• 한국수학교육학회지시리즈A:수학교육
• /
• 제22권2호
• /
• pp.5-12
• /
• 1984

mod pin Steenrod algebra $A_{p}$ 는 steenrod reduced powers p$^n$ 및 Bockstein coboundary operation $\beta$에서 algebra로서 생성되었다. 그들 사이의 관계도 알려져 있다. 이 논문에서는 iterated loop space의 $A_{p}$ -module structure를 결정하는 한 명제인 (equation omitted)를 증명했다.

• 전기학회논문지
• /
• 제66권12호
• /
• pp.1732-1739
• /
• 2017

This paper presents a sensorless vector control algorithm of closed loop Gopinath flux observer to enhance the robustness at low speed by switching P/PI mode. Closed loop Gopinath flux observer has the problem in sensorless vector control of induction motor at low speed. This paper solves the problem using the characteristic function of closed loop Gopinath flux observer. P mode shows better performance than PI mode under the cut-off frequency of observer. But P mode always has a flux error due to DC offset, so this paper combines P mode and PI mode. This algorithm shows good performance over wide speed range. The performance has been confirmed through computer simulations using MATLAB SIMULINK and experiments.

• Imaging Science in Dentistry
• /
• 제46권2호
• /
• pp.69-75
• /
• 2016

Purpose: Sufficient area in the interforaminal region is required for dental implant placement, and the anterior loop of the mandibular canal is located within the limits of this area. The aim of this study was to evaluate the prevalence and extent of the anterior loop in a Brazilian sample population using cone-beam computed tomography (CBCT). Materials and Methods: CBCT images from 250 patients (500 hemimandibles) obtained for various clinical indications were randomly selected and evaluated to determine the presence and length of the anterior loop. The length of the anterior loop was then compared based on gender, age, and the side of the mandible. The data were analyzed using the Pearson chi-square test and linear regression analysis. Results: An anterior loop was identified in 41.6% of the cases, and its length ranged from 0.25 mm to 4.00 mm (mean, $1.1{\pm}0.8mm$). The loop had a greater mean length and was significantly more prevalent in males (p=0.014). No significant differences were found between the right and left sides regarding length (p=0.696) or prevalence (p=0.650). Conclusion: In this study, a high prevalence of the anterior loop of the mandibular canal was found, and although its length varied greatly, in most cases it was less than 1 mm long. Although this is a prevalent anatomical variation, safety limits for the placement of implants in this region cannot be established before an accurate evaluation using imaging techniques in order to identify and preserve the neurovascular bundles.

• BMB Reports
• /
• 제35권5호
• /
• pp.498-507
• /
• 2002

A gene that encodes a thermostable protease, coined thermicin, has been isolated from Thermoanaerobacter yonseiensis that is expressed and characterized in E. coli.. In order to elucidate the molecular characteristics on thermostability of the enzyme, molecular modeling and mutagenesis technology were applied. In the modeling structure, the structural core, including the active site, was well conserved; whereas, the two loop regions were unique when compared to thermitase. The mutant enzyme with the small loop deleted (D190-I196), based on modeling structural information, showed identical enzyme activity. However, when the large loop was deleted (P233-P244), a little lower $K_m$ and even a lower kcat was found. This indicates that the large loop could influence catalytic activity. However, the unfolding temperature ($T_m$), which was determined by a differential-scanning calorimetry for the mutant enzyme deleted the small loop, was $96^{\circ}C$. This is $14^{\circ}C$ lower than that for the parent thermicin. These results suggest that the small loop may play a role in maintaining the proper folding of the enzyme at high temperatures, whereas the large loop might be related to catalysis.

• Molecules and Cells
• /
• 제39권4호
• /
• pp.299-309
• /
• 2016

We have previously reported the role of miR-217 in anti-cancer drug-resistance. miRNA array and miRNA hybridization analysis predicted miR-30a-3p as a target of miR-217. miR-30a-3p and miR-217 formed a negative feedback loop and regulated the expression of each other. Ago1 immunoprecipitation and co-localization analysis revealed a possible interaction between miR-30a-3p and miR-217. miR-30a-3p conferred resistance to anti-cancer drugs and enhanced the invasion, migration, angiogenic, tumorigenic, and metastatic potential of cancer cells in CAGE-dependent manner. CAGE increased the expression of miR-30a-3p by binding to the promoter sequences of miR-30a-3p, suggesting a positive feedback loop between CAGE and miR-30a-3p. miR-30a-3p decreased the expression of p53, which showed the binding to the promoter sequences of miR-30a-3p and CAGE in anti-cancer drug-sensitive cancer cells. Luciferase activity assays showed that p53 serves as a target of miR-30a. Thus, the miR-30a-3p-CAGE-p53 feedback loop serves as a target for overcoming resistance to anti-cancer drugs.

• Journal of Animal Science and Technology
• /
• 제45권6호
• /
• pp.933-938
• /
• 2003

본 연구는 한우 mt DNA D-loop 영역의 염기변이 다형성과 경제형질간의 관련성을 분석하기 위하여 수행하였다. 한우의 mtDNA D-loop 영역에서 단일염기의 치환 의해 총 25개의 polymorphic site가 확인되었다. 그중 주요 Polymorphic site의 염기변이 빈도는 169, 16042, 16093, 16119, 16255 및 16302번째 위치에서 0.891, 0.117, 0.109, 0.182, 0.197 및 0.117로 검출되었다. 169 및 16119번째 위치에서의 염기치환에 의한 MS의 효과는 -1.08(p〈0.05), 1.29(p〈0.01)로 나타났으며, 169 및 16042번째 위치에서의 염기치환에 의한 BF의 효과는 -0.31(p〈0.01)과 0.34(p〈0.01)로 나타났다. 본 연구에서 검출한 한우 mtDNA내 D-loop 영역의 염기서열 변이 빈도 등은 한우집단의 유전적 변이성 추정과 좀 더 다양한 경제형질과의 관련성 분석은 물론 모계유전 양상 분석을 통한 한우의 형성과정과 타 품종과의 계통분류적 상호 관계 등의 분석에 유용하게 활용할 수 있을 것으로 기대된다.

• 한국정보전자통신기술학회논문지
• /
• 제14권6호
• /
• pp.479-486
• /
• 2021

본 논문에서는 신호감지회로(Signal Sensing Circuit : SSC)를 추가하여 2개의 루프로 구성된 단일 커패시터 루프필터를 가진 극소형 위상고정루프(Phase Locked Loop : PLL)를 제안하였다. 위상고정루프 크기를 극단적으로 줄이기 위하여 가장 많은 면적을 차지하는 수동소자 루프필터를 극소형 단일 커패시터(2pF)로 설계하였다. 신호감지회로가 포함된 내부 부궤환 루프 출력이 외부 부궤환 루프의 단일 커패시터 루프필터 출력에 부궤환 역할을 하여 제안한 극소형 위상고정루프가 안정적으로 동작하도록 설계하였다. 위상고정루프 출력 신호 변화를 감지하는 신호 감지 회로는 루프필터의 커패시턴스 전하량을 조절하여 위상고정루프 출력 주파수의 초과 위상변이를 줄였다. 제안된 구조는 기존 구조에 비해 1/78 정도의 작은 커패시터를 가짐에도 불구하고 지터 크기는 10% 정도 차이가 난다. 본 논문의 위상고정루프는 1.8V 180nm 공정을 사용하였고, Spice를 통해 안정하게 동작하는 시뮬레이션 결과를 보여주었다.

• 한국축산식품학회지
• /
• 제25권2호
• /
• pp.218-225
• /
• 2005

본 연구는 mt DNA의 D-loop 영역을 probe로 이용한 Southern blot hybridization 분석 기법을 이용하여 한우에서 mt DNA의 RFLP를 분석하고 RFLP marker가 유생산에 미치는 영향을 분석하여 산유량 관련 DNA marker를 개발하고자 수행하였다. Mt DNA의 D-loop 영역내 404번부터 15061까지 1142 bp 크기의 염기 서열 부위를 특이적인 primer를 이용하여 PCR로 증폭하였다. Mt DNA를 HpaII, BamHI, XbaI, HinfI, EcoRI, HindII 및 RsaI 7종류의 제한효소를 이용하여 각각 절단한 후 DIG로 표지된 D-loop probe를 이용하여 검출한 결과 XbaI, RsaI, BamHI 및 HpaII 4종류의 제한효소에서 각각 RFLP 다형성이 검출되었고 EcoRI, HindIII 및 HinfI 3종류 제한효소는 변이가 존재하지 않았다. 다유 계통과 저유 계통 선발 집단간의 각 제한효소별 RFLP type의 출현빈도를 비교한 결과 BamHI 및 RsaI 제한효소에서 두 집단간의 RFLP type의 출현율에 각각 통계적 유의성(P<.05)이 인정되었다. 다유 및 저유성으로 극단의 육종가 값을 갖는 두 계통의 mt DNA D-loop영역의 염기 서열을 비교 분석한 결과 441번째 염기가 G/C, 469번째 염기는 T/C, 503번째 염기는 C/T, 569번째 염기는 G/A, 614번째 염기는 C/A그리고 644번째 염기는 C/T로 각각 염기가 치환되었고 특히, 다유 계통 개체의 677번째의 A염기가 저유 계통 개체에서는 결실되어 있다는 사실이 확인되었다. 한편, 한우 암소의 유생산에 영향을 미치는 효과를 규명하기 위하여 mt DNA RFLP 형과 송아지 이유시 체중, 생시체중 및 비유량을 측정하여 얻어진 육종가의 성적을 근거로 통계 분석한 결과 XbaI 제한효소의 RFLP type이 산유 능력 육종가와 유의적인 관련성이 확인되었다 (P<05). 즉, RFLP A type을 갖는 축군의 평균 육종가 추정치가 6.233으로 B type을 갖는 축군의 평균 육종가 추정치 0.757보다 월등히 높은 것으로 나타났다. 결론적으로 산유량과 관련성이 확인된 mt DNA RFLP type은 한우의 산유량 향상을 위한 DNA marker로 이용 가능할 것으로 기대된다.

• 대한수학회보
• /
• 제36권4호
• /
• pp.747-754
• /
• 1999

We compute the mod p homology of the double loop space of Sp(n)/U(n) by the Serre spectral sequence and the Eilenberg-Moore spectral sequence with the homology operations.

• Knee surgery & related research
• /
• 제30권4호
• /
• pp.341-347
• /
• 2018

Purpose: Tunnel widening following anterior cruciate ligament (ACL) reconstruction is commonly observed. Graft micromotion is an important contributing factor. Unlike fixed-loop devices that require a turning space, adjustable-loop devices fit the graft snugly in the tunnel. The purpose of this study is to compare tunnel widening between these devices. Our hypothesis is that the adjustable-loop device will create lesser tunnel widening. Materials and Methods: Ninety-eight patients underwent ACL reconstruction from January 2013 to December 2014. An adjustable-loop device was used in 54 patients (group 1) and a fixed-loop device was used in 44 patients (group 2). Maximum tunnel widening at 1 year was measured by the L'Insalata's method. Functional outcome was measured at 2-year follow-up. Results: The mean widening was 4.37 mm (standard deviation [SD], 2.01) in group 1 and 4.09 mm (SD, 1.98) in group 2 (p=0.511). The average International Knee Documentation Committee score was 78.40 (SD, 9.99) in group 1 and 77.11 (SD, 12.31) in group 2 (p=0.563). The average Tegner-Lysholm score was 87.25 (SD, 3.97) in group 1 and 87.29 in group 2 (SD, 4.36) (p=0.987). There was no significant difference in tunnel widening and functional outcome between the groups. Conclusions: The adjustable-loop device did not decrease the amount of tunnel widening when compared to the fixed-loop device. There was no significant difference in outcome between the two fixation devices. Level of Evidence: Level 3, Retrospective Cohort.