• Title/Summary/Keyword: P27

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Factors Affecting on Smartphone Addiction according to the Classification of Addiction-risk Groups among College Students: A Focus on Self-control (대학생의 스마트폰 중독 분류군 별 중독에 영향을 미치는 요인: 자기통제력을 중심으로)

  • Jang, In Sun;Park, Seungmi
    • Korean Journal of Adult Nursing
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    • v.27 no.6
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    • pp.634-643
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    • 2015
  • Purpose: The purpose of the study was to investigate the factors affecting on smartphone addiction according to the classification of addiction-risk groups among college students, focusing on self-control. Methods: A sample of 242 college students at K University in Seoul was recruited to participate in the study. A structured questionnaire composed of items for the self-rated smartphone addiction scale and self-control scale was used to collect data. Results: The number of students in smartphone addiction-risk group was 66 (27.3%). This study had 17.5% of the explanatory power, including perceived smartphone necessity (${\beta}=.330$, p=.007), and instant self-control (${\beta}=-.281$, p=.028) in addiction-risk group. Whereas, in non-risk group, the affecting factors included gender (${\beta}=.194$, p=.004), self-awareness of addiction (${\beta}=-.290$, p<.001), and instant self-control (${\beta}=-.281$, p<.001) with 31.3% of the explanatory power. Conclusion: There is a need to develop an intervention program to prevent the addiction of smartphones and to improve self-control among college students.

Pediatric nurses' grit and nursing intention during the COVID-19 pandemic: Mediating and moderating effects of mindset and psychological collectivism

  • Chu, Young Soo;Oh, Won-Oak;Park, Il Tae;Lee, Anna;Jung, Myung-Jin
    • Child Health Nursing Research
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    • v.27 no.4
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    • pp.395-403
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    • 2021
  • Purpose: This study aimed to identify the mediating and moderating effects of mindset and psychological collectivism, respectively, on the relationship between grit and nursing intention for children with emerging infectious diseases, including coronavirus disease 2019 (COVID-19), among pediatric nurses. Methods: We conducted a cross-sectional descriptive study with 230 pediatric nurses. Results: Grit directly impacted mindset (β=.27, p<.001) and nursing intention (β=.20, p=.001). The direct effect of mindset on nursing intension (β=.28, p<.001) and the indirect effect of grit on nursing intension via mindset (β=.08, p<.001) were significant. Accordingly, mindset mediated the effect of grit on nursing intention. The effects of grit and psychological collectivism (β=.19, p=.003), respectively, on nursing intention were significant. However, the interaction between grit and psychological collectivism was not significant. Thus, psychological collectivism did not moderate the effect of grit on nursing intention. Conclusion: The findings demonstrate the importance of pediatric nurses' grit and mindset on their intended care for patients in critical situations. Cultivating a gritty culture and developing interventions to enhance nurses' personality traits associated with their performance will be crucial, and such measures are especially salient for pediatric nurses to face the new adjustments required in the era of COVID-19.

MicroRNA-802 Promotes Osteosarcoma Cell Proliferation by Targeting p27

  • Cao, Zhong-Qing;Shen, Zan;Huang, Wei-Yi
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.12
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    • pp.7081-7084
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    • 2013
  • MicroRNAs have been demonstrated to regulate proliferation and apoptosis in many types of cancers, but biological functions in osteosarcomas remain relatively unknown. Here, we found expression of miR-802 to be up-regulated in osteosarcoma tissues in comparison with adjacent normal tissues. Enforced expression of miR-802 was able to promote cell proliferation in U2OS and MG63 cells, while miR-802 antisense oligonucleotides (antisense miR-802) inhibited cell proliferation. At the molecular level, our results further revealed that expression of p27, a negative cell-cycle regulator, was negatively regulated by miR-802. Therefore, the data reported here indicate that miR-802 is an important regulator in osteosarcoma, our findings contributing to a better understanding of important mis-regulated miRNAs in this tumour type.

The influence of social support and health promotion behaviors on nursing work performance among nurses (간호사가 지각하는 사회적 지지, 건강증진행위가 간호업무성과에 미치는 영향)

  • Choi, Eunbi;Yoo, Kyung Hee
    • The Journal of Korean Academic Society of Nursing Education
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    • v.27 no.3
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    • pp.333-341
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    • 2021
  • Purpose: The purpose of this study was to examine the predicting factors of nursing work performance. Methods: The participants in this study were 148 nurses working in S university hospital in P city. The scales included social support, health promoting lifestyle profile-II (HPLP-II), and nursing work performance. A descriptive analysis and stepwise multiple regression were used for data analysis. Results: Significant correlations were found among social support, health promotion behaviors and nursing work performance. The significant predictive factors of nursing work performance were the emotional support subscale of social support (β=.31, p<.001) and the interpersonal relations subscale of health promotion behaviors (β=.32, p<.001). These two subscales explained 27% of nursing work performance. Conclusion: Nursing education programs should include an emphasis on developing methods of emotional support and interpersonal relations in order to improve nursing work performance among clinical nurses.

NEIGHBORHOOD SPACES AND P-STACK CONVERGENCE SPACES

  • Park, Sang-Ho
    • East Asian mathematical journal
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    • v.21 no.1
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    • pp.27-39
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    • 2005
  • We will define p-stack convergence spaces and show that each neighborhood structure is uniquely determined by p-stack convergence structure. Also, we will show that p-stack convergence spaces are a generalization of neighborhood spaces.

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Studies on the Production of All-Female Populations of Olive Flounder, Paralichthys olivaceus IV. Sex Determination by Water Temperature During Sex Differentation Period (넙치 전 암컷 집단의 생산을 위한 연구 IV. 성분화 기간 중 수온에 의한 성 결정)

  • Kim Kyung-Kil;Bang In Chul;Kim Yoon
    • Journal of Aquaculture
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    • v.9 no.4
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    • pp.429-435
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    • 1996
  • We investigated the effects of rearing water temperatures during sex differentiation period on sex ratios in olive flounder, Paralichthys olivaceus. Control and gynogenetic diploid juvenile flounder reared at water temperature of 18, 21, 24 and $27^{\circ}C$ for 65 days from 35 to 100 days after hatching. Fish were sampled to examine sex ratios at 195 or 260 days after hatching. Female ratios of control and gynogenetic diploid flounder declined rapidly as water temperature increased. Sex ratio of gynogenetic diploid reared at $27^{\circ}C$ was very close to 1 : 1 ratio (P<0.01), The survival rates of control and gynogenetic diploid reared at $27^{\circ}C$ were different from other water temperature groups. The growth of body weight of control and gynogenetic diploid reared at $18^{\circ}C$ were different from other water temperature groups.

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Characterization of CYP125A13, the First Steroid C-27 Monooxygenase from Streptomyces peucetius ATCC27952

  • Rimal, Hemraj;Subedi, Pradeep;Kim, Ki -Hwa;Park, Hyun;Lee, Jun Hyuck;Oh, Tae-Jin
    • Journal of Microbiology and Biotechnology
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    • v.30 no.11
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    • pp.1750-1759
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    • 2020
  • The characterization of cytochrome P450 CYP125A13 from Streptomyces peucetius was conducted using cholesterol as the sole substrate. The in vitro enzymatic assay utilizing putidaredoxin and putidaredoxin reductase from Pseudomonas putida revealed that CYP125A13 bound cholesterol and hydroxylated it. The calculated KD value, catalytic conversion rates, and Km value were 56.92 ± 11.28 μM, 1.95 nmol min-1 nmol-1, and 11.3 ± 2.8 μM, respectively. Gas chromatography-mass spectrometry (GC-MS) analysis showed that carbon 27 of the cholesterol side-chain was hydroxylated, characterizing CYP125A13 as steroid C27-hydroxylase. The homology modeling and docking results also revealed the binding of cholesterol to the active site, facilitated by the hydrophobic amino acids and position of the C27-methyl group near heme. This orientation was favorable for the hydroxylation of the C27-methyl group, supporting the in vitro analysis. This was the first reported case of the hydroxylation of cholesterol at the C-27 position by Streptomyces P450. This study also established the catalytic function of CYP125A13 and provides a solid basis for further studies related to the catabolic potential of Streptomyces species.

Comparison of Antimicrobial and Antioxidant Activities by Different Extraction Methods in Korean Bamboos (한국산 대나무의 추출방법에 따른 항균 및 항산화 특성)

  • Choi, Hwan-Seok;Kim, Gwui-Cheol;Shin, Hyun-Jae
    • KSBB Journal
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    • v.27 no.2
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    • pp.131-135
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    • 2012
  • To develop potential cosmetic ingredients with antimicrobial and antioxidant activities of 4 Korean bamboo species (P. bambusoides, P. nigra var. henonis, P. pubescens and Sasa coreana) using three different extraction methods-water, ethanol and supercritical fluid extraction. Antimicrobial activities and DPPH assay have been examined. Among the antimicrobial activities against two test strains, Escherichia coli and Staphylococcus aureus, ethanol extracts of 3 bamboo trees, P. bambusoides, P. nigra var. henonis, and P. pubescens, showed stronger than those of supercritical extracts. However, 4 bamboo supercritical extracts showed dose-dependent increase in antioxidant activity by DPPH assay. These results suggest that water fraction of bamboo extracts may be useful for the cosmetic ingredient with low cytotoxicity.

WEYL'S TYPE THEOREMS FOR ALGEBRAICALLY (p, k)-QUASIHYPONORMAL OPERATORS

  • Rashid, Mohammad Hussein Mohammad;Noorani, Mohd Salmi Mohd
    • Communications of the Korean Mathematical Society
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    • v.27 no.1
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    • pp.77-95
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    • 2012
  • For a bounded linear operator T we prove the following assertions: (a) If T is algebraically (p, k)-quasihyponormal, then T is a-isoloid, polaroid, reguloid and a-polaroid. (b) If $T^*$ is algebraically (p, k)-quasihyponormal, then a-Weyl's theorem holds for f(T) for every $f{\in}Hol({\sigma}T))$, where $Hol({\sigma}(T))$ is the space of all functions that analytic in an open neighborhoods of ${\sigma}(T)$ of T. (c) If $T^*$ is algebraically (p, k)-quasihyponormal, then generalized a-Weyl's theorem holds for f(T) for every $f{\in}Hol({\sigma}T))$. (d) If T is a (p, k)-quasihyponormal operator, then the spectral mapping theorem holds for semi-B-essential approximate point spectrum $\sigma_{SBF_+^-}(T)$, and for left Drazin spectrum ${\sigma}_{lD}(T)$ for every $f{\in}Hol({\sigma}T))$.

The Clinical Features of Pertussis in Infancy (영아 백일해의 임상 양상)

  • Kim, Soon Ju;Kim, Sang-Eun;Kim, Jong-Hyun;Lee, Jung-Hyun;Oh, Jin Hee;Koh, Dae Kyun;Sung, Hwa Young;Yu, Jae-Yon
    • Pediatric Infection and Vaccine
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    • v.16 no.2
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    • pp.167-174
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    • 2009
  • Purpose : Pertussis was very common in the past, but reported cases have dramatically decreased. The improvement of vaccination programs and unreadiness of laboratory confirmation seems to have developed this situation. This study investigated the frequency of pertussis among infants with a paroxysmal cough and compared the clinical characteristics between infants with and without pertussis. Methods : Between June and November 2006, 27 infants admitted to the hospital that were 15-90 days old with a history of a cough for more than seven days were enrolled. The cough was described as: paroxysmal, whooping, and post-tussive vomiting. PCR and cultures for Bordetella pertussis with nasopharyngeal aspirates were obtained. The patients were divided into two groups: (1) the pertussis group that had positive results by PCR or culture; (2) the control group that had negative results by PCR and culture. Clinical and laboratory characteristics were compared between the two groups. Results : Among the 27 cases, five (18.5%) were finally diagnosed with pertussis. Only one out of the five pertussis cases was initially diagnosed with a pertussis-like syndrome on admission. Compared to the group without pertussis, the pertussis group had a significantly higher frequency of: no fever (P =0.043), a paroxysmal cough (P =0.040), cyanosis (P =0.001), non-immunized status for DTaP (P =0.047), normal auscultation (P =0.028), normal chest X-ray findings (P =0.027), high absolute lymphocyte count (P =0.039), and low CRP (P =0.046). The patients with the diagnosis of pertussis had a significantly longer duration of coughing (27.2${\pm}$10.6 vs. 12.6${\pm}$5.6 days, P =0.039). Conclusion : Pertussis should be suspected in any infant with typical symptoms of pertussis in addition to: a persistent cough without fever, accompanied by paroxysms or cyanosis prior to the age of DTaP immunization. Active laboratory confirmation should be carried out to confirm more cases with pertussis.

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