• Archives of Pharmacal Research
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• 제29권12호
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• pp.1114-1118
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• 2006

(+)-Eudesmin [4,8-bis(3,4-dimethoxyphenyl)-3,7 -dioxabicyclo[3.3.0]octane] was isolated from the stem bark of Magnolia kobus DC. var. borealis Sarg. and found to have neuritogenic activity. $50\;{\mu}M$ (+)-eudesmin induced neurite outgrowth and enhanced nerve growth factor (NGF)-mediated neurite outgrowth from PC12 cells. At this concentration, (+)-eudesmin also enhanced NGF-induced neurite-bearing activity and this activity was partially blocked by various protein kinase inhibitors. These included PD98059, a mitogen-activated protein kinase (MAPK) kinase inhibitor. GF109203X, a protein kinase C (PKC) inhibitor and H89, a protein kinase A (PKA) inhibitor. These results suggest that (+)-eudesmin can induce neurite outgrowth from PC12 cells by stimulating up-stream MAPK, PKC and PKA pathways.

• Journal of Electrical Engineering and Technology
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• 제1권4호
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• pp.528-533
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• 2006

Electrical discharges may occur in gas, liquid as well as solid insulating materials. This paper describes the investigation results on the discharges in air, silicone oil and low density polyethylene (LDPE) using needle plane electrode system under AC voltage of 50 Hz. The experimental results showed that for discharge in air (corona), discharge pulses were concentrated around the peak of applied voltage at negative half cycle. For silicone oil positive as well as negative discharges were observed which concentrated around the peak of applied voltage. The positive pulse number was smaller but the magnitude was higher than that of negative discharge. Discharges in void took place at wider range of phase of applied voltage. The unbalance in pulse number and magnitude similar to that of oil discharges were observed. For electrical treeing in LDPE, the discharges were spread before the zero cross of the applied voltage up to the peak at both positive and negative half cycles. The discharge pulse sequence analysis indicated that the PD occurrence in air, oil and void were strongly affected by the magnitude of applied voltage. However, for electrical treeing it was observed that the discharge occurrence was strongly affected by the time derivative of the applied voltage (dv/dt).

• 전자공학회논문지A
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• 제28A권9호
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• pp.721-728
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• 1991

In this paper, a magneto-optic modulator has been designed by using single crystal BSO and polycrystal ZnSe as Faraday cells. And practical core-type optical current sensors using pure iron and permalloy have been prepared and experimented. In order to obtain efficient magnetic field detection, LED(NEC OD08358, 0.87 $\mu$m) was used as optical source, PIN-PD(OD-8454)as optical receiver and multi-mode optical fiber (100/140$\mu$m) as transmission line. The characteristics matrix of the optical element was calculated by Stokes parameter, and optic modulation characteristics equations were derived by Muller matrix. Electromagnetic analysis program (FLUX 2D, micro VAX 3600) by finite element method was used to find the magnetic flux density around the core. The measuring error of the output voltage to input current has been masured below 5% in the range of 50A to 1000A. As the temperature was changed from -20$^{\circ}C$ to 60$^{\circ}C$, the maximum measurement error of the optical output has been found to be 0.5% at 60$^{\circ}C$. These experimental results show good temperature and linearity characteristics. The SNR of the overall system was 47dB in case of 600A (250.2 Oe) conductor current and the system has good noise immunity.

• International Journal of Air-Conditioning and Refrigeration
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• 제8권1호
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• pp.50-61
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• 2000

The effects of an inserted coil on flow . patterns and heat transfer performance for a horizontal rotating heat pipe have been studied experimentally. Especially, the present study is to see an internally inserted helical coil inside a RHP would lead to the same kind of results as internal fins. Visualization test conducted for an acryl tube, charged water with at a volumetric rate of 20%. When the flow kept pool regime at a low rpm(less than 1,000rpm), the movement of coil forced the water to flow in axial direction. But this pumping effect of coil disappeared, when the pool regime changed to annular one which could be created by increasing rpm. The pumping effects for RHP with an inserted coil resulted in the enhancement in both condensation heat transfer coefficient and heat transport limitation, as obtained in case of using internal fins. But all these effects became negligible in the range of higher rpm(above 1,000-1,200) with the transition of flow regime to annular flow.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 2003년도 춘계학술대회 논문집 센서 박막재료 반도체 세라믹
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• pp.219-222
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• 2003

$0.2(PbMg_{1/3}Nb_{2/3}O_3)-0.8(PbZr_{0.475}Ti_{0.525}O_3)$ 조성을 이용하여 $5{\times}5{\times}5mm^3$의 적층형 세라믹 액츄에이터 소자를 tape casting 방법으로 제작하였다. 전극재로서는 Ag-Pd를 이용하여 총 50층의 layer를 적층하였으며, 적층된 액츄에이터를 $1100^{\circ}C$의 온도에서 소결하였다. X-ray diffractometer를 이용하여 제작된 소자와 열화된 소자의 구조적인 특성을 분석하였다. 제작된 소자의 열화 특성을 알아보기 위하여 60 Hz 의 triangular wave를 인가하여 열화전과 후의 p-E hystcresis loop의 변화를 살펴보았으며, 인가된 전압의 변화에 따라서 소자에서 발생되는 양의 열을 측정하였다. 파괴된 소자의 파단면에 대한 SEM 분석을 통하여 소자의 파괴 메카니즘을 알아보도록 하였다. 이로부터 전기적 기계적 열화가 소자의 동작에 미치는 영향에 대해서 알아 보았다.

• 센서학회지
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• 제14권2호
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• pp.63-68
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• 2005

The nano-grained Pd or Pt-doped $SnO_{2}$ thin films were deposited on the alumina substrate at ambient temperature or $300^{\circ}C$ by using an R.F. magnetron sputtering system and then annealed at $650^{\cir}C$ for 1 hour or 4 hours in air. The crystallinity and microstructure of the annealed films were analyzed. A grain size of the thin films was 30 nm to 50 nm. As a result of gas sensitivity measurements to an alcohol vapor of $36^{\circ}C$, the 2 wt.% Pt-doped $SnO_{2}$ thin-film sensor deposited at $300^{\circ}C$ and annealed at $650^{\circ}C$ for 4 hours showed the highest sensitivity.

• Molecular & Cellular Toxicology
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• 제2권1호
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• pp.15-20
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• 2006

Genistein is a potent, plant-derived isoflavone that displays estrogenic activity at low concentrations but inhibits proliferation at high amounts. However, the molecular mechanism of genistein is not completely understood. In the present study, the biphasic effects (estrogenic and antiestrogenic activity) of genistein on the growth of MCF-7 cells were identified. Genistein within a low range of concentration, $1-10\;{\mu}M$, stimulated proliferation, while $50-100\;{\mu}M$ caused apoptotic cell death. Additionally, genistein at a low concentration induced estrogen receptor (ER)-mediated gene expression and ER phosphorylation. When pre-treated with PD98059, an MEK inhibitor, ER-mediated gene expression and ER phosphorylation by genistein were noticeably increased. However, the increased gene expression and phosphorylation did not enhance cell proliferation. Moreover, it was observed that ER-mediated signaling performs an important role in the MAPK pathway. The proliferation and apoptosis in genistein-treated MCF-7 cells were partially dependent on the Bcl-2 level. The addition of IC1 182, 780, an estrogen receptor antagonist, inhibited Bcl-2 expression induced by genistein. This study suggests that there is a close relationship between Bcl-2 and the ER signaling pathways in MCF-7 cells.

• 대한건축학회논문집:계획계
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• 제34권5호
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• pp.39-50
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• 2018

The purpose of this study was to examine the diverse situations and housing related consciousness affecting baby boom generation's housing and to propose new possible housing alternatives for Korean baby boom generation for their old ages. Surveys were used to conduct 1:1 interviews with the baby boom generation. This study analysed the baby boom generation's housing related consciousness regarding living in old age with/apart from their children, sense of responsibility to their children and parents, expectations of support from their children in old age, current preparedness for old age, reasons for difficulties in realizing plans for housing in old age, and housing values in old age in order to examine this generation's diverse view in relation to preparations for housing in old age. Based on the results of the analysis of variables of housing consciousness in relation to old age by each characteristic of the baby boom generation conducted in investigations of the present study thus explained, housing alternatives in old age were 1)family exchange-type housing in old age 2) multihabitation-type housing in old age 3) housing in old-age with workplaces.

• 대한건축학회논문집:계획계
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• 제34권6호
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• pp.127-134
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• 2018

The purpose of this study is to derive a model of urban regeneration business using idle facilities in the old city center. The scope of the study was set as empty houses and empty stores owned by private companies, and analyzed the 50 central city revitalization projects using idle facilities in 14 local cities in Japan. The results of this study are follows; First, as an urban regeneration strategy using idle facilities in the old town, it was a combination of other functions centering on commercial functions or introducing new functions required in the city center. Second, various financial supports have been provided to induce the utilization of idle facilities by the private sector, and different strategies have been implemented for businesses that need maintenance first. Third, based on the analysis results, it was possible to derive urban regeneration business model. Fourth, in order to operate smooth business, it is a need for an organization that is in charge of reviewing the consistency of upper-level planning and urban guiding functions such as urban revitalization plan, balance review of expenditure and revenues by cost subsidy and loan repayment, consultation among the business partners.

• 대한건축학회논문집:계획계
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• 제34권8호
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• pp.43-50
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• 2018

The purpose of this study is to analyze the effect of architectural attributes on operating revenue by concentrating on the facility side and to investigate how much individual architectural factors can affect operating revenue. The time range of this study is limited to 2015, and the spatial range is limited to a tourist hotel in Seoul that can be easily surveyed and verified. The analysis method is to confirm the significance and influence of each attribute through regression analysis. According to the results, The room part such as number of rooms or area showed a relatively low correlation with "revenue per available room (Rev.PAR)" than "average daily rate (ADR)", but showed a high correlation with non - architectural attributes such as auxiliary facilities and chain. This shows that factors that influence the operating profit of hotel are not the part of the room but the other factors such as the auxiliary facilities work more. In addition, the presence of spa and the number of auxiliary facilities in the hotel have a positive effect on the operating profit of the hotel due to the non - architectural attributes. This is expected to provide a new direction for future research in studying hotel facilities.