• 제목/요약/키워드: P242

검색결과 595건 처리시간 0.022초

Expression of Inflammasome Complex Following Various Oral Bacterial Infection in THP-1 Cells

  • Na, Hee Sam;Kim, Su Mi;Song, Yu Ri;Chung, Jin
    • International Journal of Oral Biology
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    • 제41권4호
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    • pp.237-242
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    • 2016
  • Interleukin-1b ($IL-1{\beta}$), a proinflammatory cytokine, regulates the innate immune responses against bacterial infection. Mature $IL-1{\beta}$ is produced from $pro-IL-1{\beta}$ by activated caspase-1, which in turn is activated by the inflammasome complex formation. In this study, we compared the inflammasome mRNA expression induced by S. sanguinis, S. oralis, F. nucleatum and P. intermedia. Among the tested bacteria, S. sanguinis induced the highest $IL-1{\beta}$ secretion. S. oralis, F. nucleatum and P. intermedia induced very weak $IL-1{\beta}$ secretion. S. sanguinis mostly induced the NLRP3 mRNA expressions. Although F. nucleatum did not induce high $IL-1{\beta}$ secretion, it induced high expression levels of AIM2, NLRP2, and NLRP3. No specific inflammasomes were induced by S. oralis and P.intermedia. Studying the inflammasome complex activation induced by oral bacteria may thus enhance our understanding of the pathogenesis of oral diseases.

Blended learning을 이용한 임상실습 오리엔테이션 프로그램의 효과 (Effects of a Blended Learning Orientation Program for Clinical Practicums of Nursing Students)

  • 이여진
    • 한국간호교육학회지
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    • 제14권1호
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    • pp.30-37
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    • 2008
  • Purpose: This study proposed to examine the effects of a blended-learning orientation program executed for nursing students' clinical practice. Method: The participants were 61 nursing students in the experimental group and 57 in the control group. For the experimental group, a blended-learning orientation program was executed by e-learning (on-line) and lecture-led training (off-line) from two-week before the start of clinical practice in medical-surgical nursing. For the control group, orientation was given in the traditional lecture-led training by distributing printed materials before clinical practice. A pre-test was conducted on the experimental and control group before clinical practice, and a post-test was conducted after two-week of clinical practice in order to examine the effects of the orientation program. Results: After two-week of clinical practice, differences were observed between the experimental group and the control group in adaptation to clinical practice (F=10.242, p=.002), communication skills (F=4.305, p=.040) and clinical competence (F=6.823, p=.010). Conclusions: The blended-learning orientation program enhanced nursing students' adaptation to clinical practice, improved their communication skill and increased their clinical competence. Accordingly, it is recommended to develop and apply practical education using blended-learning in the area of nursing science.

영아 어머니의 양육 태도와 모성역할 긴장과의 관계 (A Study of the Relationship between the Child-rearing Attitudes and the Maternal Role Strain in Mothers with Infants)

  • 박정모;김은주
    • 대한간호학회지
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    • 제34권2호
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    • pp.235-242
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    • 2004
  • Purpose: The main purpose of this study was to identify the correlation between the child rearing attitudes and the maternal role strain of mother with infants. Method: This study is designed as a descriptive research study and the data was collected from 82 mothers and infants by means of an interview and questionnaire in a period from July 2002 to December 2002, when they came to screen their infant's growth and developmental state at a public health center. Result: The results of this study were as follows: There was a significant positive correlation between the child rearing attitudes and maternal role strain(r.=.53, p=.000). There was a significant difference between the father's employment state and child rearing attitude of mothers(t.=5.22, p<.000). There was a significant difference between male infant and female infants in maternal role strain(t.=3.8, p=0.04). Conclusion: When the child rearing attitude was positive, the subject's maternal role strain was high. Also further research is needed on social support or other factors in the subjects in child-rearing attitudes and maternal role strain.

개심술 환자 가족의 불안에 관한 연구 (A Study on the Anxiety of Open Heart Surgery Patient's Family)

  • 최영희
    • 대한간호
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    • 제31권5호
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    • pp.29-38
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    • 1992
  • The purpose of this is to find the anxiety score of OHS pt's family and general surgery pt's family and to offer basic data. The subjects of this study were 80 : 40 were OHS pt's family in Seoul Hospital and remaining 40 were OS pt's family in Capital Hospital. The data was collected between March 1, through May 30, 1992. The instruments used for this study were Zung's The Self-Rating Anxiety Scale. The collected daLa were analyzed using percentage, descriptive statistics, $X^2-test$, t-test and Two-way Anova. The finding's were as followed: 1. Test of hypothesis "The anxiety score of the Ol-lS pt's family were similar to as pt's family" was rejected (L=0.772 P>.05) 2. The mean score of anxiety of the OHS pt's family was 1.772, The mean score of anxiety of the OS pt's family was 1,790. 3. The relationship between anxiety of the OHS pt's family and GS pt's family and family's age was significant (P<.Ol) and the relationship between anxiety and age interaction effect. (F=242.0 P<.01) In conclusion, the anxiety score of the OI-IS pt's finding and GS pt's family was all high.

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치위생과 학생의 인터넷 윤리의식과 인터넷 윤리 실천의지의 영향요인 (Factors affecting the awareness of internet ethics and the intention to practice internet ethics in dental hygiene students)

  • 김윤정
    • 한국치위생학회지
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    • 제17권6호
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    • pp.1183-1193
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    • 2017
  • Objectives: The purpose of the study was to investigate factors affecting the awareness of internet ethics and intention to practice internet ethics in dental hygiene students. Methods: A self-reported questionnaire was completed by 254 dental hygiene students in the Jeonnam area from September 1 to 22, 2017. The data were analyzed by exploratory factor analysis, Pearson's correlation analysis and multiple regression analysis using the SPSS 12.0 program. Results: Factors affecting the awareness of internet ethics were personal information sensitivity (${\beta}=0.242$, p<0.01) and ethical identity(${\beta}=0.185$, p<0.05) (Adjusted $R^2=0.143$). The factor related with intention to practice internet ethics was personal information sensitivity (${\beta}=0.464$, p<0.001) (Adjusted $R^2=0.212$). Conclusions: To improve the awareness of internet ethics and intention to practice internet ethics in dental hygiene students, it is necessary to promote internet ethics education in as a part of curriculum and develop internet ethics education's program to enhance personal information sensitivity and ethical identity.

수량적 접근 방법에 의한 이진 검색 트리 불균형도에 따른 검색 성능 비교 분석 (Quantitative approach to analyze searching efficiencies varying degrees of imbalance in a binary search tree)

  • 김숙영
    • 한국컴퓨터산업학회논문지
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    • 제3권2호
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    • pp.235-242
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    • 2002
  • 트리 재균형 과정을 최소화하기 위하여 이진 검색 트리의 불균형도에 따른 검색 성능에 관한 수량적 정보를 얻기 위한 실험이 행하여졌다. 트리를 구성하는 노드들의 좌, 우 서브트리 높이 차 인 균형 인수에 의하여 불균형도를 수량화 한 결과 불균형도가 심해질수록 검색성능이 저하됨이 실험 자료들에 의하여 확률적으로 증명되었고 (p<0.01), 노드 개수와 평균 검색 횟수 관계를 설명하기 위한 모형으로는 로그 모형 보다 선형 모형이 적합한 경향을 보였다. 그러나 균형 인수 크기가 3 미만인 노드들만으로 구성된 이진 검색 트리의 성능은 높이 균형이진 트리에 비하여 저하되지 않는 것으로 평가된다. 본 연구 결과들은 이진 트리를 자료 구조를 사용하는 소프트웨어 관리에 적용될 수 있을 것이다.

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향나무 추출물의 항말라리아 효과 (In vitro Anti-malarial Activity of Juniperus Chinensis Extract)

  • 이경호;김병수;최영호;이기형
    • 생약학회지
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    • 제43권3호
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    • pp.239-242
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    • 2012
  • This study was carried out to investigate the anti-malarial activity of Juniperus chinensis by in vitro and in vivo system using Plasmodium falciparum chloroquine-sensitive(3D7) and P. falciparum chloroquine-resistant(S20) strains. According to cytotoxicty test on NIH 3T3 cell, the ethanol extract(EtOH), ethylacetate(EtOAc) fraction and aqueous fraction possessed significant anti-malarial activity against both 3D7 and S20 strains at non-toxic concentrations(<100 /). In vitro assay, EtOAc fraction showed notable activity against 3D7 and S20 strains of P. falciparum with $IC_{50}$ values of $37{\pm}2{\mu}g/ml$ and $36{\pm}6{\mu}g/ml$. In animal test using P. falciparum infected human erythrocytes, the treatment of EtOAc fraction significantly inhibited parasitaemia in mice in a dose-dependent manner that is parasitaemia of 42%, 34% and 31% in doses of 10 mg/kg, 20 mg/kg and 40 mg/kg, respectively. The study provides data to support the medicinal importance of the J. chinensis.

대상자가 인지한 의료서비스 질과 재이용 의도와의 관계 (The Relationships Between Patient's Perceived Quality of Healthcare Service and Intention to Re-visit)

  • 노은경;오숙희
    • 간호행정학회지
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    • 제14권2호
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    • pp.176-181
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    • 2008
  • Purpose: This study was performed to identify the relationship between patient's perceived quality of healthcare services and intention to re-visit. Method: The study subjects were 242 patients from three local clinics. The data were analyzed using SPSS PC+ 12.0 program for descriptive, Pearson's correlation coefficient, and multiple regression analysis. Result: Patients' perceived quality of healthcare services was measured 5.73$\pm$0.71 using the 7-point scale. The patients' perceived quality was moderately correlated with patient satisfaction (r=0.647, p<0.001) and intention to re-visit (r=0.604, p<0.001). Also, patient satisfaction was highly correlated with intention to re-visit (r=0.788, p<0.001). 3) the reliability factor of patients' perceived quality of healthcare services and patient satisfaction were found significant predictors of intention to re-visit. Conclusion: In conclusion, service quality evaluated by patients influenced on their intention of re-visit and especially, reliability was the most significantly influential variable.

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PREPARATION AND PROPERTIES OF OIL-BASED MAGNETIC FLUIDS WITH THE SYNTHESIZED MAGNETITE

  • Jang, K.O.;Doh, S.W.;Cho, S.I.;Shon, H.J.;Hur, W.D.
    • 한국자기학회지
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    • 제5권5호
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    • pp.819-823
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    • 1995
  • The oil-based magnetic fluids were sysnthesized using ultra-fine $Fe_{3}O_{4}$ powder dispersed in hydrocarbon oil. To synthesize ultra-fine $Fe_{3}O_{4}$, we carried out the experiments varying the pH of reacting medium and the initial concentration of $Fe^{2+}$. We also investigated the amount of oleic acid to obtain a stable dispersion and the proper base oil of MF for loudspeaker application. The limits of adsorbed amount of oleic acid on the $Fe_{3}O_{4}$ surface were approximately 35~40 percents of the total magnetite weight. As the $Fe_{3}O_{4}$ content increased from 0.1g/cc to 0.6g/cc, the viscosity of oil-based magnetic fluid increased from 1,063cP to 1,828cP, and its saturation magnetization at 10kOe increased from 66G to 242G. When we tested the MF sample to a commercial speaker, improvements were noted.

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Verification of Effectiveness and Satisfaction Survey for the Korean Computer-based Cognitive Rehabilitation Programs(CoTras)

  • Chae, Soo-Gyung
    • International Journal of Internet, Broadcasting and Communication
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    • 제14권3호
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    • pp.230-242
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    • 2022
  • The purpose of this study was to verify the effectiveness of the computerized cognitive rehabilitation program in which areas and to suggest effective ways to utilize the program in the future, being conducted for 20 college students. We lasted this study from May 3 to 23, 2021. As a result of analyzing the groups using the Computer-based Cognitive Rehabilitation Program (CoTras), in terms of the difference in accuracy for the case of visual perception group B was statistically significantly improved than group C(p<0.05). In the case of attention, memory, and orientation, there was no significant difference between groups(p>0.05). In the case of reaction time difference, there was no significant difference between groups in visual perception, concentration, memory, and orientation(p>0.05). And in order to improve attention and visual perception, it is recommended to conduct the program three times with a duration of 20 minutes, and in order to improve orientation and memory, it can be said that it is helpful to conduct one experiment for at least 30 minutes rather than conducting short and frequent experiments. Through this study, we found that it is effective to apply different times according to each area to improve cognitive function. In other words, depending on the purpose of which cognitive function is to be improved, the duration of the program should be applied differently.