• The Korean Journal of Nuclear Medicine
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• v.37 no.6
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• pp.393-401
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• 2003

Objective: Pullulan derivatives (PD) can be used to make self-assembled hydrogel nanoparticles which are responsive to ionic strength. The aim of this study is to evaluate the potential of PD as a retaining carrier of radioisotope inside tumors. Materials and Methods: Four types of PD were evaluated which included pullulan acetate (PA), succinylated PA (SPA), PA-DTPA and SPA-DTPA conjugates. They were radiolabeled with Tc-99m. Labelling efficiencies were determined at 30 min, 1, 2, 4 and 12 hours after radiolabeling. CT-25 colon cancer cells were subcutaneously injected into Balb/c mice. After 2 weeks of subcutaneous injection, Tc-99m-labelled PD (Tc-99m-PD) were injected into the tumors. Whole body images of mice were obtained at 30 min, 1, 2, and 12 hr after intratumoral injection. All twenty mice were grouped into four groups by largest diameter; control A (largest diameter = 5 mm, n = 5), control B (largest diameter = 10 mm, n = 5), pullulan A (largest diameter = 5 mm, n = 5), pllulan B (largest diameter = 10 mm, n = 5). Dynamic images were obtained for 1 hour after intratumoral injection. Static images were obtained at 1 hr, 2 hr, 3 hr and 4 hr after intratumoral injection with Tc-99m pertechnetate and Tc-99m-PA. Target-to-background ratios and retention rates were calculated. Results: Labeling efficiencies of PA, SPA, PA-DTPA and SPA-DTPA were $94.5{\pm}5.9%,\;97.8{\pm}3.5%\;94.2{\pm}3.8%,\;and\;92.5{\pm}6.2%$, respectively (p>0.05). Percent retention rates (%RR) of PA and PA-DTPA were significantly higher than those of control, however, those of SP-DTPA and SPA became similar to control at 4 and 12 hr, respectively. %RR of pullulan A and pullulan B at 1, 4 and 8 hr is significantly higher than that of control (p < 0.05). However, %RR between pullulan A and pullulan B were similar. Conclusion: The lonic strength dependent PD-nanoparticles are retained in the tumor. No difference of %RR according to tumor size was noted. Therapeutic application of PD labelled with beta- or alpha- emitting radionuclides can be expected.

• Journal of the Korea Society of Computer and Information
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• v.26 no.9
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• pp.155-166
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• 2021

Recently, digital health care technology is spreading and developing in various fields. Therefore, in this paper, we realized that the field to which digital healthcare technology is not applied is the field of optometry, and implemented a digital healthcare optometry system for precise lens manufacturing. A device called Phoroptor is used to manufacture the lens, and this device sets the lens by measuring the visual acuity of the person who requested the glasses. And when the person to be measured wears glasses, a device called a PD meter is used to align the pupil center and lens focus. However, there is a limit to the convenience of precise lens production and optometry due to the absence of a database and program that can accumulate and analyze the PD measurement error, inconvenience and error due to manual control of the Phoroptor, and optometric information. Therefore, in this paper, PD meter design for more accurate PD measurement, Phoroptor design and Phoroptor control application design for automatic Phoroptor control, and a database and analysis program that automatically set lenses using optometry information for each subject had been designed. Based on this, ultimately, a digital healthcare optometry system using an optometry database has been implemented.

• Transactions of the Korean Society of Machine Tool Engineers
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• v.16 no.2
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• pp.1-7
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• 2007

Active magnetic bearing has been adopted to support the rotor by electomagnetic force without mechanical contact and lubrication process. A property of the control system for magnetic bearing is improved in accordance with making higher system gain. If the control system has integral part, an excessive overshoot response is shown by making higher integral gain. Therefore, this paper suggests a PID control system in order to eliminate the overshoot at the first stage and improve response characteristics to an impact disturbance at the status of levitation. The control gain was obtained by LQR design method which has the structure of I-PD control system in the state space. The PID control system containing prefilter has the same structure as the I-PD control system. Therefore, the PID control system adopted is able to be tuned by LQR design method. Finally, this paper shows the effect of the prefilter on the active magnetic bearing system through response experiments for levitation responses.

• 제어로봇시스템학회:학술대회논문집
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• 2005.06a
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• pp.1911-1916
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• 2005

In this study, the basic motor control system had been investigated. The Discrete-Time Feedback Error Learning (DTFEL) method is used to control this system. This method is anologous to the original continuous-time version Feedback Error Learning(FEL) control which is proposed as a control model of cerebellum in the field of computational neuroscience. The DTFEL controller consists of two main parts, a feedforward controller part and a feedback controller part. Each part will deals with different control problems. The feedback controller deals with robustness and stability, while the feedforward controller deals with response speed. The feedforward controller, used to solve the tracking control problem, is adaptable. To make such the tracking perfect, the adaptive law is designed so that the feedforward controller becomes an inverse system of the controlled plant. The novelty of FEL method lies in its use of feedback error as a teaching signal for learning the inverse model. The PD control theory is selected to be applied in the feedback part to guarantee the stability and solve the robust stabilization problems. The simulation of each individual part and the integrated one are taken to clarify the study.

• Biomolecules & Therapeutics
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• v.27 no.1
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• pp.63-70
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• 2019

Myeloid-derived suppressor cells (MDSCs) that are able to suppress T cell function are a heterogeneous cell population frequently observed in cancer, infection, and autoimmune disease. Immune checkpoint molecules, such as programmed death 1 (PD-1) expressed on T cells and its ligand (PD-L1) expressed on tumor cells or antigen-presenting cells, have received extensive attention in the past decade due to the dramatic effects of their inhibitors in patients with various types of cancer. In the present study, we investigated the expression of PD-1 on MDSCs in bone marrow, spleen, and tumor tissue derived from breast tumor-bearing mice. Our studies demonstrate that PD-1 expression is markedly increased in tumor-infiltrating MDSCs compared to expression in bone marrow and spleens and that it can be induced by LPS that is able to mediate $NF-{\kappa}B$ signaling. Moreover, expression of PD-L1 and CD80 on $PD-1^+$ MDSCs was higher than on $PD-1^-$ MDSCs and proliferation of MDSCs in a tumor microenvironment was more strongly induced in $PD-1^+$ MDSCs than in $PD-1^-$ MDSCs. Although we could not characterize the inducer of PD-1 expression derived from cancer cells, our findings indicate that the study on the mechanism of PD-1 induction in MDSCs is important and necessary for the control of MDSC activity; our results suggest that $PD-1^+$ MDSCs in a tumor microenvironment may induce tumor development and relapse through the modulation of their proliferation and suppressive molecules.

• Journal of Institute of Control, Robotics and Systems
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• v.8 no.9
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• pp.747-756
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• 2002

The automatic steering system for unmanned vehicle was developed. The magnet and MR (Magnetoresistive) sensors are used for the tue detecting system. The lateral distance between sensor and the center line of the road is determined by the linearization of the distance according to the output. The PD control theory is used for the design of the controller to compare with $H_\infty$ control theory. The $H_\infty$ control theory is used for the design of the controller to reduce the disturbance. The performance of the PD controller and $H_\infty$ controller is compared in simulations and tests. The PD controller is easy to tune in the test site. The $H_\infty$ controller is robust far the disturbances in the test results.

• 제어로봇시스템학회:학술대회논문집
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• 1991.10b
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• pp.1956-1960
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• 1991

This paper describes the measured results upon monochromatic light, compound light, and light emanated from light emitting diodes by a simplified wavemeter with a semiconductor color sensor. Since a single unit element of a semiconductor color sensor with two PN junction photodiodes has been developed, the author has fabricated the simplified wave detector by using the element. The simplified wive detector has been measured results upon monochromatic light, compound light, and light emanated from light emitting diodes. Since luminescent color of each diode locates in luminosity region, comparison of measured values of PD-150 and PD-151 resulted no remarkable difference in averaged wave length. As for monochromatic light, PD-151 showed very cross value to the color filter peak value rather than PD-150. As for compound light, PD-150 has shown such influence of long wave length light which reaches to near infrared ray with respect to PD-151.

• 한국신재생에너지학회:학술대회논문집
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• 2009.06a
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• pp.395-398
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• 2009

전기도금 방법을 사용해 각기 다른 환원 전압과 전기도금시간에서 Pd 수지상 나노와이어(Pd DNWs) 전극이 합성 되었으며 그 성장 기작을 논의하였다. 전기화학적인 도금 공정 동안 Pd DNWs 이<111>방향으로 성장하는 것을 확인할 수 있었는데, 이것은 전해질 속의 황산음이온들이 Pd 의 (111)면에 흡착하기 유리하기 때문이라고 사료된다. 가해준 환원전압이 증가함에 따라, 단 결정 수지상의 나노와이어의 가지는 길어지고 얇아지는 경향을 보였다. 이것은 전기도금 시간이 아니라 환원전압에 의해서만 나노와이어 가지의 직경이 조절됨을 보여준다

• Journal of Microbiology and Biotechnology
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• v.18 no.8
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• pp.1439-1444
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• 2008

The recombinant E. coli $\Delta$6 mutant (galR, glpK, gldA, IdhA, lacI, tpiA) was used to produce 1,3-propanediol (PD) from glucose. The 1,3-PD production increased with feedback control of the glucose concentration using fed-batch fermentation. The maximum 1,3-PD concentration produced was 43 g/l after 60 h of fermentation. Glycerol production was minimized when controlling the glucose concentration at less than 1 g/l. The expression levels of seven enzymes related to the 1,3-PD production metabolism were compared during the cell growth phase and 1,3-PD production phase, and their expression levels all increased during 1,3-PD production, with the exception of alcohol dehydrogenase.

• Journal of the Korean Society of Food Science and Nutrition
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• v.30 no.6
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• pp.1158-1163
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• 2001

This study was carried out to investigate the effect of ethanol extract of Pinus densiflora (PD) on the growth of lactic acid bacteria (LAB), A-1, B-9, K-7, M-7 isolated from kimchi. The growth of isolated LAB was inhibited significantly in the modified MRS broth containing 40 mg/mL PD ethanol extract. Ethyl acetate fraction showed the strongest antimicrobial activities against LAB strains compared to other fractions. The addition of PD ethanol extract to kimchi did not change the pH of kimchi greatly compare with the control during the fermentation for 25 days. Change of titratable acidity in control was more higher than in the PD ethanol extract added kimchi during fermentation. The growth of total bacteria and LAB was inhibited about 1 to 2 log cycle by the addition of PD ethanol extract during the kimchi fermentation for 25 days at 1$0^{\circ}C$. Sensory quality of PD ethanol extract added kimchi was lower than that of control.