncated domain, a partial-differential-equations(PDE)-constrained optimization approach is utilized, where a least-squares misfit between calculated and measured surface responses is minimized under the constraint of PML-endowed wave equations. The optimization problem iteratively solves for the unknown wave velocities with their updates calculated by Fletcher-Reeves conjugate gradient algorithms. The optimization is performed using a mesh continuation scheme through which the wave velocity profile is reconstructed in successively denser mesh conditions. Numerical results showed the robust performance of the mesh continuation scheme in reconstructing target wave velocity profile in a layered heterogeneous solid domain.

• Journal of KIISE:Software and Applications
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• v.32 no.10
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• pp.949-955
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• 2005

In this Paper, we propose fast block matching algorithm by dividing complex areas based on complexity order of reference block and square sub-block to reduce an amount of computation of full starch(FS) algorithm for fast motion estimation, while keeping the same prediction quality compared with the full search algorithm. By using the fact that matching error is proportional to the gradient of reference block, we reduced unnecessary computations with square sub-block adaptive matching scan based image complexity instead of conventional sequential matching scan and row/column based matching scan. Our algorithm reduces about $30\%$ of computations for block matching error compared with the conventional partial distortion elimination(PDE) algorithm without any prediction quality, and our algorithm will be useful in real-time video coding applications using MPEG-4 AVC or MPEG-2.

• 한국가스학회:학술대회논문집
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• 2003.10a
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• pp.120-125
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• 2003

본 연구는 원자력 발전소에 있는 방화벽의 케이블 관통부위에 설치된 CPFS(Cable Penetration Fire Stop)시스템 안에서 일어나는 동적열전달 현상을 3 차원으로 나타낼 수 있는 시험시뮬레이터에 사용될 수학적 모델과 수치계산 알고리즘의 개발에 관한 것이다. CPFS 내에서 일어나는 열전도 현상을 나타내는 지배방정식은 주어진 조건들 하에서 포물선형 편미분방정식(Parabolic PDE)으로 나타난다. 문제를 단순화하기 위해 열의 흐름을 두 성분으로 나누었다 즉, 케이블과 평행한 선을 따라서 일어나는 열전도와 벽면과 평행한 평면 위에서 일어나는 열전도로 나누었다. 먼저 선을 따라 일어나는 동적 열전도 현상을 나타내는 PDE를 연속과완화(SOR: Successive Over-Relaxation)를 적용하여 유한한 불연속점들에 대한 연립 상미분방정식(ODE)으로 전환했고, 그 연립방정식은 ODE Solver 를 이용하여 풀 수 있었다. 둘째로, 각 불연속 점에 위치한 평면 위에서 일어나는 열전도를 계산하기 위해서, 유한요소의 합을 근사식으로 이용하여 PDE를 ODE로 전환해서 계산하는 유한요소법(Finite Element Method)이 이용된다. 여기서 시간과 공간의 함수 T(x, y, z, t)인 온도는 각 선의 점들과 각 평면의 요소들에 대해서 일정한 시간간격으로 초기온도와 경계온도를 업데이트하여 계산을 반복한다. 이러한 일련의 계산결과를 바탕으로 CPFS 시스템 내에서의 온도분포의 동적인 변화를 해석한다. 결론적으로 관통하는 케이블이 CPFS 시스템의 온도분포에 매우 중요한 역할을 한다는 것을 알 수 있다. 시뮬레이션 결과는 CPFS 내의 온도분포를 쉽게 이해할 수 있도록 3 차원 그래픽으로 나타냈으며, 상용소프트웨어 FEMLAB 으로 계산한 결과와 비교해서 개발된 모델과 계산 알고리즘의 정당성을 보였다. 맞이하고 있음을 볼 수 있다. 국내광업이 21C 급변하는 산업환경에 적응하여 생존하기 위해서는 각종 첨단산업에서 요구하는 소량 다품종의 원료광물을 적기에 공급 할 수 있는 전문화된 기술력을 하루속히 확보해야 하며, 이를 위해 고품위의 원료광물 확보를 위한 탐사 및 개발을 적극 추진하고 가공기술의 선진화를 위해 선진국과의 기술제휴 등 자원산업 글로벌화 정책이 절실히 요구되고 있음을 알 수 있다. 또한 삶의 질을 향상시키려는 현대인의 가치관에 부합하기 위해서는 각종 소비제품의 원료를 제공하는 광업의 본래 목적 이외에도 자연환경 훼손을 최소화하며 개발 할 수밖에 없는 구조적인 어려움에 직면할 수밖에 없다. 이처럼 국내광업이 안고 있는 여러 가지 난제들을 극복하기 위해서는 업계와 정부가 합심하여 국내광업 육성의 중요성을 재인식하고 새로운 마음가짐으로 관련 정책을 수립 일관성 있게 추진해 나가야 할 것으로 보인다.의 연구 결과를 요약하면 다음과 같다. 첫째, 브랜드 이미지와 서비스 품질과의 관계에서 브랜드이미지는 서비스 품질의 선행변수가 될 수 있음을 증명하였으며 4개 요인의 이미지 중 사풍이미지를 제외한 영업 이미지, 제품 이미지, 마케팅 이미지가 서비스 품질에 영향을 미치고 있음을 알 수 있다. 둘째, 지각된 서비스 품질과 가격 수용성과의 관계에서, 서비스 품질은 최소 가격에 신뢰서비스 요인에서 정의 영향을 미치고 있으나 부가서비스, 환경서비스에서는 역의 영향을 미침을 알수 있고, 최대 가격에 있어서는 욕구서비스 요인은 정의 영향을 미치지만 부가서비스의 경우에는 역의 영향을 미치고 있음을 알 수 있다. 셋째, 서비스품질과 재 방문 의도와의 관계에 있어서 서비스품질은 재 방문 의도에 영향을 미침을 알 수 있다. 따라서 브랜드 이미지는 서비스품질의 선행변수가 될 수 있으며, 서비스품질은 가격 수용성과 재방문 의도에 영향을 미치고 있음을 알 수

• Korean Journal of Pharmacognosy
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• v.41 no.3
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• pp.216-220
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• 2010

Obesity is an important risk factor that significantly increases mortality and disease rates in the cardiovascular disease, diabetes, and various diseases. So far, the most powerful way to inhibit fat absorption is pancreatic lipase inhibitors. In this study, we investigated the anti-obesity effect of the extract of Juniperus rigida. Juniperus rigida extract (JRE) had a inhibitory effect on pancreatic lipase activity ($IC_{50}$=8.63 ${\mu}g$/ml). In in vivo oil-emulsion loading test, this extract also inhibited the intestinal fat absorption. In addition, we measured inhibitory effects of JRE on activity of phosphodiesterase (PDE) and hormone sensitive lipase (HSL) among the important enzymes associated with lipolysis. JRE strongly inhibited PDE activity ($IC_{50}$=4.56 ${\mu}g$/ml), whereas inhibitory effect on HSL activity was very weak compared with orlistat. As a result, JRE inhibited the absorption of fat by inhibiting the activity of pancreatic lipase and induced lipolysis through inhibition of PDE activity. Therefore, we suggest that Juniperus rigida may be a potential therapeutic agent improving obesity.

• Archives of Pharmacal Research
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• v.23 no.4
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• pp.332-337
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• 2000

This study describes the synthesis, in vitro evaluation and molecular modeling study of novel compounds for the inhibition of TNF-$\alpha$production, Among these compounds, 2-[3-(cyclopentyloxy)-4-methoxyphenyl]-1-isoindolinone (9) was selected as a lead compound and its pyridine derivative 10 was more potent in activity and safer than rolipram.

• Structural Engineering and Mechanics
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• v.4 no.6
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• pp.589-600
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• 1996

An explicit 4th order time integration scheme for solving the convection-diffusion equation is discussed in this paper. A system of ordinary differential equations are derived first by discretizing the spatial derivatives of the relevant PDE using the finite difference method. The integration of the ODEs is then carried out using a 4th order scheme and a self-adaptive technique based on the spatial grid spacing. For a non-uniform spatial grid, different time step sizes are used for the integration of the ODEs defined at different spatial points, which improves the computational efficiency significantly. A numerical example is also discussed in the paper to demonstrate the implementation and effectiveness of the method.

• Journal of Environmental Science International
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• v.21 no.5
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• pp.563-572
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• 2012

Unlike water applications, the photocatalytic technique utilizing light-emitting-diodes as an alternative light source to conventional lamp has rarely been applied for low-level indoor air purification. Accordingly, this study investigated the applicability of UV-LED to annular-type photocatalytic reactor for removal of indoor-level benzene and toluene at a low concentration range associated with indoor air quality issues. The characteristics of photocatalyst was determined using an X-ray diffraction meter and a scanning electron microscope. The photocatalyst baked at $350^{\circ}C$ exhibited the highest photocatalytic degradation efficiencies(PDEs) for both benzene and toluene, and the photocatalysts baked at three higher temperatures(450, 550, and $650^{\circ}C$) did similar PDEs for these compounds. The average PDEs over a 3-h period were 81% for benzene and close to 100% for toluene regarding the photocatalyst baked at $350^{\circ}C$, whereas they were 61 and 74% for benzene and toluene, respectively, regarding the photocatalyst baked at $650^{\circ}C$. As the light intensity increased from 2.4 to 3.5 MW $cm^{-1}$, the average PDE increased from 36 to 81% and from 44% to close to 100% for benzene and toluene, respectively. In addition, as the flow rate increased from 0.1 to 0.5 L $min^{-1}$, the average PDE decreased from 81% to close to zero and from close to 100% to 7% for benzene and toluene, respectively. It was found that the annular-type photocatalytic reactor inner-inserted with UV-LEDs can effectively be applied for the decomposition of low-level benzene and toluene under the operational conditions used in this study.

• Biomolecules & Therapeutics
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• v.27 no.1
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• pp.101-106
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• 2019

Most diabetic patients experience diabetic mellitus (DM) urinary bladder dysfunction. A number of studies evaluate bladder smooth muscle contraction in DM. In this study, we evaluated the change of bladder smooth muscle contraction between normal rats and DM rats. Furthermore, we used pharmacological inhibitors to determine the differences in the signaling pathways between normal and DM rats. Rats in the DM group received an intraperitoneal injection of 65 mg/kg streptozotocin and measured blood glucose level after 14 days to confirm DM. Bladder smooth muscle contraction was induced using acetylcholine (ACh, $10^{-4}M$). The materials such as, atropine (a muscarinic receptor antagonist), U73122 (a phospholipase C inhibitor), DPCPX (an adenosine $A_1$ receptor antagonist), udenafil (a PDE5 inhibitor), prazosin (an ${\alpha}_1$-receptor antagonist), papaverine (a smooth muscle relaxant), verapamil (a calcium channel blocker), and chelerythrine (a protein kinase C inhibitor) were pre-treated in bladder smooth muscle. We found that the DM rats had lower bladder smooth muscle contractility than normal rats. When prazosin, udenafil, verapamil, and U73122 were pre-treated, there were significant differences between normal and DM rats. Taken together, it was concluded that the change of intracellular $Ca^{2+}$ release mediated by PLC/IP3 and PDE5 activity were responsible for decreased bladder smooth muscle contractility in DM rats.

• Journal of Life Science
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• v.28 no.2
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• pp.162-169
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• 2018

Many cytoplasmic proteins are targeted to the cytoplasmic membrane of the trans-Golgi network (TGN) via an N-terminal short helix. We previously showed that the 20 N-terminal amino acids of Aplysia phosphodiesterase 4 (ApPDE4) long form are sufficient for its targeting to the plasma membrane and the TGN. The N-terminus of the ApPDE4 long form binds to PI4P and sulfatide in vitro. Therefore, in order to decipher the roles of sulfatide in Golgi complex targeting, we examined the cellular localization of sulfatide-binding peptides. In this study, we found that enhanced green fluorescent protein (EGFP) fused to the C-terminus of modified sulfatide- and heparin-binding peptides (mHSBP-EGFP) was localized to the TGN. On the other hand, its mutant, in which tryptophan was replaced with an alanine, leading to the impairment of heparin and sulfatide binding, was localized to cytosol. We also found that the TGN targeting of mHSBP-EGFP is impaired by the treatment of antimycin A, phenylarsine oxide (PAO), and adenosine but not a high concentration of wortmannin. These results suggest that PAO and adenosine-sensitive kinases, including phosphatidylinositol 4-kinase II, may play key roles in the recruitment of mHSBP-EGFP.