• Journal of the Korea Society for Simulation
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• v.15 no.2
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• pp.23-29
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• 2006

This paper studies the Internet stream server which serves multimedia stream services such as VoD and MoD. The Internet multimedia stream server is developed to provide 50 users with continuous multimedia stream contents simultaneously. This paper focuses on introducing design concepts, operation details and on evaluating system performance and doing sensitivity analysis with respect to the change of the system components. The performance evaluation is performed using simulation in order to identify the system component that mostly affects the system performance. The sensitivity analysis shows the service delay rates of the multimedia stream server depending on the user's service request pattern. Also, the analysis is made on the utilization rates of the core system components such as the PCI bus and the Ethernet card, and on the system performance change by adding more system components.

• The Journal of Internal Korean Medicine
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• v.44 no.3
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• pp.387-401
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• 2023

Objective: This study was conducted to investigate the preventive effect of herbal medicines on restenosis after percutaneous coronary intervention (PCI) by reviewing randomized controlled trials (RCTs). Methods: RCTs were searched for herbal medicine treatment after PCI using eight online databases (PubMed, CNKI, Wanfang, J-STAGE, OASIS, ScienceON, KTKP, and KISS). Studies that confirmed restenosis through coronary angiography at follow-up were selected according to the inclusion and exclusion criteria. The primary outcome was the restenosis rate, and the secondary outcome was the angina recurrence rate. Data were extracted from the final selected studies according to the research methodology and then analyzed with Review Manager 5.4.1. Study quality was assessed using Cochrane's risk-of-bias (RoB) tool. Results: Of the 252 papers obtained through the primary search, nine studies that met the selection criteria were finally selected. In these nine studies, herbal medicine combined with western medicine was used for the experimental group, and western medicine treatment was used alone for the control group. The meta-analysis result revealed that the restenosis rate and angina recurrence rate were significantly lower in the experimental group than in the control group (RR=0.34, 95% CI: 0.22-0.53, p<0.00001, I²=0% and RR=0.47, 95% CI: 0.29-0.78, p=0.004, I²=0%, respectively). Furthermore, the quality of studies assessed by Cochrane's RoB was low. Conclusions: This study showed that the combined treatment of herbal medicine and western medicine was effective in preventing restenosis and angina after PCI. As the number of papers included in this study was small, a large number of high-quality clinical studies should be considered in the future.

• Bulletin of the Korean Space Science Society
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• 2010.04a
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• pp.29.2-29.2
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• 2010

항법분야에 있어서 위성항법시스템의 다양한 오차를 제거한 정밀한 위치 정보를 이용하여 이동체에 활용하는 연구가 진행되고 있다. 실제 환경에서 이동체를 이용한 항법실험을 수행하기 전 실제 환경과 유사한 가상의 실시간 테스트베드를 구축하여 알고리즘 테스트 및 검증 실험을 수행하려 한다. 이를 위해 이동체의 운동을 시뮬레이션하는 운동궤적제어시스템과 실제의 항법신호를 시뮬레이션하는 GNSS 시뮬레이터 사이의 시각동기화는 실시간 시뮬레이션을 구현하기 위해 필수적으로 요구된다. 동기화 되지 않은 시각정보는 이동체 운동궤적제어시스템에 의해 생성된 실제의 궤적과 GNSS 시물레이터로부터 생성된 궤적사이의 오차를 유발하여 항법수신기의 부정확한 항법신호를 유발한다. 이 연구는 GNSS 시뮬레이터를 이용한 실시간 테스트베드의 구축에 있어 필요한 이동체 운동궤적의 시각동기화 기술 개발을 목표로 한다. GNSS 시뮬레이터는 Spirent 사의 GPS 시뮬레이터가 사용되었다. 이동체의 위치, 속도, 가속도와 같은 움직임을 나타내는 운동에 관한 명령은 적용되어야 하는 정확한 시각이 함께 전송되므로, 이는 그 시각 이전에 GPS 시뮬레이터에 도달해야 한다. 따라서 1초(1 Hz) 또는 0.1초(10 Hz) 사이에 원격제어시스템과 GPS 시뮬레이터사이의 시각 동기화를 구현하였다. 시뮬레이터와의 시각정보 동기화를 위해 Amplicon사의 PCI-215 타이머카드를 이용하였고, 그 결과, 이동체 운동궤적제어시스템과 시뮬레이터의 시각정보를 $10^{-3}$ 내의 위치오차를 가지는 정밀도로 동기화됨을 확인할 수 있었다.

• Communications for Statistical Applications and Methods
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• v.29 no.2
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• pp.177-191
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• 2022

This paper addresses the use of machine learning methods for causal estimation of treatment effects from observational data. Even though conducting randomized experimental trials is a gold standard to reveal potential causal relationships, observational study is another rich source for investigation of exposure effects, for example, in the research of comparative effectiveness and safety of treatments, where the causal effect can be identified if covariates contain all confounding variables. In this context, statistical regression models for the expected outcome and the probability of treatment are often imposed, which can be combined in a clever way to yield more efficient and robust causal estimators. Recently, targeted maximum likelihood estimation and causal random forest is proposed and extensively studied for the use of data-adaptive regression in estimation of causal inference parameters. Machine learning methods are a natural choice in these settings to improve the quality of the final estimate of the treatment effect. We explore how we can adapt the design and training of several machine learning algorithms for causal inference and study their finite-sample performance through simulation experiments under various scenarios. Application to the percutaneous coronary intervention (PCI) data shows that these adaptations can improve simple linear regression-based methods.

• Journal of the Korean Society of Radiology
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• v.6 no.1
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• pp.5-10
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• 2012

There is a still unsettled issue about the comparison of long-term clinical effects between sirolimus-(SES) and paclitaxel-eluting stents (PES) for the patients with acute myocardial infarction (AMI). Therefore, we performed a retrospective analysis to evaluate the 4-year clinical outcome of SES as compared with PES after percutaneous coronary intervention (PCI) in patients with AMI. From January 2004 to August 2006, all consecutive patients with acute ST-segment elevation myocardial infarction (STEMI) underwent primary PCI and acute NSTEMI underwent PCI by implantation either SES or PES were enrolled. The occurrence of death, cardiac death, recurrent infarction, target vessel revascularization (TVR) and stent thrombosis were analyzed. The composite of major adverse cardiac events (MACE; death, recurrent infarction and TVR) were also analyzed. During the study period, total 668 AMI patients had visited. Of them, total 522 patients (299 with SES and 223 with PES) were enrolled. During 4-year clinical follow-up, there were similar occurrences of death ($18.3{\pm}3.0%$ vs. $14.6{\pm}2.2%$, p=0.26), cardiac death ($11.2{\pm}2.6%$ vs. $6.8{\pm}1.52%$, p=0.39), re-infarction ($6.4{\pm}1.8%$ vs. $3.3{\pm}1.1%$, p=0.31), and stent thrombosis ($5.4{\pm}1.7%$ vs. $3.2{\pm}1.1%$, p=0.53) between the two groups, consecutively. The occurrences of TVR ($10.0{\pm}3.0%$ vs. $4.0{\pm}1.2%$, p=0.008) and MACE ($29.4{\pm}3.5%$ vs. $19.4{\pm}2.5%$, p=0.003) were significantly higher in patients treated with PES than SES. In AMI patients treated with either SES or PES implantation, SES had a significantly lower risk of TVR and MACE during 4-year clinical follow-up. Rates of death, cardiac death or recurrent infarction, and stent thrombosis were similar.

• Journal of the Korea Concrete Institute
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• v.11 no.6
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• pp.57-67
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• 1999

Optimization scheme is presented for the design of precast prestressed double-tee beams used as slabs in the parking or market structures. The objective considered is defined by a function that minimizes the hight of the double-tee beam, including the prefabricated element and the concrete topping poured in a second phase. The Sequential Quadratic Programming method is adopted to solve the problem. As an example 12 double-tee beams are designed with the design loads of the current design code of our country. The results from optimization process show that at least 29cm less in overall height than that designed by PCI design handbook. The section determined from the optimization process was refined for practical considerations. A MathCad 7.0 Pro Spreadsheet was prepared to verify all ACI requirements for flexure, shear and deflections. Flexural tests are performed on four full-scale 12.5m prototype models and show that all the specimens are fully comply the flexural strength requirements as specified by ACI 318-95. The present optimization scheme can be used for wider application of the design of precast prestressed double-tee beams with different materials and configurations particularly for in a large scale or for important designs.

• Journal of Digital Convergence
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• v.19 no.12
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• pp.661-673
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• 2021

This study is a descriptive study to understand the effect on the health behavior compliance of men who got coronary intervention, focusing on the elapsed period. The subjects of this study were 249 men who underwent coronary intervention at a university hospital, and the collected data were analyzed using Stepwise multiple regression. As a result of the study, the influencing factors the implementation of healthy behaviors were self-regulation(β=0.35, p<.001), risk factors among educational request(β=-0.26, p<.001), and the elapsed period(β=0.19, p<.001), marital status(β=0.15, p=.001), educational level(β=-0.12, p=.035), and the total explanatory power was 29.1%. IIn order to increase the health behavior performance of male patients who underwent coronary intervention, it is necessary to develop a program that can strengthen the autonomous motivation of subjects with high severity and elapsed time of less than 1 year and more than 1 year.

• Polymer(Korea)
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• v.29 no.2
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• pp.140-145
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• 2005

Effects of the polyol type and the hard segment content of thermoplastic polyurethane (TPU) on the crystallization of hard segments in TPUs were studied employing differential scanning calorimetry. Diols used for the preparation of TPUs were poly(tetramethylene ether glycol) (PTMEG), poly(propylene glycol) (PPG), polycaprolactone (PCL), poly(butylene adipate) (PBA) the molecular weights of which were 2000 and the hard segments contents of TPUs were $35\~44\;wt\%$. We found that crystallization of hard segments in TPUs were observed at higher temperatures and became faster with increasing hard segment contents of TPUs. The crystallization rate of TPU was also affected by the types of polyols used for the preparation of TPUs. It is postulated that lower miscibility of soft segments and hard segments results in higher crystallization rate and increase of cooling crystallization temperatures due to better hydrogen bending between hard segments in melts.

• Journal of Soil and Groundwater Environment
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• v.18 no.1
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• pp.36-45
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• 2013

We analyzed natural radionuclides in 80 wells in volcanic rock areas and investigated environmental characteristics. Uranium and radon concentrations ranged from ND to $9.70{\mu}g/L$ (median value: 0.21) ${\mu}g/L$, 38~29,222 pCi/L (median value: 579), respectively. In case of gross-${\alpha}$, 26 samples exceeded MDA (minimum detectable activity, < 0.9 pCi/L) value and the activity values ranged from 1.05 to 8.06 pCi/L. The radionuclides concentrations did not exceed USEPA MCL (maximum contaminant level) value of Uranium ($30{\mu}g/L$) and gross-${\alpha}$ (15 pCi/L). But Rn concentrations in 4 samples exceeded USEPA AMCL (Alternative maximum contaminant level, 4,000 pci/L) and one of them showed a significantly higher value (29,222 pCi/L) than the others. The levels of uranium concentrations in volcanic rock aquifer regions were detected in order of andesite, miscellaneous volcanic rocks, rhyolite, basalt aquifer regions. Radon, however, was detected in order of miscellaneous volcanic rocks, rhyolite, andesite, basalt aquifer regions. The correlation coefficient between uranium and radon was r = 0.45, but we found that correlations of radionuclides with in-situ data or major ions were weak or no significant. The correlation coefficient between the depth of wells and uranium concentrations was a slightly higher than that of depth of wells and radons. Radionuclide concentrations in volcanic rock aquifers showed lower levels than those of other rock aquifers such as granite, metamorphic rock aquifers, etc. This result may imply difference of host rock's bearing-radioactive-mineral contents among rock types of aquifers.

• Radiation Oncology Journal
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• v.16 no.3
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• pp.291-301
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• 1998

Purpose : A retrospective study was conducted comparing single daily fraction (SDF) thoracic radiotherapy (TRT) with twice daily (BID) TRT to determine the potential benefit of BID TRT in limited-stage small cell lung cancer (SCLC). Endpoints of the study were response. survival, pattern of failure, and acute toxicity. Materials and Methods : Between November 1989 to December 1996, 78 patients with histologically proven limited-stage SCLC were treated at the Department of Therapeutic Radiology, Chungnam National University Hospital. Of these, 9 were irradiated for palliative intent, and 1 had recurrent disease. Remaining 68 patients were enrolled in this study. There were 26 patients with a median age of 58 years, and 22 (85$\%$) ECOG performance score of less than 1 in SDF TRT. There were 42 patients with a median age of 57 years, and 36 (86$\%$) ECOG performance score of less than 1 in BID TRT By radiation fractionation regimen, there were 26 in SDF TRT and 42 in BID TRT. SDF TRT consisted of 180 cGy, 5 days a week. BID TRT consisted of 150 cGy BID, 5 days a week in 13 of 42 and 120 cGy BID, in 29 of 42. And the twice daily fractions were separated by at least 4 hours. Total radiotherapy doses were between 5040 and 6940 cGy (median, 5040 cGy) in SDF TRT and was between 4320 and 5100 cGy (median, 4560 cGy) in BID TRT. Prophylactic cranial irradiation (PCI) was recommended for patients who achieved a CR. The recommended PCI dose was 2500 cGy/10 fractions. Chemotherapy consisted of CAV (cytoxan 1000 mg/$m^2$, adriamycin 40 mg/$m^2$, vincristine 1 mg/$m^2$) alternating with VPP (cisplatin 60 mg/$m^2$, etoposide 100 mg/$m^2$) every 3 weeks in 25 (96$\%$) of SDF TRT and in 40 (95$\%$) of BID TRT. Median cycle of chemotherapy was six in both group. Timing for chemotherapy was sequential in 23 of SDF TRT and in 3 BID TRT, and concurrent in 3 of SDF TRT and in 39 of BID TRT Follow-up ranged from 2 to 99 months (median, 14 months) in both groups. Results : Of the 26 SDF TRT, 9 (35$\%$) achieved a complete response (CR) and 14 (54$\%$) experienced a partial response (PR). Of the 42 BID TRT, 18 (43$\%$) achieved a CR and 23 (55$\%$) experienced a PR. There was no significant response difference between the two arms (p=0.119). Overall median and 2-year survival were 15 months and 26.8$\%$, respectively. The 2-year survivals were 26.9$\%$ and 28$\%$ in both arm, respectively (p=0.51). The 2-rear survivals were 35$\%$ in CR and 24.2$\%$ in PR, respectively. The grade 2 to 3 esophageal toxicities and grade 2 to 4 neutropenias were more common in BID TRT (p=0.028 0.003). There was no difference in locoregional and distant metastasis between the two arms (p=0 125 and 0.335, respectively). The most common site of distant metastasis was the brain. Conclusion : The median survival and 2-year survival were 17 months and 20.9$\%$ in SDF TRT with sequential chemotherapy, and 15 months and 28$\%$ in BID TRT with concurrent chemotherapy, respectively. We did not observe a substantial improvement of long-term survival in the BID TRT with concurrent chemotherapy compared with standard schedules of SDF TRT with sequential chemotherapy. The grade 2 to 3 esophageal toxicities and glade 2 to 4 neutropenias were more common in BID TRT with concurrent chemotherapy. Although the acute toxicities were more common in BID TRT with concurrent chemotherapy than SDF TRT with sequential chemotherapy, a concurrent chemotherapy and twice daily TRT was feasible. However further patient accrual and long-term follow up are needed to determine the potential benefits of BID TRT in limited-stage SCLC.